KEGG   ENZYME: 1.3.99.38
Entry
EC 1.3.99.38                Enzyme                                 

Name
menaquinone-9 beta-reductase;
MenJ
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
Sysname
menaquinone-9 oxidoreductase (beta-dihydromenaquinone-9-forming)
Reaction(IUBMB)
menaquinone-9 + reduced acceptor = beta-dihydromenaquinone-9 + acceptor [RN:R11654]
Reaction(KEGG)
R11654
Substrate
menaquinone-9 [CPD:C21526];
reduced acceptor [CPD:C00030]
Product
beta-dihydromenaquinone-9 [CPD:C21527];
acceptor [CPD:C00028]
Comment
The enzyme from the bacterium Mycobacterium tuberculosis reduces the beta-isoprene unit of menaquinone-9, forming the predominant form of menaquinone found in mycobacteria. Contains FAD.
History
EC 1.3.99.38 created 2017
Orthology
K21401  menaquinone-9 beta-reductase
Genes
DZE: Dd1591_3653
PFL: PFL_4132(peaF)
PPRC: PFLCHA0_c41930(pimS)
PPRO: PPC_4233(peaF)
PAR: Psyc_0420
PUR: AOC03_12425
PRR: AT705_23065
MAQ: Maqu_3481
MHC: MARHY3376
MAD: HP15_3251
MARJ: MARI_31780
PIN: Ping_0255
CJA: CJA_3756
LFA: LFA_0725
LHA: LHA_3260
LOK: Loa_02056
NOC: Noc_0982
NHL: Nhal_2960
NWA: Nwat_2054
TEE: Tel_09085
APAC: S7S_13435
RSE: F504_4888
BVE: AK36_4696
CABA: SBC2_78080
MPT: Mpe_A0164
CFU: CFU_1088
LCH: Lcho_0390
RGE: RGE_45910
PCA: Pcar_2388
DDE: Dde_2189
DMA: DMR_43240
DAL: Dalk_3740
ADE: Adeh_0390
MXA: MXAN_6635
PLA: Plav_0369
BID: Bind_2603
MSL: Msil_3389
RVA: Rvan_0164
MCG: GL4_0230
MALG: MALG_02703
RHC: RGUI_4105
AHT: ANTHELSMS3_01125(menJ)
MALU: KU6B_00490
HNE: HNE_0988
SMAZ: LH19_24455
SPHU: SPPYR_3716
SWI: Swit_1188
SPHD: HY78_20635
SPHM: G432_10295
STAX: MC45_14690
SSAN: NX02_25505
SPKC: KC8_12715
SPMI: K663_17026
SPHR: BSY17_1413
SINB: SIDU_17555
SPHT: K426_22264
SHUM: STHU_03270
PMW: B2K_24105
PSWU: SY83_22380
MTU: Rv0561c
MTC: MT0587
MRA: MRA_0568
MTUR: CFBS_0585
MTD: UDA_0561c
MTUE: J114_03000
MTUH: I917_04010
MTUL: TBHG_00558
MTUT: HKBT1_0585
MTUU: HKBT2_0585
MBB: BCG_0606c
MBT: JTY_0576
MBX: BCGT_0344
MAF: MAF_05680
MMIC: RN08_0627
MLE: ML2276
MLB: MLBr02276
MPA: MAP_4057c
MAO: MAP4_4180
MAVI: RC58_20735
MAVU: RE97_20785
MAV: MAV_4582
MIT: OCO_44660
MIA: OCU_44400
MID: MIP_06784
MYO: OEM_44850
MIR: OCQ_45800
MLP: MLM_3747
MUL: MUL_0663
MMI: MMAR_0910
MMM: W7S_22485
MHAD: B586_19210
MSHG: MSG_00789
MHAS: MHAS_00789 MHAS_00882(menJ_1) MHAS_04956(menJ_2)
CGL: NCgl0455(Cgl0472)
CGB: cg0557
CGU: WA5_0455
CGT: cgR_0575
CGM: cgp_0557
CGJ: AR0_02910
CEF: CE0482
CDI: DIP0428
CJK: jk1864
CUR: cu0264
CPSE: CPTA_00834
CPSU: CPTB_00698
CPSF: CPTC_00360
CRD: CRES_1917
CVA: CVAR_2418
CTER: A606_09975
COA: DR71_1400
CSP: WM42_1010
CPHO: CPHO_01820
CAQU: CAQU_01560
CAMG: CAMM_02250
CMIN: NCTC10288_02183(pcpB_2)
NSR: NS506_00068(sqlE)
RER: RER_17080
ROP: ROP_16660
REQ: REQ_36950
RHB: NY08_4819
GBR: Gbro_1099
SRT: Srot_0939
SCO: SCO4559(SCD16A.24c)
