KEGG   ENZYME: 1.4.1.20Help
Entry
EC 1.4.1.20                 Enzyme                                 

Name
phenylalanine dehydrogenase;
L-phenylalanine dehydrogenase;
PHD
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-phenylalanine:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB)
L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH + H+ [RN:R00688]
Reaction(KEGG)
Substrate
L-phenylalanine [CPD:C00079];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
phenylpyruvate [CPD:C00166];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzymes from Bacillus badius and Sporosarcina ureae are highly specific for L-phenylalanine; that from Bacillus sphaericus also acts on L-tyrosine.
History
EC 1.4.1.20 created 1989
Pathway
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K00270  phenylalanine dehydrogenase
Genes
BHA: BH0218(pdh)
BAG: Bcoa_2696
BIF: N288_11510
BACO: OXB_2922
BEO: BEH_00940
BON: A361_12115
BHK: B4U37_11725
BKO: CKF48_14850
OIH: OB2878
GKA: GK2031(pdh)
GTN: GTNG_1916
GGH: GHH_c20750(pdh)
ANM: GFC28_427(pdh)
AAMY: GFC30_1772(pdh)
ANL: GFC29_1197(pdh)
VPN: A21D_01988(pdh)
PSYO: PB01_19085
ESI: Exig_0386
EAN: Eab7_0362(pdh)
JEO: JMA_35970
 » show all
Taxonomy
Reference
1  [PMID:3112142]
  Authors
Asano Y, Nakazawa A, Endo K.
  Title
Novel phenylalanine dehydrogenases from Sporosarcina ureae and Bacillus sphaericus. Purification and characterization.
  Journal
J Biol Chem 262:10346-54 (1987)
Reference
2  [PMID:3311741]
  Authors
Asano Y, Nakazawa A, Endo K, Hibino Y, Ohmori M, Numao N, Kondo K.
  Title
Phenylalanine dehydrogenase of Bacillus badius. Purification, characterization and gene cloning.
  Journal
Eur J Biochem 168:153-9 (1987)
DOI:10.1111/j.1432-1033.1987.tb13399.x
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.20
IUBMB Enzyme Nomenclature: 1.4.1.20
ExPASy - ENZYME nomenclature database: 1.4.1.20
BRENDA, the Enzyme Database: 1.4.1.20
CAS: 69403-12-9

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