Entry
Name
methylamine dehydrogenase (amicyanin);
amine dehydrogenase;
primary-amine dehydrogenase;
amine: (acceptor) oxidoreductase (deaminating);
primary-amine:(acceptor) oxidoreductase (deaminating)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With a copper protein as acceptor
BRITE hierarchy
Sysname
methylamine:amicyanin oxidoreductase (deaminating)
Reaction(IUBMB)
methylamine + H2O + 2 amicyanin = formaldehyde + NH3 + 2 reduced amicyanin [RN:
R00606 ]
Reaction(KEGG)
Substrate
Product
Comment
Contains tryptophan tryptophylquinone (TTQ) cofactor. The enzyme oxidizes aliphatic monoamines and diamines, histamine and ethanolamine, but not secondary and tertiary amines, quaternary ammonium salts or aromatic amines.
History
EC 1.4.9.1 created 1978 as EC 1.4.99.3, modified 1986, transferred 2011 to EC 1.4.98.1, transferred 2011 to EC 1.4.9.1
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K08685 quinohemoprotein amine dehydrogenase
K15228 methylamine dehydrogenase light chain
K15229 methylamine dehydrogenase heavy chain
Genes
YMO : HRD69_07500 HRD69_07515
VFU : vfu_A02015 vfu_A02018
VFL : AL536_13995 AL536_14010
PGH : FH974_17590 FH974_17605
PRE : PCA10_23420(mauB) PCA10_23450(mauA) PCA10_32510(peaA) PCA10_34250(mauB) PCA10_34280(mauA)
PFUW : KF707C_23300 KF707C_23330 KF707C_25120
PCQ : PcP3B5_29870 PcP3B5_30140(aauA) PcP3B5_30170(aauB)
PMUI : G4G71_11895(peaA) G4G71_16135 G4G71_16150
PNT : G5B91_13190(peaA) G5B91_15900 G5B91_15915 G5B91_33160(peaA)
PPG : PputGB1_2221 PputGB1_2224 PputGB1_2475
PEN : PSEEN2552 PSEEN2555 PSEEN2977
PKC : PKB_2656(mauA) PKB_2659(mauB) PKB_2912
PSET : THL1_3122 THL1_3125 THL1_3144 THL1_3147 THL1_3176
PYM : AK972_2150 AK972_2153
PUM : HGP31_18355 HGP31_18370 HGP31_22220(peaA)
PLAL : FXN65_11130 FXN65_11145 FXN65_11785(peaA)
PMAO : PMYSY11_1047 PMYSY11_1050(mauA)
PSEP : C4K39_3038 C4K39_3041
PXN : HU772_009655 HU772_009670 HU772_012685(peaA)
PASG : KSS96_11100 KSS96_11115
PTW : TUM18999_24310 TUM18999_32970 TUM18999_33000
PIZ : LAB08_R20860 LAB08_R20890 LAB08_R42330(peaA)
PKM : PZ739_15150(peaA) PZ739_16400 PZ739_16415
PSOA : PSm6_45540 PSm6_50130 PSm6_50160
PKJ : Q1W70_18750(peaA) Q1W70_25785 Q1W70_25800
SPSH : FM037_08780 FM037_08795
GAG : Glaag_4148 Glaag_4151
PMES : FX988_02772 FX988_02775
HMI : soil367_17600 soil367_17615
MMAF : GCM100_19830 GCM100_19860
GAI : IMCC3135_19700(aauA) IMCC3135_19715(aauB) IMCC3135_20060
ADI : B5T_00161 B5T_00164 B5T_00533 B5T_00536
MARS : A8C75_10935 A8C75_13875
MGEO : CFI10_12590(peaA) CFI10_12680(peaA)
MSEC : LN244_10005(peaA) LN244_10130(peaA)
NCU : F0U83_05970(peaA) F0U83_06020(peaA)
AJP : AMJAP_2431 AMJAP_2439
SUTR : L0B52_07765 L0B52_07780
CUH : BJN34_11000 BJN34_11020 BJN34_23755 BJN34_23770
REU : Reut_B4077 Reut_B4080
CBW : RR42_s0274 RR42_s0277
CCUP : BKK81_28180 BKK81_28195
CUP : BKK80_28180 BKK80_28195
CUU : BKK79_34095 BKK79_34110
