KEGG   ENZYME: 1.4.3.15
Entry
EC 1.4.3.15                 Enzyme                                 
Name
D-glutamate(D-aspartate) oxidase;
D-glutamic-aspartic oxidase;
D-monoaminodicarboxylic acid oxidase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
Sysname
D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating)
Reaction(IUBMB)
(1) D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2 [RN:R00279];
(2) D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2
Reaction(KEGG)
R00279;
(other) R00359
Substrate
D-glutamate [CPD:C00217];
H2O [CPD:C00001];
O2 [CPD:C00007];
D-aspartate [CPD:C00402]
Product
2-oxoglutarate [CPD:C00026];
NH3 [CPD:C00014];
H2O2 [CPD:C00027];
oxaloacetate [CPD:C00036]
Comment
A flavoprotein (FAD). D-Glutamate and D-aspartate are oxidized at the same rate. Other D-monoaminodicarboxylates, and other D- and L-amino acids, are not oxidized. cf. EC 1.4.3.7, D-glutamate oxidase and EC 1.4.3.1, D-aspartate oxidase.
History
EC 1.4.3.15 created 1983, modified 2012
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Reference
1
  Authors
Mizushima S.
  Title
Purified D-glutamic-aspartic oxidase of Aspergillus ustus.
  Journal
J Gen Appl Microbiol 3:233-239 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.15
IUBMB Enzyme Nomenclature: 1.4.3.15
ExPASy - ENZYME nomenclature database: 1.4.3.15
BRENDA, the Enzyme Database: 1.4.3.15
CAS: 9029-20-3

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Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
All databases (17)   

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