KEGG   ENZYME: 1.4.1.26Help
Entry
EC 1.4.1.26                 Enzyme                                 

Name
2,4-diaminopentanoate dehydrogenase (NAD+);
DAPDH (ambiguous)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2R,4S)-2,4-diaminopentanoate:NADP+ oxidoreductase (deaminating)
Reaction(IUBMB)
(2R,4S)-2,4-diaminopentanoate + H2O + NAD+ = (2R)-2-amino-4-oxopentanoate + NH3 + NADH + H+ [RN:R04200]
Reaction(KEGG)
Substrate
(2R,4S)-2,4-diaminopentanoate [CPD:C03943];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
(2R)-2-amino-4-oxopentanoate [CPD:C03341];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from an unknown bacterium in an environmental sample, has some activity with (2R,4R)-2,4-diaminopentanoate. It has very low activity with NADP+ (cf. EC 1.4.1.12, 2,4-diaminopentanoate dehydrogenase).
History
EC 1.4.1.26 created 2017
Pathway
ec00472  D-Arginine and D-ornithine metabolism
ec01100  Metabolic pathways
Orthology
K21672  2,4-diaminopentanoate dehydrogenase
Genes
PRG: RB151_036990
PALA: CO695_07830
PHEI: NCTC12003_03184
PRQ: CYG50_20115
PRJ: NCTC6933_03276
PRE: PCA10_28380
SPOI: IMCC21906_00314 IMCC21906_00847 IMCC21906_01025
ZAL: AZF00_09390 AZF00_09405
OSG: BST96_03310
HJA: BST95_01350 BST95_01355 BST95_02910
LHK: LHK_02682(dapB-1)
GME: Gmet_2230
DDS: Ddes_0477
ADE: Adeh_4039
MXA: MXAN_4674
CCX: COCOR_04871(dapB1)
SUR: STAUR_5466(dapB)
MLO: mll2179
GAK: X907_1091
SWI: Swit_2076
SPHR: BSY17_3841
BLAS: BSY18_822
BCL: ABC0939
SMU: SMU_527
SMJ: SMULJ23_1460(dapB1)
SMUA: SMUFR_0455
SSA: SSA_2021
SGO: SGO_0387
EMU: EMQU_2449
CSQ: CSCA_0127
CACE: CACET_c17480(dapB2)
AMT: Amet_2367
AOE: Clos_1699
CDF: CD630_04420(ord)
PDC: CDIF630_00570(ord)
PDF: CD630DERM_04420(ord)
CST: CLOST_1294(ord)
DSY: DSY3805
ELM: ELI_1411
AWO: Awo_c34400(dapB2)
TTE: TTE1234
THX: Thet_1426
TOC: Toce_1489
PFT: JBW_01651
ERH: ERH_1328
LPIL: LIP_2751
MHAS: MHAS_00058(ord_1) MHAS_00144(ord_2) MHAS_00761(ord_3) MHAS_01009(ord_5) MHAS_01281(ord_6) MHAS_01434(ord_7) MHAS_01895(ord_8) MHAS_03263(ord_9) MHAS_03413(ord_10) MHAS_03448(ord_11) MHAS_03947(ord_14) MHAS_04581(ord_15)
REQ: REQ_08310
GOM: D7316_01176(ord_1) D7316_01207(ord_2) D7316_02397(ord_4) D7316_02416(ord_5)
SGR: SGR_475
SGB: WQO_32495
SBH: SBI_01547
SFI: SFUL_6900
SALU: DC74_5517
SALL: SAZ_29140
STRM: M444_30835
SPRI: SPRI_0523
SFK: KY5_6975
PAC: PPA2276
PAW: PAZ_c23740(dapB2)
PACC: PAC1_11610
PACH: PAGK_2185
CACN: RN83_00010
NCA: Noca_0426
TCU: Tcur_3673
FAL: FRAAL4027
AMD: AMED_7503
AMN: RAM_38560
AMM: AMES_7392
AMZ: B737_7392
AOI: AORI_4152 AORI_5626(dapB)
CAI: Caci_5962
BLO: BL0836
BLJ: BLD_0569
BLF: BLIF_0905
BLL: BLJ_0914
BLM: BLLJ_0783
BLG: BIL_10530
BLA: BLA_0924(dapB)
BBB: BIF_02266
BBC: BLC1_1080
BLV: BalV_1084
BLW: W7Y_1124
BLS: W91_1149
BANI: Bl12_1046
BANL: BLAC_05660
BANM: EN10_05695
CWO: Cwoe_0529
OLS: Olsu_0652
RCA: Rcas_2891
TRO: trd_1461(dapB)
TTR: Tter_0366
EMI: Emin_0479
EPO: Epro_1033
SBR: SY1_03600
SRU: SRU_1744
SRM: SRM_01957
TME: Tmel_0905
TAF: THA_1160
THER: Y592_05345
FNO: Fnod_1646
PMO: Pmob_1166
MARN: LN42_08170
DTN: DTL3_0759
KOL: Kole_0356
AFU: AF_0634
HALH: HTSR_1253
HHSR: HSR6_1326(dapB)
SMR: Smar_0092
IAG: Igag_1701
HBU: Hbut_1431
CMA: Cmaq_1015
VDI: Vdis_2453
VMO: VMUT_0813
LOKI: Lokiarch_19170(rex)
 » show all
Taxonomy
Reference
1  [PMID:19251850]
  Authors
Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M.
  Title
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.
  Journal
J Bacteriol 191:3162-7 (2009)
DOI:10.1128/JB.01777-08
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.26
IUBMB Enzyme Nomenclature: 1.4.1.26
ExPASy - ENZYME nomenclature database: 1.4.1.26
BRENDA, the Enzyme Database: 1.4.1.26

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