KEGG   ENZYME: 1.4.1.23
Entry
EC 1.4.1.23                 Enzyme                                 
Name
valine dehydrogenase (NAD+)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-valine:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB)
L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH + H+ [RN:R01434]
Reaction(KEGG)
R01434
Substrate
L-valine [CPD:C00183];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
3-methyl-2-oxobutanoate [CPD:C00141];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from Streptomyces spp. has no activity with NADP+ [cf. EC 1.4.1.8, valine dehydrogenase (NADP+)].
History
EC 1.4.1.23 created 2012
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00271  valine dehydrogenase (NAD+)
Genes
ERZER308_11830
EUZDVS28_a4860
MYVG155_25940
MFTXA26_52600
MHEVMHEL_32040 MHEL_42550
MAUBMAUB_06010(vdh)
MPHUMPHO_06620(vdh)
MMUCC1S78_015025
MMATMMAGJ_11070
MBOKMBOE_02870
MSENK3U95_04450
MDFK0O62_03320
ASDAS9A_2940
NCYNOCYR_1282(vdh)
NSLBOX37_22850
NSRNS506_07055
NODFOH10_23790
NADNCTC11293_05547(vdh_2)
NHUH0264_35515
NYALTV02_37465
NYUD7D52_30680
RHARHA1_ro01628
RERRER_40180(vdh)
REYO5Y_18650
REBXU06_18805
RQIC1M55_19895
ROPROP_13250(vdh)
ROAPd630_LPD05767
RPYY013_11145 Y013_15265
RBYCEJ39_22015
RHBNY08_1997
RAVAAT18_15685
RFAA3L23_00329(vdh)
RHSA3Q41_03078(vdh)
RHWBFN03_11755
RRZCS378_05340
RHQIM25_02895
RHODAOT96_00280
RRT4535765_04132(vdh)
RKOJWS14_08325 JWS14_42330
RGOKYT97_27185
ROZCBI38_10045
RPSKJWS13_37855
RGORNMQ04_17925
GOQACH46_01675
GTABCM27_24780
GOCCXX93_04170
GSIP5P27_18100
TOYFO059_01250
SCOSCO4089(SCD25.25c)
SALBXNR_2839
SMASAVERM_4132(vdh)
SGRSGR_3880
SGBWQO_16310
SFISFUL_3855
SANLKZO11_16625
SGRFSGFS_057730
SCYER2B67_16775
SCBSCAB_47881(vdh)
SSXSACTE_3513
SVLStrvi_0535
SHYSHJG_5008
SHOSHJGH_4771
SRCM271_23645
SMALSMALA_4135
SSOII1A49_24725
SFASfla_3000
SBHSBI_05732
SVESVEN_3844
SDVBN159_4703(vdh)
SALSSLNWT_3941
STRPF750_3772
SCIB446_18335
SLVSLIV_17980(vdh)
SGUSGLAU_16260(vdh)
SVTSVTN_20025
STREGZL_04879
SCWTU94_17370
SLDT261_4453
SLCSL103_01270
SXISXIM_29470
STRMM444_16950
STRCAA958_18465
SAMBSAM23877_3591(vdh)
SPRISPRI_3940
SCZABE83_16935
SCXAS200_24370
SRWTUE45_03647(vdh_3)
STRFASR50_17700
SLEsle_37550(sle_37550)
SRNA4G23_02617(vdh_1)
SPAVSpa2297_15750
STRTA8713_14890
SCLFBB341_13055
SGSAVL59_46270
STSIA4E84_19130
SKYD0C37_17215
SALWCP975_16815
SGMGCM10017557_39900(vdh)
SCADDN051_20830
SPHWNFX46_38840
SLSSLINC_4065
SNRSNOUR_22285(vdh)
SALUDC74_4008
SALLSAZ_21190
SPLULK06_016990
STRDNI25_20165
