KEGG   ENZYME: 1.4.3.25Help
Entry
EC 1.4.3.25                 Enzyme                                 

Name
L-arginine oxidase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
L-arginine:oxygen oxidoreductase (deaminating)
Reaction(IUBMB)
L-arginine + H2O + O2 = 5-guanidino-2-oxopentanoate + NH3 + H2O2 [RN:R11604]
Reaction(KEGG)
Substrate
L-arginine [CPD:C00062];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
5-guanidino-2-oxopentanoate [CPD:C03771];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
Contains FAD. The enzyme from cyanobacteria can also act on other basic amino acids with lower activity. The enzyme from the bacterium Pseudomonas sp. TPU 7192 is highly specific.
History
EC 1.4.3.25 created 2017
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K21639  L-arginine oxidase
Genes
SYC: syc0596_c
SYF: Synpcc7942_0946
SYU: M744_11970
Taxonomy
Reference
1  [PMID:5570437]
  Authors
Miller DL, Rodwell VW
  Title
Metabolism of basic amino acids in Pseudomonas putida. Intermediates in L-arginine catabolism.
  Journal
J Biol Chem 246:5053-8 (1971)
Reference
2  [PMID:6766743]
  Authors
Pistorius EK, Voss H
  Title
Some properties of a basic L-amino-acid oxidase from Anacystis nidulans.
  Journal
Biochim Biophys Acta 611:227-40 (1980)
DOI:10.1016/0005-2744(80)90059-5
Reference
3  [PMID:17542496]
  Authors
Gau AE, Heindl A, Nodop A, Kahmann U, Pistorius EK
  Title
L-amino acid oxidases with specificity for basic L-amino acids in cyanobacteria.
  Journal
Z Naturforsch C 62:273-84 (2007)
DOI:10.1515/znc-2007-3-419
  Sequence
[syc:syc0596_c]
Reference
4  [PMID:26672462]
  Authors
Matsui D, Terai A, Asano Y
  Title
L-Arginine oxidase from Pseudomonas sp. TPU 7192: Characterization, gene cloning, heterologous expression, and application to L-arginine determination.
  Journal
Enzyme Microb Technol 82:151-7 (2016)
DOI:10.1016/j.enzmictec.2015.10.002
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.25
IUBMB Enzyme Nomenclature: 1.4.3.25
ExPASy - ENZYME nomenclature database: 1.4.3.25
BRENDA, the Enzyme Database: 1.4.3.25

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