KEGG   ENZYME: 1.3.99.12Help
Entry
EC 1.3.99.12                Enzyme                                 

Name
2-methylacyl-CoA dehydrogenase;
branched-chain acyl-CoA dehydrogenase;
2-methyl branched chain acyl-CoA dehydrogenase;
2-methylbutanoyl-CoA:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
2-methylbutanoyl-CoA:acceptor oxidoreductase
Reaction(IUBMB)
2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor [RN:R03173]
Reaction(KEGG)
R03173 > R03172;
(other) R02661
Show
Substrate
2-methylbutanoyl-CoA [CPD:C01033];
acceptor [CPD:C00028]
Product
2-methylbut-2-enoyl-CoA [CPD:C03345];
reduced acceptor [CPD:C00030]
Comment
Also oxidizes 2-methylpropanoyl-CoA. Not identical with EC 1.3.8.1 (butyryl-CoA dehydrogenase), EC 1.3.8.7 (medium-chain acyl-CoA dehydrogenase), EC 1.3.8.8 (long-chain acyl-CoA dehydrogenase), EC 1.3.8.9 (very-long-chain acyl-CoA dehydrogenase) or EC 1.3.99.10 (isovaleryl-CoA dehydrogenase).
History
EC 1.3.99.12 created 1986
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09478  short/branched chain acyl-CoA dehydrogenase
K11410  short/branched chain acyl-CoA dehydrogenase
Genes
HSA: 36(ACADSB)
PTR: 745464(ACADSB)
PPS: 100991276(ACADSB)
GGO: 101132470(ACADSB)
PON: 100171571(ACADSB)
NLE: 100603582(ACADSB)
MCC: 707487(ACADSB)
MCF: 102133754(ACADSB)
CSAB: 103216651(ACADSB)
RRO: 104658093(ACADSB)
RBB: 108519576(ACADSB)
CJC: 100396089(ACADSB)
SBQ: 101028121(ACADSB)
MMU: 66885(Acadsb)
RNO: 25618(Acadsb)
MUN: 110563205 110564692
CGE: 100766828(Acadsb)
NGI: 103729261(Acadsb)
HGL: 101698912(Acadsb)
CCAN: 109691642(Acadsb)
OCU: 100351868(ACADSB)
TUP: 102474463(ACADSB)
CFA: 477856(ACADSB)
AML: 100470228(ACADSB)
UMR: 103657958(ACADSB)
ORO: 101373794(ACADSB)
FCA: 101092794(ACADSB)
PTG: 102951023(ACADSB)
AJU: 106969392(ACADSB)
BTA: 504301(ACADSB)
BOM: 102266366(ACADSB)
BIU: 109579124(ACADSB)
PHD: 102329883
CHX: 102177588(ACADSB)
OAS: 101102606(ACADSB)
SSC: 100154810(ACADSB)
CFR: 102517479(ACADSB)
CDK: 105085769(ACADSB)
BACU: 102999342(ACADSB)
LVE: 103077062(ACADSB)
OOR: 101289781(ACADSB)
DLE: 111172226(ACADSB)
ECB: 100057998(ACADSB)
EPZ: 103543854 103557817 103562711
EAI: 106847757(ACADSB)
MYB: 102253452(ACADSB)
MYD: 102769159(ACADSB)
MNA: 107532676(ACADSB)
HAI: 109396916(ACADSB)
RSS: 109436395(ACADSB)
PALE: 102891849(ACADSB)
LAV: 100658432(ACADSB)
TMU: 101353141
MDO: 100025277(ACADSB)
SHR: 100925751(ACADSB)
PCW: 110192795(ACADSB)
OAA: 100086999(ACADSB)
GGA: 423947(ACADSB)
MGP: 100542282(ACADSB)
CJO: 107316256(ACADSB)
APLA: 101793844(ACADSB)
ACYG: 106038988(ACADSB)
TGU: 100217590(ACADSB)
LSR: 110468433(ACADSB)
SCAN: 103813777(ACADSB)
GFR: 102040450(ACADSB)
FAB: 101819094(ACADSB)
PHI: 102100927(ACADSB)
PMAJ: 107206820(ACADSB)
CCAE: 111931386(ACADSB)
CCW: 104694570(ACADSB)
ETL: 114070836(ACADSB)
