KEGG ENZYME: 1.4.3.13

ENZYME: 1.4.3.13

Entry

EC 1.4.3.13                 Enzyme

Name

protein-lysine 6-oxidase;
lysyl oxidase

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor

Sysname

protein-L-lysine:oxygen 6-oxidoreductase (deaminating)

Reaction(IUBMB)

[protein]-L-lysine + O2 + H2O = [protein]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 [RN:R04239]

Reaction(KEGG)

R04239

Substrate

[protein]-L-lysine [CPD:C02188];
O2 [CPD:C00007];
H2O [CPD:C00001]

Product

[protein]-(S)-2-amino-6-oxohexanoate [CPD:C03531];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]

Comment

Also acts on protein 5-hydroxylysine. This enzyme catalyses the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices [4]. These reactions play an important role for the development, elasticity and extensibility of connective tissue. The enzyme is also active on free amines, such as cadaverine or benzylamine [4,5]. Some isoforms can also use [protein]-N(6)-acetyl-L-lysine as substrate deacetamidating the substrate [6].

History

EC 1.4.3.13 created 1980, modified 1983

Orthology

K00277

protein-lysine 6-oxidase

Genes

HSA:

4015(LOX)

PTR:	471614(LOX)

PPS:	100978437(LOX)

GGO:	101136249(LOX)

PON:	100457685(LOX)

PPYG:

129037218(LOX)

NLE:	100605848(LOX)

HMH:	116470894(LOX)

SSYN:

129493159(LOX)

MCC:	699997(LOX)

MCF:	102132184(LOX)

MTHB:

126957529

MNI:	105500045(LOX)

CSAB:

103244411(LOX)

CATY:

105599668(LOX)

PANU:

101009863(LOX)

TGE:	112625888(LOX)

MLEU:

105545034(LOX)

RRO:	104666992(LOX)

RBB:	108520384(LOX)

TFN:	117065963(LOX)

PTEH:

111530193(LOX)

CANG:

105527394(LOX)

CJC:	100407991(LOX)

SBQ:	101048786(LOX)

CIMI:

108306781(LOX)

ANAN:

105714464(LOX)

MMUR:

105884562(LOX)

LCAT:

123648610(LOX)

PCOQ:

105826346(LOX)

OGA:	100957484(LOX)

MMU:	16948(Lox)

MCAL:

110284684(Lox)

MPAH:

110333071(Lox)

RNO:	24914(Lox)

MCOC:

116087156(Lox)

ANU:	117719781(Lox)

MUN:	110561997(Lox)

CGE:

100764517

MAUA:

101827746(Lox)

PROB:

127234043(Lox)

PLEU:

114694772(Lox)

MORG:

121441932 121453380

MFOT:

126506023

AAMP:

119814493(Lox)

NGI:	103739770(Lox)

HGL:	101724460(Lox)

CCAN:

109686562(Lox)

DSP:	122103966(Lox)

PLOP:

125352074(Lox)

NCAR:

124987504

MMMA:

107143186(Lox)

OCU:

100357045

OPI:	101536754(LOX)

TUP:	102485593(LOX)

GVR:	103594373(LOX)

CFA:	481478(LOX)

CLUD:

112649935(LOX)

VVP:	112910209(LOX)

VLG:	121495447(LOX)

NPO:	129494909(LOX)

AML:	100471188(LOX)

UMR:	103670545(LOX)

UAH:	113261637(LOX)

UAR:	123790423(LOX)

ELK:

111148308

LLV:

125100791

MPUF:

101674938(LOX)

MNP:	132028872(LOX)

MLK:	131832565(LOX)

NVS:	122916359(LOX)

ORO:	101373448(LOX)

EJU:	114209620(LOX)

ZCA:	113929629(LOX)

MLX:	118016567(LOX)

NSU:	110591030(LOX)

LWW:	102749417(LOX)

FCA:	101092985(LOX)

PYU:	121010594(LOX)

PBG:	122486687(LOX)

PVIV:

125168681(LOX)

LRUF:

124522216

PPAD:

109278881(LOX)

PUC:

125935424

AJU:

106975167

HHV:	120219985(LOX)

BTA:	280841(LOX)

BOM:	102276831(LOX)

BIU:	109561863(LOX)

BBUB:

102397091(LOX)

BBIS:

104993159(LOX)

CHX:	102169472(LOX)

