KEGG ENZYME: 1.4.1.16

ENZYME: 1.4.1.16

Entry

EC 1.4.1.16                 Enzyme

Name

diaminopimelate dehydrogenase;
meso-alpha,epsilon-diaminopimelate dehydrogenase;
meso-diaminopimelate dehydrogenase

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor

Sysname

meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)

Reaction(IUBMB)

meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+ [RN:R02755]

Reaction(KEGG)

R02755

Substrate

meso-2,6-diaminoheptanedioate [CPD:C00680];
H2O [CPD:C00001];
NADP+ [CPD:C00006]

Product

L-2-amino-6-oxoheptanedioate [CPD:C03871];
NH3 [CPD:C00014];
NADPH [CPD:C00005];
H+ [CPD:C00080]

History

EC 1.4.1.16 created 1981

Pathway

ec00300

Lysine biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K03340

diaminopimelate dehydrogenase

Genes

PMR:

PMI0150

PMIB:

BB2000_0314

PVL:	AOB99_03565

PVG:	CRN77_00455

PHAU:

PH4a_10775

PROT:

BTA34_02460

PCOL:

F1325_03720

PCIB:

F9282_03540

PPEE:

I6G31_05760

PAPP:

QQS39_03945

PSI:

S70_05250

PSX:

DR96_162

PSTA:

BGK56_08125

PTHA:

OI982_18545

PRG:	RB151_034360(ddh)

PALA:

CO695_09150

PHEI:

NCTC12003_01013(ddh)

PRQ:	CYG50_21290

PRJ:	NCTC6933_03031(ddh)

PVC:	G3341_04960

PMAG:

JI723_05310

PHAG:

PZ638_04950

PZJ:	QS795_013250

MMK:

MU9_1099

MWI:	MNY66_12545

LPV:	HYN51_05185

PRAG:

EKN56_13215

PFQ:	QQ39_04950

LRI:	NCTC12151_02519(ddh)

LGB:	V8L73_13385

PSJ:	PSJM300_13000

ACX:	Achr_22250

PBB:	AKN87_06490

DCE:	O6P33_03505

PBAU:

OS670_19685

MBS:	MRBBS_3827(ddh)

PRW:	PsycPRwf_0683

PUR:	AOC03_01195

PSYC:

DABAL43B_2080

PSYY:

DLE54_03600

PRAE:

MN210_04765

AID:	CTZ23_03480

ADV:	DJ533_05515

AWU:	BEN71_15855

ALW:	FOB21_15185

ACHI:

CDG60_04335

ATG:	J4G44_05200

APOT:

MZO21_02845

MMEO:

OOT43_10755

RHH:	E0Z06_07400

TGR:

Tgr7_1592

HPIS:

P1P91_02530

OCM:	CBP12_05260

OPF:	CBP31_13355

IGN:	MMG00_08780

ILV:	WMO13_00940

WCN:	PE074_07245

ORB:	IPMB12_10075

SINI:

GT972_08685

GPB:	HDN1F_28820(ddh)

CCUP:

BKK81_33865

BTRM:

SAMEA390648702348(ddh)

BOJ:	CBF45_10505

PUT:

PT7_3660

PUS:	CKA81_10010

POLL:

OEG81_03640

AALN:

Q3V95_01110

CDN:	BN940_07121

AFA:	UZ73_15015

AFQ:

AFA_14700

AAQU:

D3M96_15610

AAMM:

FE795_13565

ALCN:

MID00_12175

PHN:	PAEH1_06230

OUR:	CEQ07_10595

OUE:	I6G29_06435

KGY:	EHF36_10905

RFR:

Rfer_1518

AJS:

Ajs_2757

DAC:

Daci_2479

DEL:	DelCs14_4183

DTS:	BI380_11875

DHK:	BO996_11590

DLA:	I6G47_11815

CTT:	CtCNB1_3320

CTES:

O987_19680

CKE:	B5M06_11060

COF:	FOZ74_12680

CRJ:	QMY55_16330

ADN:	Alide_1487

ADK:	Alide2_3439

OTD:	J1M35_03835

DPY:	BA022_02455

DLS:	P4826_01685

DIJ:	HND92_12210

DIA:	Dtpsy_2247

SIMP:

C6571_15485

MELM:

C7H73_10800

MELA:

C6568_01905

MJE:	LVC68_06495

HAR:	HEAR2481(ddh)

OFO:	BRW83_0212(ddh)

OVB:	NB640_06940

OAL:	NB647_00770

NII:	Nit79A3_2698

NCO:	AAW31_00705

TSW:	VA613_06000

THU:	AC731_001535

THAU:

C4PIVTH_2670(dapdh)

DDZ:	DSYM_25360

CCO:	CCC13826_1251(ddh)

CGRA:

CGRAC_1064(ddh)

CSPF:

CSF_0917(ddh)

CRX:	CRECT_1233(ddh)

CCOR:

CCORG_1485(ddh)

CSHO:

CSHOW_0916(ddh)

CCAQ:

CCAL_0848(ddh)

ASK:	EI285_05620

ATP:	ATR_1025(ddh)

ACIB:

ACBT_1441(ddh)

ACRE:

ACRYA_1021(ddh)

ALAN:

ALANTH_1244(ddh)

AFC:	AFAEC_1025(ddh)

ATHR:

ATH_1023(ddh)

APOC:

APORC_0931(ddh)

PCA:

Pcar_2787

PEF:	A7E78_06410

DDS:

Ddes_1119

DPG:	DESPIGER_1507

DEF:	CNY67_07015

VIN:	AKJ08_2232

OTE:

Oter_4154

OLE:	K0B96_00385

ELUT:

CKA38_04350

AMU:

Amuc_0581

AGL:

PYTT_1914

ABIW:

Abiwalacus_06630

AMAK:

J5W79_07320

VBC:	C5Q97_19590

EMI:

Emin_1048

FSU:	Fisuc_0002

FSC:

FSU_0395

BTH:

BT_1979

BTHO:

Btheta7330_01067(ddh)

BFR:

BF3690

BFS:	BF9343_3390

BFG:	BF638R_3505

BFB:	VU15_16515

BHL:	Bache_3222

BOA:	Bovatus_02055(ddh)

BCEL:

BcellWH2_01403(ddh)

BCAC:

CGC64_17795

BCAE:

A4V03_13265

BZG:	C4H11_00340

BHF:	C3V43_05600

BIS:	DXK01_021815

BUN:	Bun01g_37060

BEG:	INE88_00914(ddh)

BSTE:

K6V31_07070

BFE:	K6V30_24025

BNO:	K8P02_13270

BHUM:

JXR92_016835

BFC:	BacF7301_25025

BSAL:

K6V25_20390

BFIN:

BFINE_55310

BACE:

H1A11_11405

BVU:

BVU_1659

BSA:	Bacsa_2579

BDO:	EL88_19995

BDH:	GV66_08595

PCOP:

I6J50_17120

PGI:

PG_0806

PGN:

PGN_0830

PGT:	PGTDC60_1925

PAH:	Poras_1203

PCRE:

NCTC12858_00444(ddh)

PCAG:

NCTC12856_02073(ddh)

PEND:

LA319_05790

PORP:

J4862_06610

PBT:	ING2E5B_1540(ddh)

PMUC:

ING2E5A_1339(ddh)

PET:	PEIBARAKI_5179

PSAC:

PSM36_2295(ddh)

PROJ:

KDN43_08860

DYS:	G7050_13290

DYH:	G7051_13645

PDI:

BDI_3565

PARC:

CI960_00940

PMER:

INE87_02090(ddh)

PGOL:

K6V26_18475

PJO:	LK449_00015 LK449_19295

PFAI:

NXY11_17385

TFO:

BFO_1811

TOH:	BCB71_06885

PARY:

A4V02_06740

MGOD:

E7746_08080

DUN:	FDZ78_00785

DDB:	E7747_00165

DUQ:	E7745_11720

PII:	NF347_07265

BVS:	BARVI_03000

COPR:

Cop2CBH44_30020

CFAS:

Cfast33896_01140

OSP:	Odosp_1546

BUY:	D8S85_12685

BVIR:

I6J59_03595

BFH:	F1611_16790

PMZ:	HMPREF0659_A6106

PDN:	HMPREF9137_1783

PIT:	PIN17_A1039

PDT:	Prede_0951

PRO:	HMPREF0669_01219

PFUS:

ADJ77_00730

PJE:	CRM71_06410

PNI:	J5A59_02785

PMUF:

J4864_00500

PHIS:

J5A62_01650

PHER:

prwr041_03100

PVF:	J5A55_01585

PSCJ:

J4856_10935

PCOU:

L6468_03190

PBIV:

QP022_10215

PRU:

PRU_2042

PCOI:

LK433_04500

POC:	NCTC13071_02708(ddh)

PBY:	L6471_11645

SHOI:

KUA50_008300

SBAO:

L6469_06495

PEO:	AS203_07010

PBUC:

LK429_06410

ALQ:	C7Y71_009490

PCLR:

PC1C4_06600

ALD:	GFH31_05040

AIT:	AI2BBH_16930

ASX:	CDL62_00300

ALKQ:

M9189_04935

PSN:	Pedsa_1251

SHT:	KO02_08070

MYR:	MYRA21_2854(ddh)

MPW:

MPR_1710

MOD:	AS202_13985

MYZ:	BK054_13535

MOA:	I6I89_07705

MALS:

NWE55_15780

DIN:	Selin_2063

MSCH:

N508_001857(ddh)

NDE:

NIDE3823

BSED:

DN745_12495

BFD:	NCTC4823_02682(ddh)

BACO:

OXB_3226

BAQU:

K6959_15875

BACF:

AM500_23225

CSOA:

LIS82_05355

BDA:	FSZ17_06460

OCN:	CUC15_05150

OCB:	CV093_05415

AXL:	AXY_06490(ddh)

LSP:

Bsph_3035

LGY:	T479_10490

LFU:	HR49_11360

LYS:	LBYS11_11950

LYB:	C3943_16180

LYZ:	DCE79_09235

LPAK:

GDS87_12910

LAGR:

FJQ98_13885

LMAC:

I6G82_08085

LYC:	FH508_0011280

LCAP:

ICJ70_11740

LIU:	OU989_11720

LLB:	R6U77_06885

LYQ:	MY533_11485

VNT:	OLD84_03520

VIK:	KFZ58_02870

LAO:	AOX59_10155

LEX:	Len3610_00310

PSYO:

PB01_18360

AIA:	AWH56_003710

BLEN:

NCTC4824_02855(ddh)

SFOR:

QNH23_09020

ACHP:

QR721_02045

HYI:	K2M58_03845

NAMP:

KPF49_05730

NMY:	CJ229_003585

BCOP:

JD108_03830

BRUM:

NDK47_04910

GYM:	GYMC10_4995

PLV:	ERIC2_c02960(ddh)

PBD:	PBOR_16600

PGM:	PGRAT_14355

POD:	PODO_24560

PAEN:

P40081_16835

PAEF:

R50345_24285

PAEQ:

R50912_15705

PAEA:

R70723_14315

PAEE:

R70331_13775

PAEH:

H70357_15910

PAEJ:

H70737_24240

PIH:	UB51_02800

PRI:	PRIO_3117(ddh)

PSON:

JI735_23345

POW:	IJ21_02300

PXL:	BS614_25935

PDH:	B9T62_10550

PIB:	BBD41_20725

PCX:	LPB68_06065

PVO:	PVOR_26810

PLW:	D5F53_04940

PLEN:

EIM92_01650

PLUT:

EI981_02905

PALB:

EJC50_25715

PBK:	Back11_45420

PPRT:

ET464_17605

PBAC:

HUB98_09795

PRZ:	GZH47_15550

PLYC:

GXP70_01510

PTRI:

KDC22_14905

PALO:

E6C60_2624

PCEL:

HUB94_03295

PTJ:	JRJ22_11745

PTHI:

NDS46_02235

PMAH:

PTQ21_28840

PAMY:

P9222_14185

PDY:	QJQ58_20535

PMAE:

LMZ02_08770

PWN:	QNH46_02985

PSPN:

L1F29_32660

PPOG:

QPK24_10660

PPAB:

KET34_26085

PGLU:

A3958_02645

PEZZ:

HW560_13710

TCO:	Theco_1094

COH:	EAV92_07185

COHN:

KCTCHS21_54990

CCHL:

FPL14_10860

CHEB:

HH215_19600

COHL:

J4772_35305

SACA:

FFV09_04320

PLIG:

NAG76_03140

SIV:

SSIL_2217

SSIL:

SOLI23_07585

SOB:	CSE16_10520

KUR:	ASO14_1345

KZO:	NCTC404_02331(ddh)

SPSY:

AZE41_07965

SPOR:

SporoP33_02010

SPOP:

SporoP37_02665

SURE:

SporoP32a_02620

SPOS:

DV702_06375

SPAE:

E2C16_02965

SPOO:

J3U78_01050

SURL:

BI350_06775

STHO:

QNH10_16245

STRB:

QWT68_03280

SOW:	QWT69_05920

SJT:	PGH26_09525

VIJ:	JNUCC6_18790

UTH:	DKZ56_10220

NTR:	B0W44_04290

ESS:	ATZ33_06345

EGV:	EGCR1_00605

EAV:	EH197_09270

ERAF:

J9537_02470

ERX:	ATZ35_14855

THL:	TEH_03760(ddh)

VPI:	BW732_00470

VFV:	K5K99_09315

AUR:	HMPREF9243_1274

AUN:	AWM73_03615

ASAN:

AWM72_07700

AUH:	AWM75_00440

ALOY:

CJ190_003725

AMIT:

DBT49_0004360

ATJ:	DBT50_009870

ABAE:

CL176_04675

GSG:	CYJ72_010920

FCT:	NRE15_12340

CRN:	CAR_c12320(ddh)

CAW:	Q783_05605

CARC:

NY10_629

CVD:	LHA31_00680

JEP:	BW721_07625

JEH:	EJN90_07205

JAR:	G7057_06235

JPO:	G7058_05260

DINC:

QNK01_02150

CTC:

CTC_02532

CTET:

BN906_02779

CNO:	NT01CX_0433

CBK:

CLL_A3000

CBN:

CbC4_2183

CBT:

CLH_2749

CLB:	Clo1100_0671

CBV:

U729_1583

CCHV:

BTM20_05760

CIA:	BEN51_12255

CSEP:

CP523_01845

CCOH:

SAMEA4530647_2233(ddh)

CCAA:

KQH81_16810

CTHD:

CDO33_04005

CLOD:

C820_002050(ddh)

CTH:

Cthe_0922

CTX:	Clo1313_1295

CCL:	Clocl_2080

HSC:	HVS_16175(ddh)

CCE:

Ccel_2533

RHER:

EHE19_006350

RPAY:

P0092_04010

CSS:	Cst_c19600(ddh2)

CSD:

Clst_1878

FPLA:

A4U99_15295

RAL:	Rumal_1291

RUM:

CK1_20790

SMAN:

C12CBH8_00920

PALM:

RBG61_12545

INT:	RX717_00610

STH:

STH1425

CMIC:

caldi_23920

SWO:

Swol_0940

SALQ:

SYNTR_0814

DSY:

DSY0242

DHD:

Dhaf_0187

DDH:	Desde_0169

DDL:	Desdi_0152

DFG:	B0537_00125

HCV:	FTV88_2313

EVN:	NQ558_04880

ALAC:

JYE50_13390

AHC:	JYE49_13600

PROM:

QO263_06025

BPRS:

CK3_21290

CBAF:

JS518_11285

BPB:

bpr_I0298

BFI:

CIY_14290

BHU:

bhn_I0383

BCRO:

NQ527_08190

ROB:

CK5_18050

BYL:	A4V09_13095

BHAN:

CGC63_05045

BLAU:

DQQ01_04600

BPRO:

PMF13cell1_02548(ddh)

BLAB:

EYS05_10165

BLIQ:

INP51_08365

BWX:	NQ550_05455

BMAS:

LK422_13510

BLAR:

LC508_10895

BLUI:

Blut17040_27080

BCOC:

BLCOC_16220(ddh)

BHV:	BLHYD_27020(ddh)

CPY:

Cphy_2659

CSCI:

HDCHBGLK_01253(ddh)

CHYL:

CE91St63_00810

CSH:	Closa_0123

CSO:

CLS_20310

LXA:	OW255_20270

BPRL:

CL2_13780

ARF:	AR1Y2_0013

ACAC:

EYQ97_17455

HSD:	SD1D_0623(ddh)

LUA:	D4A81_06550

LGG:	QJR73_06250

EHL:

EHLA_0471

RTO:

RTO_26020

RGN:	RGna_07830

RLR:	NQ541_08525

CBOL:

CGC65_18255

CASP:

NQ535_10570

ECLF:

QMP25_14180

DLO:	K5I24_05490

DFM:	NQ560_00465

WCP:	H9Q76_09190

SSUN:

H9Q77_06990

MFOR:

NQ534_12865

STOM:

QU660_00860

HHJ:	NQ487_01440

LBW:	C3V36_09215

CLE:	Clole_2654

CEW:	EKH84_16090

VGU:	HYG85_02875

AMIJ:

EQM06_07400

ABUT:

Ami103574_11400

PHX:	KGNDJEFE_01825(ddh)

TEP:	TepRe1_0343 TepRe1_2001

TAE:	TepiRe1_0380(ddh) TepiRe1_2158(ddh)

BACG:

D2962_03545 D2962_15745

KME:	H0A61_00374(ddh)

PED:	ING2D1G_0503(ddh)

MHAP:

JFY71_09795

CAD:	Curi_c28460(ddh)

KPAR:

JL105_02940

TIZ:	RBU61_18865

VPR:

Vpar_0329

VAT:	B7L28_01785

VRM:	44547418_00350(ddh)

VDN:	NCTC11831_00315(ddh)

VNK:	VEIT17_03210

VRG:	OKW85_01730

DPN:	BCB69_04270

SSG:	Selsp_0198

SRI:	SELR_03300(ddh)

SELE:

ADJ74_06150

SELO:

AXE86_03395

SELT:

BCS37_09330

SDIA:

QU667_09425

STIM:

H1B31_04700

SGBI:

P3F81_11870

SSPH:

SPSPH_038940(ddh)

AFN:	Acfer_0990

AIN:

Acin_0942

LCG:	L3BBH23_21360

AMUO:

KWG62_00440

ALLO:

KWG61_09760

EHN:	H9Q80_11875

ERM:	EYR00_08115

FCZ:	IMF26_00605

ACL:

ACL_0763

CCU:	Ccur_13630

ELE:

Elen_0753

EYY:	EGYY_05500

EGD:	GS424_012715

AEQ:

AEQU_0447

AHAT:

ADCFC_19510

BWA:	HLV38_00955

RTS:	CE91St31_24430

CGL:	Cgl2617(Cgl2617)

CGB:	cg2900(ddh)

CGU:	WA5_2528(Ddh)

CGT:

cgR_2525

CGS:	C624_12875

CGG:	C629_12880

CGM:	cgp_2900(ddh)

CGJ:

AR0_12640

CGQ:	CGLAR1_12505

CGX:	SB89_12340

CEF:	CE2498(ddh)

CUR:	cu1936(ddh)

CUA:	CU7111_1859(ddh)

CHN:	A605_12020

CMD:	B841_11040

COA:

DR71_1201

CHM:	B842_11015

CMQ:	B840_10740(ddh)

CEI:	CEPID_10565(ddh)

CTED:

CTEST_11385(ddh)

CDX:	CDES_11895(ddh)

CCJZ:

ccrud_11815

CSPH:

CSPHI_00485

CXE:	FOB82_06245

CRL:	NCTC7448_01350(ddh)

CSUR:

N24_2703(ddh)

CCYS:

SAMEA4530656_0215(ddh)

CYZ:	C3B44_09875

CAMC:

I6I65_08150

CKW:	CKALI_01995(ddh)

CCOE:

CETAM_11400(ddh)

COK:	COCCU_11815(ddh)

CFY:	I6L56_09035

CPSL:

KBP54_10680

CHIN:

J5O04_11965

CFAC:

CFAEC_11485(ddh)

CATR:

CATRI_11280(ddh)

CHAN:

CHAN_00755(ddh)

CGF:	CGUA_11365(ddh)

CSUE:

QP029_01605

CBRE:

QP027_09490

CIK:	H0194_07935

CORN:

BJP05_00435

BFV:	C628_12970

PSOW:

ABI214_23800

GOQ:	ACH46_00380

CBQ:	AL705_02055

TOY:	FO059_12740

MSUW:

GCM10025863_06920

MEST:

PTQ19_08735

MVD:	AWU67_10630

MSPO:

KXZ72_01445

LDN:	H9L06_02200

LLUT:

K1X41_00445

LARI:

KI794_07855

GMN:	GMOLON4_1340(ddh)

ARM:

ART_1975

ARL:	AFL94_00705

AAQ:	AOC05_12210

ARY:	ATC04_17305

ACRY:

AC20117_19940

ASUF:

MNQ99_08880

APOA:

J0916_11505

AAI:	AARI_01410(ddh)

GCR:	GcLGCM259_2435

GLU:	F0M17_00695

GPR:	JQN66_00770

GMY:

XH9_07830

GNC:	QQS42_00675

MLU:	Mlut_19060

MICK:

B1A86_00009455

MYU:	M8233_09045

MICU:

SOY78_03025

AUL:	DCC27_012035

AIG:	QDX25_11945

PALU:

CJ193_001860

BFA:	Bfae_19670

BRV:	CFK39_02230

BRZ:	CFK38_09090

HMM:	R3I40_07140

SANW:

G7063_09000

PSEI:

GCE65_08245

GYU:	FE374_00140

MCU:	HMPREF0573_10717

TPY:	CQ11_07205

TPYO:

X956_00505

TBW:	NCTC13354_00986(ddh)

TPEC:

HLG82_10195

TBER:

QPC17_08610

ASG:	FB03_06260

AUU:	CJ184_003050

ATIM:

CYJ17_0001880

ACTT:

DDD63_02850

AOS:	AXE84_06435

ACTP:

B6G06_01355

ACTC:

CHIBA101_2093

ACTO:

C3V41_10850

ANE:	ATCC27039_26750

AHW:	NCTC11636_02225(ddh)

AIR:	NCTC12972_00086(ddh)

ASLA:

NCTC11923_00067(ddh)

AVC:	NCTC10951_02639(ddh)

AWE:	JG540_08605

AMAM:

HPC72_08615

AREP:

ID810_01585

AMAS:

QU670_12075

ACAP:

MANAM107_06850

AUO:	R3I39_04100

ALIL:

D5R93_10690

ACTH:

JJJ15_08460

ACHN:

JJJ14_11015

FSL:	EJO69_11145

FLH:	EJ997_12780

WIK:	H8R18_08795

WNE:	PIG85_04410

GEU:	CJ185_000510

VCB:	CYK25_006855

BSUE:

BS3272_02775

ABAO:

BEQ56_10965

ARAM:

KAR29_00655

TTA:	Theth_1310

PHY:	AJ81_04975

MVN:	Mevan_0344

MARO:

MarbSA_08200

MHI:

Mhar_0438

» show all

Reference

1 [PMID:10904]

Authors

Misono H, Togawa H, Yamamoto T, Soda K.

Title

Occurrence of meso-alpha, epsilon-diaminopimelate dehydrogenase in Bacillus sphaericus.

Journal

Biochem Biophys Res Commun 72:89-93 (1976)
DOI:10.1016/0006-291X(76)90964-5

Reference

2 [PMID:762012]

Authors

Misono H, Togawa H, Yamamoto T, Soda K

Title

Meso-alpha,epsilon-diaminopimelate D-dehydrogenase: distribution and the reaction product.

Journal

J Bacteriol 137:22-7 (1979)
DOI:10.1128/JB.137.1.22-27.1979

Sequence

[ag:BAB07799]

Other DBs

ExplorEnz - The Enzyme Database:

1.4.1.16

IUBMB Enzyme Nomenclature:

1.4.1.16

ExPASy - ENZYME nomenclature database:

1.4.1.16

BRENDA, the Enzyme Database:

1.4.1.16

CAS:	60894-21-5

DBGET integrated database retrieval system