BUR : Bcep18194_B0601 Bcep18194_B0604
BCM : Bcenmc03_5222 Bcenmc03_5225
BCH : Bcen2424_5059 Bcen2424_5062
BAC : BamMC406_4994 BamMC406_4997
BMJ : BMULJ_04934 BMULJ_04937
BMK : DM80_4965 DM80_4968(aauA)
BMUL : NP80_4958(aauA) NP80_4961
BCT : GEM_3380 GEM_3383 GEM_5082
BCED : DM42_5686 DM42_5689(aauA)
BCEP : APZ15_27590 APZ15_27605
BDL : AK34_3489 AK34_3492(aauA)
BCON : NL30_01045 NL30_01060
BTEI : WS51_08585 WS51_08600
BSEM : WJ12_31395 WJ12_31410
BPSL : WS57_02710 WS57_02725 WS57_10400
BMEC : WJ16_29835 WJ16_29850
BSTG : WT74_30205 WT74_30220
BSTL : BBJ41_25375 BBJ41_25390 BBJ41_34655 BBJ41_34670
BANN : JFN94_21045(peaA) JFN94_29355 JFN94_29370
BARI : NLX30_25745 NLX30_25760
BGF : BC1003_3869 BC1003_3872
BYI : BYI23_B006010 BYI23_B006040
BUE : BRPE67_BCDS08290 BRPE67_BCDS08320
BURK : DM992_22970 DM992_22985
BGE : BC1002_1587 BC1002_1590
BCAI : K788_0000141 K788_0000144
PHS : C2L64_30710 C2L64_30725
PTER : C2L65_27370 C2L65_27385
PMEG : FNZ07_14525 FNZ07_14540
PSAA : QEN71_14395 QEN71_14410
BUO : BRPE64_BCDS07560 BRPE64_BCDS07590
AXY : AXYL_02123 AXYL_02126
AXO : NH44784_037061 NH44784_037091
AXN : AX27061_1937 AX27061_1940
AXX : ERS451415_01935(aauB) ERS451415_01938(aauA)
ADT : APT56_09285 APT56_09300
AIS : BUW96_00985 BUW96_01000
ASW : CVS48_14415 CVS48_14430
ACHR : C2U31_25675 C2U31_25690
ACHB : DVB37_08350 DVB37_08365
ADY : HLG70_12820 HLG70_12835
AAEG : RA224_22495 RA224_22510
PUS : CKA81_14940 CKA81_14955
AKA : TKWG_18915 TKWG_18935
AMIM : MIM_c29740(mauA) MIM_c29770(mauB)
CDN : BN940_17491 BN940_17506
AAMM : FE795_01630 FE795_01645
METP : C1M51_14860 C1M51_14875
EBA : ebA2235(qhpA) ebA5178(qhpA)
APET : ToN1_01780(qhpA1) ToN1_38420(qhpA2)
DDEN : KI615_16540 KI615_16555
DECH : GBK02_00305 GBK02_00320
QAU : KI612_13825 KI612_13840
AZO : azo1239(qhpA) azo2257(mauA) azo2260(maub)
AOA : dqs_1354 dqs_2388 dqs_2391
AZR : CJ010_14330 CJ010_14345
TMZ : Tmz1t_0761 Tmz1t_2982
THU : AC731_014475 AC731_014490 AC731_017170
MESP : C1M53_03980 C1M53_03995
RBS : RHODOSMS8_03492(aauA) RHODOSMS8_03495(aauB)
MEA : Mex_1p2770(mauB) Mex_1p2773(mauA)
METD : C0214_27025(mauA) C0214_27040(mauB)
HNI : W911_02545 W911_02560
FIL : BN1229_v1_3765(mauB) BN1229_v1_3768(mauA)
FIY : BN1229_v1_3755(mauB) BN1229_v1_3758(mauA)
PEM : OF122_03140 OF122_03155
PLEO : OHA_1_02005(MadB) OHA_1_02008(MadA)
CEH : CEW89_12055 CEW89_12070
RHP : LPB142_09660 LPB142_09675
PDE : Pden_1703 Pden_4730 Pden_4733
PAMI : JCM7686_0163 JCM7686_0166
PYE : A6J80_01745(peaA) A6J80_21995(mauB) A6J80_22010(mauA)
PKD : F8A10_18985(peaA) F8A10_20020(mauA) F8A10_20035(mauB)
PMEH : JWJ88_20975(mauB) JWJ88_20990(mauA)
PALP : JHW40_00705(mauB) JHW40_00720(mauA)
PDIM : PAF18_02540 PAF18_02555
HML : HmaOT1_16775 HmaOT1_16790
NAR : Saro_1685 Saro_1688 Saro_3028 Saro_3818 Saro_3821
NPP : PP1Y_Mpl7173 PP1Y_Mpl7192
NOT : C7W88_08020(peaA) C7W88_11135 C7W88_11150 C7W88_11315 C7W88_11330