OAS:	101112220(LOX)

BTAX:

128051553(LOX)

ODA:	120864680(LOX)

CCAD:

122440080(LOX)

MBEZ:

129559069(LOX)

SSC:	100525278(LOX)

CFR:	102512711(LOX)

CBAI:

105082060(LOX)

CDK:	105105055(LOX)

VPC:	102536056(LOX)

BACU:

103012553(LOX)

BMUS:

118892905(LOX)

LVE:	103078614(LOX)

OOR:	101269698(LOX)

DLE:	111182358(LOX)

PCAD:

102993985(LOX)

PSIU:

116750841(LOX)

NASI:

112407735(LOX)

ECB:	100064016(LOX)

EPZ:	103557838(LOX)

EAI:	106842835(LOX)

MYB:	102253224(LOX)

MMYO:

118656205(LOX)

MLF:	102421922(LOX)

MDT:	132233324(LOX)

PKL:	118702754(LOX)

EFUS:

103285926(LOX)

MNA:	107540921(LOX)

DRO:	112315003(LOX)

SHON:

118975159(LOX)

AJM:	119063969(LOX)

PDIC:

114510267(LOX)

PHAS:

123818134(LOX)

MMF:	118641778(LOX)

PPAM:

129083877(LOX)

HAI:	109379076(LOX)

RFQ:	117025039(LOX)

PALE:

102888004(LOX)

PGIG:

120590869(LOX)

PVP:	105290866(LOX)

RAY:	107511146(LOX)

MJV:	108390293(LOX)

TOD:	119243553(LOX)

SARA:

101543655(LOX)

SETR:

126006071(LOX)

LAV:	100658633(LOX)

TMU:

101355891

ETF:	101641772(LOX)

DNM:	101420519(LOX)

MDO:	100027065(LOX)

GAS:	123231345(LOX)

SHR:	100920619(LOX)

AFZ:

127562288

PCW:	110223807(LOX)

TVP:	118831367(LOX)

OAA:	100076972(LOX)

GGA:	396474(LOX)

PCOC:

116239888(LOX)

CJO:	107306724(LOX)

TPAI:

128089319(LOX)

LMUT:

125686608(LOX)

NMEL:

110389631(LOX)

APLA:

101796992(LOX)

ACYG:

106047401(LOX)

CATA:

118258310(LOX)

AFUL:

116500630(LOX)

TGU:	100223043(LOX)

LSR:	110479174(LOX)

PMOA:

120513571(LOX)

OTC:	121331504(LOX)

PRUF:

121362571(LOX)

FAB:	101817182(LOX)

OMA:	130264869(LOX)

PHI:	102109004(LOX)

PMAJ:

107216161(LOX)

CCAE:

111941266(LOX)

CCW:	104690454(LOX)

ETL:	114055337(LOX)

ZAB:	102061613(LOX)

ZLE:	135459935(LOX)

SVG:	106851991(LOX)

MMEA:

130574497(LOX)

HRT:	120765874(LOX)

SATI:

136374653(LOX)

FPG:	101917045(LOX)

FCH:	102050081(LOX)

SHAB:

115619594(LOX)

TALA:

104363843(LOX)

ACHC:

115336592(LOX)

HLE:	104828196(LOX)

AGEN:

126036194

GCL:

127027612

DPUB:

104300375(LOX)

CUCA:

104061078(LOX)

RTD:	128902241(LOX)

AROW:

112974482(LOX)

DNE:	112992377(LOX)

AMJ:	102559899(LOXL5B) 102571028(LOX)

CPOO:

109323579(LOX) 109324851

GGN:

109294688

CMY:	102941654(LOX)

CCAY:

125636403(LOX)

DCC:	119855933(LOX)

CPIC:

101944676(LOX)

TST:	117879055(LOX)

CABI:

116831038(LOX)

MRV:	120408464(LOX)

ACS:	100558882(lox)

ASAO:

132767234(LOX) 132781535

PVT:	110072652 110084345(LOX)

SUND:

121923132(LOX) 121937079

PBI:	103066382(LOX)

CTIG:

120301974(LOX) 120305337

TSR:	106540749(LOX)

PGUT:

117674681(LOX)

APRI:

131188274

PTEX:

113449331(LOX)

NSS:	113415978(LOX) 113425514

VKO:	123031240(LOX)

PMUA:

114588561 114606468(LOX)

