| Entry |
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| Name |
all-trans-retinol 13,14-reductase;
retinol saturase;
RetSat;
(13,14)-all-trans-retinol saturase;
all-trans-retinol:all-trans-13,14-dihydroretinol saturase
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
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| Sysname |
all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase
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| Reaction(IUBMB) |
all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor [RN: R07163]
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| Reaction(KEGG) |
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| Substrate |
all-trans-13,14-dihydroretinol [CPD: C15492];
acceptor [CPD: C00028]
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| Product |
all-trans-retinol [CPD: C00473];
reduced acceptor [CPD: C00030]
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| Comment |
The reaction is only known to occur in the opposite direction to that given above, with the enzyme being specific for all-trans-retinol as substrate. Neither all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers are substrates. May play a role in the metabolism of vitamin A.
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| History |
EC 1.3.99.23 created 2005
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| Pathway |
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| Orthology |
| K09516 | all-trans-retinol 13,14-reductase |
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| Genes |
» show all
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| Reference |
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| Authors |
Moise AR, Kuksa V, Imanishi Y, Palczewski K |
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| Title |
Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.3.99.23 |
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