KEGG   ENZYME: 1.4.3.13
Entry
EC 1.4.3.13                 Enzyme                                 
Name
protein-lysine 6-oxidase;
lysyl oxidase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
Sysname
protein-L-lysine:oxygen 6-oxidoreductase (deaminating)
Reaction(IUBMB)
[protein]-L-lysine + O2 + H2O = [protein]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 [RN:R04239]
Reaction(KEGG)
R04239
Substrate
[protein]-L-lysine [CPD:C02188];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
[protein]-(S)-2-amino-6-oxohexanoate [CPD:C03531];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
Also acts on protein 5-hydroxylysine. This enzyme catalyses the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices [4]. These reactions play an important role for the development, elasticity and extensibility of connective tissue. The enzyme is also active on free amines, such as cadaverine or benzylamine [4,5]. Some isoforms can also use [protein]-N(6)-acetyl-L-lysine as substrate deacetamidating the substrate [6].
History
EC 1.4.3.13 created 1980, modified 1983
Orthology
K00277  protein-lysine 6-oxidase
Genes
HSA4015(LOX)
PTR471614(LOX)
PPS100978437(LOX)
GGO101136249(LOX)
PON100457685(LOX)
NLE100605848(LOX)
MCC699997(LOX)
MCF102132184(LOX)
CSAB103244411(LOX)
CATY105599668(LOX)
PANU101009863(LOX)
TGE112625888(LOX)
RRO104666992(LOX)
RBB108520384(LOX)
TFN117065963(LOX)
PTEH111530193(LOX)
CJC100407991(LOX)
SBQ101048786(LOX)
MMUR105884562(LOX)
OGA100957484(LOX)
MMU16948(Lox)
MCAL110284684(Lox)
MPAH110333071(Lox)
RNO24914(Lox)
MCOC116087156(Lox)
MUN110561997(Lox)
CGE100764517
PLEU114694772(Lox)
NGI103739770(Lox)
HGL101724460(Lox)
CCAN109686562(Lox)
DSP122103966(Lox)
NCAR124987504
OCU100357045(LOX)
OPI101536754(LOX)
TUP102485593(LOX)
CFA481478(LOX)
VVP112910209(LOX)
VLG121495447(LOX)
AML100471188(LOX)
UMR103670545(LOX)
UAH113261637(LOX)
UAR123790423(LOX)
ELK111148308
LLV125100791
MPUF101674938(LOX)
ORO101373448(LOX)
EJU114209620(LOX)
ZCA113929629(LOX)
MLX118016567(LOX)
FCA101092985(LOX)
PYU121010594(LOX)
PBG122486687(LOX)
PPAD109278881(LOX)
AJU106975167(LOX)
HHV120219985(LOX)
BTA280841(LOX)
BOM102276831(LOX)
BIU109561863(LOX)
BBUB102397091(LOX)
CHX102169472(LOX)
OAS101112220(LOX)
ODA120864680(LOX)
CCAD122440080(LOX)
SSC100525278(LOX)
CFR102512711(LOX)
CBAI105082060(LOX)
CDK105105055(LOX)
VPC102536056(LOX)
BACU103012553(LOX)
LVE103078614(LOX)
OOR101269698(LOX)
DLE111182358(LOX)
PCAD102993985(LOX)
PSIU116750841(LOX)
ECB100064016(LOX)
EPZ103557838(LOX)
EAI106842835(LOX)
MYB102253224(LOX)
MMYO118656205(LOX)
MLF102421922(LOX)
MNA107540921(LOX)
PKL118702754(LOX)
HAI109379076(LOX)
DRO112315003(LOX)
SHON118975159(LOX)
AJM119063969(LOX)
PDIC114510267(LOX)
PHAS123818134(LOX)
MMF118641778(LOX)
RFQ117025039(LOX)
PALE102888004(LOX)
PGIG120590869(LOX)
PVP105290866(LOX)
RAY107511146(LOX)
MJV108390293(LOX)
TOD119243553(LOX)
SARA101543655(LOX)
LAV100658633(LOX)
TMU101355891
DNM101420519(LOX)
MDO100027065(LOX)
GAS123231345(LOX)
SHR100920619(LOX)
PCW110223807(LOX)
OAA100076972(LOX)
GGA396474(LOX)
PCOC116239888(LOX)
CJO107306724(LOX)
NMEL110389631(LOX)
APLA101796992(LOX)
AFUL116500630(LOX)
TGU100223043(LOX)
LSR110479174(LOX)
PMOA120513571(LOX)
OTC121331504(LOX)
PRUF121362571(LOX)
FAB101817182(LOX)
PHI102109004(LOX)
PMAJ107216161(LOX)
CCAE111941266(LOX)
CCW104690454(LOX)
ETL114055337(LOX)
ZAB102061613(LOX)
FPG101917045(LOX)
FCH102050081(LOX)
TALA104363843(LOX)
ACHC115336592(LOX)
AROW112974482(LOX)
DNE112992377(LOX)
AMJ102559899(LOXL5B) 102571028(LOX)
