KEGG   ENZYME: 1.4.1.21
Entry
EC 1.4.1.21                 Enzyme                                 
Name
aspartate dehydrogenase;
AspDH;
NAD-dependent aspartate dehydrogenase;
NADH2-dependent aspartate dehydrogenase;
NADP+-dependent aspartate dehydrogenase;
nadX (gene name);
L-aspartate:NAD(P)+ oxidoreductase (deaminating)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-aspartate:NAD(P)+ oxidoreductase (2-iminosuccinate-forming)
Reaction(IUBMB)
L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+ (overall reaction) [RN:R07164 R07165];
(1a) L-aspartate + NAD(P)+ = 2-iminosuccinate + NAD(P)H + H+ [RN:R07407 R07410];
(1b) 2-iminosuccinate + H2O = oxaloacetate + NH3 (spontaneous) [RN:R13023]
Reaction(KEGG)
Substrate
L-aspartate [CPD:C00049];
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
2-iminosuccinate [CPD:C05840]
Product
oxaloacetate [CPD:C00036];
NH3 [CPD:C00014];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
2-iminosuccinate [CPD:C05840]
Comment
The enzyme is strictly specific for L-aspartate as substrate. It produces the unstable compound 2-iminosuccinate, which, in the presence of water, hydrolyses spontaneously to form oxaloacetate. The enzyme from some archaea and thermophilic bacteria is likely to transfer 2-iminosuccinate directly to EC 2.5.1.72, quinolinate synthase, preventing its hydrolysis and enabling the de novo biosynthesis of NAD+.
History
EC 1.4.1.21 created 2005, modified 2022
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
Orthology
K06989  aspartate dehydrogenase
Genes
HSA554235(ASPDH)
PTR468963(ASPDH)
PPS100991588(ASPDH)
PON100458998(ASPDH)
NLE100582846(ASPDH)
HMH116478129(ASPDH)
MCC719609(ASPDH)
MCF102127481(ASPDH)
MTHB126943129
MNI105497153(ASPDH)
CSAB103235088(ASPDH)
CATY105595331(ASPDH)
PANU101000721(ASPDH)
TGE112613051(ASPDH)
MLEU105528951(ASPDH)
RRO104667233(ASPDH)
RBB108535792(ASPDH)
TFN117091633(ASPDH)
PTEH111519937(ASPDH)
CANG105514734(ASPDH)
CJC100398830(ASPDH)
SBQ101043066(ASPDH)
CIMI108291991(ASPDH)
MMUR105865549(ASPDH)
LCAT123623775(ASPDH)
PCOQ105809344(ASPDH)
OGA100966944(ASPDH)
MMU68352(Aspdh)
MCAL110298152(Aspdh)
MPAH110334327(Aspdh)
RNO292875(Aspdh)
MCOC116102127(Aspdh)
ANU117720258(Aspdh)
MUN110546841(Aspdh)
CGE100755598(Aspdh)
MAUA101836570(Aspdh)
PROB127213868(Aspdh)
PLEU114684330(Aspdh)
MORG121453252(Aspdh)
MFOT126488181
AAMP119802833(Aspdh)
NGI103743703(Aspdh)
HGL101725004
CPOC100719302(Aspdh)
CCAN109683860(Aspdh)
DORD105994278(Aspdh)
DSP122125628(Aspdh)
PLOP125338524(Aspdh)
NCAR124967170
MMMA107151210(Aspdh)
OPI101516226(ASPDH)
TUP102486263(ASPDH)
GVR103593091(ASPDH)
CFA611841(ASPDH)
CLUD112645096(ASPDH)
VVP112931209(ASPDH)
VLG121475608(ASPDH)
NPO129501039(ASPDH)
AML100484510(ASPDH)
UMR103657276(ASPDH)
UAH113247280(ASPDH)
UAR123778011(ASPDH)
ELK111160613
LLV125089390
MPUF101672077(ASPDH)
MNP132005386(ASPDH)
MLK131817579(ASPDH)
NVS122911779(ASPDH)
ORO101373096(ASPDH)
EJU114199573(ASPDH)
ZCA113935382(ASPDH)
MLX117998329(ASPDH)
NSU110579231(ASPDH)
LWW102741542(ASPDH)
FCA101099166(ASPDH)
PYU121018953(ASPDH)
PCOO112851202(ASPDH)
PBG122493814(ASPDH)
LRUF124511702
PTG102961245(ASPDH)
PPAD109253004(ASPDH)
PUC125915272
AJU106983134
HHV120242680(ASPDH)
BOM102284425(ASPDH)
BIU109571906
BBUB102410288(ASPDH)
BBIS104995688(ASPDH)
CHX102176455(ASPDH)
OAS101118046(ASPDH)
BTAX128063391(ASPDH)
ODA120872019(ASPDH)
CCAD122421508(ASPDH)
MBEZ129546507(ASPDH)
SSC100511638(ASPDH)
CFR102516988(ASPDH)
CBAI105062669(ASPDH)
CDK105100165(ASPDH)
VPC102526710(ASPDH)
BACU103008927(ASPDH)
LVE103083700(ASPDH)
OOR101285253(ASPDH)
