Entry |
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Name |
primary-amine oxidase;
amine oxidase (ambiguous);
amine oxidase (copper-containing);
amine oxidase (pyridoxal containing) (incorrect);
benzylamine oxidase (incorrect);
CAO (ambiguous);
copper amine oxidase (ambiguous);
Cu-amine oxidase (ambiguous);
Cu-containing amine oxidase (ambiguous);
diamine oxidase (incorrect);
diamino oxhydrase (incorrect);
histamine deaminase (ambiguous);
histamine oxidase (ambiguous);
monoamine oxidase (ambiguous);
plasma monoamine oxidase (ambiguous);
polyamine oxidase (ambiguous);
semicarbazide-sensitive amine oxidase (ambiguous);
SSAO (ambiguous)
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Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
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Sysname |
primary-amine:oxygen oxidoreductase (deaminating)
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Reaction(IUBMB) |
RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2 [RN: R01853]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
A group of enzymes that oxidize primary monoamines but have little or no activity towards diamines, such as histamine, or towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, monoamine oxidase, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. In some mammalian tissues the enzyme also functions as a vascular-adhesion protein (VAP-1).
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History |
EC 1.4.3.21 created 2007 (EC 1.4.3.6 created 1961, part-incorporated 2008)
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Pathway |
ec00260 | Glycine, serine and threonine metabolism |
ec00950 | Isoquinoline alkaloid biosynthesis |
ec00960 | Tropane, piperidine and pyridine alkaloid biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
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Genes |
» show all
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Reference |
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Authors |
Haywood GW, Large PJ. |
Title |
Microbial oxidation of amines. Distribution, purification and properties of two primary-amine oxidases from the yeast Candida boidinii grown on amines as sole nitrogen source. |
Journal |
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Reference |
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Authors |
Tipping AJ, McPherson MJ |
Title |
Cloning and molecular analysis of the pea seedling copper amine oxidase. |
Journal |
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Sequence |
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Reference |
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Authors |
Lyles GA. |
Title |
Mammalian plasma and tissue-bound semicarbazide-sensitive amine oxidases: biochemical, pharmacological and toxicological aspects. |
Journal |
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Reference |
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Authors |
Wilce MC, Dooley DM, Freeman HC, Guss JM, Matsunami H, McIntire WS, Ruggiero CE, Tanizawa K, Yamaguchi H |
Title |
Crystal structures of the copper-containing amine oxidase from Arthrobacter globiformis in the holo and apo forms: implications for the biogenesis of topaquinone. |
Journal |
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Sequence |
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Reference |
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Authors |
Lee Y, Sayre LM. |
Title |
Reaffirmation that metabolism of polyamines by bovine plasma amine oxidase occurs strictly at the primary amino termini. |
Journal |
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Reference |
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Authors |
Houen G. |
Title |
Mammalian Cu-containing amine oxidases (CAOs): new methods of analysis, structural relationships, and possible functions. |
Journal |
APMIS Suppl 96:1-46 (1999) |
Reference |
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Authors |
Andres N, Lizcano JM, Rodriguez MJ, Romera M, Unzeta M, Mahy N. |
Title |
Tissue activity and cellular localization of human semicarbazide-sensitive amine oxidase. |
Journal |
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Reference |
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Authors |
Saysell CG, Tambyrajah WS, Murray JM, Wilmot CM, Phillips SE, McPherson MJ, Knowles PF. |
Title |
Probing the catalytic mechanism of Escherichia coli amine oxidase using mutational variants and a reversible inhibitor as a substrate analogue. |
Journal |
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Reference |
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Authors |
O'Sullivan J, Unzeta M, Healy J, O'Sullivan MI, Davey G, Tipton KF. |
Title |
Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do. |
Journal |
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Reference |
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Authors |
Airenne TT, Nymalm Y, Kidron H, Smith DJ, Pihlavisto M, Salmi M, Jalkanen S, Johnson MS, Salminen TA. |
Title |
Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.4.3.21 |
ExPASy - ENZYME nomenclature database: | 1.4.3.21 |
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