KEGG   ENZYME: 1.3.99.23Help
Entry
EC 1.3.99.23                Enzyme                                 

Name
all-trans-retinol 13,14-reductase;
retinol saturase;
RetSat;
(13,14)-all-trans-retinol saturase;
all-trans-retinol:all-trans-13,14-dihydroretinol saturase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase
Reaction(IUBMB)
all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor [RN:R07163]
Reaction(KEGG)
Substrate
all-trans-13,14-dihydroretinol [CPD:C15492];
acceptor [CPD:C00028]
Product
all-trans-retinol [CPD:C00473];
reduced acceptor [CPD:C00030]
Comment
The reaction is only known to occur in the opposite direction to that given above, with the enzyme being specific for all-trans-retinol as substrate. Neither all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers are substrates. May play a role in the metabolism of vitamin A.
History
EC 1.3.99.23 created 2005
Pathway
ec00830  Retinol metabolism
Orthology
K09516  all-trans-retinol 13,14-reductase
Genes
HSA: 54884(RETSAT)
PTR: 470420(RETSAT)
PPS: 100980971(RETSAT)
GGO: 101149338(RETSAT)
PON: 100433966(RETSAT)
NLE: 100603439(RETSAT)
MCC: 695058(RETSAT)
MCF: 102124463(RETSAT) 102143939
CSAB: 103219951 103219955(RETSAT)
RRO: 104654618 104659297 104659735
RBB: 108519778(RETSAT)
CJC: 100403605 100415049(RETSAT)
SBQ: 101034084(RETSAT)
MMU: 67442(Retsat)
RNO: 246298(Retsat)
CGE: 100750576(Retsat)
NGI: 103739785(Retsat)
HGL: 101708622(Retsat)
CCAN: 109686179(Retsat)
OCU: 100348884(RETSAT)
TUP: 102474082(RETSAT)
CFA: 483083(RETSAT)
AML: 100476977(RETSAT)
UMR: 103671449(RETSAT)
ORO: 101382507(RETSAT)
FCA: 101090345(RETSAT)
PTG: 102958364(RETSAT)
AJU: 106978216(RETSAT)
BTA: 614455(RETSAT)
BOM: 102279340(RETSAT)
BIU: 109566179(RETSAT)
PHD: 102318558(RETSAT)
CHX: 102171615(RETSAT)
OAS: 101123106(RETSAT)
SSC: 100519138(RETSAT)
CFR: 102506909(RETSAT)
CDK: 105104148(RETSAT)
BACU: 103009686(RETSAT)
LVE: 103068788(RETSAT)
OOR: 101286968(RETSAT)
ECB: 100067379(RETSAT)
EPZ: 103548266(RETSAT)
EAI: 106838606(RETSAT)
MYB: 102241000(RETSAT)
MYD: 102764075(RETSAT)
HAI: 109371326(RETSAT)
RSS: 109436171(RETSAT)
PALE: 102897460(RETSAT)
LAV: 100676269(RETSAT)
TMU: 101345756 101346268
MDO: 100030257(RETSAT) 100030337
SHR: 100921830(RETSAT) 100922093
OAA: 100087168(RETSAT) 100088936
GGA: 101751434(RETSATL) 426549(RETSAT)
MGP: 100544741(RETSAT)
CJO: 107323640(RETSAT) 107325116
APLA: 101800761(RETSAT)
ACYG: 106048918(RETSAT) 106049844
TGU: 101233661(RETSAT)
GFR: 102039565(RETSAT)
FAB: 101818337(RETSAT)
PHI: 102104553 102109927(RETSAT)
PMAJ: 107199008 107213871(RETSAT)
CCAE: 111938901(RETSAT)
CCW: 104683179(RETSAT)
FPG: 101915211 101922352(RETSAT)
FCH: 102050507(RETSAT) 102055717
CLV: 102089222(RETSAT) 102091836
EGZ: 104121761(RETSAT)
AAM: 106493808(RETSAT)
ASN: 102369670(RETSAT)
AMJ: 102576004(RETSAT)
PSS: 102451524(RETSAT)
CMY: 102937353 102947614(RETSAT)
CPIC: 101937097 101948187(RETSAT)
ACS: 100552731(retsat) 100552879 100554362 100554559
PVT: 110079148 110079149 110079156 110089218(RETSAT)
GJA: 107114725(RETSAT)
XLA: 108702543 494824(retsat.L)
XTR: 100158500(retsat) 100488563
NPR: 108783994 108792471