DLE111181102(ASPDH)
PCAD102977422(ASPDH)
PSIU116743836(ASPDH)
NASI112415489(ASPDH)
ECB111775246(ASPDH)
EPZ103543350(ASPDH)
EAI106845486(ASPDH)
MYB102247701(ASPDH)
MYD102767203(ASPDH)
MMYO118649299(ASPDH)
MNA107531836(ASPDH)
PKL118718775(ASPDH)
EFUS103297606(ASPDH)
HAI109391040(ASPDH)
DRO112310042(ASPDH)
AJM119052005(ASPDH)
PDIC114511720(ASPDH)
PHAS123830273(ASPDH)
MMF118638341(ASPDH)
RFQ117035611(ASPDH)
PPAM129082962(ASPDH)
PALE102878612(ASPDH)
PGIG120615567(ASPDH)
PVP105301778(ASPDH)
RAY107500464(ASPDH)
MJV108397934(ASPDH)
TOD119248680(ASPDH)
SARA101553382(ASPDH)
TMU101343021
ETF101664264(ASPDH)
DNM101444918(ASPDH)
GAS123255201(ASPDH)
SHR100935136(ASPDH)
AFZ127556845
PCW110197917(ASPDH)
OAA114814597(ASPDH)
GGA101749079(ASPDH)
MGP104917106(ASPDH)
CJO107307151(ASPDH)
LMUT125687702(ASPDH)
NMEL110392022(ASPDH)
AFUL116501748(ASPDH)
TGU115491539(ASPDH)
LSR110481765(ASPDH)
PMOA120506287(ASPDH)
OTC121337854(ASPDH)
PRUF121348556(ASPDH)
PHI102108482(ASPDH)
ETL114072334(ASPDH)
FCH102051070(ASPDH)
TALA122153259(ASPDH)
AGEN126034888
ASN102379311(ASPDH)
AMJ102562574(ASPDH)
PSS102452013(ASPDH)
CMY102942202(ASPDH)
CCAY125628323(ASPDH)
DCC119847192(ASPDH)
CPIC101932416(ASPDH)
CABI116823911
MRV120388148(ASPDH)
ACS100563350(aspdh)
ASAO132778074(ASPDH)
PVT110086937(ASPDH)
SUND121933505(ASPDH)
PBI103054992(ASPDH)
PMUR107282369(ASPDH)
CTIG120314586(ASPDH)
TSR106542527(ASPDH)
PGUT117669049(ASPDH)
PTEX113442919(ASPDH)
NSS113413350(ASPDH)
VKO123030592(ASPDH)
PMUA114582574(ASPDH)
PRAF128399664(ASPDH)
ZVI118095808(ASPDH)
HCG128328833(ASPDH)
GJA107115523(ASPDH)
STOW125445218(ASPDH)
EMC129338240(ASPDH)
XLA108697271(aspdh.S)
XTR548417(aspdh)
NPR108794232(ASPDH)
RTEM120920150 120921221
BBUF120982094(ASPDH)
MUO115466640(ASPDH)
GSH117367380(ASPDH)
DRE447919(aspdh)
SRX107731187 107736706 107754162
SANH107690305(aspdh)
SGH107560744 107567544(aspdh)
CCAR109069550(aspdh)
CAUA113046919(aspdh)
CGIB127952804
PTET122335730(aspdh)
LROH127162948(aspdh)
OMC131536399(aspdh)
PPRM120489114(aspdh)
RKG130075302(aspdh)
MAMB125279479(aspdh)
CIDE127508697
MASI127450503 127451774
TROS130562126(aspdh)
TDW130425723(aspdh)
MANU129436256(aspdh)
IPU100529011(aspdh)
IFU128601803(aspdh)
PHYP113528454(aspdh)
SMEO124396911(aspdh)
TFD113641174(aspdh)
TVC132860588(aspdh)
AMEX103022704(aspdh)
CMAO118821268(aspdh)
EEE113589868(aspdh)
CHAR105894962(aspdh)
TRU101077325(aspdh)
TFS130514429(aspdh)
TNGGSTEN00038381G001
LCO109136720(aspdh)
NCC104942713(aspdh)
TBEN117492402(aspdh)
CGOB115011807(aspdh)
PGEO117451054(aspdh)
GACU117544107(aspdh)
ELY117268780(aspdh)
EFO125880008(aspdh)
PLEP121956564(aspdh)
SLUC116065198(aspdh)
ECRA117958356(aspdh)
ESP116703763(aspdh)
PFLV114569320(aspdh)
GAT120827239(aspdh)
PPUG119220136(aspdh)
AFB129098101(aspdh)
CLUM117734506(aspdh)
MSAM119886615(aspdh)
CUD121503337(aspdh)
ALAT119013376(aspdh)
MZE101485812(aspdh)
ONL100704104(aspdh)
OAU116314578(aspdh)
OLA101155692(aspdh)
OML112146380(aspdh)
XMA102224340(aspdh)
XCO114160007(aspdh)
XHE116735650(aspdh)
PRET103469091(aspdh)
PFOR103145418(aspdh)
PLAI106951623(aspdh)
PMEI106931191(aspdh)
GAF122822356(aspdh)
CVG107095144(aspdh)
CTUL119781683(aspdh)
GMU124862301 124864056
NFU107376659(aspdh)
KMR108242971(aspdh)
ALIM106528139(aspdh)
NWH119422207(aspdh)
AOCE111565340(aspdh)
MCEP124997532(aspdh)
CSEM103392976(aspdh)
POV109641468(aspdh)
SSEN122785100(aspdh)
HHIP117766758(aspdh)
HSP118123858(aspdh)
LCF108881011
SDU111230271(aspdh)
SLAL111649093(aspdh)
XGL120807581(aspdh)
HCQ109514857(aspdh)
SSCV125984164
SBIA133514314(aspdh)
PEE133414519(aspdh)
