KEGG ENZYME: 1.4.1.24

ENZYME: 1.4.1.24

Entry

EC 1.4.1.24                 Enzyme

Name

3-dehydroquinate synthase II;
DHQ synthase II;
MJ1249 (gene name);
aroB' (gene name)

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor

Sysname

2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating)

Reaction(IUBMB)

2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+ = 3-dehydroquinate + NH3 + NADH + H+ [RN:R08569]

Reaction(KEGG)

R08569

Substrate

2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate;
H2O [CPD:C00001];
NAD+ [CPD:C00003]

Product

3-dehydroquinate [CPD:C00944];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization.

History

EC 1.4.1.24 created 2012

Pathway

ec00400

Phenylalanine, tyrosine and tryptophan biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K11646

3-dehydroquinate synthase II

Genes

GHL:	GM160_10825

BUG:	BC1001_PA6183

DEL:	DelCs14_2367

DDS:

Ddes_0337

DFI:	AXF13_12005

DPG:	DESPIGER_2217

DEF:	CNY67_12560

DTR:	RSDT_0005(aroB)

DFL:

DFE_3006

PSYF:

N1030_15300

DSB:	LN040_08750

DMA:

DMR_05360

DCB:	C3Y92_17725

DGG:

DGI_0593

DDE:

Dde_3488

DMS:	E8L03_13390

DSA:	Desal_3064

DHY:	DESAM_21549

DAF:	Desaf_1880

DAS:

Daes_0955

DPI:

BN4_11437

DEJ:	AWY79_15690

PPRF:

DPRO_2849

PSEL:

GM415_01300

DDN:	DND132_3202

PSEF:

PSDVSF_32830

PPOR:

JCM14722_26370

PNW:

SYK_31780

PTHE:

LF599_04810

PMEN:

V8V93_07995

DSX:	GD604_03175

DSD:	GD606_15910

PBIZ:

LWC08_10795

DVU:

DVU_0461

DVL:

Dvul_2476

DVM:

DvMF_1750

DVG:	Deval_0422

CLIH:

KPS_001996

TMUR:

JBF11_09510

DBA:

Dbac_2808

DOA:	AXF15_05890

DESU:

NLA06_14005

THEW:

TDMWS_00180

DRT:

Dret_0115

DMM:	dnm_037720(aroB1)

DEK:	DSLASN_18970

DAO:	Desac_0651

SFU:

Sfum_2724

DAW:	HS1_002355

AAE:

aq_1922

HYA:	HY04AAS1_0883

HHO:	HydHO_0879

HYS:	HydSN_0902

HTH:

HTH_1199

HTE:	Hydth_1191

TAL:

Thal_0223

TRD:	THERU_02290

SUL:	SYO3AOP1_0392

SAF:	SULAZ_0497

PMX:	PERMA_1476

TAM:	Theam_1067

DTE:	Dester_0533

TTK:

TST_1081

AXL:

AXY_21120

HHD:	HBHAL_4201

SJE:	AAV35_010780

GRC:	GI584_21530

GCS:	MUN88_08725

GSM:	MUN87_10150

SEDD:

ERJ70_18380

QDO:	H9Q78_12445

MJA:

MJ_1249

MFE:	Mefer_0373

MVU:	Metvu_0910

MFS:	MFS40622_0687

MIF:	Metin_0931

MJH:	JH146_0476

MESG:

MLAUSG7_1286(aroB)

MESA:

MLASG1_0490(aroB)

MIG:	Metig_1087

MMP:

MMP0006

MMQ:	MmarC5_1678

MMX:	MmarC6_0943

MMZ:	MmarC7_1003

MMD:

GYY_00030

MMAK:

MMKA1_00060(aroB)

MMAO:

MMOS7_00060(aroB)

MMAD:

MMJJ_10950(griH)

MAE:

Maeo_1164

MVN:	Mevan_1215

MVO:

Mvol_1425

MOK:	Metok_0735

METF:

CFE53_04710

MTH:

MTH_580

MMG:	MTBMA_c09610(aroB)

MWO:	MWSIV6_0940(aroB')

MTEE:

MTTB_10060

METC:

MTCT_0504

METE:

tca_00549(griH)

METZ:

METMT2_0850

METK:

FVF72_08660

MTHM:

FZP57_04500

METJ:

FZP68_04965

MST:

Msp_0090

METB:

AW729_06720

MEIS:

PXD04_04255

MRU:	mru_0998(aroB)

MSI:

Msm_0055

MEB:	Abm4_0655(aroB)

MMIL:

sm9_1017(aroB2)