SCT: SCAT_3477
SBH: SBI_06095
SHY: SHJG_5701
SALS: SLNWT_2679
SALU: DC74_3890
SALL: SAZ_20640
STRE: GZL_04998
SLD: T261_4585
STRM: M444_20265
SPRI: SPRI_3283
SRW: TUE45_05115 TUE45_pSRc_0269(TUE45_pSRTUE45c_0269)
SLE: sle_30720(sle_30720)
STRD: NI25_16280
SLAU: SLA_4371
SALJ: SMD11_3759
SFK: KY5_4703
SGE: DWG14_03568(menJ_1)
SRJ: SRO_3151
KSK: KSE_45110
LXL: KDY119_00726(menJ)
LXX: Lxx00640
MLV: CVS47_02778(menJ)
ART: Arth_3131
ARM: ART_2292
AAU: AAur_3101
ACH: Achl_2826
KRH: KRH_05430
BCV: Bcav_3230
LMOI: VV02_22150
XCE: Xcel_0468
IDO: I598_1718
CFL: Cfla_2717
CFI: Celf_0932
SERJ: SGUI_2781
BLIN: BLSMQ_1076
PAC: PPA1938
PACC: PAC1_09895
PACH: PAGK_1851
CACN: RN83_09970
PFRE: RM25_0475
ACIJ: JS278_00884(menJ)
MPH: MLP_07970
NCA: Noca_0714
PSIM: KR76_04620
TFU: Tfu_2696
NDA: Ndas_5052
NAL: B005_2609
TCU: Tcur_4420
ACE: Acel_0266
KRA: Krad_0648
SEN: SACE_6903
AMD: AMED_0519
AMN: RAM_02660
AMM: AMES_0517
AMZ: B737_0518
AOI: AORI_0517
AMYY: YIM_45130
PSEA: WY02_17895
PSEE: FRP1_24890
PSEH: XF36_23680
PAUT: Pdca_03530(menJ)
SESP: BN6_80350
KAL: KALB_8301
ACTI: UA75_02560
ACAD: UA74_02555
ALO: CRK60135
ASE: ACPL_444
ACTS: ACWT_0329
CAI: Caci_8053
SNA: Snas_1273
AHE: Arch_0292
TPYO: X956_08330
TBI: Tbis_0279
CWO: Cwoe_2871
SYW: SYNW0992
SYG: sync_1459
SYNR: KR49_01850
SYND: KR52_09290
PSER: ABRG53_3720(fixC)
PMT: PMT_0413
GLJ: GKIL_0405(gltD)
TRO: trd_0563
STI: Sthe_1006
TTR: Tter_2279
PNL: PNK_2190
PUV: PUV_15360
OTE: Oter_3634
CAA: Caka_1004
MKC: kam1_1630
RBA: RB8854
RUL: UC8_40480
IPA: Isop_3154
ACA: ACP_2715
SUS: Acid_1355
GAU: GAU_2587
SRU: SRU_1596
SRM: SRM_01795(fixC)
SGN: SGRA_3391
PHE: Phep_1644
CHU: CHU_1087(ydiS) CHU_3796
DFE: Dfer_2035
SLI: Slin_3185
FAE: FAES_1600(fixC)
FLM: MY04_4979
FJO: Fjoh_3806
FJG: BB050_03555(kmo_2)
MARM: YQ22_18205
CBAL: M667_15685
DDO: I597_1943
NDO: DDD_3157
KAN: IMCC3317_45040(ubiI)
CPC: Cpar_1202
PPH: Ppha_2269
PAA: Paes_1407
CTS: Ctha_0810
KOL: Kole_0145
LFI: LFML04_2339(fixC)
MOX: DAMO_0700
MAC: MA_2751
MHOR: MSHOH_1509
MEMA: MMAB1_0279(fixC)
NPH: NP_3024A
PIS: Pisl_0388
PCL: Pcal_1119
PAS: Pars_1355
PYR: P186_1544
POG: Pogu_0859
TNE: Tneu_1739
TTN: TTX_1079(FixC-2)
TUZ: TUZN_0741
VDI: Vdis_1508
VMO: VMUT_0107
TPE: Tpen_1199
 » show all
Reference
1  [PMID:26436137]
  Authors
Upadhyay A, Fontes FL, Gonzalez-Juarrero M, McNeil MR, Crans DC, Jackson M, Crick DC
  Title
Partial Saturation of Menaquinone in Mycobacterium tuberculosis: Function and Essentiality of a Novel Reductase, MenJ.
  Journal
ACS Cent Sci 1:292-302 (2015)
DOI:10.1021/acscentsci.5b00212
  Sequence
[mtu:Rv0561c]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.99.38
IUBMB Enzyme Nomenclature: 1.3.99.38
ExPASy - ENZYME nomenclature database: 1.3.99.38
BRENDA, the Enzyme Database: 1.3.99.38

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