NOR : FA702_12465(peaA) FA702_12490 FA702_12505 FA702_14885 FA702_14900 FA702_20775 FA702_20790
NDR : HT578_04720(peaA) HT578_17915 HT578_17930
SMAG : AN936_02850 AN936_02865
SMAZ : LH19_18390 LH19_18405
SWI : Swit_3251 Swit_3254 Swit_4363 Swit_4365
SPHD : HY78_09285 HY78_09300
SPHM : G432_07310 G432_07325
SSAN : NX02_15530 NX02_15540 NX02_15555
SBIN : SBA_ch1_01450 SBA_ch1_01480 SBA_ch1_16750
SPHR : BSY17_2364(peaA) BSY17_2810(mauA) BSY17_2813
SHYD : CJD35_17800 CJD35_17815 CJD35_17865(peaA)
SYA : A6768_01720(peaA) A6768_17000 A6768_17015
SMIC : SmB9_02170 SmB9_02200 SmB9_03800 SmB9_03830
GFA : MKW11_12685(mauA) MKW11_12700
GDI : GDI0271(mauB) GDI0273(mauA) GDI1806(mauB) GDI1807(mauA)
GDJ : Gdia_0035 Gdia_0036 Gdia_2335 Gdia_2337
GXL : H845_1153 H845_1154 H845_1163 H845_1164 H845_1172 H845_1175
KEU : S101446_00287(mauB) S101446_00288(mauA) S101446_00300 S101446_00301 S101446_00310 S101446_00313
APT : APA01_04540 APA01_04570
APW : APA42C_04540 APA42C_04570
APF : APA03_04540 APA03_04570
APU : APA07_04540 APA07_04570
APG : APA12_04540 APA12_04570
APQ : APA22_04540 APA22_04570
APX : APA26_04540 APA26_04570
APZ : APA32_04540 APA32_04570
APK : APA386B_1936(mauB) APA386B_1939(mauA)
ASZ : ASN_2153(mauB) ASN_2156(mauA)
ASV : WG31_02710 WG31_02725
AACE : A0U92_10600 A0U92_10615
APOM : CPF11_05025(mauA) CPF11_05040
ATO : CIW82_01900(mauA) CIW82_01915
ACET : DS739_02395 DS739_02410(mauA)
AOY : EOV40_002245 EOV40_002260(mauA)
NTN : D5366_10130 D5366_10145(mauA)
NCB : C0V82_12865 C0V82_12880
ECOG : FIV45_14145(peaA) FIV45_16005(peaA)
AVP : AVENP_0707 AVENP_0712
ADZ : ADFLV_0614 ADFLV_1358
RCR : NCTC10994_01857(mauA)
» show all
Taxonomy
Reference
Authors
de Beer R, Duine JA, Frank J, Large PJ.
Title
The prosthetic group of methylamine dehydrogenase from Pseudomonas AM1: evidence for a quinone structure.
Journal
Reference
Authors
Eady RR, Large PJ.
Title
Purification and properties of an amine dehydrogenase from Pseudomonas AM1 and its role in growth on methylamine.
Journal
Reference
Authors
Eady RR, Large PJ.
Title
Microbial oxidation of amines. Spectral and kinetic properties of the primary amine dehydrogenase of Pseudomonas AM1.
Journal
Reference
Authors
Cavalieri C, Biermann N, Vlasie MD, Einsle O, Merli A, Ferrari D, Rossi GL, Ubbink M
Title
Structural comparison of crystal and solution states of the 138 kDa complex of methylamine dehydrogenase and amicyanin from Paracoccus versutus.
Journal
Reference
Authors
Meschi F, Wiertz F, Klauss L, Cavalieri C, Blok A, Ludwig B, Heering HA, Merli A, Rossi GL, Ubbink M
Title
Amicyanin transfers electrons from methylamine dehydrogenase to cytochrome c-551i via a ping-pong mechanism, not a ternary complex.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.4.9.1
ExPASy - ENZYME nomenclature database: 1.4.9.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.4.9.1
BRENDA, the Enzyme Database: 1.4.9.1