KEGG   ENZYME: 1.4.3.22
Entry
EC 1.4.3.22                 Enzyme                                 
Name
diamine oxidase;
amine oxidase (ambiguous);
amine oxidase (copper-containing) (ambiguous);
CAO (ambiguous);
Cu-containing amine oxidase (ambiguous);
copper amine oxidase (ambiguous);
diamine oxidase (ambiguous);
diamino oxhydrase (ambiguous);
histaminase;
histamine deaminase (incorrect);
semicarbazide-sensitive amine oxidase (incorrect);
SSAO (incorrect)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
Sysname
histamine:oxygen oxidoreductase (deaminating)
Reaction(IUBMB)
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2 [RN:R02150]
Reaction(KEGG)
Substrate
histamine [CPD:C00388];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
(imidazol-4-yl)acetaldehyde;
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 (primary-amine oxidase) but unlike EC 1.4.3.4 (monoamine oxidase), they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.
History
EC 1.4.3.22 created 2007 (EC 1.4.3.6 created 1961, part-incorporated 2008)
Pathway
ec00330  Arginine and proline metabolism
ec00340  Histidine metabolism
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K11182  diamine oxidase
Genes
HSA26(AOC1)
PTR107975990(AOC1)
PPS100973977(AOC1)
GGO101145709(AOC1)
PON100173768(AOC1)
NLE100598250(AOC1)
MCC714112(AOC1)
MCF102141942(AOC1)
CSAB103227226(AOC1)
CATY105584732(AOC1)
PANU101022639(AOC1)
TGE112620088(AOC1)
RRO104675391(AOC1)
RBB108531161(AOC1)
TFN117072053(AOC1)
PTEH111551462(AOC1)
CJC100414302(AOC1)
SBQ101033597(AOC1)
CSYR103249599(AOC1)
MMUR105883171(AOC1)
LCAT123647521(AOC1)
OGA100957748(AOC1)
MMU243376(Aoc1l1) 243377(Aoc1l3) 69761(Aoc1l2) 76507(Aoc1)
MCAL110296626(Aoc1) 110296761 110296945 110297026
MPAH110316605 110316610 110317089 110317172
RNO312316(Doxl1) 312317(Doxl2) 65029(Aoc1)
MCOC116098863 116098864 116098865 116098866
MUN110551277 110551279 110551298
CGE100763954 100771382
MAUA121138472
PLEU114700050 114700051 114700052 114700053
MORG121439935 121440030 121440036
AAMP119807353 119807862 119807917
NGI103745300 103745301 103745358 103745360 103745361
HGL101712557(Aoc1)
CPOC100735646(Aoc1)
CCAN109694449(Aoc1)
DORD105993860(Aoc1)
DSP122105942(Aoc1)
NCAR124991550
OCU100347103(AOC1)
OPI101521505(AOC1)
TUP102495583(AOC1)
CFA475536(AOC1)
CLUD112663912(AOC1)
VVP112916289(AOC1)
VLG121490161(AOC1)
AML100484243(AOC1)
UMR103660997(AOC1)
UAH113241424(AOC1)
UAR123789633(AOC1)
ELK111154511
LLV125081368
MPUF101676852(AOC1)
ORO101381594(AOC1)
EJU114198028(AOC1)
ZCA113910982(AOC1)
MLX118026779(AOC1)
FCA101096221(AOC1)
PYU121022919(AOC1)
PBG122488525(AOC1)
PTG102955637(AOC1)
PPAD109252362(AOC1)
AJU106974449(AOC1)
HHV120230887(AOC1)
BTA509751(AOC1)
BOM102275498(AOC1)
BIU109557791(AOC1)
BBUB102401037(AOC1)
CHX102177774(AOC1)
OAS101112561(AOC1)
ODA120877884(AOC1)
SSC100517436(AOC1)
CFR102522082(AOC1)
CBAI105080841(AOC1)
CDK105105709(AOC1)
VPC102536442(AOC1)
BACU103017288(AOC1)
LVE103087882(AOC1)
OOR101279845(AOC1)
DLE111182632(AOC1)
PCAD102985231(AOC1)
PSIU116759874(AOC1)
ECB100063930(AOC1)
EPZ103544966(AOC1)
EAI106823380(AOC1)
MYB102256259(AOC1)
MYD102751704 102773146
MMYO118679433 118679451
