Entry
Name
glycine dehydrogenase (cyanide-forming);
hydrogen cyanide synthase;
HCN synthase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)
Reaction(IUBMB)
glycine + 2 acceptor = hydrogen cyanide + CO2 + 2 reduced acceptor [RN:
R05704 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme from Pseudomonas sp. contains FAD. The enzyme is membrane-bound, and the 2-electron acceptor is a component of the respiratory chain. The enzyme can act with various artificial electron acceptors, including phenazine methosulfate.
History
EC 1.4.99.5 created 2002
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K10814 hydrogen cyanide synthase HcnA
K10815 hydrogen cyanide synthase HcnB
K10816 hydrogen cyanide synthase HcnC
Genes
VCY : IX92_17720 IX92_17725 IX92_17730
VCT : JV59_21340 JV59_21345 JV59_21350
VNP : KW548_21885 KW548_21890 KW548_21895
PHOT : L4174_010245 L4174_010250
SALY : E8E00_15310 E8E00_15315 E8E00_15320
SCOT : HBA18_15205 HBA18_15210 HBA18_15215
SPRO : N7E60_17180 N7E60_17185 N7E60_17190
PAE : PA2193(hcnA) PA2194(hcnB) PA2195(hcnC)
PAEV : N297_2266 N297_2267 N297_2268
PAEI : N296_2266 N296_2267 N296_2268
PAU : PA14_36310(hcnC) PA14_36320(hcnB) PA14_36330(hcnA)
PAP : PSPA7_3101(hcnC) PSPA7_3102(hcnB) PSPA7_3103(hcnA)
PAG : PLES_31301(hcnC) PLES_31311(hcnB) PLES_31321(hcnA)
PAF : PAM18_2840(hcnC) PAM18_2841(hcnB) PAM18_2842(hcnA)
PNC : NCGM2_3175(hcnA) NCGM2_3176(hcnB) NCGM2_3177(hcnC)
PDK : PADK2_14680 PADK2_14685 PADK2_14690
PSG : G655_14175 G655_14180 G655_14185
PRP : M062_11375 M062_11380 M062_11385
PAEP : PA1S_14755 PA1S_14760 PA1S_14765
PAER : PA1R_gp5664 PA1R_gp5665 PA1R_gp5666
PAEM : U769_14355 U769_14360 U769_14365
PAEL : T223_15985 T223_15990 T223_15995
PAES : SCV20265_3179 SCV20265_3180 SCV20265_3181
PAEU : BN889_02406(hcnA) BN889_02407(hcnB) BN889_02408(hcnC)
PAEG : AI22_19020 AI22_19025 AI22_19030
PAEC : M802_2263 M802_2264 M802_2265
PAEO : M801_2265 M801_2266 M801_2267
SECH : B18_22880 B18_22885 B18_22890
PPAA : B7D75_14070 B7D75_14075 B7D75_14080
PMOL : CLJ08_13065 CLJ08_13070 CLJ08_13075
PMOS : O165_023000 O165_023005 O165_023010
PFL : PFL_2577(hcnA) PFL_2578(hcnB) PFL_2579(hcnC)
PPRC : PFLCHA0_c26420(hcnA) PFLCHA0_c26430(ooxA) PFLCHA0_c26440
PPRO : PPC_2622(hcnA) PPC_2623(hcnB) PPC_2624(hcnC)
PFE : PSF113_2367(hcnA) PSF113_2368(hcnB) PSF113_2369(hcnC)
PZA : HU749_018035(hcnC) HU749_018040(hcnB) HU749_018045(hcnA)
PFO : Pfl01_3514(hcnC) Pfl01_3515(hcnB) Pfl01_3516(hcnA)
PMAN : OU5_6068 OU5_6069 OU5_6070
PCG : AXG94_04380 AXG94_04385 AXG94_04390
PMED : E3Z27_16665(hcnC) E3Z27_16670(hcnB) E3Z27_16675(hcnA)
PKR : AYO71_19305 AYO71_19310 AYO71_19315
PEN : PSEEN5520(hcnC) PSEEN5521(hcnB) PSEEN5522(hcnA)
PBA : PSEBR_a3359 PSEBR_a3360 PSEBR_a3361
PBC : CD58_12305 CD58_12310 CD58_12315
PCH : EY04_11740 EY04_11745 EY04_11750
PCZ : PCL1606_36260 PCL1606_36270 PCL1606_36280
PCP : JM49_18105 JM49_18110 JM49_18115
PCHP : C4K32_2519 C4K32_2520 C4K32_2521
PFZ : AV641_13585 AV641_13590 AV641_13595
PLQ : AA042_19290 AA042_19295 AA042_19300
PALK : PSAKL28_52480 PSAKL28_52490 PSAKL28_52500
PSW : LK03_05925 LK03_05930
PPV : NJ69_19230 NJ69_19235 NJ69_19240
PSEM : TO66_12560 TO66_12565 TO66_12570
PSEC : CCOS191_5263(hcnC) CCOS191_5264(hcnB) CCOS191_5265(hcnA)
PPSY : AOC04_10125 AOC04_10130 AOC04_10135
PSOS : POS17_2580(hcnA) POS17_2581(hcnB) POS17_2582(hcnC)
PKE : DLD99_17555 DLD99_17560 DLD99_17565
PGY : AWU82_10070 AWU82_10075 AWU82_10080
PVK : EPZ47_12195(hcnA) EPZ47_12200(hcnB) EPZ47_12205(hcnC)
PBZ : GN234_05950(hcnC) GN234_05955(hcnB) GN234_05960(hcnA)