PTAO133465586(aspdh)
BPEC110158220(aspdh)
MALB109958884(aspdh)
BSPL114860839(aspdh)
SJO128378739(aspdh)
SASA106591495 106601950 106606414
STRU115171859 115207644
OTW112237787(aspdh)
OMY110487448(aspdh) 110511852
OGO124020626 124020627
OKI109876546(aspdh)
SALP112078660(aspdh)
SNH120043782(aspdh)
CCLU121551577 123482639
ELS105007708(aspdh)
SFM108941640(aspdh)
PKI111836844(aspdh)
AANG118216523(aspdh)
PSPA121305968(aspdh)
ARUT117970905 117970906
PSEX120543168(aspdh)
LCM102359378(ASPDH)
RTP109912393(aspdh)
CPLA122543220(aspdh)
HOC132836991(aspdh)
LERI129713353(aspdh)
PMRN116945529(ASPDH)
LRJ133351357(ASPDH)
BFO118426573
BBEL109465502
CIN100184692
SCLV120329627
SPU115926640 585815
LPIC129255016
APLC110982300
AJC117124536
SKO100369721
BCOO119085277
DPXDAPPUDRAFT_305350
DMK116928422
DPZ124352536
PVM113814917
PJA122261940
PCHN125031540
PMOO119593508
HAME121873524
PCLA123746103
CQD128685094
ESN126980674
HAZT108682961
EAF111712730
LSM121115273
TCF131886261
PPOI119109680 119110711
ISC121837579
DSV119464338
RSAN119401352
RMP119164015
VDE111246737
VJA111266911
DPTE113798752
DFR124498158
CSCU111615658
PTEP107452582 107452803
UDV129224442
SDM118197485
LPOL106470129
PMEO129581452
CELCELE_F17C8.9(F17C8.9)
CBRCBG_17998
CRQGCK72_010039
HROHELRODRAFT_103179
LGILOTGIDRAFT_119936
PVUL126815560
PCAN112562160
GAE121389685
HRF124131978
HRJ124276975
CRG105333864
CVN111136573
CANU128187288
OED125664484
MYI110458570
PMAX117333347
MCAF127712441
MMER123534441
RPHI132739073
DPOL127872103
LAK106178052 106178148
ADF107328243
AMIL114968985
PDAM113679302
SPIS111333019
DGT114520534 114538257
XEN124447576
HMG100203319
HSY130623313
AQU100635018 100635143
AAFAURANDRAFT_13917
EHXEMIHUDRAFT_199949 EMIHUDRAFT_214926
NGRNAEGRDRAFT_62082
ENCECL_04254
ENLA3UG_18775
ECLGEC036_36510
ECLEECNIH2_18965
ECLNECNIH4_04300
ECLIECNIH5_17875
ECLXLI66_18645
ECLYLI62_20105
ECLZLI64_17535
ECLOENC_31770
EHMAB284_07145
EXFBFV63_18305
ECLAECNIH3_17955
ECLCECR091_17890
EKBBFV64_19155
ENOECENHK_18425
EECEcWSU1_03724(nadX)
ELGBH714_21140
ECANCWI88_03910
EPTHWQ17_17435
EBGFAI37_10705
ENDA4308_03105
ENZG0034_18830
ENSHWQ15_04025
ENKLOC22_06790
EHUD5067_0004040
EMORL6Y89_18010
KPNKPN_03362
KPMKPHS_44280
KPHKPNIH24_06740
KPVKPNIH29_22295
KPWKPNIH30_22300
KPYKPNIH31_21555
KPGKPNIH32_23155
KPCKPNIH10_22055
KPQKPR0928_21565
KPTVK055_4120
KPRKPR_4627(aspD)
KPJN559_0875
KPID364_17305
KPAKPNJ1_00873
KPSKPNJ2_00907
KPBFH42_12780
KPNEKU54_004280
KPNULI86_04285
KOCAB185_11485
KQUAVR78_00685
EAEEAE_03000
EARCCG33381
KPASLUW96_02525
KLCK7H21_04020
RORRORB6_22705
RONTE10_23710
RPLNB1209_03920
RAODSD31_04155
RTGNCTC13098_01033(nadX)
EBTEBL_c05930
CNTJT31_15900
KASKATP_07670(nadX)
KCYRIN60_03880
LEIC2U54_00380
LEEDVA44_04050
LERGNG29_18915
LEAGNG26_18310
LPNUKQ929_03310
LEYDVA43_22585
LAZA8A57_17380
YREHEC60_14180
IZHFEM41_00940
PSGCG163CM_43930(nadX)
EBFD782_0775
EBUCUC76_19480
YSIBF17_03510
YROCH64_1868
SMARSM39_3550
SMACSMDB11_3365
SMWSMWW4_v1c40670
SPESpro_3958
SRRSerAS9_4164
SRLSOD_c39140(nadX)
SRYM621_21025
SPLYQ5A_020975(nadX)
SRSSerAS12_4165
SRASerAS13_4165
SMAFD781_3679
SLQM495_20670
SERFL085_08165
SERSSERRSCBI_19775
SFWWN53_02570
SFGAV650_25295
SRZAXX16_1406
SERMCLM71_19210
SQUE4343_20600
SFJSAMEA4384070_4073(nadX)
SOFNCTC11214_02673(nadX)
SSURATE40_017050
SURIJ0X03_03570
SRHZFO014_14945
SENPKHA73_19870
SNEMNLX84_20655
SNEVOI978_11040
SFOZ042_06940
ETORIN69_18380
PANPPSNIH2_01795
PCDC2E16_17280
MINTC7M51_02642(nadX)
MTHIC7M52_00215(nadX)
PSIS70_18990
PSXDR96_2715
PSTABGK56_01080
PRGRB151_040040(nadX)
PVCG3341_12280
PMAGJI723_12280
