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Entry
EC 1.4.1.24                 Enzyme                                 

Name
3-dehydroquinate synthase II;
DHQ synthase II;
MJ1249 (gene name);
aroB' (gene name)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB)
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+ = 3-dehydroquinate + NH3 + NADH + H+ [RN:R08569]
Reaction(KEGG)
Substrate
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate;
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
3-dehydroquinate [CPD:C00944];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization.
History
EC 1.4.1.24 created 2012
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K11646  3-dehydroquinate synthase II
Genes
DEL: DelCs14_2367
DVM: DvMF_1750
DVG: Deval_0422
DDE: Dde_3488
DDS: Ddes_0337
DDN: DND132_3202
DMA: DMR_05360
DSA: Desal_3064
DHY: DESAM_21549
DGG: DGI_0593
DTR: RSDT_0005(aroB)
DFL: DFE_3006
DAS: Daes_0955
DPI: BN4_11437
PPRF: DPRO_2849
DBA: Dbac_2808
DRT: Dret_0115
AXL: AXY_21120
AAE: aq_1922
HTH: HTH_1199
TAL: Thal_0223
TTK: TST_1081
MJA: MJ_1249
MMP: MMP0006
MMD: GYY_00030
MAE: Maeo_1164
MVO: Mvol_1425
MTH: MTH_580
MMG: MTBMA_c09610(aroB)
METC: MTCT_0504
MWO: MWSIV6_0940(aroB')
METE: tca_00549(griH)
MST: Msp_0090
MSI: Msm_0055
MRU: mru_0998(aroB)
MEB: Abm4_0655(aroB)
MMIL: sm9_1017(aroB2)
MEYE: TL18_05335
MOL: YLM1_0541
METH: MBMB1_1071
MFC: BRM9_1273(aroB)
MCUB: MCBB_0940(aroB')
MFV: Mfer_0601
MKA: MK1408
AFU: AF_0229
FPL: Ferp_2249
GAC: GACE_1229
GAH: GAH_01752
MEAR: Mpt1_c10440(aroB')
MARC: AR505_0509
MAC: MA_4592
MBAR: MSBR2_2306
MBAK: MSBR3_2365
MMA: MM_1272
MMAC: MSMAC_0044
METM: MSMTP_0059
MTHE: MSTHC_1505
MTHR: MSTHT_1781
MHOR: MSHOH_0049
MBU: Mbur_2000
MMET: MCMEM_0228
MMH: Mmah_0240
MPY: Mpsy_1419
MTP: Mthe_0539
MCJ: MCON_1239(aroB)
MHI: Mhar_0787
MHU: Mhun_1034
MLA: Mlab_1653
MEMA: MMAB1_2642
MPI: Mpet_2704
MBN: Mboo_1559
MPL: Mpal_2609
MPD: MCP_1668
MEZ: Mtc_1382(aroB)
RCI: RRC152(aroB)
HAL: VNG_0310C
HSL: OE_1475F(aroB)
HHB: Hhub_1456(aroB)
HALH: HTSR_1438(aroB)
HHSR: HSR6_1510(aroB)
HSU: HLASF_0625(aroB)
HSF: HLASA_0621(aroB)
HMA: rrnAC1879(aroB)
HHI: HAH_2395(aroB)
NPH: NP_2238A(aroB)
NMO: Nmlp_1201(aroB)
HUT: Huta_1180
HTI: HTIA_1102
HMU: Hmuk_3035
HWA: HQ_1155A(aroB)
HWC: Hqrw_1192(aroB)
HVO: HVO_0792(aroB)
HME: HFX_0757
HLA: Hlac_1277
HTU: Htur_0813
NMG: Nmag_2808(aroB)
NAT: NJ7G_4142
SALI: L593_01230
NMR: Nmar_0552
NID: NPIRD3C_1722(aroB)
NIN: NADRNF5_1626(aroB)
NCT: NMSP_1119(aroB')
NGA: Ngar_c16220(aroB)
NVN: NVIE_005840(aroB)
NEV: NTE_01959
TAA: NMY3_02543(griH)
NFN: NFRAN_0127(aroB)
NCV: NCAV_0389(aroB)
NBV: T478_0479
NDV: NDEV_0553(aroB)
KCR: Kcr_1100
BARB: AOA66_0831(aroB')
LOKI: Lokiarch_16770(aroB')
 » show all
Taxonomy
Reference
1  [PMID:15182204]
  Authors
White RH.
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
  Sequence
[mja:MJ_1249]
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.24
IUBMB Enzyme Nomenclature: 1.4.1.24
ExPASy - ENZYME nomenclature database: 1.4.1.24
BRENDA, the Enzyme Database: 1.4.1.24

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