PATA : JWU58_10955 JWU58_10960(hcnB) JWU58_10965(hcnC)
PDW : BV82_2272(hcnC) BV82_2273(hcnB) BV82_2274(hcnA)
PZE : HU754_011890(hcnA) HU754_011895(hcnB) HU754_011900(hcnC)
PMOE : HV782_018050(hcnC) HV782_018055(hcnB) HV782_018060
PSEP : C4K39_2594 C4K39_2595 C4K39_2596
PPII : QL104_13580(hcnA) QL104_13585(hcnB) QL104_13590(hcnC)
PVW : HU752_010780(hcnA) HU752_010785(hcnB) HU752_010790(hcnC)
PXA : KSS93_02125(hcnA) KSS93_02130(hcnB) KSS93_02135(hcnC)
PTZ : HU718_018835(hcnC) HU718_018840(hcnB) HU718_018845(hcnA)
PQI : KH389_26980(hcnC) KH389_26985(hcnB) KH389_26990(hcnA)
PXN : HU772_024760(hcnC) HU772_024765(hcnB) HU772_024770(hcnA)
PHV : HU739_001835 HU739_001840(hcnB) HU739_001845(hcnC)
PFAK : KSS94_26940(hcnC) KSS94_26945(hcnB) KSS94_26950(hcnA)
PMUY : KSS95_03225(hcnA) KSS95_03230(hcnB) KSS95_03235(hcnC)
PMAM : KSS90_25305(hcnC) KSS90_25310(hcnB) KSS90_25315(hcnA)
PALV : KSS97_11955(hcnA) KSS97_11960(hcnB) KSS97_11965(hcnC)
PCAS : LOY40_11445(hcnA) LOY40_11450(hcnB) LOY40_11455(hcnC)
PORY : EJA05_27955(hcnC) EJA05_27960(hcnB) EJA05_27965(hcnA)
PTK : EXN22_01415(hcnC) EXN22_01420(hcnB) EXN22_01425(hcnA)
PIE : HU724_017695(hcnC) HU724_017700(hcnB) HU724_017705
PWY : HU734_001010(hcnA) HU734_001015(hcnB) HU734_001020(hcnC)
PGF : J0G10_18790(hcnC) J0G10_18795(hcnB) J0G10_18800(hcnA)
PSII : NF676_16570(hcnC) NF676_16575(hcnB) NF676_16580
PSIH : LOY51_26750(hcnC) LOY51_26755(hcnB) LOY51_26760(hcnA)
PFIT : KJY40_18150(hcnC) KJY40_18155(hcnB) KJY40_18160(hcnA)
PNB : NK667_14425(hcnC) NK667_14430(hcnB) NK667_14435(hcnA)
PCUC : PSH97_17330(hcnC) PSH97_17335(hcnB) PSH97_17340
PRHZ : CRX69_04945 CRX69_04950 CRX69_04955
PSHS : JJN09_08615(hcnC) JJN09_08620(hcnB) JJN09_08625(hcnA)
PHEF : PSH57_16520(hcnC) PSH57_16525(hcnB) PSH57_16530(hcnA)
PLIS : NN484_21100(hcnA) NN484_21105(hcnB) NN484_21110(hcnC)
PBEJ : PSH84_21855(hcnC) PSH84_21860(hcnB) PSH84_21865(hcnA)
PBAM : NUH87_07930(hcnC) NUH87_07935(hcnB) NUH87_07940(hcnA)
THAT : H3N35_17380 H3N35_17385 H3N35_17390
TACT : SG35_018375 SG35_018380 SG35_018385
TVD : SG34_010900 SG34_010905 SG34_010910
PRR : AT705_00060 AT705_00065 AT705_00070
PLZ : S4054249_17860 S4054249_17865 S4054249_17870
PALN : B0W48_15825 B0W48_15830 B0W48_15835
PPIS : B1L02_03835 B1L02_03840
PSEN : PNC201_13070(hcnC) PNC201_13075(hcnB) PNC201_13080(hcnA)
PVB : J5X90_12455 J5X90_12460 J5X90_12465
PSAZ : PA25_08410(hcnC) PA25_08420(hcnB) PA25_08430(hcnA)
PFLI : CTT31_13375 CTT31_13380 CTT31_13385
PMAZ : R5H13_13860 R5H13_13865 R5H13_13870
CVI : CV_1682(hcnC) CV_1683(hcnB) CV_1684(hcnA)
CVC : BKX93_21640 BKX93_21645 BKX93_21650
CHRO : CXB49_13965 CXB49_13970 CXB49_13975
CHRI : DK842_15670 DK842_15675 DK842_15680
CHRB : DK843_21200 DK843_21205 DK843_21210
CRZ : D1345_05980 D1345_05985 D1345_05990
CHAE : CH06BL_12990(hcnC) CH06BL_13000(hcnB) CH06BL_13010(hcnA)
MSAG : GCM10017556_23080(hcnC)
» show all
Taxonomy
Reference
Authors
Wissing F.
Title
Cyanide production from glycine by a homogenate from a Pseudomonas species.
Journal
Reference
Authors
Castric PA
Title
Glycine metabolism by Pseudomonas aeruginosa: hydrogen cyanide biosynthesis.
Journal
Sequence
Reference
Authors
Laville J, Blumer C, Von Schroetter C, Gaia V, Defago G, Keel C, Haas D
Title
Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0.
Journal
Sequence
Reference
Authors
Blumer C, Haas D.
Title
Mechanism, regulation, and ecological role of bacterial cyanide biosynthesis.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.4.99.5
ExPASy - ENZYME nomenclature database: 1.4.99.5