PRAF:

128405902 128423259(LOX)

ZVI:	118076839(LOX) 118086060

HCG:	128347651(LOX) 128347899

GJA:	107121950(LOX)

STOW:

125432735 125436326(LOX)

EMC:	129334917(LOX)

XLA:	108707204(lox.S) 734204(lox.L)

XTR:	780067(lox)

NPR:	108791659 108799190(LOX)

RTEM:

120913806 120932053(LOX)

BBUF:

120988464(LOX) 120990934

BGAR:

122928991(LOX)

MUO:	115463222(LOX) 115481119

GSH:	117352545 117352546 117364560

DRE:	100124531(loxl5b) 103911450 404621(loxa)

SRX:	107713278 107726222 107733348 107740551 107744153 107744154

SANH:

107686455 107687932 107688470(lox) 107696862 107698563 107704580

SGH:	107549379 107562574 107566396(lox) 107569406 107578202 107596248

CCAR:

109052012 109057450 109073443 109087603 109087612 109087621 109100885 109101193 109101345

CAUA:

113045254 113046247 113052788 113052841 113054132 113074970 113087085 113094196 113099105 113106902 113110400 113111892

CGIB:

127965825 128021370 128023927

PTET:

122335626(loxl5b) 122352893(loxa)

LROH:

127172553(loxa) 127174597(loxl5b)

OMC:	131526694(loxl5b) 131548747(loxa)

PPRM:

120474938(loxl5b) 120481978(loxa)

RKG:	130075350(loxl5b) 130087109(loxa)

MAMB:

125250714(loxl5b) 125256564(loxa)

CIDE:

127505324 127520622

CERY:

137003132(loxl5b) 137027474(loxa)

MASI:

127432759 127433256 127441443 127442681

TROS:

130545672(loxa) 130554608(loxl5b)

TDW:	130411704(loxa) 130417809(loxl5b)

MANU:

129443445(loxl5b) 129447198(loxa)

IPU:	108265136 108277371(loxa) 108280695(loxl5b)

IFU:	128607811 128620096(loxa) 128624474(loxl5b)

PHYP:

113532232(lox) 113533206 113544153

SMEO:

124393997(loxa) 124400032 124402758(loxl5b)

TFD:	113645263(loxl5b) 113655978 113661327(loxa)

TVC:	132853529 132861011(loxl5b) 132863513(loxa)

TRN:	134302655(loxl5b) 134317984 134332315(loxa)

AMEX:

103032299(loxl5b) 103038245(loxa) 103039369 103043200(loxl5a)

CMAO:

118797445(loxl5b) 118813247 118824968(loxa)

EEE:	113570987(lox) 113575169 113585954

CHAR:

105895569(loxa) 105900937(loxl5a) 105906924 105907551

TRU:	101062132 101070353 101079320

TFS:	130516903(loxa) 130525791 130528572(loxl5a) 130538654

TNG:	GSTEN00017324G001 GSTEN00027760G001 GSTEN00028864G001 GSTEN00031042G001

LCO:	104923293 104923472(lox) 104924628 104931423

NCC:	104944446 104953666 104961306

TBEN:

117472903 117476642(loxa) 117497759(loxl5a) 117500135(loxl5b)

CGOB:

115007100 115013610(lox) 115017234 115022107

PGEO:

117445750(loxl5a) 117452879 117456240(loxa) 117462514(loxl5b)

GACU:

117534818(loxl5a) 117541446 117558120(loxa)

EMAC:

134865552 134868927(loxa) 134869233(loxl5a) 134873907

ELY:	117251980 117254282(loxl5a) 117269322(loxa)

EFO:	125890830 125895663(loxl5a) 125901840 125906126(loxa)

PLEP:

121941192(loxl5a) 121951559 121959795(loxa) 121965070

SLUC:

116035105(loxa) 116045902(loxl5b) 116054423 116055490(loxl5a)

ECRA:

117944418 117950366(loxl5a) 117954214(loxl5b) 117959307(loxa)

ESP:	116690159(lox) 116696174 116698712

PFLV:

114555699 114561749 114565526 114571472

GAT:	120816563 120824413(loxl5a) 120832258(loxa)

PPUG:

119202456 119217197(loxl5a) 119225276 119226535(loxa)

AFB:	129089357 129094736(loxl5a) 129101416 129102371(loxa)

CLUM:

117729769(loxl5a) 117736053 117740408(loxa) 117746681(loxl5b)

PSWI:

130196724 130197590(loxl5b) 130205796(loxa)

MSAM:

119891852 119901390(loxl5a) 119901867 119914443(loxa)

SCHU:

122866044 122876811 122877980(loxl5a) 122886743

CUD:	121509897 121512378(loxl5a) 121520512 121525525(loxa)

ALAT:

119010578 119019237 119028907(loxl5a) 119029445(loxa)

MZE:	101470139 101477010 101483892

ONL:	100695665 100702891 100704050 100708791(lox)

OAU:	116313460 116313579 116322468(loxa) 116323169(loxl5a)

OLA:	101164730(lox) 101166747 101168667 101171929

OML:	112147810(loxl5b) 112150387 112150727(loxl5a) 112163226(loxa)

CSAI:

133450973 133451857 133455289(loxa) 133457803(loxl5a)

XMA:	102219592 102222632 102227597 102232659

XCO:	114145970 114150071 114150510 114154798

XHE:	116721188 116724972 116725320 116730483(lox)

PRET:

103464096 103470817(lox) 103473689 103479881

PFOR:

103138502 103138504 103146069 103148481 103148498 103152616(lox)

PLAI:

106938519 106942922 106945932(lox) 106950660 106955326 106959077

PMEI:

106914783 106918983(lox) 106925484 106927960 106933761 106933762

GAF:	122819453(loxa) 122827632 122838618(loxl5a) 122840972(loxl5b)

PPRL:

129365912 129366691(loxa) 129375011(loxl5a) 129377930(loxl5b)

CVG:	107084642(lox) 107092672 107094219 107100672

CTUL:

119771583(loxa) 119784849 119785803(loxl5a) 119787860(loxl5b)

GMU:	124869548(loxl5b) 124872327(loxa) 124873657(loxl5a) 124877397

NFU:	107372900 107383593 107386123(lox) 107393124

KMR:	108230650(loxl5a) 108232567(loxa) 108232849(loxl5b) 108245865

ALIM:

106511976 106514508 106516863 106533445

NWH:	119407822(loxl5a) 119412992 119414726(loxl5b) 119425020(loxa)

AOCE:

111565540 111567323 111568365 111585553

MCEP:

124997012(loxA) 125009514(loxl5a) 125010318(loxl5b) 125012806

CSEM:

103390487 103393429 103396464 103398001

POV:	109625786 109626121 109644542 109645284

SSEN:

122759948 122769856 122780697(loxl5a) 122781447(loxa)

HHIP:

117760716(loxl5a) 117772056(loxa) 117778753

HSP:	118114723 118118367(loxl5b) 118121146(loxl5a) 118126002(loxa)

PPLT:

128424821(loxa) 128437763 128448423(loxl5a) 128455156(loxl5b)

SMAU:

118285378(loxa) 118310561 118313937 118318781(loxl5a)

LCF:	108875130 108879892(loxa) 108881345 108884171(loxl5b)

SDU:	111231064 111232717 111234195 111239245

SLAL:

111645427 111650185 111668089(lox) 111669146

XGL:	120790981(loxl5a) 120799137 120805439 120806114(loxa)

HCQ:	109507291 109513468 109516887 109523566

SSCV:

125976089 125980091 125984542 125994128

SBIA:

133490761(loxa) 133499465 133504011(loxl5a) 133510899

PEE:	133400203 133406031(loxl5a) 133411962(loxl5b) 133413674(loxa)

PTAO:

133464996(loxa) 133475798 133481335(loxl5a) 133489353

BPEC:

110160052 110160517 110164111 110170694

MALB:

109955438 109963419 109967459

BSPL:

114845143 114854775(loxl5a) 114863196 114866810(loxa)

SJO:	128362227(loxl5a) 128364608 128368900(loxl5b) 128380725(loxa)

SASA:

100195194(lyox) 106564861(lox) 106569609 106573825 106585899 106600516

STRU:

115151734 115157530 115159447 115165018 115169282 115204186

OTW:	112219411 112226444 112231090(loxa) 112238492 112246614 112252183

OMY:	100189621(loxa) 110499862 110508305 110509899 110525209 110530787

OGO:	123991602 124007221(loxa) 124009306 124034678 124041694 124048845

ONE:	115101261 115101752 115108876 115116135 115120838 115124253

OKI:	109868574 109872314 109874026 109878301 109888539

OKE:	118371509 118385200 118387632 118392843 118394865 118401412

SALP:

111952944 111961509 111964111 111978867 112070768

SNH:	120020069 120021310 120026143 120050164 120054072 120056140

CCLU:

121535418 121541765(loxa) 121577141 121581269 121582403 121584349

ELS:	105011451 105014993 105021664(lox) 105022892

SFM:	108919826 108921520 108932061 108937978

PKI:	111847584 111849767 111856535

AANG:

118207126 118224965(loxl5a) 118229304

LOC:	102697184 102697992(lox)

PSPA:

121300708 121301656 121302574 121315403

ARUT:

117401353 117408559 117966201 117973219

PSEX:

120532701 120537645

LCM:	102364058(LOX) 102365752

CMK:	103188143(loxl5a)

RTP:	109911408 109932236

CPLA:

122560697 122565226

HOC:	132823680 132828823

LERI:

129695807 129710978

PMRN:

116950740

LRJ:

133354273

BFO:

118414450

BBEL:

109486753

DME:	Dmel_CG11335(Loxl1)

DGR:

6567693

CCAT:

101452065

BOD:

106623022

BDR:

105231009

RZE:	108353887 108375400

AOQ:

129235811

TDA:

119686177

SCAC:

106094729

LSQ:

119614027

GFS:

119638189

» show all

Reference

1 [PMID:4838158]

Authors

Harris ED, Gonnerman WA, Savage JE, O'Dell BL.

Title

Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta.

Journal

Biochim Biophys Acta 341:332-44 (1974)
DOI:10.1016/0005-2744(74)90226-5

Reference

2 [PMID:33171]

Authors

Rayton JK, Harris ED.

Title

Induction of lysyl oxidase with copper. Properties of an in vitro system.

Journal

J Biol Chem 254:621-6 (1979)

Reference

3 [PMID:7318]

Authors

Stassen FL.

Title

Properties of highly purified lysyl oxidase from embryonic chick cartilage.

Journal

Biochim Biophys Acta 438:49-60 (1976)
DOI:10.1016/0005-2744(76)90222-9

Reference

4 [PMID:11779117]

Authors

Palamakumbura AH, Trackman PC.

Title

A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples.

Journal

Anal Biochem 300:245-51 (2002)
DOI:10.1006/abio.2001.5464

Reference

5 [PMID:6147351]

Authors

Kagan HM, Williams MA, Williamson PR, Anderson JM.

Title

Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates.

Journal

J Biol Chem 259:11203-7 (1984)

Reference

6 [PMID:20439985]

Authors

Rodriguez HM, Vaysberg M, Mikels A, McCauley S, Velayo AC, Garcia C, Smith V

Title

Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor.

Journal

J Biol Chem 285:20964-74 (2010)
DOI:10.1074/jbc.M109.094136

Sequence

[hsa:4017]

Reference

7 [PMID:20306300]

Authors

Kim YM, Kim EC, Kim Y

Title

The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin.

Journal

Mol Biol Rep 38:145-9 (2011)
DOI:10.1007/s11033-010-0088-0

Sequence

[hsa:4017]

Reference

8 [PMID:23319596]

Authors

Xu L, Go EP, Finney J, Moon H, Lantz M, Rebecchi K, Desaire H, Mure M

Title

Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells.

Journal

J Biol Chem 288:5357-63 (2013)
DOI:10.1074/jbc.C112.421768

Sequence

[hsa:4017]

Reference

9 [PMID:28065600]

Authors

Ma L, Huang C, Wang XJ, Xin DE, Wang LS, Zou QC, Zhang YS, Tan MD, Wang YM, Zhao TC, Chatterjee D, Altura RA, Wang C, Xu YS, Yang JH, Fan YS, Han BH, Si J, Zhang X, Cheng J, Chang Z, Chin YE

Title

Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation.

Journal

Mol Cell 65:296-309 (2017)
DOI:10.1016/j.molcel.2016.12.002

Other DBs

ExplorEnz - The Enzyme Database:

1.4.3.13

IUBMB Enzyme Nomenclature:

1.4.3.13

ExPASy - ENZYME nomenclature database:

1.4.3.13

BRENDA, the Enzyme Database:

1.4.3.13

CAS:	99676-44-5

DBGET integrated database retrieval system