KEGG ENZYME: 1.4.1.23

ENZYME: 1.4.1.23

Entry

EC 1.4.1.23 Enzyme

Name

valine dehydrogenase (NAD+)

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-valine:NAD+ oxidoreductase (deaminating)

Reaction(IUBMB)

L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH + H+ [RN:R01434]

Reaction(KEGG)

R01434

Substrate

L-valine [CPD:C00183];
H2O [CPD:C00001];
NAD+ [CPD:C00003]

Product

3-methyl-2-oxobutanoate [CPD:C00141];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme from Streptomyces spp. has no activity with NADP+ [cf. EC 1.4.1.8, valine dehydrogenase (NADP+)].

History

EC 1.4.1.23 created 2012

Pathway

ec00280

Valine, leucine and isoleucine degradation

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K00271

valine dehydrogenase (NAD+)

Genes

MYV:	G155_25940

MFT:	XA26_52600

ASD:

AS9A_2940

NCY:	NOCYR_1282(vdh)

NSL:	BOX37_22850

NSR:	NS506_07055

NOD:	FOH10_23790

NAD:	NCTC11293_05547(vdh_2)

RHA:	RHA1_ro01628

RER:	RER_40180(vdh)

REY:

O5Y_18650

REB:	XU06_18805

ROP:	ROP_13250(vdh)

ROA:	Pd630_LPD05767

RPY:	Y013_11145 Y013_15265

RHB:

NY08_1997

RAV:	AAT18_15685

RFA:	A3L23_00329(vdh)

RHW:	BFN03_11755

RHS:	A3Q41_03078(vdh)

RRZ:	CS378_05340

RQI:	C1M55_19895

RHQ:	IM25_02895

RHOD:

AOT96_00280

RRT:	4535765_04132(vdh)

RBY:	CEJ39_22015

GOQ:	ACH46_01675

GTA:	BCM27_24780

GOC:	CXX93_04170

TOY:	FO059_01250

SCO:	SCO4089(SCD25.25c)

SALB:

XNR_2839

SMA:	SAVERM_4132(vdh)

SGR:

SGR_3880

SGB:

WQO_16310

SCB:	SCAB_47881(vdh)

SSX:	SACTE_3513

SVL:	Strvi_0535

SCT:	SCAT_3355(vdh)

SCY:	SCATT_33470

SFA:

Sfla_3000

SBH:

SBI_05732

SHY:

SHJG_5008

SHO:	SHJGH_4771

SVE:

SVEN_3844

SDV:	BN159_4703(vdh)

SALS:

SLNWT_3941

STRP:

F750_3772

SFI:

SFUL_3855

SCI:	B446_18335

SRC:	M271_23645

SALU:

DC74_4008

SALL:

SAZ_21190

SLV:	SLIV_17980(vdh)

SGU:	SGLAU_16260(vdh)

SVT:	SVTN_20025

STRE:

GZL_04879

SCW:	TU94_17370

SLD:

T261_4453

SLC:	SL103_01270

SXI:	SXIM_29470

STRM:

M444_16950

STRC:

AA958_18465

SAMB:

SAM23877_3591(vdh)

SPRI:

SPRI_3940

SCZ:	ABE83_16935

SCX:	AS200_24370

SRW:	TUE45_03647(vdh_3)

STRF:

ASR50_17700

SLE:	sle_37550(sle_37550)

SRN:	A4G23_02617(vdh_1)

SPAV:

Spa2297_15750

STRT:

A8713_14890

SCLF:

BB341_13055

SGS:	AVL59_46270

STSI:

A4E84_19130

SLS:	SLINC_4065

SNR:	SNOUR_22285(vdh)

SPLU:

LK06_016990

STRD:

NI25_20165

SNW:	BBN63_17965

SAUO:

BV401_24460

SSIA:

A7J05_18770

SVU:	B1H20_18400

SPUN:

BFF78_22345

SGV:	B1H19_20000

SMAL:

SMALA_4135

SLAU:

SLA_3928

SALF:

SMD44_04086(vdh)