PTHAOI982_04335
PHAGPZ638_16610
PRAGEKN56_00430
PFQQQ39_00800
LRINCTC12151_00054(nadX)
FAUFraau_1819
RGLCS053_05620
DCSISN74_17275
PAEPA3505
PAEVN297_3628
PAEIN296_3628
PAECM802_3627
PAEOM801_3493
PREPCA10_15620(nadX)
PFUWKF707C_16600
PCQPcP3B5_08000(nadX)
PFCPflA506_5348
PMUDNCTC8068_05350(nadX)
PSVPVLB_18275
PALKPSAKL28_39290
PSILPMA3_18860
PEZHWQ56_28400
PPIIQL104_31060
PVWHU752_013715
PSAMHU731_015635
PSHHHU773_000560
PTKEXN22_08370
PHYGJTY93_27005
PCRPcryo_1256
PSOPSYCG_06625
PSYCDABAL43B_1054
ACBA1S_0956
ABYABAYE2838
ABCACICU_00917
ABNAB57_1031
ABBABBFA_02632(nadX)
ABXABK1_0941
ABZABZJ_01057
ABRABTJ_02855
ABDABTW07_1046
ABHM3Q_1254
ABADABD1_09080
ABJBJAB07104_01051
ABABBJAB0715_01069
ABAJBJAB0868_01065
ABAZP795_12930
ABKLX00_04805 LX00_09365
ABAUIX87_00755 IX87_20070
ABAAIX88_06785
ABWBL01_11485
ABALABLAC_17220
ACCBDGL_000233(nadX)
ANORR32_13355
ALCOTEC02_14105
ACALBUM88_04605
ASEII8T81_14220
ACDAOLE_14565
ACIACIAD0997
ACWA0J50_12670
ACVAMD27_03990
AHLAHTJS_05510
ASOLBEN76_08650
ALABFG52_11175
ARJDOM24_08175
AGUAS4_33790(nadX)
AUGURS_1868
ADSFPL17_02585
ABERBSR55_07185
AGYLFPL18_13955
AVZHWI77_11005
AVIVLF296_11000
SEURFM038_019280
PHAPSHAb0019
LALAT746_01320
TTUTERTU_1273
GAIIMCC3135_20465(nadX)
WOCBA177_04350
CSACsal_0141
HHUAR456_06880
HCOLOKO_02885(nadX)
HBEBEI_0086(nadX)
HTXEKK97_03410(nadX)
HBHE4T21_01305
MRZKDW95_12615
ZDFAN401_14370
IGNMMG00_11830
WCNPE074_00755
VMSLVJ82_01745
RSORSp0722
RSEF504_4495
RPUCDC45_21225
RNCGO999_17695
RSLRPSI07_mp0621(nadX)
RSNRSPO_m01055(nadX)
RSMCMR15_mp10693(nadX)
RSYRSUY_39230(nadX)
RSGJK151_01740
RPIRpic_4503
RPFRpic12D_4635
RPJN234_24510
RMNTK49_17095
RINACS15_4622
RWEKOL96_07580
REHH16_B0736(h16_B0736)
CNCCNE_2c06790(nadX)
CUHBJN34_24880
REUReut_B3576
CTIRALTA_B0572(nadX)
CBWRR42_m2774
CCUPBKK81_20610
CUPBKK80_21270
CUUBKK79_26485
CPAUEHF44_27465
COXE0W60_08540
CCAMM5D45_27270
CUKKB879_21110
BMABMAA1329
BMVBMASAVP1_0312
BMLBMA10229_0588
BMNBMA10247_A0979
BMALDM55_4193
BMAEDM78_3324
BMAQDM76_4893
BMAIDM57_10405
BMAFDM51_4982
BMAZBM44_4157
BMABBM45_3279
BPSBPSS0903
BPMBURPS1710b_A2501
BPLBURPS1106A_A1241
BPDBURPS668_A1314
BPSEBDL_4191
BPSMBBQ_5234
BPSUBBN_4362
BPSDBBX_6031
BPZBP1026B_II0990
BPQBPC006_II1257
BPKBBK_3535
BPSHDR55_4433
BPSABBU_5128
BPSOX996_4139
BUTX994_6222
BTEBTH_II1494
BTQBTQ_4781
BTJBTJ_3413
BTZBTL_4261
BTDBTI_5722
BTVBTHA_3696
BTHEBTN_3430
BTHMBTRA_4181
BTHADR62_3503
BTHLBG87_4237
BOKDM82_5076
BOCBG90_5519
BUUWS70_21935
BSAVWS86_23270
BHGI6G56_23465
BUDAQ610_26145
BURBcep18194_B1112
BCMBcenmc03_5598
BCHBcen2424_4702
BCJBCAM1845
BCENDM39_5965
BCEWDM40_4673
BCEOI35_5723
BAMBamb_4096
BACBamMC406_4561
BMJBMULJ_04511
BMUBmul_3991
BMKDM80_5299
BMULNP80_4617
BCTGEM_3772
BCEDDM42_6105
BCEPAPZ15_29505
BDLAK34_3789
BPYRABD05_26430
BCONNL30_02835
BUBBW23_5498
BDFWI26_22255
BLATWK25_25800
BTEIWS51_06760
BSEMWJ12_29350
BPSLWS57_04780
BMECWJ16_10170 WJ16_27970
BSTGWT74_28390
BSTLBBJ41_22815
BANNJFN94_27405
BARINLX30_28170
BAENL3V59_23485
BUGBC1001_4727
BGFBC1003_5026
BGDbgla_2g11350
BGOBM43_4782
BYIBYI23_C011310
BUEBRPE67_CCDS00790(nadX)
BULBW21_5409
BUQAC233_26410
BGPBGL_2c01270
BPLAbpln_2g01270
BURKDM992_31210
BXEBxe_B0182
BXBDR64_5528
BPHBphy_4240
BPXBUPH_01292 BUPH_08279
BPYBphyt_7066
BUZAYM40_34985
BFNOI25_5072 OI25_5516
BCAIK788_0000827
PARBCJU94_28350
PHSC2L64_32595
PTERC2L65_29265 C2L65_45115
PGPCUJ91_29825
PCJCUJ87_28245
PTSCUJ90_23475
PCAFDSC91_003069
PTROG5S35_32840
PGISI6I06_27840
PACPFAZ97_32805
PACSFAZ98_16345
PDIOPDMSB3_3298.1(nadX)
PBRYNDK50_07380 NDK50_21560
PSAAQEN71_16940 QEN71_41325