MLF102429483 102429790 102437933 102438245
MNA107524935(AOC1)
PKL118704793 118704794
HAI109389675(AOC1)
DRO112308354(AOC1)
SHON118975541(AOC1)
AJM119039221(AOC1)
PDIC114508131(AOC1)
PHAS123817970(AOC1)
MMF118620405(AOC1)
RFQ117017972(AOC1)
PALE102880369(AOC1)
PGIG120601491(AOC1)
PVP105309118(AOC1)
RAY107520313(AOC1)
MJV108391836(AOC1)
TOD119248227 119251584(AOC1)
SARA101546506(AOC1)
LAV100668068 100668351(AOC1)
TMU101356291
DNM101432392(AOC1)
MDO100017902(AOC1)
GAS123249248(AOC1)
SHR100915360(AOC1)
PCW110201979(AOC1)
OAA100075142 100092837
GGA100858159(AOC1)
PCOC116242830(AOC1)
CJO107308680(AOC1)
NMEL110390704(AOC1)
AFUL116486715(AOC1)
TGU115494067(AOC1)
LSR110475119(AOC1)
PMOA120510541(AOC1)
OTC121334879(AOC1)
PRUF121356980(AOC1)
FAB101814988
PHI102101625(AOC1)
PMAJ107214654(AOC1)
FPG101917962(AOC1)
FCH102057016(AOC1)
CLV102084607(AOC1)
ACUN113477547(AOC1)
ACHC115338959(AOC1)
AAM106500478
AROW112973601(AOC1)
NPD112956255(AOC1)
DNE112994715(AOC1)
ASN102380706(AOC1)
AMJ102569229(AOC1)
CPOO109305661(AOC1)
CMY119565483(AOC1)
CPIC101932586(AOC1)
CABI116826256(AOC1)
MRV120397756(AOC1)
ACS100557987(aoc1)
PVT110082530(AOC1)
SUND121932802(AOC1)
PBI103060423(AOC1)
PMUR107299028(AOC1)
TSR106538995(AOC1)
PGUT117669219(AOC1)
VKO123019558(AOC1)
PMUA114607277(AOC1) 114607667
ZVI118092275(AOC1)
GJA107108215(AOC1)
STOW125441204(AOC1)
XLA108695581(aoc1.S) 108705560
XTR100486601(aoc1)
NPR108803230(AOC1)
RTEM120941749(AOC1)
BBUF121000742 121000746
BGAR122939047 122939163
DRE555401(aoc1)
SRX107713450 107753085
SANH107667202 107687273
SGH107553388 107574283
CCAR109050071(aoc1) 109066974
CAUA113042653 113068779
PPRM120467772 120467773 120467774 120467781(aoc1)
MAMB125258191(aoc1)
IPU108276865(aoc1)
PHYP113526925(aoc1)
SMEO124383752(aoc1)
TFD113644436(aoc1)
AMEX103033242(aoc1)
EEE113573000(aoc1)
TRU101078662(aoc1)
TNGGSTEN00016700G001
LCO104927590(aoc1)
NCC104965259(aoc1)
CGOB115025641(aoc1)
ELY117264363(aoc1)
EFO125881975(aoc1)
PLEP121960670(aoc1)
SLUC116048943(aoc1)
ECRA117937727(aoc1)
ESP116672336(aoc1)
PFLV114548835 114549419
GAT120811880(aoc1)
PPUG119198447(aoc1)
MSAM119899852 119899859 119899864 119906205(aoc1) 119913472
CUD121527017(aoc1)
ALAT119008442(aoc1)
MZE101467347(aoc1)
ONL100696662(aoc1)
OAU116331837(aoc1)
OLA101163530(aoc1)
OML112151334(aoc1)
XMA102236337(aoc1)
XCO114136404(aoc1)
XHE116711418(aoc1)
PRET103482350(aoc1)
PFOR103143938(aoc1)
PLAI106938000(aoc1)
PMEI106915179(aoc1)
GAF122824085(aoc1)
CVG107086520(aoc1)
CTUL119791859(aoc1)
GMU124857735(aoc1)
NFU107382765(aoc1)
KMR108246408(aoc1)
ALIM106528598(aoc1)
NWH119426645(aoc1)
AOCE111562815(aoc1)
MCEP125024411(aoc1)
CSEM103376876(aoc1)
POV109629489(aoc1)
HHIP117753890(aoc1)
HSP118098734(aoc1)
LCF108881560(aoc1)
SDU111228279(aoc1)
SLAL111657042(aoc1)
XGL120789767(aoc1)
HCQ109518117(aoc1)
BPEC110165585(aoc1)
MALB109953334(aoc1)
BSPL114854500(aoc1)
SASA106590278
OTW112216529 112227831
OMY110489795(aoc1) 110535211
OGO123990292 124039670(aoc1)
ONE115104538 115130247
SALP111953200 111972976
SNH120027726 120050370(aoc1)
CCLU121569139
ELS105019484(aoc1)
SFM108935426(aoc1)
PKI111840061(aoc1)
AANG118226141(aoc1)
LOC102689197(aoc1)
PSPA121312820 121314292