SALJ:

SMD11_3646(vdh)

SLX:	SLAV_18280(vdh2)

STRO:

STRMOE7_18600

SFK:

KY5_3884

SNZ:	DC008_16435

SGE:	DWG14_04464(vdh_5)

SRJ:

SRO_3881

SLK:	SLUN_18880

SKY:	D0C37_17215

SDX:	C4B68_21100

SGD:	ELQ87_20185

SQZ:	FQU76_15500

SCYA:

EJ357_21860

SAST:

CD934_14305

SNQ:	CP978_16635

STIR:

DDW44_14150

SKA:	CP970_01500 CP970_22610

SGZ:	C0216_29650

SVN:	CP980_17820

KSK:	KSE_41600(vdh)

KAB:	B7C62_18445

KAU:	B6264_10555

KIT:	CFP65_4081

STRI:

C7M71_014185

TEH:	GKE56_13860

PHW:	G7075_14640

PEI:	H9L10_15330

NCA:

Noca_4313

NDK:	I601_0879(vdh)

NOY:	EXE57_14085

NOI:	FCL41_01755

NOO:	FE634_18835

NDP:	E2C04_02340

NSN:	EXE58_10265

PSIM:

KR76_25220

AER:	AERYTH_02625

AEZ:	C3E78_00975 C3E78_01905

AEB:	C6I20_13735

AEF:	GEV26_02040

MUZ:	H4N58_02200

TCU:

Tcur_0296

ACTW:

F7P10_23015

SRO:

Sros_8995

NOA:	BKM31_48590

NOW:	GBF35_48125

FRA:	Francci3_0097

FRE:	Franean1_7207

FRI:	FraEuI1c_7081

FAL:	FRAAL0132(vdh)

FSY:	FsymDg_0277

GOB:

Gobs_4753

BSD:	BLASA_4637

MMAR:

MODMU_5123(vdh)

SVI:	Svir_28230

SACC:

EYD13_15480(vdh3)

AMD:

AMN:

AMM:

AMZ:

AOI:

AJA:	AJAP_30675(vdh)

AMQ:	AMETH_5418(gdhA1) AMETH_5508

AMYC:

CU254_28145 CU254_42095

AMYB:

BKN51_01020

AAB:	A4R43_37595 A4R43_38030

AMYY:

YIM_40015(vdh2) YIM_40475(pdh)

AORI:

SD37_32375

PMAD:

BAY61_24020

STP:	Strop_0159

SAQ:

Sare_0168

MAU:	Micau_0222

MIL:

MICB:

MTUA:

MICH:

MTEM:

MCAB:

VMA:	VAB18032_05395 VAB18032_12700

ASE:	ACPL_241(vdh)

AMS:

AMIS_1270

ACTN:

L083_0144(vdh)

AFS:

AFR_00765

ACTS:

ACWT_0126

PLK:	CIK06_01030

PLAB:

PLAT:

PFLA:

PSUU:

CAI:

SNA:

TBI:

BSOL:

CWO:	Cwoe_4404 Cwoe_5610

ERZ:	ER308_11830

EUZ:	DVS28_a4860

» show all

Reference

1 [PMID:3182727]

Authors

Vancurova I, Vancura A, Volc J, Neuzil J, Flieger M, Basarova G, Behal V.

Title

Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens.

Journal

J Bacteriol 170:5192-6 (1988)
DOI:10.1128/JB.170.11.5192-5196.1988

Reference

2 [PMID:2324704]

Authors

Navarrete RM, Vara JA, Hutchinson CR

Title

Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2).

Journal

J Gen Microbiol 136:273-81 (1990)
DOI:10.1099/00221287-136-2-273

Sequence

[sco:SCO4089]

Other DBs

ExplorEnz - The Enzyme Database:

1.4.1.23

IUBMB Enzyme Nomenclature:

1.4.1.23

ExPASy - ENZYME nomenclature database:

1.4.1.23

BRENDA, the Enzyme Database:

1.4.1.23

DBGET integrated database retrieval system