PPKU875_18035
PPNODA70_10545
PPNMLV28_20515
PRBX636_16085
PPULRO07_14810
PSPUNA29_22330
PAPISG18_13665 SG18_14690
PVEUC34_05990
POXMB84_10430
PTXABW99_12560
PFGAB870_17015
PNRAT302_01085 AT302_13325
PANDDRB87_05375
PFIBPI93_011780 PI93_022255
PCOMNTU39_06910
CABASBC2_52700(nadX_1) SBC2_81260(nadX_2)
BUOBRPE64_CCDS00980
CABKNK8_77000 NK8_82050
BPEBP0567 BP1922
BPCBPTD_0576 BPTD_1894
BPERBN118_0921 BN118_3500
BPETB1917_1714 B1917_3487
BPEUQ425_14660 Q425_35820
BPARBN117_0255 BN117_1450 BN117_4327
BPABPP0257 BPP2295
BBHBN112_1768 BN112_3157 BN112_3641
BBRBB0260 BB1747 BB4781
BBMBN115_0245 BN115_1649 BN115_4458
BBXBBS798_0255 BBS798_1648 BBS798_4557
BAVBAV2441
BHOD560_2985
BHMD558_2961
BHZACR54_01428(nadX)
BTRMSAMEA390648704134(nadX)
BBROBAU06_23775
BFZBAU07_03915 BAU07_23965
BPDZBBN53_14650
BOHAKI39_14235 AKI39_22760
BGMCAL15_10730
BOJCBF45_01120 CBF45_08870
BGVCAL12_15670 CAL12_20595
AXYAXYL_04286
AXONH44784_057651
AXNAX27061_4026
AXXERS451415_04045(nadX)
ADTAPT56_18815
AISBUW96_10620
ASWCVS48_06345 CVS48_22910
ACHRC2U31_16625
ACHBDVB37_17320
ADYHLG70_02700
ACHOH4P35_16675
AMUIPE062_13660
APESFOC84_24435
AAEGRA224_11670
PUTPT7_3205
PUDG9Q38_11195
PUSCKA81_16895
POLLOEG81_01385
AKATKWG_07660
AFAUZ73_02795
AAQUD3M96_13205
PHNPAEH1_07375
ODIODI_R3090
BOZDBV39_18980
ODHDHf2319_03150
OURCEQ07_10640
OUEI6G29_06515
PIGEGT29_00760 EGT29_02180 EGT29_16640
PACRFXN63_21690
KGYEHF36_01305 EHF36_08995
RHYRD110_02340
POLBpro_3686
POSDT070_01375
POOF7R28_08075
DACDaci_0952
DELDelCs14_5572
DTSBI380_19935
DHKBO996_04840
DLAI6G47_19870
VAPVapar_3166
VPEVarpa_3589
VPDVAPA_1c32530(nadX)
VBOCKY39_14770 CKY39_21980
CTTCtCNB1_4615
CTESO987_27360
CODOLAD35_19225
CTEZCT3_40030(nadX)
AANTHUK68_13265
CRJQMY55_23590
OTKC6570_07085
HYNF9K07_11735 F9K07_22040
DRGH9K76_11985
PKTAT984_19020
ATERMW290_29080
HSEHsero_4681
HSZACP92_23390
HHTF506_19630
HRBHrubri_1303
HEEhmeg3_00135
HHFE2K99_23280
HFRG5S34_07790
CARELT85_0538
MUMFCL38_03855
XYKGT347_06945
XYGR9X41_02020
BBAYA4V04_03390 A4V04_09290
APETToN1_02130(nadX)
MCICA4R28_14775
MAMOA6B35_33435
MESPC1M53_19045
MESRFGU64_17550
MESMeso_0824
AAKAA2016_3969
AMIHCO731_02616(nadX)
AMISAmn_24970
ANJAMD1_2515(nadX)
NKIKW403_11300 KW403_13255
NRHT8J41_11260
EMXFKV68_20985
EAHFA04_32110
ENPJVX98_29335
AVVRvVAT039_pl06520(nadX)
ALEGCFBP4996_28095
AVIAvi_9150
RJGCCGE525_35930
RHRCKA34_28130 CKA34_28995
RADCO657_10725
NENNCHU2750_42570(nadX) NCHU2750_43420(nadX) NCHU2750_48250
OANOant_4396
OAHDR92_3848
OPSA8A54_22030
OCRHGK82_15105
OCLGTN27_12950
BJAbll6567(bll6567)
BJUBJ6T_28610
BJPRN69_13980
BRSS23_17600
BRCBCCGELA001_10165
BRADBF49_5096
BICLMTR13_01995
BRKCWS35_15120
BOTCIT37_21765
BRQCIT40_24670
BGQX265_10355
BGZXH91_09320
BSYMCIT39_23670
BBETF8237_23935
BARHWN72_37545
BVZBRAD3257_2684(nadX)
BELBE61_75330
BDGLPJ38_14560
BSEPHAP48_0028630
BQBJ4P68_0029860
BSEIKMZ68_10745
BBANJ4G43_039020
BCANBcanWSM471_28850
BAUTQA635_31055
BBRAQA636_32615
BGKIC762_09280
BCOUIC761_09195
BPAHQA639_12010
BXNI3J27_28280
BROSQUH67_33085
BRAZLRP30_34980
RPBRPB_0147 RPB_3108
RBKE0H22_17060
VGOGJW-30_1_01281(nadX)
TRBHB776_12130
TALZRPMA_18060
BOPAXW83_17240
BOSBSY19_4400
BVVBHK69_08085
BOIBLM15_24315
BOFFQV39_24550 FQV39_24895 FQV39_30835
AZCAZC_4388
STARG3545_20370 G3545_23200
APRAG3A50_09690 G3A50_21125
MMESMMSR116_04725
MTADM6G65_23560
CHELAL346_20720
RHZRHPLAN_08010 RHPLAN_32260 RHPLAN_59480
HDIHDIA_2157(nadX)
MEYTM49_04070
MMEDMame_03212(nadX)
AUBLXB15_15140
PSINCAK95_26410 CAK95_27285
PSFPSE_1841
PPHRAPZ00_22210
LAPACP90_08605
LAGGB0E33_20675
SIWGH266_03965 GH266_08205 GH266_14850