DRE: 325922(retsat) 563241(si:ch1073-13h15.3) 677660(retsatl) 777751(zgc:154169)
SRX: 107708985 107720034 107737865 107739437 107755357 107755369 107755370
SANH: 107674695 107676090 107676091 107693675 107699030
SGH: 107562027 107591477(retsat) 107601362 107601381 107601603
CCAR: 109051257 109052113(retsat) 109066427 109066428
IPU: 108257121 108274341 108274342
AMEX: 103027967 103033552 103037098 103042924 103044667 107196803 111192380 111192420
TRU: 101062884 101065125 101078075
TNG: GSTEN00021055G001 GSTEN00026983G001 GSTEN00027856G001
LCO: 104926440(retsat) 104928682 104933951
NCC: 104945044 104946857(retsat) 104950774
MZE: 101465824 101476159 101478120(retsat)
OLA: 101155933(retsat) 101162403 101173846
XMA: 102218343 102226433 102230433 102238190
PRET: 103468165 103469338 103469375 103481656
NFU: 107378557(retsat) 107387676 107396584
KMR: 108237697(retsat) 108246350
CSEM: 103381816 103392752 103393594
LCF: 108872757 108876653 108898512
SDU: 111217763(retsat) 111220358 111223679
HCQ: 109506812(retsat) 109513268 109532534
BPEC: 110154418 110159281 110162270
MALB: 109963184 109973700 109974888
SASA: 100196171(retst) 106589635 106600793 106607466
OTW: 112258607 112258608
ELS: 105007254 105013106 105021176
SFM: 108928164 108941533
LCM: 102345865 102360472
CMK: 103183764(retsat)
BFO: BRAFLDRAFT_119025 BRAFLDRAFT_121336 BRAFLDRAFT_121337 BRAFLDRAFT_76397
CIN: 100179991
SPU: 581285
APLC: 110976469
SKO: 100372363 100379022
DPX: DAPPUDRAFT_191625 DAPPUDRAFT_304083 DAPPUDRAFT_308270
BMY: Bm1_02785
LOA: LOAG_09468
HRO: HELRODRAFT_110282
LGI: LOTGIDRAFT_198008
CRG: 105318951 105318952 105333941 105342600
MYI: 110462201 110462205
LAK: 106169298 106174680 106174688
NVE: NEMVE_v1g183264
EPA: 110244961
HMG: 100203715 100211766
TAD: TRIADDRAFT_22982
AQU: 100636736
MIS: MICPUN_104514
APRO: F751_5582
MBR: MONBRDRAFT_21832
SRE: PTSG_08987
SMIN: v1.2.001388.t1(symbB.v1.2.001388.t1) v1.2.038022.t1(symbB.v1.2.038022.t1)
TPS: THAPSDRAFT_10254 THAPSDRAFT_11636
AAF: AURANDRAFT_25702
NGD: NGA_2046300
SPAR: SPRG_01865
EHX: EMIHUDRAFT_450714 EMIHUDRAFT_459817
GTT: GUITHDRAFT_166294
NGR: NAEGRDRAFT_81787
SFO: Z042_11050
EPE: CI789_12920
PGB: H744_1c0308
PALC: A0T30_04650
PVR: PverR02_11535
PCH: EY04_25815
PCZ: PCL1606_11740
PCP: JM49_05865
PSEM: TO66_25870
MBAH: HYN46_15320
MAQ: Maqu_0318
MHC: MARHY0264
MAD: HP15_4014
MBS: MRBBS_2585(retsat)
MSR: AU15_13495
MSX: AU14_10335
MPQ: ABA45_12175
MARI: ACP86_10740
MLQ: ASQ50_09605
MSQ: BKP64_05780 BKP64_13955
MARA: D0851_14060
SAGA: M5M_04330
MTHD: A3224_14675
MICC: AUP74_00620(crtI)
MAGA: Mag101_00865
MII: BTJ40_21290
HCH: HCH_01940
HSI: BOX17_01045
ADI: B5T_03524
APAC: S7S_04685
AXE: P40_16590
TOL: TOL_2373
TOR: R615_05830
OAI: OLEAN_C25570
OME: OLMES_1043
SOK: D0B54_16325
BUZ: AYM40_35710
BEB: AEM42_13430
DES: DSOUD_1216 DSOUD_2555
DEU: DBW_1759(mnmC)
DSA: Desal_0539
DAF: Desaf_3664
DHY: DESAM_21154
DOA: AXF15_06235
DAK: DaAHT2_1135
DSF: UWK_00118
DTO: TOL2_C38330
SCU: SCE1572_04195
CCRO: CMC5_000610
SAMY: DB32_001289 DB32_003351
MRM: A7982_02084 A7982_06391 A7982_08722
HOH: Hoch_3011
SULI: C1J05_16265