CPOO109323579(LOX) 109324851
GGN109294688
CMY102941654(LOX)
CPIC101944676(LOX)
TST117879055(LOX)
CABI116831038(LOX)
MRV120408464(LOX)
ACS100558882(lox)
PVT110072652 110084345(LOX)
SUND121923132(LOX) 121937079
PBI103066382(LOX)
TSR106540749(LOX)
PGUT117674681(LOX)
VKO123031240(LOX)
PMUA114588561 114606468(LOX)
ZVI118076839(LOX) 118086060
GJA107121950(LOX)
XLA108707204(lox.S) 734204(lox.L)
XTR780067(lox)
NPR108791659 108799190(LOX)
RTEM120913806 120932053(LOX)
BBUF120988464(LOX) 120990934
BGAR122928991(LOX)
DRE100124531(loxl5b) 103911450 404621(loxa)
SRX107713278 107726222 107733348 107740551 107744153 107744154
SANH107686455 107687932 107688470(lox) 107696862 107698563 107704580
SGH107549379 107562574 107566396(lox) 107569406 107578202 107596248
CCAR109052012 109057450 109073443 109087603 109087612 109087621 109100885 109101193 109101345
CAUA113045254 113046247 113052788 113052841 113054132 113074970 113087085 113094196 113099105 113106902 113110400 113111892
IPU108265136 108277371(loxa) 108280695(loxl5b)
PHYP113532232(lox) 113533206 113544153
SMEO124393997(loxa) 124400032 124402758(loxl5b)
TFD113645263(loxl5b) 113655978 113661327(loxa)
AMEX103032299 103038245 103039369(lox) 103043200
EEE113570987(lox) 113575169 113585954
TRU101062132 101070353 101079320
TNGGSTEN00017324G001 GSTEN00027760G001 GSTEN00028864G001 GSTEN00031042G001
LCO104923293 104923472(lox) 104924628 104931423
NCC104944446 104953666 104961306
CGOB115007100 115013610(lox) 115017234 115022107
ELY117251980 117254282(loxl5a) 117269322(loxa)
PLEP121941192(loxl5a) 121951559 121959795(loxa) 121965070
SLUC116035105(loxa) 116045902(loxl5b) 116054423 116055490(loxl5a)
ECRA117944418 117950366(loxl5a) 117954214(loxl5b) 117959307(loxa)
PFLV114555699 114561749 114565526 114571472
GAT120816563 120824413(loxl5a) 120832258(loxa)
PPUG119202456 119217197(loxl5a) 119225276 119226535(loxa)
MSAM119891852 119901390(loxl5a) 119901867 119914443(loxa)
CUD121509897 121512378(loxl5a) 121520512 121525525(loxa)
MZE101470139 101477010 101483892
ONL100695665 100702891 100704050 100708791(lox)
OAU116313460 116313579 116322468(loxa) 116323169(loxl5a)
OLA101164730(lox) 101166747 101168667 101171929
OML112147810(loxl5b) 112150387 112150727(loxl5a) 112163226(loxa)
XMA102219592 102222632 102227597 102232659
XCO114145970 114150071 114150510 114154798
XHE116721188 116724972 116725320 116730483(lox)
PRET103464096 103470817(lox) 103473689 103479881
PFOR103138502 103138504 103146069 103148481 103148498 103152616(lox)
PLAI106938519 106942922 106945932(lox) 106950660 106955326 106959077
PMEI106914783 106918983(lox) 106925484 106927960 106933761 106933762
GAF122819453(loxa) 122827632 122838618(loxl5a) 122840972(loxl5b)
CVG107084642(lox) 107092672 107094219 107100672
CTUL119771583(loxa) 119784849 119785803(loxl5a) 119787860(loxl5b)
GMU124869548(loxl5b) 124872327(loxa) 124873657(loxl5a) 124877397
NFU107372900 107383593 107386123(lox) 107393124
KMR108230650(loxl5a) 108232567(loxa) 108232849(loxl5b) 108245865
ALIM106511976 106514508 106516863 106533445
NWH119407822(loxl5a) 119412992 119414726(loxl5b) 119425020(loxa)
AOCE111565540 111567323 111568365 111585553
CSEM103390487 103393429 103396464 103398001
POV109625786 109626121 109644542 109645284
SSEN122759948 122769856 122780697(loxl5a) 122781447(loxa)
HHIP117760716(loxl5a) 117772056(loxa) 117778753
LCF108875130(lox) 108879892 108881345 108884171
SDU111231064 111232717 111234195 111239245
SLAL111645427 111650185 111668089(lox) 111669146
XGL120790981(loxl5a) 120799137 120805439 120806114(loxa)