PHRC6569_02285
PSTGE8M01_01690 E8M01_20925
LIZLGH83_08570
ACUTMRB58_19230 MRB58_21810
CAKCaul_5291
SILSPO2880
SITTM1040_1595
RUAD1823_20135
RUTFIU92_19505(nadX)
RCONK3740_15030
JANJann_1451
RDERD1_3642
RLIRLO149_c008210
RPONG3256_03980
DSHDshi_0239(nadX)
KVLKVU_1272
KVUEIO_1806
PGDGal_04118
PHPPhaeoP97_03807
PHQD1820_18860
OAROA238_c02590
OTMOSB_07960(nadX)
LMDMETH_15670
CIDP73_2157
CEHCEW89_04460
MALGMALG_04776
PABYGa0080574_TMP811
SULZC1J03_01250
RMMROSMUCSMR3_01810(nadX)
ROKRAK1035_1377
RIDRIdsm_01037(nadX)
AHTANTHELSMS3_02149(nadX)
THAACFI11_19795
ROTFIV09_10485(nadX)
MALUKU6B_14270(nadX)
PLCGRVY76_17490
RMAIMACH21_27410(nadX)
PDEPden_1041
PAROCUV01_02420
PFISJHX87_03085
PSTLJHW45_06935
PVERE3U25_02305
RMBK529_015830
TSCOR1T40_19610 R1T40_21765
PPSOQPJ95_05220
PPRUFDP22_19360
PALWPSAL_034910(nadX)
PSHQF3W81_11180
PGVSL003B_1871
THASC6Y53_19825
GCEKYE46_09775
AMYLQBD29_07755
AMAQGO499_03240
RHOCQTA57_07675
FAQG5B39_15540
NREBES08_25080
SPHPLH20_03880
SMAGAN936_00625 AN936_00695
SMAZLH19_00635 LH19_00705
STERAOA14_03940
SGISGRAN_3560(nadX)
SPHOC3E99_12615
SSANNX02_18995
SPKCKC8_11550
PMASNCF86_16585
AACEA0U92_13860
RGIRGI145_18860
ROSCTJ15_17700
RMUCFOB66_20830
RMTIAI58_13860 IAI58_15960
RFLRmf_32830(nadX)
RCVPFY06_07640 PFY06_19500
KHAIFJ82_10770
SRFLHU95_07690
SHUMSTHU_23560(nadX_1) STHU_30900(nadX_2) STHU_46520(nadX_3) STHU_50980
SVCSTVA_25120(nadX_1) STVA_32060(nadX_2) STVA_49620(nadX_3) STVA_50890
STELSTAQ_02140(nadX_1) STAQ_21260(nadX_2) STAQ_28410(nadX_3) STAQ_46150
NCBC0V82_23335 C0V82_23365
FERFNB15_12385
HTQFRZ44_43980(nadX)
HADHFRZ61_41870(nadX)
ELIOKO353_02940
NACINUH88_05840
THART8K17_16820 T8K17_24330
MYXQEG98_21620
BFDNCTC4823_03477(nadX)
BACOOXB_3514
BEOBEH_13495
BONA361_11420 A361_14270
BKOCKF48_22790
CFIRNAF01_10275(nadX) NAF01_13180(nadX)
CPSSM5V91_06990(nadX) M5V91_10090
LYZDCE79_14840(nadX)
HNZP9989_04225
FARABE41_017590
FECQNH15_07445(nadX)
BSJUP17_10930
PBUTDTO10_24450(nadX)
PFRIL8956_11770(nadX)
SCIBHUG20_15250(nadX)
SCIAHUG15_01715(nadX)
NCMQNK12_10895(nadX) QNK12_17685(nadX)
MSEMGMB29_08080(nadX)
TEIQS257_21435
NAMPKPF49_07885(nadX)
NMYCJ229_006095(nadX)
BCHSJNE38_06190(nadX) JNE38_24415(nadX)
PSABPSAB_06900
PBJVN24_20300
ACYCJI721_04785
SIVSSIL_0567
SSILSOLI23_15925
PLNPlano_0608
PKUAUO94_13310
PRTAUC31_06360
PLLI858_004185
PANABBH88_17535
PDGBCM40_12595
PHCBBI08_16155
PPLABBI15_15490
PFAEAJGP001_03915
PMATBBI11_04680
PGQFK545_11565(nadX)
SPORSporoP33_06440
SPOPSporoP37_06920
SURESporoP32a_06860
SPOSDV702_10780(nadX)
SPAEE2C16_03295(nadX) E2C16_12085(nadX)
SPOOJ3U78_10585(nadX)
SURLBI350_16210
STHOQNH10_10505(nadX)
JEPBW721_06390
JARG7057_07650
FPAFPR_28370
ACOLK5I23_15805
RHORHOM_09620
BLIQINP51_06680
CPYCphy_2124
LACYA4V08_25555
CSHClosa_3242
CBOLCGC65_06090
CBARPATL70BA_1256
ETMCE91St48_00690 CE91St48_00890
FAAHMPREF0389_00713
NCDACONDI_00004(nadX)
PIVNCTC13079_01117(nadX)
MHAPJFY71_00635
TISP3962_10320
STEDSPTER_11050(nadX)
ERHERH_0204
ERSK210_08205
ERIEEI45_08145
ERDG7062_03930
ERZER308_14025
MSHGMSG_04191(nadX)
MSTOMSTO_48410(nadX)
CGTcgR_1126
CGSC624_06000
CGGC629_06000
CARcauri_0710
CCGCCASEI_09430
CSTACSTAT_08675
CAMGCAMM_08855
CSURN24_1156
RPYY013_10970 Y013_15090
RBYCEJ39_21760
RHQIM25_02695
RRT4535765_04095(nadX)
RTMG4H71_07145
RGORNMQ04_17710
DITC3V38_02375
DPCA6048_13305
DLUA6035_12405
SALBXNR_0361
SAMBSAM23877_2857
SPRISPRI_6557
SPAVSpa2297_11980
SKYD0C37_03340
STRDNI25_24750
SFKKY5_1481
SKACP970_35285
SCHACP983_02320
SPLACP981_04330
SXNIAG42_28765
SGJIAG43_30210
SDURM4V62_33615
SVIOHWN34_02700