ARUT117435824(aoc1)
LCM102354448(AOC1)
RTP109924491
BFO118408402 118417782 118417844 118418228 118418426
BBEL109473389 109473390 109473691 109473692 109473966 109475039
LGILOTGIDRAFT_118163 LOTGIDRAFT_118238 LOTGIDRAFT_120790 LOTGIDRAFT_133255 LOTGIDRAFT_137098 LOTGIDRAFT_159693 LOTGIDRAFT_159859 LOTGIDRAFT_224288
PCAN112553730 112554426 112554427 112554474 112572350
BGT106051633 106051897 106051898 106055791 106065387 106072430 106074955 106079478
GAE121366314 121368131 121376554 121379177 121383343 121388690
HRF124113939 124117460 124117462 124117463 124117472 124117480 124123687 124146804 124146827 124147235 124149720
HRJ124253577 124255670 124261729 124262034 124262226 124288962 124288964 124289009 124290976 124290998
CRG105317726 105317731 105319659 105326517 105333031 105336069 105338020 105344412 117683425
MYI110451868 110456357 110456359 110456366 110456370 110458341 110463954
PMAX117334092 117334093 117334094 117334729 117334774 117334905 117335048 117339064
MMER123523139 123524764 123531663 123532570 123538506 123559568 123559569 123566673 123566674
OBI106869685 106870602 106880971
OSN115220554 115226162 115229303
LAK106153941 106161605 106162659 106164094 106169091 106175867 106179266 106181241
SMMSmp_017610
SHXMS3_0018730
OVIT265_13327 T265_15957
EGLEGR_03941
NVE116612167 116614151 5506426 5506432 5512395
EPA110238468 110241103 110247868 110247869 110247923 110247925 110247926
ATEN116304360 116307723 116308551 116308554
ADF107333816 107333827 107337677 107352948
AMIL114956446 114960919 114962028 114962043
PDAM113675191 113677914 113679149 113679167
SPIS111322076 111327136 111327159
DGT114527068 114527069 114527154 114527237
CRECHLRE_13g572750v5
MNGMNEG_1864
CSLCOCSUDRAFT_46300
ACANACA1_076120
TGOTGME49_286782
FCYFRACYDRAFT_244491
 » show all
Reference
1
  Authors
Zeller, E.A.
  Title
Diamine oxidases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 313-335.
Reference
2  [PMID:182134]
  Authors
Crabbe MJ, Waight RD, Bardsley WG, Barker RW, Kelly ID, Knowles PF.
  Title
Human placental diamine oxidase. Improved purification and characterization of a copper- and manganese-containing amine oxidase with novel substrate specificity.
  Journal
Biochem J 155:679-87 (1976)
DOI:10.1042/bj1550679
Reference
3  [PMID:8182053]
  Authors
Chassande O, Renard S, Barbry P, Lazdunski M
  Title
The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter.
  Journal
J Biol Chem 269:14484-9 (1994)
  Sequence
[hsa:26]
Reference
4  [PMID:10668504]
  Authors
Houen G.
  Title
Mammalian Cu-containing amine oxidases (CAOs): new methods of analysis, structural relationships, and possible functions.
  Journal
APMIS Suppl 96:1-46 (1999)
Reference
5  [PMID:12072962]
  Authors
Elmore BO, Bollinger JA, Dooley DM.
  Title
Human kidney diamine oxidase: heterologous expression, purification, and characterization.
  Journal
J Biol Inorg Chem 7:565-79 (2002)
DOI:10.1007/s00775-001-0331-1
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.22
IUBMB Enzyme Nomenclature: 1.4.3.22
ExPASy - ENZYME nomenclature database: 1.4.3.22
BRENDA, the Enzyme Database: 1.4.3.22

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