| Entry |
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| Name |
leucine dehydrogenase;
L-leucine dehydrogenase;
L-leucine:NAD+ oxidoreductase, deaminating;
LeuDH
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| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
L-leucine:NAD+ oxidoreductase (deaminating)
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| Reaction(IUBMB) |
L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+ [RN: R01088]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Also acts on isoleucine, valine, norvaline and norleucine.
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| History |
EC 1.4.1.9 created 1972
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| Pathway |
| ec00280 | Valine, leucine and isoleucine degradation |
| ec00290 | Valine, leucine and isoleucine biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
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| Genes |
| XPH: | XppCFBP6546_04670(XppCFBP6546P_04670) |
| PRE: | PCA10_42250(ldh) PCA10_47390(ldh) |
| PFUW: | KF707C_13910 KF707C_47090 |
| PALC: | A0T30_06840 A0T30_14845 |
| PPRC: | PFLCHA0_c09910(yqiT) |
| PMUD: | NCTC8068_00974(ldh) |
| PFW: | PF1751_v1c09880(ldh) |
| PPSY: | AOC04_13560 AOC04_15895 |
| PSET: | THL1_4272 THL1_4748 |
| PALL: | UYA_15265 UYA_17100 |
| POJ: | PtoMrB4_41490(ldh_1) PtoMrB4_46580(ldh_2) |
| PPSH: | G5J76_19780 G5J76_22425 |
| PLAL: | FXN65_20595 FXN65_22810 |
| PSEJ: | HNQ25_08415 HNQ25_10225 |
| PKH: | JLK41_14525 JLK41_16520 |
| PTY: | JWV26_01315 JWV26_03320 |
| PMAO: | PMYSY11_0918(ldh) PMYSY11_3133(ldh) |
| PWZ: | J7655_06490 J7655_08095 |
| PTW: | TUM18999_42130(ldh_1) TUM18999_50530(ldh_2) |
| PTAE: | NCTC10697_03144(ldh_1) NCTC10697_03593(ldh_2) |
| PHF: | NLY38_08550 NLY38_19000 |
| PSOA: | PSm6_03170(ldh_1) PSm6_10390(ldh_2) |
| PZD: | KQ248_00065 KQ248_22350 |
| SCAA: | TUM17387_23300(ldh) |
| KIM: | G3T16_03500 G3T16_14340 |
| CEY: | CleRT_04440 CleRT_05880 |
| ALG: | AQULUS_16550(ldh_1) AQULUS_19950(ldh_2) |
| LLG: | 44548918_01841(gdhA) |
| LJR: | NCTC11533_01986(gdhA) |
| LCJ: | NCTC11976_01351(ldh) |
| LWA: | SAMEA4504053_2513(gdhA_2) |
| LSS: | NCTC12082_00031(gdhA) |
| LADL: | NCTC12735_01295(ldh) |
| MARS: | A8C75_17205 A8C75_20465 |
| MSEC: | LN244_00965 LN244_03770 |
| MRZ: | KDW95_18465 KDW95_21715 |
| BSAN: | CHH28_08985 CHH28_12080 |
| NCU: | F0U83_06065 F0U83_13230 |
| NJP: | NEJAP_2297 NEJAP_2985 |
| AJP: | AMJAP_0344 AMJAP_2751 |
| REH: | H16_B0449(h16_B0449) |
| REU: | Reut_B5816 Reut_C6219 |
| CBW: | RR42_m2084 RR42_s0423 |
| PLG: | NCTC10937_04329(ldh) |
| LABR: | CHH27_16120 CHH27_16580 |
| LABP: | FJ695_07140 FJ695_10130 |
| ACUT: | MRB58_17020 MRB58_24365 |
| TSV: | DSM104635_01267(ldh) |
| PPIC: | PhaeoP14_01857(ldh) |
| RMM: | ROSMUCSMR3_02235(ldh) |
| RID: | RIdsm_00787(ldh_1) RIdsm_03966(ldh_2) |
| HNE: | HNE_1615(ldh1) HNE_2735(ldh2) |
| NOV: | TQ38_012850 TQ38_019680 TQ38_019975 |
| NOG: | GKE62_13835 GKE62_14900 GKE62_14915 GKE62_17290 |
| SPHK: | SKP52_12340(ldh1) SKP52_15415(ldh2) |
| SPHP: | LH20_07375 LH20_07755 |
| SMAG: | AN936_03740 AN936_11630 AN936_12440 |
| SMAZ: | LH19_12770 LH19_13720 |
| STER: | AOA14_17450 AOA14_17950 |