STUBMMF93_01840
SSPNLXH13_01260
SLONLGI35_11550
SDRZNEH16_24080
STUDSTRTU_005400
MSUWGCM10025863_27470
MVDAWU67_16660
AMAUDSM26151_04230(nadX)
LDNH9L06_04415
PSEVUSB125703_00894(nadX)
ARRARUE_c20700(nadX)
ARLAFL94_01985
ARYATC04_16060
ARZAUT26_09855
ARNCGK93_08015
ARXARZXY2_1986(nadX)
ACITHPK19_12845 HPK19_19970(nadX)
ARIUM93_05805
AAUAAur_1938
PUEFV140_10125
PNVJMY29_17230
PSULAU252_12745
AAIAARI_04360
GLUF0M17_01875
GPRJQN66_02005
GMYXH9_06670
GNCQQS42_01995
RSARSal33209_3277
AULDCC27_009730
AIGQDX25_09720
CMUAP8192_13870
PAEYKUF55_07745
PALUCJ193_007775
BLYA2T55_14455
BLINBLSMQ_3174
BSPOL1F31_14920
PROPQQ658_01360
ACTWF7P10_23250
SPIQOHA34_32855
AMQAMETH_6040
AMYCCU254_12220
BALADSM104299_00965(nadX)
IAMHC251_17465
STISthe_2207
UAMUABAM_00824
VAIBU251_05270
TPITREPR_0938
TRIDYE50_12295
OCKEXM22_12025
FVAFV113G1_02350
BXYBXY_25590
BOABovatus_03408(nadX)
BCELBcellWH2_00602(nadX)
BISDXK01_018245
BNOK8P02_01985
BSALK6V25_09460
BVUBVU_0071
BDOEL88_16190
BDHGV66_00415
PSACPSM36_0473
PROJKDN43_00665
DYSG7050_01115
DYHG7051_01490
PMERINE87_01340
PGOLK6V26_06040
PJOLK449_09530
PFAINXY11_04215
PSNPedsa_0313
SHTKO02_10440
CAOCelal_0257
AHZAPS56_13320
FBAFIC_01249
TMATM1643
TMMTmari_1652
TMITHEMA_06030
TMWTHMA_1684
TMQTHMB_1684
TMXTHMC_1684
TPTTpet_1148
TNPTnap_1163
TRQTRQ2_1186
TNACTN_0745
THQT2812B_05930
THZCELL2_06045
THRTRQ7_05155
TTATheth_0476
TMETmel_1582
TAFTHA_1920
THPBG95_08380
THERY592_08465
TFEJYK00_01480(nadX)
FPEFerpe_1742
FIANA23_08550(nadX)
FRRIB67_03005
OCYOSSY52_13050(nadX)
MPZMarpi_1296
MARNLN42_06965
MAEOJRV97_05000(nadX)
OCSOF820_02550(nadX)
MJAMJ_0915
MFEMefer_0063
MVUMetvu_0079
MFSMFS40622_1244
MIFMetin_0200
MJHJH146_0993
MESGMLAUSG7_1552(nadX)
MESAMLASG1_1121(nadX)
MIGMetig_0410
MMPMMP0737
MMQMmarC5_0845
MMXMmarC6_0148
MMZMmarC7_1758
MMDGYY_02555
MMAKMMKA1_07920(nadX)
MMAOMMOS7_07830(nadX)
MMADMMJJ_02380(nadX)
MAEMaeo_0848
MVNMevan_1607
MVOMvol_0924
MOKMetok_0075
METFCFE53_00520
MTHMTH_973
MMGMTBMA_c13590(nadX)
MWOMWSIV6_1362(nadX)
MTEEMTTB_04450
METCMTCT_0884
METEtca_00936(nadX)
METZMETMT2_1004
METKFVF72_06730
MTHMFZP57_06500
METJFZP68_04160
MSTMsp_1148
METBAW729_10035
MEISPXD04_01920
MRUmru_0675
MSIMsm_0464
MEBAbm4_0406(nadX1) Abm4_1625(nadX2)
MMILsm9_0549
MEYETL18_02580
MOLYLM1_0320
MAROMarbSA_17600
METVK4897_02835
MELMetbo_0419
MEWMSWAN_0861 MSWAN_1954
METHMBMB1_1584(nadX)
MFCBRM9_0819
MFIDSM1535_0782(nadX)
MCUBMCBB_0898(nadX_1) MCBB_1882(nadX_3)
METNBK008_02555 BK008_07220
METTCIT01_02615
METOCIT02_10030
MEMEHYG87_03960
MFEGGCM10025860_01240 GCM10025860_11570
MFVMfer_0043
MKAMK0094
AFUAF_1838
AFGAFULGI_00020940
AVEArcve_1622
FPLFerp_0170
MBAMbar_A1866
MBYMSBRM_0820
MBWMSBRW_2869
MBARMSBR2_1572
MBAKMSBR3_1577
MACMA_0958
MMAMM_2072
MMAZMmTuc01_2140
MMJMSMAS_2613
MMACMSMAC_1806
MVCMSVAZ_0762
MEKMSKOL_0747
MLSMSLAZ_2509
METMMSMTP_2527
MEFMSWH1_2475
MEQMSWHS_2569
MSJMSSAC_0880
MSZMSSIH_0820
MSWMSSIT_0849
MTHRMSTHT_1334
MTHEMSTHC_1958
MHORMSHOH_3277
MFZAOB57_005795
MBUMbur_1681
MMETMCMEM_2162
MELOJ7W08_09795
MMHMmah_1981
MHAZBHR79_03720
MEVMetev_1018
MZHMzhil_0389
MPYMpsy_1281
MZIHWN40_02230
MMAVRE476_07975
MSEBRE474_04560
MHZMetho_0340
MEHFMmiHf6_10980(nadX)
MEESMmiEs2_13580(nadX)
MTPMthe_0242
MCJMCON_1163
MHIMhar_0006
MHUMhun_2354
MRTJKHC33_15825(nadX)
MLAMlab_0766 Mlab_1665
MEMMemar_0819
MBGBN140_0872
MEMAMMAB1_1143(nadX)
MCHKMchiMG62_09500
MSUMOH143_10810(nadX)
MRCR6Y96_04815(nadX)
MPIMpet_2710
MENDL6E24_08985(nadX)
MEFWF1737_11025(nadX)
MAQERJ40_11555(nadX)
MOUOU421_03455(nadX)
MESBL1S32_07055(nadX)
MANQL1994_11465(nadX)
MBNMboo_0500
MFOMetfor_2687