HCQ109507291 109513468 109516887 109523566
BPEC110160052 110160517 110164111 110170694
MALB109955438 109963419 109967459
SASA100195194(lyox) 106564861(lox) 106569609 106573825 106585899 106600516
OTW112219411 112226444 112231090(loxa) 112238492 112246614 112252183
OMY100189621(loxa) 110499862 110508305 110509899 110525209 110530787
OGO123991602 124007221(loxa) 124009306 124034678 124041694 124048845
ONE115101261 115101752 115108876 115116135 115120838 115124253
SALP111952944 111961509 111964111 111978867 112070768
SNH120020069 120021310 120026143 120050164 120054072 120056140
ELS105011451 105014993 105021664(lox) 105022892
SFM108919826 108921520 108932061 108937978
PKI111847584 111849767 111856535
AANG118207126 118224965(loxl5a) 118229304
LOC102697184 102697992(lox)
PSPA121300708 121301656 121302574 121315403
ARUT117401353 117408559 117966201 117973219
LCM102364058(LOX) 102365752
CMK103188143(loxl5a)
RTP109911408 109932236
BFO118414450
BBEL109486753
DMEDmel_CG11335(Loxl1)
DGR6567693
CCAT101452065
BOD106623022
SCAC106094729
 » show all
Reference
1  [PMID:4838158]
  Authors
Harris ED, Gonnerman WA, Savage JE, O'Dell BL.
  Title
Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta.
  Journal
Biochim Biophys Acta 341:332-44 (1974)
DOI:10.1016/0005-2744(74)90226-5
Reference
2  [PMID:33171]
  Authors
Rayton JK, Harris ED.
  Title
Induction of lysyl oxidase with copper. Properties of an in vitro system.
  Journal
J Biol Chem 254:621-6 (1979)
Reference
3  [PMID:7318]
  Authors
Stassen FL.
  Title
Properties of highly purified lysyl oxidase from embryonic chick cartilage.
  Journal
Biochim Biophys Acta 438:49-60 (1976)
DOI:10.1016/0005-2744(76)90222-9
Reference
4  [PMID:11779117]
  Authors
Palamakumbura AH, Trackman PC.
  Title
A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples.
  Journal
Anal Biochem 300:245-51 (2002)
DOI:10.1006/abio.2001.5464
Reference
5  [PMID:6147351]
  Authors
Kagan HM, Williams MA, Williamson PR, Anderson JM.
  Title
Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates.
  Journal
J Biol Chem 259:11203-7 (1984)
Reference
6  [PMID:20439985]
  Authors
Rodriguez HM, Vaysberg M, Mikels A, McCauley S, Velayo AC, Garcia C, Smith V
  Title
Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor.
  Journal
J Biol Chem 285:20964-74 (2010)
DOI:10.1074/jbc.M109.094136
  Sequence
[hsa:4017]
Reference
7  [PMID:20306300]
  Authors
Kim YM, Kim EC, Kim Y
  Title
The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin.
  Journal
Mol Biol Rep 38:145-9 (2011)
DOI:10.1007/s11033-010-0088-0
  Sequence
[hsa:4017]
Reference
8  [PMID:23319596]
  Authors
Xu L, Go EP, Finney J, Moon H, Lantz M, Rebecchi K, Desaire H, Mure M
  Title
Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells.
  Journal
J Biol Chem 288:5357-63 (2013)
DOI:10.1074/jbc.C112.421768
  Sequence
[hsa:4017]
Reference
9  [PMID:28065600]
  Authors
Ma L, Huang C, Wang XJ, Xin DE, Wang LS, Zou QC, Zhang YS, Tan MD, Wang YM, Zhao TC, Chatterjee D, Altura RA, Wang C, Xu YS, Yang JH, Fan YS, Han BH, Si J, Zhang X, Cheng J, Chang Z, Chin YE
  Title
Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and  Deacetylimination Modulation.
  Journal
Mol Cell 65:296-309 (2017)
DOI:10.1016/j.molcel.2016.12.002
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.13
IUBMB Enzyme Nomenclature: 1.4.3.13
ExPASy - ENZYME nomenclature database: 1.4.3.13
BRENDA, the Enzyme Database: 1.4.3.13
CAS: 99676-44-5

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