KEGG   ENZYME: 1.4.1.26
Entry
EC 1.4.1.26                 Enzyme                                 

Name
2,4-diaminopentanoate dehydrogenase (NAD+);
DAPDH (ambiguous)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2R,4S)-2,4-diaminopentanoate:NADP+ oxidoreductase (deaminating)
Reaction(IUBMB)
(2R,4S)-2,4-diaminopentanoate + H2O + NAD+ = (2R)-2-amino-4-oxopentanoate + NH3 + NADH + H+ [RN:R04200]
Reaction(KEGG)
R04200
Substrate
(2R,4S)-2,4-diaminopentanoate [CPD:C03943];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
(2R)-2-amino-4-oxopentanoate [CPD:C03341];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from an unknown bacterium in an environmental sample, has some activity with (2R,4R)-2,4-diaminopentanoate. It has very low activity with NADP+ (cf. EC 1.4.1.12, 2,4-diaminopentanoate dehydrogenase).
History
EC 1.4.1.26 created 2017
Pathway
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K21672  2,4-diaminopentanoate dehydrogenase
Genes
CEH: CEW89_15600
EAV: EH197_05050
VCP: H9L18_06400
VHY: G7082_14535
CSQ: CSCA_0127
CACE: CACET_c17480(dapB2)
CEU: A7L45_16560
CFM: BJL90_14515
CARG: RSJ17_08675
CDRK: B9W14_17905
AMT: Amet_2367
AOE: Clos_1699
CDF: CD630_04420(ord)
PDC: CDIF630_00570(ord)
PDF: CD630DERM_04420(ord)
CST: CLOST_1294(ord)
TTE: TTE1234
THX: Thet_1426
TOC: Toce_1489
KME: H0A61_00511(ord)
PFT: JBW_01651
MPHU: MPHO_01310
PAC: PPA2276
PAW: PAZ_c23740(dapB2)
PACC: PAC1_11610
PACH: PAGK_2185
CACN: RN83_00010
SBR: SY1_03600
TME: Tmel_0905
TAF: THA_1160
THER: Y592_05345
FNO: Fnod_1646
OCY: OSSY52_03900(ord)
PMO: Pmob_1166
MARN: LN42_08170
DTN: DTL3_0759
KOL: Kole_0356
ASAC: ATHSA_0997
 » show all
Reference
1  [PMID:19251850]
  Authors
Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M
  Title
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.
  Journal
J Bacteriol 191:3162-7 (2009)
DOI:10.1128/JB.01777-08
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.26
IUBMB Enzyme Nomenclature: 1.4.1.26
ExPASy - ENZYME nomenclature database: 1.4.1.26
BRENDA, the Enzyme Database: 1.4.1.26

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