FPG: 101917969(ACADSB)
FCH: 102057808(ACADSB)
CLV: 102096980(ACADSB)
EGZ: 104128327(ACADSB)
NNI: 104022112(ACADSB)
ACUN: 113481576(ACADSB)
AAM: 106494200(ACADSB)
ASN: 102386096(ACADSB)
AMJ: 102577069(ACADSB)
PSS: 102458654(ACADSB)
CMY: 102942130(ACADSB)
CPIC: 101938408(ACADSB)
ACS: 100556766(acadsb)
PVT: 110087224(ACADSB)
PBI: 103066261(ACADSB)
PMUR: 107285940(ACADSB)
GJA: 107116296(ACADSB)
XLA: 494679(acadsb.L)
XTR: 448259(acadsb)
NPR: 108784780(ACADSB)
DRE: 100037342(acadsb)
SRX: 107746745
SANH: 107684586
SGH: 107574492 107580754
IPU: 108273611(acadsb)
PHYP: 113527247(acadsb)
AMEX: 103042655(acadsb)
EEE: 113588401(acadsb)
TRU: 101075946(acadsb)
TNG: GSTEN00012530G001
LCO: 104926628(acadsb)
NCC: 104954036(acadsb)
MZE: 101471898(acadsb)
OLA: 101163855(acadsb)
XMA: 102220838(acadsb)
PRET: 103481581(acadsb)
NFU: 107387801(acadsb)
KMR: 108246997(acadsb)
CSEM: 103381955(acadsb)
LCF: 108899015(acadsb)
SDU: 111220345(acadsb)
HCQ: 109523983(acadsb)
BPEC: 110165473(acadsb)
MALB: 109962961(acadsb)
SASA: 106575476 106577431
SALP: 112075854
ELS: 105009552(acadsb)
SFM: 108939566(acadsb)
PKI: 111853681(acadsb)
LCM: 102365761(ACADSB)
CMK: 103185437(acadsb)
BFO: BRAFLDRAFT_74917
APLC: 110988182
SKO: 100378591
DME: Dmel_CG3902(CG3902)
DPO: Dpse_GA17761
DAN: Dana_GF10801
DER: 6545091
DPE: 6595810
DSE: Dsec_GM14915
DSI: Dsimw501_GD12323(Dsim_GD12323)
DWI: 6645938
DYA: Dyak_GE22545 Dyak_GE22549
DGR: Dgri_GH16965
DMO: Dmoj_GI11829
DNV: 108650232
DHE: 111592256
DVI: Dvir_GJ13529
MDE: 101890297
AGA: AgaP_AGAP009783
AAG: 5569333
CQU: CpipJ_CPIJ009148
AME: 409712
BIM: 100749552
BTER: 100649947
SOC: 105198238 105200366
MPHA: 105829763 105836416
AEC: 105143927
ACEP: 105618707 105620526
PBAR: 105428815
HST: 105185846 109504503
DQU: 106744734 106751200
CFO: 105250026
LHU: 105674413
PGC: 109859061
OBO: 105285330 105286634
PCF: 106790286
NVI: 100120366 103315463
MDL: 103579394
TCA: 657543 660569
DPA: 109540223
NVL: 108567387 108567469
BMOR: 733139(Acade)
DPL: KGM_211032A KGM_211032B
PMAC: 106716140
PRAP: 111002788
HAW: 110372345
TNL: 113505313
PXY: 105383530
API: 100161123
DNX: 107163553
AGS: 114124068
CLEC: 106664106
PHU: Phum_PHUM226870 Phum_PHUM226980
ZNE: 110839588
FCD: 110852222
DPX: DAPPUDRAFT_216649
TUT: 107368035 107368037 107368406
DPTE: 113793263
CEL: CELE_C55B7.4(acdh-1) CELE_K06A5.6(acdh-3) CELE_T10E9.9(acdh-4)
CBR: CBG12633 CBG12644(Cbr-acdh-1) CBG12664
NAI: NECAME_06715
TSP: Tsp_04649
LGI: LOTGIDRAFT_235352
PCAN: 112563554
CRG: 105329007
MYI: 110442658
OBI: 106881672
LAK: 106173907
OVI: T265_13702
NVE: NEMVE_v1g118418
EPA: 110246509
ADF: 107338768
PDAM: 113681854
SPIS: 111331973
HMG: 100205931
TAD: TRIADDRAFT_58518
AQU: 100640316
CME: CYME_CML080C
DDI: DDB_G0282967(acadsb)
DPP: DICPUDRAFT_44750