MPLMpal_1416 Mpal_2777
MPDMCP_1121(nadX)
MEZMtc_1071(nadX)
RCIRCIX226(nadX)
HAADMW046_15085(nadX)
HLSKU306_03860
SRUBC2R22_03390 C2R22_21805
HALGHUG10_10880
HAHHalar_1793
MELUMTLP_09930
TARTALC_01415
MAXMMALV_15260
MERMMINT_14910
MEARMpt1_c00970(nadX)
MEUZKRP56_07330(nadX)
MARCAR505_0143
ABIAboo_0362
ACFAciM339_0681
IHOIgni_0786 Igni_1349
IISEYM_00160 EYM_06320
IPCIPA_01770
HBUHbut_0678
PFMPyrfu_0280
PDLPyrde_0813
PAREPYJP_08320
PYRP186_0988
THELIG193_08095(nadX)
NMRNmar_1240
NIRNSED_06950
NKRNKOR_07040
NIDNPIRD3C_0870(nadX)
NINNADRNF5_0703(nadX)
NIWNisw_07520
NCLC5F47_06775
NOXC5F49_06750
NUEC5F50_09360
NIPNsoK4_01805
NZTNZOSNM25_000580
NCTNMSP_0435(nadX)
NICDSQ20_07740
NGANgar_c18470(nadX)
NVNNVIE_003700(nadX)
NEVNTE_01698
TAANMY3_03096(nadX)
NFNNFRAN_0511(nadX)
NCVNCAV_0858(nadX)
CSYCENSYa_0959
NBVT478_0473(nadX)
TAHSU86_009275
NIUDSQ19_06970
NCKQVH35_11270
NDVNDEV_1222(nadX)
FLTSv326_0601
AGWQT03_C0001G0281
 » show all
Reference
1
  Authors
Kretovich, W.L., Kariakina, T.I., Weinova, M.K., Sidelnikova, L.I. and Kazakova, O.W.
  Title
The synthesis of aspartic acid in Rhizobium lupini bacteroids.
  Journal
Plant Soil 61:145-156 (1981)
Reference
2  [PMID:9819709]
  Authors
Okamura T, Noda H, Fukuda S, Ohsugi M.
  Title
Aspartate dehydrogenase in vitamin B12-producing Klebsiella pneumoniae IFO 13541.
  Journal
J Nutr Sci Vitaminol (Tokyo) 44:483-90 (1998)
DOI:10.3177/jnsv.44.483
Reference
3  [PMID:12496312]
  Authors
Yang Z, Savchenko A, Yakunin A, Zhang R, Edwards A, Arrowsmith C, Tong L
  Title
Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643.
  Journal
J Biol Chem 278:8804-8 (2003)
DOI:10.1074/jbc.M211892200
  Sequence
[tma:TM1643]
Reference
4  [PMID:16731057]
  Authors
Yoneda K, Kawakami R, Tagashira Y, Sakuraba H, Goda S, Ohshima T.
  Title
The first archaeal L-aspartate dehydrogenase from the hyperthermophile Archaeoglobus fulgidus: gene cloning and enzymological characterization.
  Journal
Biochim Biophys Acta 1764:1087-93 (2006)
DOI:10.1016/j.bbapap.2006.04.006
  Sequence
[afu:AF_1838]
Reference
5  [PMID:17651440]
  Authors
Yoneda K, Sakuraba H, Tsuge H, Katunuma N, Ohshima T.
  Title
Crystal structure of archaeal highly thermostable L-aspartate dehydrogenase/NAD/citrate ternary complex.
  Journal
FEBS J 274:4315-25 (2007)
DOI:10.1111/j.1742-4658.2007.05961.x
  Sequence
[afu:AF_1838]
Reference
6  [PMID:21468714]
  Authors
Li Y, Kawakami N, Ogola HJ, Ashida H, Ishikawa T, Shibata H, Sawa Y.
  Title
A novel L-aspartate dehydrogenase from the mesophilic bacterium Pseudomonas aeruginosa PAO1: molecular characterization and application for L-aspartate production.
  Journal
Appl Microbiol Biotechnol 90:1953-62 (2011)
DOI:10.1007/s00253-011-3208-4
  Sequence
[pae:PA3505]
Reference
7  [PMID:21821928]
  Authors
Li Y, Ishida M, Ashida H, Ishikawa T, Shibata H, Sawa Y.
  Title
A non-NadB type L-aspartate dehydrogenase from Ralstonia eutropha strain JMP134: molecular characterization and physiological functions.
  Journal
Biosci Biotechnol Biochem 75:1524-32 (2011)
DOI:10.1271/bbb.110216
  Sequence
Reference
8  [PMID:22120624]
  Authors
Li Y, Ogola HJ, Sawa Y.
  Title
L-aspartate dehydrogenase: features and applications.
  Journal
Appl Microbiol Biotechnol 93:503-16 (2012)
DOI:10.1007/s00253-011-3730-4
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.21
IUBMB Enzyme Nomenclature: 1.4.1.21
ExPASy - ENZYME nomenclature database: 1.4.1.21
BRENDA, the Enzyme Database: 1.4.1.21
CAS: 37278-97-0

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