KEGG   ENZYME: 1.4.1.12Help
Entry
EC 1.4.1.12                 Enzyme                                 

Name
2,4-diaminopentanoate dehydrogenase;
2,4-diaminopentanoic acid C4 dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2R,4S)-2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)
Reaction(IUBMB)
(2R,4S)-2,4-diaminopentanoate + H2O + NAD(P)+ = (2R)-2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+ [RN:R04200 R04201]
Reaction(KEGG)
Substrate
(2R,4S)-2,4-diaminopentanoate [CPD:C03943];
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
(2R)-2-amino-4-oxopentanoate [CPD:C03341];
NH3 [CPD:C00014];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)].
History
EC 1.4.1.12 created 1976, modified 2017
Pathway
ec00310  Lysine degradation
ec00330  Arginine and proline metabolism
ec00472  D-Arginine and D-ornithine metabolism
Orthology
K21672  2,4-diaminopentanoate dehydrogenase
Genes
PRG: RB151_036990
PALA: CO695_07830
PHEI: NCTC12003_03184
PRQ: CYG50_20115
PRE: PCA10_28380
SPOI: IMCC21906_00314 IMCC21906_00847 IMCC21906_01025
ZAL: AZF00_09390 AZF00_09405
OSG: BST96_03310
HJA: BST95_01350 BST95_01355 BST95_02910
SDF: ACG33_03790 ACG33_12600
LHK: LHK_02682(dapB-1)
GME: Gmet_2230
DDS: Ddes_0477
ADE: Adeh_4039
MXA: MXAN_4674
CCX: COCOR_04871(dapB1)
SUR: STAUR_5466(dapB)
MLO: mll2179
SWI: Swit_2076
SPHR: BSY17_3841
BLAS: BSY18_822
BCL: ABC0939
SMU: SMU_527
SMJ: SMULJ23_1460(dapB1)
SMUA: SMUFR_0455
SSA: SSA_2021
SGO: SGO_0387
EMU: EMQU_2449
CSQ: CSCA_0127
CACE: CACET_c17480(dapB2)
AMT: Amet_2367
AOE: Clos_1699
CDF: CD630_04420(ord)
PDC: CDIF630_00570(ord)
PDF: CD630DERM_04420(ord)
CST: CLOST_1294(ord)
DSY: DSY3805
ELM: ELI_1411
AWO: Awo_c34400(dapB2)
TTE: TTE1234
THX: Thet_1426
TOC: Toce_1489
PFT: JBW_01651
ERH: ERH_1328
LPIL: LIP_2751
REQ: REQ_08310
SGR: SGR_475
SGB: WQO_32495
SBH: SBI_01547
SFI: SFUL_6900
SALU: DC74_5517
SALL: SAZ_29140
STRM: M444_30835
SPRI: SPRI_0523
SFK: KY5_6975
PAC: PPA2276
PAW: PAZ_c23740(dapB2)
PACC: PAC1_11610
PACH: PAGK_2185
CACN: RN83_00010
NCA: Noca_0426
TCU: Tcur_3673
FAL: FRAAL4027
AMD: AMED_7503
AMN: RAM_38560
AMM: AMES_7392
AMZ: B737_7392
AOI: AORI_4152 AORI_5626(dapB)
CAI: Caci_5962
BLO: BL0836
BLJ: BLD_0569
BLF: BLIF_0905
BLL: BLJ_0914
BLM: BLLJ_0783
BLG: BIL_10530
BLA: BLA_0924(dapB)
BBB: BIF_02266
BBC: BLC1_1080
BLV: BalV_1084
BLW: W7Y_1124
BLS: W91_1149
BANI: Bl12_1046
BANL: BLAC_05660
BANM: EN10_05695
CWO: Cwoe_0529
OLS: Olsu_0652
RCA: Rcas_2891
TRO: trd_1461(dapB)
TTR: Tter_0366
EMI: Emin_0479
EPO: Epro_1033
SBR: SY1_03600
SRU: SRU_1744
SRM: SRM_01957
TME: Tmel_0905
TAF: THA_1160
THER: Y592_05345
FNO: Fnod_1646
PMO: Pmob_1166
MARN: LN42_08170
DTN: DTL3_0759
KOL: Kole_0356
AFU: AF_0634
HALH: HTSR_1253
HHSR: HSR6_1326(dapB)
SMR: Smar_0092
IAG: Igag_1701
HBU: Hbut_1431
CMA: Cmaq_1015
VDI: Vdis_2453
VMO: VMUT_0813
LOKI: Lokiarch_19170(rex)
 » show all
Taxonomy
Reference
1  [PMID:4684685]
  Authors
Somack R, Costilow RN.
  Title
2,4-diaminopentanoic acid C 4  dehydrogenase. Purification and properties of the protein.
  Journal
J Biol Chem 248:385-8 (1973)
  Sequence
Reference
2
  Authors
Stadtman, T.C.
  Title
Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase).
  Journal
Adv Enzymol Relat Areas Mol Biol 38:441-445 (1973)
Reference
3  [PMID:4394942]
  Authors
Tsuda Y, Friedmann HC.
  Title
Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide.
  Journal
J Biol Chem 245:5914-26 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.12
IUBMB Enzyme Nomenclature: 1.4.1.12
ExPASy - ENZYME nomenclature database: 1.4.1.12
BRENDA, the Enzyme Database: 1.4.1.12
CAS: 39346-26-4

DBGET integrated database retrieval system