Entry
Name
menaquinone-9 beta-reductase;
MenJ
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
menaquinone-9 oxidoreductase (beta-dihydromenaquinone-9-forming)
Reaction(IUBMB)
menaquinone-9 + reduced acceptor = beta-dihydromenaquinone-9 + acceptor [RN:
R11654 ]
Reaction(KEGG)
Substrate
Product
beta-dihydromenaquinone-9 [CPD:
C21527 ];
acceptor [CPD:
C00028 ]
Comment
The enzyme from the bacterium Mycobacterium tuberculosis reduces the beta-isoprene unit of menaquinone-9, forming the predominant form of menaquinone found in mycobacteria. Contains FAD.
History
EC 1.3.99.38 created 2017
Orthology
K21401 menaquinone-9 beta-reductase
Genes
MSA : Mycsm_00693 Mycsm_02171
MYV : G155_11095 G155_25215
MYE : AB431_04330 AB431_09945
MDX : BTO20_05635 BTO20_23860
MNM : MNVM_12670(menJ) MNVM_32650
MGAU : MGALJ_05080 MGALJ_52200(menJ)
MSHJ : MSHI_28760 MSHI_36150(menJ)
MKY : IWGMT90018_09100(menJ)
MADI : A7U43_20825 A7U43_26015
MSM : MSMEG_1028 MSMEG_1132 MSMEG_2308
MSG : MSMEI_0998 MSMEI_1100 MSMEI_2249
MSB : LJ00_05100 LJ00_05635 LJ00_11480
MSN : LI99_05100 LI99_05635 LI99_11480
MSH : LI98_05100 LI98_05635 LI98_11485
MSP : Mspyr1_08090 Mspyr1_36340
MCB : Mycch_0707 Mycch_1075 Mycch_1788
MNE : D174_06035 D174_10300
MYN : MyAD_05920 MyAD_10090
MFT : XA26_22840 XA26_51070
MPHL : MPHLCCUG_01007 MPHLCCUG_01008 MPHLCCUG_01962
MLL : B1R94_04495 B1R94_19195
MRH : MycrhN_1009 MycrhN_5991
MTHN : 4412656_00678 4412656_01486
MHAS : MHAS_00882(menJ_1) MHAS_04956(menJ_2)
MDU : MDUV_24490 MDUV_36230(menJ)
MCHT : MCHIJ_02600(menJ) MCHIJ_46540
MDR : MDOR_04100(menJ) MDOR_12300
MAUU : NCTC10437_00792 NCTC10437_01907
MMAG : MMAD_09370(menJ) MMAD_20100
MMOR : MMOR_34580 MMOR_44320 MMOR_56890(menJ)
MFX : MFAL_16080 MFAL_21920
MAIC : MAIC_16890 MAIC_47900(menJ)
MALV : MALV_16430 MALV_26510(menJ)
MTY : MTOK_30750(menJ) MTOK_38740
MPSC : MPSYJ_01560(menJ) MPSYJ_46070
MARZ : MARA_20290 MARA_30060(menJ)
MGAD : MGAD_18950 MGAD_41540 MGAD_50340(menJ)
MHEV : MHEL_13760(menJ) MHEL_41680 MHEL_43160
MSAR : MSAR_00830 MSAR_23830(menJ)
MANY : MANY_03060 MANY_48200(menJ)
MAUB : MAUB_08460 MAUB_11680 MAUB_17950 MAUB_23100(menJ)
MPOF : MPOR_12830(menJ) MPOR_24070
MPHU : MPHO_01440 MPHO_31050 MPHO_47390(menJ) MPHO_53320
MMUC : C1S78_002390 C1S78_017730 C1S78_020875 C1S78_023570
MMAT : MMAGJ_40100(menJ) MMAGJ_52750
MBOK : MBOE_01400(menJ) MBOE_52420
MFG : K6L26_21245 K6L26_26420
MFLV : NCTC10271_03489 NCTC10271_04354
MCEE : MCEL_17220 MCEL_25790(menJ)
MBRM : L2Z93_002652 L2Z93_003317
MMON : EWR22_04035 EWR22_09275
MGO : AFA91_27995 AFA91_33040
MHOL : K3U96_17600 K3U96_22640
