KEGG   ENZYME: 1.4.1.25Help
Entry
EC 1.4.1.25                 Enzyme                                 

Name
L-arginine dehydrogenase;
dauB (gene name);
anabolic L-arginine dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-arginine:NAD(P)+ oxidoreductase (deaminating)
Reaction(IUBMB)
L-arginine + H2O + NAD(P)+ = 5-guanidino-2-oxopentanoate + NH3 + NAD(P)H + H+ [RN:R11031 R11032]
Reaction(KEGG)
Substrate
L-arginine [CPD:C00062];
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
5-guanidino-2-oxopentanoate [CPD:C03771];
NH3 [CPD:C00014];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, which has been isolated from the bacterium Pseudomonas aeruginosa PAO1, forms with EC 1.4.99.6, D-arginine dehydrogenase, a two-enzyme complex involved in the racemization of D- and L-arginine.
History
EC 1.4.1.25 created 2017
Pathway
ec00472  D-Arginine and D-ornithine metabolism
ec01100  Metabolic pathways
Orthology
K19744  L-arginine dehydrogenase
Genes
PALH: B1H58_18955
PPR: PBPRB0030(PA3862)
PAE: PA3862(dauB)
PAEV: N297_3988
PAEI: N296_3988
PAU: PA14_14020
PAP: PSPA7_1243
PAG: PLES_11121
PAF: PAM18_1076
PNC: NCGM2_5052
PAEP: PA1S_05510
PAEM: U769_05545
PAEL: T223_05460
PAEG: AI22_28105
PAEC: M802_3986
PAEO: M801_3854
PMY: Pmen_3566
PFL: PFL_1045
PPRO: PPC_1082
PFB: VO64_5502
PMAN: OU5_2435
PKC: PKB_0989
PSEM: TO66_05260
PSOS: POS17_1042
PANR: A7J50_2221
PSET: THL1_1153
PSIL: PMA3_04250
BCN: Bcen_0365
BCJ: BCAL3157
BCEN: DM39_657
BCEW: DM40_1511
BCEO: I35_0706
BAM: Bamb_0723
BMU: Bmul_2539
BMK: DM80_839
BMUL: NP80_860
BCT: GEM_2683
BCED: DM42_982
BDL: AK34_2328
BCON: NL30_11560
BLAT: WK25_03945
BTEI: WS51_14505
BSEM: WJ12_03835
BPSL: WS57_21640
BMEC: WJ16_03870
BSTG: WT74_04145
BPH: Bphy_3431
BFN: OI25_6281
SHZ: shn_32355
SMAZ: LH19_04515
STRE: GZL_01015
 » show all
Taxonomy
Reference
1  [PMID:19139398]
  Authors
Li C, Lu CD
  Title
Arginine racemization by coupled catabolic and anabolic dehydrogenases.
  Journal
Proc Natl Acad Sci U S A 106:906-11 (2009)
DOI:10.1073/pnas.0808269106
  Sequence
[pae:PA3862]
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.25
IUBMB Enzyme Nomenclature: 1.4.1.25
ExPASy - ENZYME nomenclature database: 1.4.1.25
BRENDA, the Enzyme Database: 1.4.1.25

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