| SGI: | SGRAN_2658(ldh) SGRAN_3000(ldh2) |
| SPHQ: | BWQ93_01290 BWQ93_08310 |
| SPHO: | C3E99_05710 C3E99_10370 |
| SPHX: | E5675_06140 E5675_13265 |
| SINA: | KNJ79_12305 KNJ79_16800 |
| SPHU: | SPPYR_0813(ldh) SPPYR_1057(ldh) |
| SPHI: | TS85_08180 TS85_11675 |
| SPLK: | AV944_05985 AV944_16480 |
| SPHA: | D3Y57_02645 D3Y57_06430 |
| SPAU: | DRN02_009905 DRN02_017880 |
| SPAP: | H3Z74_07150 H3Z74_14985 |
| SCHY: | GVO57_02900 GVO57_08535 |
| SSUA: | FPZ54_04555 FPZ54_19235 |
| SFLA: | SPHFLASMR4Y_01279(ldh) |
| BLAS: | BSY18_22 BSY18_2937 |
| SPZR: | G5C33_05980 G5C33_05990 G5C33_14930 G5C33_18175 |
| AMX: | AM2010_116 AM2010_742 |
| PMAS: | NCF86_06290 NCF86_10415 |
| CMAN: | A9D14_08080 A9D14_16915 |
| CCRO: | CMC5_007100 CMC5_032400 |
| PCAY: | FRD00_21620 FRD00_23530 |
| GJF: | M493_12170 M493_12345 |
| PARG: | PspKH34_11530(yqiT_1) |
| BLEN: | NCTC4824_01775(bcd) |
| SDP: | NCTC12225_00433(dhlE) |
| SSTE: | SAMEA4384403_1260(dhlE) |
| BAYD: | BSPP4475_11535(gdhA) |
| PSAB: | PSAB_04665 PSAB_13610 |
| PBJ: | VN24_08750 VN24_17500 |
| PRI: | PRIO_1162(ldh1) PRIO_3732(ldh5) |
| PXL: | BS614_01600 BS614_05430 |
| PBAC: | HUB98_15735 HUB98_19080 HUB98_22790 |
| PSOP: | KP014_08180 KP014_18685 |
| PMAH: | PTQ21_03785 PTQ21_07170 |
| PAMY: | P9222_03210 P9222_06810 |
| DAI: | Desaci_3322 Desaci_4535 |
| FWA: | DCMF_16555 DCMF_18320 |
| AACX: | DEACI_0616 DEACI_2774 |
| ACAE: | HYG86_16045 HYG86_16060 |
| THEP: | DYI95_005740 DYI95_005745 |
| TTE: | TTE2202(GdhA3) TTE2203(GdhA4) |
| HOR: | Hore_06730 Hore_06750 |
| AFT: | BBF96_08650 BBF96_08665 |
| KME: | H0A61_02459(ldh_1) H0A61_02772(ldh_2) |
| SRW: | TUE45_pSRc_0492(ldh) |
| AMAU: | DSM26151_22690(ldh) |
| AMAV: | GCM10025877_07270(ldh_2) |
| ASIC: | Q0Z83_002840 Q0Z83_029200 |
| BALA: | DSM104299_04803(ldh_1) DSM104299_05636(ldh_2) |
| CWO: | Cwoe_1545 Cwoe_2247 Cwoe_4384 |
| SBAE: | DSM104329_04601(ldh_2) |
| RIV: | Riv7116_1653 Riv7116_1899 |
| NSPH: | BDGGKGIB_00537(ldh) |
| SNG: | SNE_A05300(ldh-A) SNE_A22050(ldh-B) |
| AMUC: | Pan181_29100(ldh_1) |
| UAM: | UABAM_00679 UABAM_03312 |
| SDJ: | NCTC13534_04154(ldh) |
| STHA: | NCTC11429_04949(ldh) |
| FOK: | KK2020170_16900(vdh) |
| PHG: | KCTC32516_02251(ldh) |
| KOS: | KORDIASMS9_03834(ldh) |
| PTAN: | CRYO30217_01447(ldh) |
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| Reference |
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| Authors |
SANWAL BD, ZINK MW. |
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| Title |
L-Leucine dehydrogenase of Bacillus cereus. |
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| Journal |
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| Reference |
2 |
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| Authors |
Zink, M.W. and Sanwal, B.D. |
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| Title |
The distribution and substrate specificity of L-leucine dehydrogenase. |
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| Journal |
Arch Biochem Biophys 99:72-77 (1962) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.4.1.9 |
| ExPASy - ENZYME nomenclature database: | 1.4.1.9 |
| BRENDA, the Enzyme Database: | 1.4.1.9 |
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