DFA: DFA_08597(acadsb)
ACAN: ACA1_384630
SMIN: v1.2.033419.t1(symbB.v1.2.033419.t1)
PTI: PHATRDRAFT_20310
FCY: FRACYDRAFT_187779(ACD2)
TPS: THAPSDRAFT_269127(ACD3)
AAF: AURANDRAFT_58548
PIF: PITG_06732 PITG_15615
PSOJ: PHYSODRAFT_350120 PHYSODRAFT_351306
SPAR: SPRG_03679
EHX: EMIHUDRAFT_464665
GTT: GUITHDRAFT_156886
LIF: LINJ_35_2780
LDO: LDBPK_352780
LMI: LMXM_34_2730
LBZ: LBRM_34_2630
NGR: NAEGRDRAFT_56367
AKA: TKWG_20020
SIMP: C6571_14795
SCO: SCO2779(acdH)
SALB: XNR_4209
SMA: SAVERM_5275(fadE4)
SGR: SGR_4756
SGB: WQO_11760
SCB: SCAB_58001(acdH)
SSX: SACTE_2272
SVL: Strvi_8097
SCT: SCAT_1857(yngJ)
SCY: SCATT_18520
SFA: Sfla_4110
SBH: SBI_06919
SHY: SHJG_4280
SHO: SHJGH_4044
SVE: SVEN_2568
SDV: BN159_5499(yngJ1)
SALS: SLNWT_2338
STRP: F750_2606
SFI: SFUL_2370
SCI: B446_14660
SRC: M271_31140
SALU: DC74_3256
SALL: SAZ_17345
SLV: SLIV_23780
SGU: SGLAU_12675
SVT: SVTN_13735
STRE: GZL_05657
SCW: TU94_12155
SLD: T261_5312
SLC: SL103_05390
SXI: SXIM_37940
STRM: M444_13330
STRC: AA958_10345
SAMB: SAM23877_2814(yngJ)
SPRI: SPRI_4763
SCZ: ABE83_24135
SCX: AS200_28470
SRW: TUE45_03394(mmgC_7)
STRF: ASR50_13510
SLE: sle_44610(sle_44610)
SRN: A4G23_01831(mmgC_3)
SPAV: Spa2297_11770
STRT: A8713_11110
SCLF: BB341_18610
SGS: AVL59_41555
STSI: A4E84_14650
SLS: SLINC_3198
SNR: SNOUR_26450
SPLU: LK06_010705
STRD: NI25_24960
SNW: BBN63_22830
SAUO: BV401_17700
SSIA: A7J05_23365
SVU: B1H20_11010
SPUN: BFF78_26595
SGV: B1H19_15645
SMAL: SMALA_2810
SLAU: SLA_2529
SALF: SMD44_03078(acdH)
SALJ: SMD11_4398(acdH)
SLX: SLAV_23940(mmgC10)
STRO: STRMOE7_14480
SFK: KY5_2919
SNZ: DC008_12255
KSK: KSE_26850(fadE3)
KAB: B7C62_10610 B7C62_33350
KAU: B6264_16500
KIT: CFP65_2503
STRI: C7M71_009610
BSD: BLASA_1278
MMAR: MODMU_1452
AAB: A4R43_37215
ACM: AciX9_0500
CTM: Cabther_A0832
 » show all
Taxonomy
Reference
1  [PMID:6401712]
  Authors
Ikeda Y, Dabrowski C, Tanaka K.
  Title
Separation and properties of five distinct acyl-CoA dehydrogenases from rat liver mitochondria. Identification of a new 2-methyl branched chain acyl-CoA dehydrogenase.
  Journal
J Biol Chem 258:1066-76 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.99.12
IUBMB Enzyme Nomenclature: 1.3.99.12
ExPASy - ENZYME nomenclature database: 1.3.99.12
BRENDA, the Enzyme Database: 1.3.99.12
CAS: 85130-32-1

  All links  
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (5)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Gene (2335)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (322)   
   KEGG MGENES (218)   
   RefGene (1793)   
Protein sequence (87)   
   UniProt (75)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (104)   
   RefSeq(nuc) (30)   
   GenBank (39)   
   EMBL (35)   
All databases (2544)   

Download RDF
DBGET integrated database retrieval system