KEGG   ENZYME: 1.3.99.23Help
Entry
EC 1.3.99.23                Enzyme                                 

Name
all-trans-retinol 13,14-reductase;
retinol saturase;
RetSat;
(13,14)-all-trans-retinol saturase;
all-trans-retinol:all-trans-13,14-dihydroretinol saturase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase
Reaction(IUBMB)
all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor [RN:R07163]
Reaction(KEGG)
Substrate
all-trans-13,14-dihydroretinol [CPD:C15492];
acceptor [CPD:C00028]
Product
all-trans-retinol [CPD:C00473];
reduced acceptor [CPD:C00030]
Comment
The reaction is only known to occur in the opposite direction to that given above, with the enzyme being specific for all-trans-retinol as substrate. Neither all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers are substrates. May play a role in the metabolism of vitamin A.
History
EC 1.3.99.23 created 2005
Pathway
ec00830  Retinol metabolism
Orthology
K09516  all-trans-retinol 13,14-reductase
Genes
HSA: 54884(RETSAT)
PTR: 470420(RETSAT)
PPS: 100980971(RETSAT)
GGO: 101149338(RETSAT)
PON: 100433966(RETSAT)
NLE: 100603439(RETSAT)
MCC: 695058(RETSAT)
MCF: 102124463(RETSAT) 102143939
CSAB: 103219951 103219955(RETSAT)
RRO: 104654618 104659297 104659735
RBB: 108519778(RETSAT)
CJC: 100403605 100415049(RETSAT)
SBQ: 101034084(RETSAT)
MMU: 67442(Retsat)
RNO: 246298(Retsat)
CGE: 100750576(Retsat)
NGI: 103739785(Retsat)
HGL: 101708622(Retsat)
CCAN: 109686179(Retsat)
OCU: 100348884(RETSAT)
TUP: 102474082(RETSAT)
CFA: 483083(RETSAT)
AML: 100476977(RETSAT)
UMR: 103671449(RETSAT)
ORO: 101382507(RETSAT)
FCA: 101090345(RETSAT)
PTG: 102958364(RETSAT)
AJU: 106978216(RETSAT)
BTA: 614455(RETSAT)
BOM: 102279340(RETSAT)
BIU: 109566179(RETSAT)
PHD: 102318558(RETSAT)
CHX: 102171615(RETSAT)
OAS: 101123106(RETSAT)
SSC: 100519138(RETSAT)
CFR: 102506909(RETSAT)
CDK: 105104148(RETSAT)
BACU: 103009686(RETSAT)
LVE: 103068788(RETSAT)
OOR: 101286968(RETSAT)
ECB: 100067379(RETSAT)
EPZ: 103548266(RETSAT)
EAI: 106838606(RETSAT)
MYB: 102241000(RETSAT)
MYD: 102764075(RETSAT)
HAI: 109371326(RETSAT)
RSS: 109436171(RETSAT)
PALE: 102897460(RETSAT)
LAV: 100676269(RETSAT)
MDO: 100030257(RETSAT) 100030337
SHR: 100921830(RETSAT) 100922093
OAA: 100087168(RETSAT) 100088936
GGA: 101751434(RETSATL) 426549(RETSAT)
MGP: 100544741(RETSAT)
CJO: 107323640(RETSAT) 107325116
APLA: 101800761(RETSAT)
ACYG: 106048918(RETSAT) 106049844
TGU: 101233661(RETSAT)
GFR: 102039565(RETSAT)
FAB: 101818337(RETSAT)
PHI: 102104553 102109927(RETSAT)
PMAJ: 107199008 107213871(RETSAT)
CCW: 104683179(RETSAT)
FPG: 101915211 101922352(RETSAT)
FCH: 102050507(RETSAT) 102055717
CLV: 102089222(RETSAT) 102091836
EGZ: 104121761(RETSAT)
AAM: 106493808(RETSAT)
ASN: 102369670(RETSAT)
AMJ: 102576004(RETSAT)
PSS: 102451524(RETSAT)
CMY: 102937353 102947614(RETSAT)
CPIC: 101937097 101948187(RETSAT)
GJA: 107114725(RETSAT)
XLA: 108702543 494824(retsat.L)
XTR: 100158500(retsat) 100488563
DRE: 325922(retsat) 563241(si:ch1073-13h15.3) 677660(retsatl) 777751(zgc:154169)
CMK: 103183764(retsat)
CIN: 100179991
SPU: 581285
APLC: 110976469
BMY: Bm1_02785
EPA: 110244961
AQU: 100636736
APRO: F751_5582
SMIN: v1.2.001388.t1(symbB.v1.2.001388.t1) v1.2.038022.t1(symbB.v1.2.038022.t1)
SPAR: SPRG_01865
PSEM: TO66_25870
MAQ: Maqu_0318
MHC: MARHY0264
MAD: HP15_4014
MBS: MRBBS_2585(retsat)
SAGA: M5M_04330
MICC: AUP74_00620(crtI)
HCH: HCH_01940
ADI: B5T_03524
APAC: S7S_04685
AXE: P40_16590
TOL: TOL_2373
DEU: DBW_1759(mnmC)
DSF: UWK_00118
HOH: Hoch_3011
TMO: TMO_b0402
MSTE: MSTE_02045
SBH: SBI_00884
SHY: SHJG_5939
SMAL: SMALA_5829
SRO: Sros_4146
AMN: RAM_20535
AMM: AMES_3981
AMZ: B737_3981
SAQ: Sare_1053
GLJ: GKIL_3930(gltD)
BRM: Bmur_0577
EPO: Epro_0950
BOA: Bovatus_04065(crtI)
TFO: BFO_0007
PSAC: PSM36_2772
AFD: Alfi_1533
CPI: Cpin_1874
LBY: Lbys_1480
FJO: Fjoh_1077
FJG: BB050_01531(crtI)
COC: Coch_1995
CHZ: CHSO_4664
IAG: Igag_1801
KCR: Kcr_0408
 » show all
Taxonomy
Reference
1  [PMID:15358783]
  Authors
Moise AR, Kuksa V, Imanishi Y, Palczewski K.
  Title
Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase.
  Journal
J Biol Chem 279:50230-42 (2004)
DOI:10.1074/jbc.M409130200
  Sequence
[mmu:67442]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.99.23
IUBMB Enzyme Nomenclature: 1.3.99.23
ExPASy - ENZYME nomenclature database: 1.3.99.23
BRENDA, the Enzyme Database: 1.3.99.23
CAS: 879291-21-1

DBGET integrated database retrieval system