KEGG   ENZYME: 1.3.99.33Help
Entry
EC 1.3.99.33                Enzyme                                 

Name
urocanate reductase;
urdA (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
dihydrourocanate:acceptor oxidoreductase
Reaction(IUBMB)
dihydrourocanate + acceptor = urocanate + reduced acceptor [RN:R10330]
Reaction(KEGG)
Substrate
dihydrourocanate [CPD:C20522];
acceptor [CPD:C00028]
Product
urocanate [CPD:C00785];
reduced acceptor [CPD:C00030]
Comment
The enzyme from the bacterium Shewanella oneidensis MR-1 contains a noncovalently-bound FAD and a covalently-bound FMN. It functions as part of an anaerobic electron transfer chain that utilizes urocanate as the terminal electron acceptor. The activity has been demonstrated with the artificial donor reduced methylviologen.
History
EC 1.3.99.33 created 2013
Pathway
ec00340  Histidine metabolism
Orthology
K17363  urocanate reductase
Genes
SON: SO_4620
SBM: Shew185_4193
SBN: Sbal195_4325
SBT: Sbal678_4357
SPC: Sputcn32_3795
SHP: Sput200_0127
SSE: Ssed_0694
SPL: Spea_3574
SHN: Shewana3_4004
SHW: Sputw3181_0118
SHL: Shal_2847
SWD: Swoo_3912
CTC: CTC_01847
AOE: Clos_0178
CPY: Cphy_3885
APR: Apre_0378
ELE: Elen_0488
 » show all
Taxonomy
Reference
1  [PMID:23078170]
  Authors
Bogachev AV, Bertsova YV, Bloch DA, Verkhovsky MI
  Title
Urocanate reductase: identification of a novel anaerobic respiratory pathway in Shewanella oneidensis MR-1.
  Journal
Mol Microbiol 86:1452-63 (2012)
DOI:10.1111/mmi.12067
  Sequence
[son:SO_4620]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.99.33
IUBMB Enzyme Nomenclature: 1.3.99.33
ExPASy - ENZYME nomenclature database: 1.3.99.33
BRENDA, the Enzyme Database: 1.3.99.33

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