Entry |
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Name |
lysine 6-dehydrogenase;
L-lysine epsilon-dehydrogenase;
L-lysine 6-dehydrogenase;
LysDH
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Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
L-lysine:NAD+ 6-oxidoreductase (deaminating)
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Reaction(IUBMB) |
L-lysine + NAD+ = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NADH + H+ + NH3 (overall reaction) [RN: R10054];
(1a) L-lysine + NAD+ + H2O = (S)-2-amino-6-oxohexanoate + NADH + H+ + NH3 [RN: R00446];
(1b) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous) [RN: R02317]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme is highly specific for L-lysine as substrate, although S-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly. While the enzyme from Agrobacterium tumefaciens can use only NAD+, that from the thermophilic bacterium Geobacillus stearothermophilus can also use NADP+, but more slowly [1,4].
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History |
EC 1.4.1.18 created 1989, modified 2006, modified 2011
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Pathway |
ec00960 | Tropane, piperidine and pyridine alkaloid biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
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Genes |
» show all
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Reference |
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Authors |
Misono H, Nagasaki S. |
Title |
Occurrence of L-lysine epsilon-dehydrogenase in Agrobacterium tumefaciens. |
Journal |
J Bacteriol 150:398-401 (1982) |
Reference |
2 |
Authors |
Misono, H., Uehigashi, H., Morimoto, E. and Nagasaki, S. |
Title |
Purification and properties of L-lysine epsilon-dehydrogenase from Agrobacterium tumefaciens. |
Journal |
Agric Biol Chem 49:2253-2255 (1985) |
Reference |
|
Authors |
Misono H, Hashimoto H, Uehigashi H, Nagata S, Nagasaki S. |
Title |
Properties of L-lysine epsilon-dehydrogenase from Agrobacterium tumefaciens. |
Journal |
J Biochem (Tokyo) 105:1002-8 (1989) |
Reference |
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Authors |
Heydari M, Ohshima T, Nunoura-Kominato N, Sakuraba H. |
Title |
Highly stable L-lysine 6-dehydrogenase from the thermophile Geobacillus stearothermophilus isolated from a Japanese hot spring: characterization, gene cloning and sequencing, and expression. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.4.1.18 |
ExPASy - ENZYME nomenclature database: | 1.4.1.18 |
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