SNWBBN63_17965
SAUOBV401_24460
SSIAA7J05_18770
SVUB1H20_18400
SPUNBFF78_22345
SGVB1H19_20000
SLAUSLA_3928
SALFSMD44_04086(vdh)
SALJSMD11_3646(vdh)
SLXSLAV_18280(vdh2)
STROSTRMOE7_18600
SFKKY5_3884
SNZDC008_16435
SGEDWG14_04464(vdh_5)
SRJSRO_3881
SLKSLUN_18880
SDXC4B68_21100
SGDELQ87_20185
SQZFQU76_15500
SCYAEJ357_21860
SASTCD934_14305
SNQCP978_16635
STIRDDW44_14150
SKACP970_01500 CP970_22610
SGZC0216_29650
SVNCP980_17820
SNKCP967_16165
SHAWCEB94_19620
SRKFGW37_15225
SFICEIZ62_17115
SGALCP966_17395
SSPODDQ41_14715
SVRCP971_15530
SPADDVK44_14735
SFYGFH48_21570
SAQUEJC51_23855
SGFHEP81_04050
SCAVCVT27_17565
SSEOD0Z67_13810
SBYH7H31_14555
SRIMCP984_21015
SSUBCP968_17920
SPHVF9278_22730
SCINCP977_18440
SFUGCNQ36_16490
SPACB1H29_19550
STSUB7R87_15105
SCHACP983_22500
SGXH4W23_21300
SCOECP976_21095
SBATG4Z16_17790
SSPBCP982_04260 CP982_20750
SNFJYK04_04218(vdh)
SPLACP981_18385
SBROGQF42_22000
STUIGCM10017668_33070(vdh)
SATAC5746_21835
SCHFIPT68_17510
SHUNDWB77_03731(vdh)
SHARHUT13_15315
SCYGS1361_19230(vdh)
SFEUIM697_02330
SLIAHA039_18145
SDWK7C20_17615
SVDCP969_19085
SCALI6J39_18270
SAUHSU9_015885
SFBCP974_14175
SMOBJ7W19_15025
SPRACP972_17310
SPEUCGZ69_17135
SROIIAG44_21765
SXNIAG42_16920
SGJIAG43_14885
SHKJ2N69_17625
SANUK7396_19215
SDDD9753_18580
SACTDMT42_18675
SMAOCAG99_12380
SGOBtest1122_14155
SINEKI385_21670
SLFJEQ17_22180
SDECL3078_21880
SAOVG3H79_19325
SDURM4V62_22555 M4V62_41915
SYANNRK68_16190
SRUGF0345_14985
SAKBK1J60_22980
STAALDH80_19250
SNIGHEK616_72160(vdh)
SVIOHWN34_14620
SCAEIHE65_23520
STUBMMF93_17690
SSPNLXH13_21680
SCIRSTRCI_003950
SXTKPP03845_104041(vdh)
SLONLGI35_22370
SDRZNEH16_15055
STUDSTRTU_003795
STEEF3L20_30830
SENGOJ254_10280
SGKPET44_15670
SANTQR300_20605
SYUNMOV08_22695
SARGHKX69_18220
SJNRI060_22400
SCYNN8I84_19880
SOVQZH56_19115
SFIYF0344_16335
SHAUK9S39_24125
SKGKJK29_19725
SCOAQU709_22080
SLAIP8A22_18630
SROCRGF97_15295
SFPQUY26_20750
SCHGNRO40_14145
STTNBSL84_18705
SCTSCAT_3355(vdh)
SCYSCATT_33470
KSKKSE_41600(vdh)
KABB7C62_18445
KAUB6264_10555
KITCFP65_4081
KISHUT16_19220
STRIC7M71_014185
YIALO772_16800
STRHGXP74_38730
ABRYNYE86_02000
AGLAOIE69_21890
TEHGKE56_13860
PHWG7075_14640
PEIH9L10_15330
GYUFE374_11755
NCANoca_4313
NDKI601_0879(vdh)
NOYEXE57_14085
NOIFCL41_01755
NOOFE634_18835
NDPE2C04_02340
NSNEXE58_10265
NANOG5V58_24920
NMESH9L09_07335
NPIG7071_06825
NAQUENKNEFLB_00649(vdh)
NROK8W59_15710
NOQLN652_10850
NCQK6T13_15530
NPCKUV85_10885
NPSKRR39_22090
NMARHPC71_18945
PSIMKR76_25220
AERAERYTH_02625
AEZC3E78_00975 C3E78_01905