MEYE:

TL18_05335

MOL:

YLM1_0541

MARO:

MarbSA_04650

METV:

K4897_00695

MEL:	Metbo_1360

MEW:	MSWAN_0908

METH:

MBMB1_1071

MFC:	BRM9_1273(aroB)

MFI:	DSM1535_1957

MCUB:

MCBB_0940(aroB')

MSUB:

BK009_02845

METN:

BK008_10570

METT:

CIT01_09450

METO:

CIT02_02140

MEME:

HYG87_09825

MFEG:

GCM10025860_20000

MFV:

Mfer_0601

MKA:

MK1408

AFU:

AF_0229

AFG:	AFULGI_00002150

APO:	Arcpr_0974

AVE:	Arcve_0431

AST:	Asulf_00977

FPL:

Ferp_2249

GAC:

GACE_1229

GAH:

GAH_01752

MBA:	Mbar_A0921

MBY:	MSBRM_0074

MBW:	MSBRW_0077

MBAR:

MSBR2_2306

MBAK:

MSBR3_2365

MAC:

MA_4592

MMA:

MM_1272

MMAZ:

MmTuc01_1318

MMJ:	MSMAS_0044

MMAC:

MSMAC_0044

MVC:	MSVAZ_3440

MEK:	MSKOL_3400

MLS:	MSLAZ_0043

METM:

MSMTP_0059

MEF:	MSWH1_0052

MEQ:	MSWHS_0055

MSJ:	MSSAC_0061

MSZ:	MSSIH_0054

MSW:	MSSIT_0054

MTHR:

MSTHT_1781

MTHE:

MSTHC_1505

MHOR:

MSHOH_0049

MFZ:	AOB57_008130

MBU:

Mbur_2000

MMET:

MCMEM_0228

MELO:

J7W08_11210

MMH:

Mmah_0240

MHAZ:

BHR79_02310

MPOT:

BKM01_06040

MEV:	Metev_1693

MZH:	Mzhil_0267

MPY:

Mpsy_1419

MZI:	HWN40_01700

MMAV:

RE476_08615

MSEB:

RE474_05175

MHZ:	Metho_0267

MEHF:

MmiHf6_11120(aroB')

MEES:

MmiEs2_13760(aroB')

MTP:

Mthe_0539

MCJ:	MCON_1239(aroB)

MHI:

Mhar_0787

MHU:

Mhun_1034

MRTJ:

KHC33_11775

MLA:

Mlab_1653

MEM:	Memar_1301

MBG:	BN140_2037

MEMA:

MMAB1_2642

MCHK:

MchiMG62_14870

MSUM:

OH143_00740

MRC:	R6Y96_03095

MPI:

Mpet_2704

MEND:

L6E24_08070

MEFW:

F1737_11250

MAQE:

RJ40_08665

MFK:	E2N92_08855

MOU:	OU421_03440

MESB:

L1S32_07040

MANQ:

L1994_00980

MBN:

Mboo_1559

MFO:	Metfor_1591

MPL:

Mpal_2609

MPD:

MCP_1668

MEZ:	Mtc_1382(aroB)

RCI:	RRC152(aroB)

MJK:	N2V74_06110

HAL:

VNG_0310C

HSL:	OE_1475F(aroB)

HANR:

LJ422_01360

HDL:	HALDL1_05735

HHB:	Hhub_1456(aroB)

HAGS:

JT689_02645

HABO:

JRZ79_01150

HNO:	LT974_02315

HLU:	LT972_11235

HANX:

ABSL23_07240

HALH:

HTSR_1438(aroB)

HHSR:

HSR6_1510(aroB)

HSU:	HLASF_0625(aroB)

HSF:	HLASA_0621(aroB)

HAHS:

HSRCO_0972

SALR:

FQU85_02210

HALR:

EFA46_006150

HJE:	HacjB3_14330

HDO:	MUK72_03650

HALX:

M0R89_10650

HAXZ:

M0R88_11040

HAYC:

NGM10_05225

HAXY:

NGM07_17215

SALI:

L593_01230

SAIM:

K0C01_01380

HARA:

AArcS_2624

HMA:	rrnAC1879(aroB)

HHI:	HAH_2395(aroB)

HHN:	HISP_12195

HAB:	SG26_04505

HTA:	BVU17_11655

HALJ:

G9465_07490

HSIN:

KDQ40_01450

NPH:	NP_2238A(aroB)

NMO:	Nmlp_1201(aroB)

NHO:	HWV23_11645

NSAL:

HWV07_13605

HUT:

Huta_1180

HTI:

HTIA_1102

HALA:

Hrd1104_09450

HASV:

SVXHr_0434

HABN:

HBNXHr_0420

HMU:

Hmuk_3035

HALZ:

E5139_02440

HALL:

LC1Hm_2380

HAZP:

GBQ70_02440

HALI:

BV210_04325

HSN:	DV733_05020

HDS:	HSR122_2612

HRR:	HZS55_09330

HPEL:

HZS54_13415

HLT:	I7X12_04885

HARC:

HARCEL1_12960

SSAI:

N0B31_00465

HAAD:

MW046_10350

HWA:	HQ_1155A(aroB)

HWC:	Hqrw_1192(aroB)

HVO:	HVO_0792(aroB)

HALE:

G3A49_03985

HLN:	SVXHx_0751

HME:

HFX_0757

HGI:	ABY42_03780

HLS:	KU306_08500

HBO:	Hbor_24250

HAQ:	DU484_08630

HAJ:	DU500_08670

HAER:

DU502_05970

HRA:	EI982_07825

HLM:	DV707_11410

HALM:

FCF25_10555

HLA:

Hlac_1277

HALP:

DOS48_06140

HALB:

EKH57_03850

HEZZ:

EO776_07620

HALQ:

Hrr1229_015375

HSS:	J7656_08785

HSAI:

HPS36_14195

HAZZ:

KI388_05330

SRUB:

C2R22_04760

HAE:	halTADL_0574

HALN:

B4589_008490

HALG:

HUG10_01105

HALU:

HUG12_16490

HMP:	K6T50_14130

HRE:	K6T36_14075

HRM:	K6T25_02710

HACB:

Hbl1158_05905

HDF:	AArcSl_0523

HAH:	Halar_0977

HTU:

Htur_0813

HSAL:

JMJ58_04845

HAKZ:

J0X25_11125

NMG:	Nmag_2808(aroB)

HXA:	Halxa_4001

NAT:

NJ7G_4142

NPE:	Natpe_3306

NVR:	FEJ81_15815

NPL:	FGF80_14920

NAY:	HYG81_12450

HALY:

HYG82_19465

HJT:	DVR14_06630

HLO:	J0X27_10805

NGE:	Natgr_1033

HRU:	Halru_2308

SAWL:

NGM29_17405

HALV:

NGM15_08625

NOU:	Natoc_0631

HLR:	HALLA_07820

HLC:	CHINAEXTREME00870

NAJ:	B1756_11610

NAG:	AArcMg_0899

NAN:	AArc1_2810

NARA:

QQ977_05995

NBG:	DV706_03270

NAS:	GCU68_10245

HDA:	BB347_01125

MELU:

MTLP_01130

MEAM:

MU439_07200

MEAE:

QEN48_03020

TAR:	TALC_00561

MAX:	MMALV_05110

MER:	MMINT_14410

MEAR:

Mpt1_c10440(aroB')

MEUZ:

KRP56_01770

MARC:

AR505_0509

KCR:

Kcr_1100

NMR:

Nmar_0552

NIR:	NSED_02800

NKR:	NKOR_02860

NID:	NPIRD3C_1722(aroB)

NIN:	NADRNF5_1626(aroB)

NIW:	Nisw_02105

NCL:	C5F47_02840

NOX:	C5F49_03020

NUE:	C5F50_04215

NIP:	NsoK4_05580

NZT:	NZOSNM25_001460

NCT:	NMSP_1119(aroB')

NIC:	DSQ20_03070

NGA:	Ngar_c16220(aroB)

NVN:	NVIE_005840(aroB)

NEV:

NTE_01959

TAA:	NMY3_02543(griH)

NFN:	NFRAN_0127(aroB)

NCV:	NCAV_0389(aroB)

NDV:	NDEV_0553(aroB)

CSY:	CENSYa_0201

CSU:	CSUB_C0896

NBV:

T478_0479

TAH:	SU86_003325

NIU:	DSQ19_02825

NCK:	QVH35_06865

CCAI:

NAS2_0560

BARB:

AOA66_0831(aroB')

LOKI:

Lokiarch_16770(aroB')

» show all

Reference

1 [PMID:15182204]

Authors

White RH

Title

L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.

Journal

Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127

Sequence

[mja:MJ_1249]

Other DBs

ExplorEnz - The Enzyme Database:

1.4.1.24

IUBMB Enzyme Nomenclature:

1.4.1.24

ExPASy - ENZYME nomenclature database:

1.4.1.24

BRENDA, the Enzyme Database:

1.4.1.24

DBGET integrated database retrieval system