Entry |
|
Name |
carotenoid phi-ring synthase;
crtU (gene name) (ambiguous)
|
Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
|
Sysname |
carotenoid beta-ring:acceptor oxidoreductase/methyltranferase (phi-ring forming)
|
Reaction(IUBMB) |
carotenoid beta-end group + 2 acceptor = carotenoid phi-end group + 2 reduced acceptor [RN: R12115]
|
Reaction(KEGG) |
|
Substrate |
carotenoid beta-end group [CPD: C21915];
acceptor [CPD: C00028]
|
Product |
carotenoid phi-end group [CPD: C21916];
reduced acceptor [CPD: C00030]
|
Comment |
The enzyme, found in green sulfur bacteria, some cyanobacteria and some actinobacteria, introduces additional double bonds to the carotenoid beta-end group, leading to aromatization of the ionone ring. As a result, one of the methyl groups at C-1 is transferred to position C-2. It is involved in the biosynthesis of carotenoids with phi-type aromatic end groups such as chlorobactene, beta-isorenieratene, and isorenieratene.
|
History |
EC 1.3.99.39 created 2018
|
Pathway |
|
Orthology |
K09879 | carotenoid phi-ring synthase / carotenoid chi-ring synthase |
|
Genes |
» show all
|
Reference |
|
Authors |
Moshier SE, Chapman DJ |
Title |
Biosynthetic studies on aromatic carotenoids. Biosynthesis of chlorobactene. |
Journal |
|
Reference |
|
Authors |
Krugel H, Krubasik P, Weber K, Saluz HP, Sandmann G. |
Title |
Functional analysis of genes from Streptomyces griseus involved in the synthesis of isorenieratene, a carotenoid with aromatic end groups, revealed a novel type of carotenoid desaturase. |
Journal |
|
Reference |
|
Authors |
Frigaard NU, Maresca JA, Yunker CE, Jones AD, Bryant DA. |
Title |
Genetic manipulation of carotenoid biosynthesis in the green sulfur bacterium Chlorobium tepidum. |
Journal |
|
Sequence |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 1.3.99.39 |
|