TMO: TMO_b0402
MCB: Mycch_1101
MSTE: MSTE_02045
NTP: CRH09_20455
RAV: AAT18_04545
SBH: SBI_00884
SHY: SHJG_5939
SHO: SHJGH_5701
SPRI: SPRI_0136 SPRI_7217
SGS: AVL59_00750
SAUO: BV401_33035
SSIA: A7J05_16465
SMAL: SMALA_5829
KSK: KSE_64530 KSE_66010
KAU: B6264_12910
PPC: HMPREF9154_0765
AEZ: C3E78_13425
SRO: Sros_4146
AMN: RAM_20535
AMM: AMES_3981
AMZ: B737_3981
AMYB: BKN51_12670
SAQ: Sare_1053
AOS: AXE84_10435
ANE: AN27039_2496 AN27039_2497
LBO: LBWT_22970
HHG: XM38_029020
GLP: Glo7428_4859
CYP: PCC8801_0425
CYN: Cyan7425_1174
CYH: Cyan8802_0436
CYJ: Cyan7822_0323
GLJ: GKIL_3930(gltD)
CALO: Cal7507_3900
NCN: BZZ01_18240
PLP: Ple7327_0865
LAJ: A0128_04955 A0128_21385
TPX: Turpa_2439 Turpa_2590
BRM: Bmur_0577
EPO: Epro_0950
BSA: Bacsa_3282
BDO: EL88_24305
BDH: GV66_06675
BOA: Bovatus_04065(crtI)
BCEL: BcellWH2_03901(crtI) BcellWH2_05158
BACC: BRDCF_p1242
TFO: BFO_0007
TOH: BCB71_04235
PARY: A4V02_06345
PSAC: PSM36_2772
PDN: HMPREF9137_2072 HMPREF9137_2073
PEO: AS203_11525 AS203_11530
PJE: CRM71_11795 CRM71_11800
AFD: Alfi_1533
MBAS: ALGA_4156 ALGA_4157
CPI: Cpin_1874
CBAE: COR50_10740
NSO: NIASO_17955
NIA: A8C56_00545
SPHN: BV902_10955
MUH: HYN43_023195
LBY: Lbys_1480
ALS: DJ013_13670
FBT: D770_07445
CHK: D4L85_32060
FJO: Fjoh_1077
FJG: BB050_01531(crtI)
FPC: FPSM_02402
FPY: FPG101_12040
FPO: FPG3_11605
FPQ: IB65_11510
FPV: IA03_11285
FPW: IA04_11160
FPK: IA06_11245
FCO: FCOL_11740
FKI: FK004_05275 FK004_05395
COC: Coch_1995
COL: AM608_02500
CHG: AXF12_09130
CAPN: CBG49_07060
CGH: CGC50_02300
CLK: CGC53_01625
CSPU: CGC55_04205
FBC: FB2170_12061
MARB: CJ263_06170 CJ263_19825
LAN: Lacal_2095 Lacal_2583
ZGA: ZOBELLIA_2053 ZOBELLIA_4651
ASL: Aeqsu_0055 Aeqsu_0325 Aeqsu_0911
MYR: MYRA21_1157
MOD: AS202_05425
MYZ: BK054_05305
CHZ: CHSO_4664
CGN: OK18_06260
CIH: ATE47_18475
CHH: A0O34_10845
CIO: CEQ15_16680
CHRY: CEY12_12870
CPIP: CJF12_15830
AALG: AREALGSMS7_04491
FEK: C1H87_13000 C1H87_13015
TAJ: C1A40_07450
AQB: D1818_01255 D1818_03555 D1818_21520 D1818_24875
AQA: D1815_06215 D1815_07425 D1815_10395
EMAR: D1013_11545 D1013_19105
OHO: Oweho_0312 Oweho_1210
AST: Asulf_01918
IAG: Igag_1801
KCR: Kcr_0408
 » show all
Taxonomy
Reference
1  [PMID:15358783]
  Authors
Moise AR, Kuksa V, Imanishi Y, Palczewski K.
  Title
Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase.
  Journal
J Biol Chem 279:50230-42 (2004)
DOI:10.1074/jbc.M409130200
  Sequence
[mmu:67442]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.99.23
IUBMB Enzyme Nomenclature: 1.3.99.23
ExPASy - ENZYME nomenclature database: 1.3.99.23
BRENDA, the Enzyme Database: 1.3.99.23
CAS: 879291-21-1

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Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (16077)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (444)   
   KEGG MGENES (10045)   
   RefGene (5565)   
   EGENES (22)   
Protein sequence (152)   
   UniProt (91)   
   SWISS-PROT (5)   
   RefSeq(pep) (56)   
DNA sequence (148)   
   RefSeq(nuc) (60)   
   GenBank (46)   
   EMBL (42)   
All databases (16385)   

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