MSEN : K3U95_05255 K3U95_18685
MPAE : K0O64_04095 K0O64_09295
MRF : MJO55_03930 MJO55_09225
MDF : K0O62_04830 K0O62_10355
MCRO : MI149_04720 MI149_09630
MGRO : FZ046_10255 FZ046_15375
MAUS : JN090_03750 JN090_09265
MFRE : EXE63_04500 EXE63_10195
MKR : MKOR_18200 MKOR_24130
MPAK : MIU77_13015 MIU77_15805
MMV : MYCMA_06310 MYCMA_2185
MABB : MASS_3347 MASS_3942
MABL : MMASJCM_3406 MMASJCM_3948
MCHE : BB28_14625 BB28_17235 BB28_20235
MIZ : BAB75_18245 BAB75_22420
MSTE : MSTE_02883 MSTE_03384 MSTE_04101
MSAO : MYCSP_15615 MYCSP_18245
MSAL : DSM43276_03195 DSM43276_03738
MJD : JDM601_0555 JDM601_2783
MTER : 4434518_00447 4434518_00555 4434518_02747
MMIN : MMIN_04980 MMIN_22640(menJ)
MHIB : MHIB_00550(menJ) MHIB_22170
MHER : K3U94_03235 K3U94_15950
MVM : MJO54_03255 MJO54_15970
CMIN : NCTC10288_02183(pcpB_2)
CCYS : SAMEA4530656_2083(kmo)
NWL : NWFMUON74_65210(menJ)
NSPU : IFM12276_56880(menJ)
ROZ : CBI38_08110 CBI38_33720
SANL : KZO11_02540 KZO11_21960
SCYE : R2B67_14035 R2B67_33380
STRP : F750_0487 F750_4174
SVT : SVTN_00450 SVTN_22265
SCZ : ABE83_14455 ABE83_32305
SRW : TUE45_05115 TUE45_pSRc_0269(TUE45_pSRTUE45c_0269)
SLE : sle_30720(sle_30720)
SNW : BBN63_04240 BBN63_13440
SVU : B1H20_02285 B1H20_20960
SNK : CP967_14025 CP967_32065
SFIC : EIZ62_13495 EIZ62_31870
SVR : CP971_01940 CP971_14050
SCAV : CVT27_02295 CVT27_20130
SNF : JYK04_04996(menJ_2) JYK04_08103(menJ_4)
SATA : C5746_05880 C5746_24135
SHUN : DWB77_03310(menJ_2)
SCAL : I6J39_02410 I6J39_20780
SMAO : CAG99_10715 CAG99_12270
STAA : LDH80_00855 LDH80_17235
STUB : MMF93_19275 MMF93_31540
SXT : KPP03845_104398(menJ_2)
SLAI : P8A22_16220 P8A22_34660
STTN : BSL84_03330 BSL84_19490
STPB : QR97_06480 QR97_37685
KAU : B6264_09090 B6264_28780
KCH : O1G21_04725 O1G21_17160
YIM : J5M86_02625 J5M86_09410
DEM : LGT36_011115 LGT36_013865
NAQU : ENKNEFLB_04056(menJ_2)
AGRA : AGRA3207_001506 AGRA3207_004733
AMAZ : LUW76_11435 LUW76_30565
ACIR : OG979_21885 OG979_30115
BSD : BLASA_0813 BLASA_4453
BLAP : MVA48_11765 MVA48_18775
MMAR : MODMU_0999 MODMU_1000
ACTY : OG774_10295 OG774_24095
PFLA : Pflav_063420 Pflav_074530
RUB : GBA63_09515 GBA63_18775
RMAR : GBA65_11565 GBA65_18435
AYM : YM304_03970 YM304_41470
AQZ : KSP35_01235 KSP35_17635
IAM : HC251_16305 HC251_21940
DHI : LH044_05250 LH044_15715
» show all
Taxonomy
Reference
Authors
Upadhyay A, Fontes FL, Gonzalez-Juarrero M, McNeil MR, Crans DC, Jackson M, Crick DC
Title
Partial Saturation of Menaquinone in Mycobacterium tuberculosis: Function and Essentiality of a Novel Reductase, MenJ.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.3.99.38