KEGG   ENZYME: 1.4.3.13Help
Entry
EC 1.4.3.13                 Enzyme                                 

Name
protein-lysine 6-oxidase;
lysyl oxidase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
protein-L-lysine:oxygen 6-oxidoreductase (deaminating)
Reaction(IUBMB)
[protein]-L-lysine + O2 + H2O = [protein]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 [RN:R04239]
Reaction(KEGG)
Substrate
[protein]-L-lysine [CPD:C02188];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
[protein]-(S)-2-amino-6-oxohexanoate [CPD:C03531];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
Also acts on protein 5-hydroxylysine. This enzyme catalyses the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices [4]. These reactions play an important role for the development, elasticity and extensibility of connective tissue. The enzyme is also active on free amines, such as cadaverine or benzylamine [4,5]. Some isoforms can also use [protein]-N(6)-acetyl-L-lysine as substrate deacetamidating the substrate [6].
History
EC 1.4.3.13 created 1980, modified 1983
Orthology
K00277  protein-lysine 6-oxidase
Genes
HSA: 4015(LOX)
PTR: 471614(LOX)
PPS: 100978437(LOX)
GGO: 101136249(LOX)
PON: 100457685(LOX)
NLE: 100605848(LOX)
MCC: 699997(LOX)
MCF: 102132184(LOX)
CSAB: 103244411(LOX)
RRO: 104666992(LOX)
RBB: 108520384(LOX)
CJC: 100407991(LOX)
SBQ: 101048786(LOX)
MMU: 16948(Lox)
RNO: 24914(Lox)
MUN: 110561997(Lox)
CGE: 100764517
NGI: 103739770(Lox)
HGL: 101724460(Lox)
CCAN: 109686562(Lox)
OCU: 100357045(LOX)
TUP: 102485593(LOX)
CFA: 481478(LOX)
AML: 100471188(LOX)
UMR: 103670545(LOX)
ORO: 101373448(LOX)
FCA: 101092985(LOX)
PTG: 102972003(LOX)
AJU: 106975167(LOX)
BTA: 280841(LOX)
BOM: 102276831(LOX)
BIU: 109561863(LOX)
PHD: 102330037(LOX)
CHX: 102169472(LOX)
OAS: 101112220(LOX)
SSC: 100525278(LOX)
CFR: 102512711(LOX)
CDK: 105105055
BACU: 103012553(LOX)
LVE: 103078614(LOX)
OOR: 101269698(LOX)
DLE: 111182358(LOX)
ECB: 100064016(LOX)
EPZ: 103557838(LOX)
EAI: 106842835(LOX)
MYB: 102253224(LOX)
MYD: 102760252(LOX)
MNA: 107540921(LOX)
HAI: 109379076(LOX)
RSS: 109445545(LOX)
PALE: 102888004(LOX)
LAV: 100658633(LOX)
TMU: 101355891
MDO: 100027065(LOX)
SHR: 100920619(LOX)
PCW: 110223807(LOX)
OAA: 100076972(LOX)
GGA: 396474(LOX)
CJO: 107306724(LOX)
APLA: 101796992(LOX)
ACYG: 106047401(LOX)
TGU: 100223043(LOX)
LSR: 110479174(LOX)
SCAN: 103821482(LOX)
GFR: 102041923(LOX)
FAB: 101817182(LOX)
PHI: 102109004(LOX)
PMAJ: 107216161(LOX)
CCAE: 111941266(LOX)
CCW: 104690454(LOX)
ETL: 114055337(LOX)
FPG: 101917045(LOX)
FCH: 102050081(LOX)
CLV: 102096315(LOX)
EGZ: 104124232(LOX)
NNI: 104012428(LOX)
ACUN: 113489611(LOX)
ASN: 102380184(LOX)
AMJ: 102559899(LOXL5B) 102571028(LOX)
PSS: 102455646(LOX)
CMY: 102941654(LOX)
CPIC: 101944676(LOX)
ACS: 100558882(lox)
PVT: 110072652 110084345(LOX)
PBI: 103066382(LOX)
PMUR: 107289433(LOX)
GJA: 107121950(LOX)
XLA: 108707204(lox.S) 734204(lox.L)
XTR: 780067(lox)
NPR: 108799190(LOX)
DRE: 404621(loxa)
IPU: 108265136(lox) 108277371(Lox) 108280695(Lox)
ELS: 105014993 105021664(lox)
LCM: 102364058(LOX) 102365752
CMK: 103182380(lox) 103188143
DME: Dmel_CG11335(Loxl1)
 » show all
Taxonomy
Reference
1  [PMID:4838158]
  Authors
Harris ED, Gonnerman WA, Savage JE, O'Dell BL.
  Title
Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta.
  Journal
Biochim Biophys Acta 341:332-44 (1974)
DOI:10.1016/0005-2744(74)90226-5
Reference
2  [PMID:33171]
  Authors
Rayton JK, Harris ED.
  Title
Induction of lysyl oxidase with copper. Properties of an in vitro system.
  Journal
J Biol Chem 254:621-6 (1979)
Reference
3  [PMID:7318]
  Authors
Stassen FL.
  Title
Properties of highly purified lysyl oxidase from embryonic chick cartilage.
  Journal
Biochim Biophys Acta 438:49-60 (1976)
DOI:10.1016/0005-2744(76)90222-9
Reference
4  [PMID:11779117]
  Authors
Palamakumbura AH, Trackman PC.
  Title
A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples.
  Journal
Anal Biochem 300:245-51 (2002)
DOI:10.1006/abio.2001.5464
Reference
5  [PMID:6147351]
  Authors
Kagan HM, Williams MA, Williamson PR, Anderson JM.
  Title
Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates.
  Journal
J Biol Chem 259:11203-7 (1984)
Reference
6  [PMID:20439985]
  Authors
Rodriguez HM, Vaysberg M, Mikels A, McCauley S, Velayo AC, Garcia C, Smith V
  Title
Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor.
  Journal
J Biol Chem 285:20964-74 (2010)
DOI:10.1074/jbc.M109.094136
  Sequence
[hsa:4017]
Reference
7  [PMID:20306300]
  Authors
Kim YM, Kim EC, Kim Y
  Title
The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin.
  Journal
Mol Biol Rep 38:145-9 (2011)
DOI:10.1007/s11033-010-0088-0
  Sequence
[hsa:4017]
Reference
8  [PMID:23319596]
  Authors
Xu L, Go EP, Finney J, Moon H, Lantz M, Rebecchi K, Desaire H, Mure M
  Title
Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells.
  Journal
J Biol Chem 288:5357-63 (2013)
DOI:10.1074/jbc.C112.421768
  Sequence
[hsa:4017]
Reference
9  [PMID:28065600]
  Authors
Ma L, Huang C, Wang XJ, Xin DE, Wang LS, Zou QC, Zhang YS, Tan MD, Wang YM, Zhao TC, Chatterjee D, Altura RA, Wang C, Xu YS, Yang JH, Fan YS, Han BH, Si J, Zhang X, Cheng J, Chang Z, Chin YE
  Title
Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and  Deacetylimination Modulation.
  Journal
Mol Cell 65:296-309 (2017)
DOI:10.1016/j.molcel.2016.12.002
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.13
IUBMB Enzyme Nomenclature: 1.4.3.13
ExPASy - ENZYME nomenclature database: 1.4.3.13
BRENDA, the Enzyme Database: 1.4.3.13
CAS: 99676-44-5

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