| Entry |
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| Name |
valine dehydrogenase (NAD+)
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| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
L-valine:NAD+ oxidoreductase (deaminating)
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| Reaction(IUBMB) |
L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH + H+ [RN: R01434]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme from Streptomyces spp. has no activity with NADP+ [cf. EC 1.4.1.8, valine dehydrogenase (NADP+)].
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| History |
EC 1.4.1.23 created 2012
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| Pathway |
| ec00280 | Valine, leucine and isoleucine degradation |
| ec01110 | Biosynthesis of secondary metabolites |
| ec01130 | Biosynthesis of antibiotics |
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| Orthology |
| K00271 | valine dehydrogenase (NAD+) |
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| Genes |
» show all
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| Reference |
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| Authors |
Vancurova I, Vancura A, Volc J, Neuzil J, Flieger M, Basarova G, Behal V. |
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| Title |
Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens. |
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| Journal |
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| Reference |
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| Authors |
Navarrete RM, Vara JA, Hutchinson CR |
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| Title |
Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2). |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.4.1.23 |
| ExPASy - ENZYME nomenclature database: | 1.4.1.23 |
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