| Entry |
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| Name |
glutaryl-CoA dehydrogenase (acceptor);
GDHDes;
nondecarboxylating glutaryl-coenzyme A dehydrogenase;
nondecarboxylating glutaconyl-coenzyme A-forming GDH;
glutaryl-CoA dehydrogenase (non-decarboxylating)
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
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| Sysname |
glutaryl-CoA:acceptor 2,3-oxidoreductase (non-decarboxylating)
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| Reaction(IUBMB) |
glutaryl-CoA + acceptor = (E)-glutaconyl-CoA + reduced acceptor [RN: R05579]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
(E)-glutaconyl-CoA [CPD: C02411];
reduced acceptor [CPD: C00030]
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| Comment |
The enzyme contains FAD. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (EC 1.3.8.6), and a nondecarboxylating enzyme (this entry). The two enzymes cause different structural changes around the glutaconyl carboxylate group, primarily due to the presence of either a tyrosine or a valine residue, respectively, at the active site.
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| History |
EC 1.3.99.32 created 2012, modified 2013
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K16173 | glutaryl-CoA dehydrogenase (non-decarboxylating) |
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| Genes |
» show all
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| Reference |
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| Authors |
Wischgoll S, Taubert M, Peters F, Jehmlich N, von Bergen M, Boll M |
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| Title |
Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Wischgoll S, Demmer U, Warkentin E, Gunther R, Boll M, Ermler U |
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| Title |
Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.3.99.32 |
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