AEBC6I20_13735
AEFGEV26_02040
ASEZH9L21_13395
ADBNP095_13330
AWNNQV15_01750
MUZH4N58_02200
TCUTcur_0296
ACTWF7P10_23015
AGRAAGRA3207_003776
AMAZLUW76_23375
ACIROG979_16065
SPIQOHA34_21965
ACTQOG417_04540
SROSros_8995
NOABKM31_48590
NOWGBF35_48125
NCXNocox_39445(vdh5)
NGNLCN96_52925
NFSOIE67_51360
TBITbis_3346
MHAIOHB01_06905
FRAFrancci3_0097
FREFranean1_7207
FALFRAAL0132(vdh)
FSYFsymDg_0277
FRIFraEuI1c_7081
GOBGobs_4753
BSDBLASA_4637
BLAPMVA48_17935
MMARMODMU_5123(vdh)
SVISvir_28230
SACCEYD13_15480(vdh3)
AMDAMED_6963
AMNRAM_35720
AMMAMES_6856
AMZB737_6856
AOIAORI_1764
AJAAJAP_30675(vdh)
AMQAMETH_5418(gdhA1) AMETH_5508
AMYCCU254_28145 CU254_42095
AMYBBKN51_01020
AABA4R43_37595 A4R43_38030
AMYYYIM_40015(vdh2) YIM_40475(pdh)
AORISD37_32375
AACDLWP59_31645
APRTMUY14_01740
AROONQK81_14145
ATHML1857_30080 L1857_34545
ARHDVSH64_24200
PBROHOP40_19665
KBUQ4V64_24830
PMADBAY61_24020
STPStrop_0159
SAQSare_0168
MAUMicau_0222
MILML5_0206
MICBMicB006_0216
MTUACSH63_24590
MICHFJK98_01015
MTEMGCE86_26655
MCABHXZ27_00895
MSAGGCM10017556_28020
VMAVAB18032_05395 VAB18032_12700
MCRAID554_14775
VERHUT12_00950 HUT12_01655
MENOJiend_26500
MCHLPVK74_22135
MFEUH1D33_07895
MPRNQ3V37_06015
MHAWRMN56_10560
ASEACPL_241(vdh)
AMSAMIS_1270
ACTNL083_0144(vdh)
AFSAFR_00765
ACTSACWT_0126
AIHAiant_44210
ACTRAsp14428_45710 Asp14428_76480
ACTLL3i22_001290
ASICQ0Z83_086750
AOUACTOB_000127 ACTOB_004620
PLKCIK06_01030
PLABC6361_32285
PLATC6W10_31115
PFLAPflav_071710
PSUUPsuf_034430
ATLAthai_66210
ASERAsera_09040
PRYPrubr_23290
CATICS0771_14940
DVCDvina_52190
DFUDfulv_46625
DROSDrose_36680
DAURDaura_49780
DMATDmats_46640
NHYJQS43_25005
CCAZCOUCH_00180
CAICaci_0299
SNASnas_5981
NAVJQS30_16150
GLYK3N28_16720
BSOLFSW04_01380
CWOCwoe_4404 Cwoe_5610
IAMHC251_23170
 » show all
Reference
1  [PMID:3182727]
  Authors
Vancurova I, Vancura A, Volc J, Neuzil J, Flieger M, Basarova G, Behal V.
  Title
Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens.
  Journal
J Bacteriol 170:5192-6 (1988)
DOI:10.1128/JB.170.11.5192-5196.1988
Reference
2  [PMID:2324704]
  Authors
Navarrete RM, Vara JA, Hutchinson CR
  Title
Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2).
  Journal
J Gen Microbiol 136:273-81 (1990)
DOI:10.1099/00221287-136-2-273
  Sequence
[sco:SCO4089]
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.23
IUBMB Enzyme Nomenclature: 1.4.1.23
ExPASy - ENZYME nomenclature database: 1.4.1.23
BRENDA, the Enzyme Database: 1.4.1.23

DBGET integrated database retrieval system