KEGG ENZYME: 1.5.1.1

ENZYME: 1.5.1.1

Entry

EC 1.5.1.1                  Enzyme

Name

1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H];
Delta1-pyrroline-2-carboxylate reductase;
DELTA1-pyrroline-2-carboxylate reductase;
DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous);
AbLhpI;
pyrroline-2-carboxylate reductase;
L-proline:NAD(P)+ 2-oxidoreductase

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-pipecolate/L-proline:NAD(P)+ 2-oxidoreductase

Reaction(IUBMB)

(1) L-pipecolate + NAD(P)+ = 1-piperideine-2-carboxylate + NAD(P)H + H+ [RN:R02201 R02203];
(2) L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ [RN:R01246 R01249]

Reaction(KEGG)

R01246 R01249 R02201 R02203

Substrate

L-pipecolate [CPD:C00408];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
L-proline [CPD:C00148]

Product

1-piperideine-2-carboxylate [CPD:C04092];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
1-pyrroline-2-carboxylate [CPD:C03564]

Comment

The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.21, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.

History

EC 1.5.1.1 created 1961, modified 2015

Pathway

ec00310

Lysine degradation

ec00330

Arginine and proline metabolism

ec00960

Tropane, piperidine and pyridine alkaloid biosynthesis

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K19743

1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

Genes

ENB:	ELK40_00500

BGJ:	AWC36_18660

BIZ:	HC231_23665

LBQ:	CKQ53_13775

SOD:

Sant_2254

PAZO:

AYR47_02320

PCH:	EY04_18125

PSES:

PSCI_5175

PSIL:

PMA3_09465

PPII:

QL104_12510

SPIU:

SPICUR_00995

SROS:

BBH56_00065

MRZ:	KDW95_19460

PSE:

NH8B_0270

AMAH:

DLM_1509

MAER:

DAI18_10290

RSO:

RSc3352

RSE:

F504_3400

RPU:	CDC45_17140

RNC:	GO999_00495

RSC:	RCFBP_10114

RSL:	RPSI07_0093

RSN:	RSPO_c00089

RSM:	CMR15_10116

RSY:	RSUY_01390(rapL_1)

RPI:

Rpic_3546

RPF:	Rpic12D_3222

RPJ:	N234_20505

RMN:	TK49_02570

RIN:	ACS15_3655

RWE:	KOL96_23325

REH:	H16_A3673(h16_A3673)

CNC:	CNE_1c36230

CUH:	BJN34_19590

REU:	Reut_A3381

RME:

Rmet_3527

CTI:	RALTA_A3129

CBW:	RR42_m4138

CGD:

CR3_2832

CCUP:

BKK81_01450

CUP:	BKK80_00785

CUU:	BKK79_11375

CPAU:

EHF44_05820

COX:	E0W60_27530

CCAM:

M5D45_17265

CCAX:

KZ686_03315

CUK:	KB879_30735

CNAN:

A2G96_00785

BMA:

BMAA1290

BMV:	BMASAVP1_0266

BML:	BMA10229_0536

BMN:	BMA10247_A1031

BMAL:

DM55_4233

BMAE:

DM78_3939

BMAQ:

DM76_4933

BMAI:

DM57_10585

BMAF:

DM51_4945

BMAZ:

BM44_4196

BMAB:

BM45_3318

BPS:

BPSS0940

BPM:	BURPS1710b_A2543

BPL:	BURPS1106A_A1291

BPD:	BURPS668_A1371

BPSE:

BDL_4230

BPSM:

BBQ_5196

BPSU:

BBN_4400

BPSD:

BBX_6071

BPZ:	BP1026B_II1030

BPQ:	BPC006_II1306

BPK:

BBK_3495

BPSH:

DR55_4394

BPSA:

BBU_5089

BPSO:

X996_4178

BUT:

X994_6182

BTE:	BTH_II1457

BTQ:

BTQ_4743

BTJ:

BTJ_5685

BTZ:

BTL_4224

BTD:

BTI_5755

BTV:

BTHA_3733

BTHE:

BTN_3467

BTHM:

BTRA_4218

BTHA:

DR62_3540

BTHL:

BG87_4200

BOK:

DM82_5110

BOC:

BG90_5484

BUU:	WS70_22180

BSAV:

WS86_23435

BHG:	I6G56_23295

BUD:	AQ610_25980

BVI:	Bcep1808_4889 Bcep1808_6676

BVE:

AK36_4029

BUR:	Bcep18194_B1663

BCM:	Bcenmc03_5997

BCH:	Bcen2424_4357

BCJ:

BCAM1485

BCEN:

DM39_3532

BCEW:

DM40_4351

BCEO:

I35_5339

BAM:

Bamb_3766

BAC:	BamMC406_4240

BMJ:	BMULJ_04243(ocd)

BMU:

Bmul_4263

BMK:

DM80_3437

BMUL:

NP80_4355

BCT:

GEM_4275

BCED:

DM42_3604

BCEP:

APZ15_32020

BDL:

AK34_4045

BPYR:

ABD05_28725

BCON:

NL30_05175

BUB:

BW23_5154

BDF:	WI26_20365

BLAT:

WK25_24125

BTEI:

WS51_05030

BSEM:

WJ12_27260

BPSL:

WS57_06730

BMEC:

WJ16_25790

BSTG:

WT74_26205

BSTL:

BBJ41_20490

BANN:

JFN94_24455

BARI:

NLX30_31130

BAEN:

L3V59_20620

BSER:

R0290_26645

BGL:	bglu_2g07030

BGU:

KS03_5219

BUG:	BC1001_5631

BGF:	BC1003_5729

BGD:	bgla_2g12060

BGO:

BM43_4860

BYI:	BYI23_B003960 BYI23_C005280

BUK:

MYA_4327

BUE:	BRPE67_BCDS06550 BRPE67_CCDS06230

BUL:

BW21_5442

BUQ:	AC233_30570

BGP:	BGL_2c21310

BPLA:

bpln_2g21410

BUM:	AXG89_39245

BUI:	AX768_21115

BURK:

DM992_18470

BXE:

Bxe_B1765

BXB:

DR64_7069

BPH:

Bphy_3343

BGE:	BC1002_3728

BPX:	BUPH_06129

BPY:	Bphyt_4907

BUZ:	AYM40_24630

BFN:

OI25_4196

BCAI:

K788_0008493

PSPW:

BJG93_16945 BJG93_30575

PARA:

BTO02_28190

PARB:

CJU94_20935

PHS:	C2L64_27315

PTER:

C2L65_21185

PGP:	CUJ91_25630 CUJ91_31175

PCJ:	CUJ87_19665

PTS:	CUJ90_18630

PCAF:

DSC91_001681

PMEG:

FNZ07_10020

PGIS:

I6I06_21310

PACP:

FAZ97_20335

PEW:	KZJ38_30745

PDIO:

PDMSB3_1300.1(lhpI)

PBRY:

NDK50_30150

PSAA:

QEN71_08000

PKF:	RW095_09140

PPAI:

E1956_39885

PHUN:

U0042_12440(lhpI) U0042_27810(lhpI)

PLAD:

PPGU16_34060

PPK:	U875_23685

PPNO:

DA70_16420

PPNM:

LV28_14325

PRB:	X636_10455

PPUL:

RO07_08380

PSPU:

NA29_04175

PAPI:

SG18_08825

PVE:	UC34_24400

POX:	MB84_04495

PTX:	ABW99_16995

PFG:	AB870_11355

PNR:	AT302_07940

PAND:

DRB87_22880

PFIB:

PI93_024530

PCOM:

NTU39_26725

PANN:

PanNE5_14580

PANX:

OYT13_24710

CABA:

SBC2_64960(ocd_1)

BUO:	BRPE64_BCDS09290

CABK:

NK8_37950

TVL:	FAZ95_32665

TCAR:

U0034_23370(lhpI)

POLL:

OEG81_03290

AKA:	TKWG_24615

AMIM:

MIM_c39830

AALN:

Q3V95_01910

CDN:	BN940_16136

BPSI:

IX83_00760

AFA:	UZ73_14790

AFQ:

AFA_14940

AAQU:

D3M96_15870

AAMM:

FE795_13800

ALCN:

MID00_11930

PHN:	PAEH1_12825

ODI:

ODI_R1977

PARK:

LSG25_19450

RHF:	EUB48_17055

RHOB:

HTY51_02325

POS:	DT070_01085

POO:	F7R28_08365

PVAC:

HC248_02698(ocd_2)

ACK:	C380_05510

ACRA:

BSY15_502

ACID:

CBP33_04675

ACIP:

CBP36_05100

ACIN:

CBP34_04635

ACIS:

CBP35_13835

ATEM:

PQV96_19515

ACIV:

EXV95_23470

AAV:

Aave_3400

AAA:

Acav_1835

AMON:

H9L24_20900

VEI:

Veis_1338

DAC:

Daci_2152

DEL:	DelCs14_4535

DTS:	BI380_13765

DHK:	BO996_10010

DLA:	I6G47_13785

VAZ:	H7F35_30915

CTT:	CtCNB1_3667

CTES:

O987_21445

CKE:	B5M06_09815

COF:	FOZ74_12640

CTEZ:

CT3_32400

CRJ:	QMY55_18045

RTA:

Rta_32100

OTK:	C6570_17210

OTD:	J1M35_04290

HYR:

BSY239_30

HYB:

Q5W_19710

HYY:	JNX00_20310

MPT:

Mpe_A1509

METP:

C1M51_00665

RDP:	RD2015_1338

ROI:	N4261_19955

KIA:	G8A07_07865

PKT:	AT984_14370

PAQA:

K9V56_017615

PAIS:

PFX98_19555

MIU:	ABE85_00125

HSE:	Hsero_0176

HSZ:	ACP92_00875

HHT:	F506_21360

HRB:	Hrubri_0191

HEE:	hmeg3_22520

HHF:	E2K99_01140

HFR:	G5S34_00880

HEW:	HBDW_01740

CFU:

CFU_3543

CARE:

LT85_4058

CPRA:

CPter91_4367

MENY:

LSQ66_19835

MPLI:

E1742_14480

NOK:	FAY22_03770

GLC:	JQN73_04585

ACTB:

RHM62_06685

TTW:	LCC91_00420

NET:

Neut_2213

ZMO:

ZMO1975

ZMN:

Za10_1195

ZMB:

ZZ6_1206

ZMI:

ZCP4_1234

ZMC:	A265_01223

ZMR:	A254_01222

GOH:

B932_1581

GAL:	A0U94_09505

GTI:	FXF46_03430

GFA:	MKW11_03325

GXL:

H845_2323

KNA:	B0W47_06280

KEU:	S101446_01615

KSC:	CD178_02861

APT:	APA01_08140

APW:	APA42C_08140

APF:	APA03_08140

APU:	APA07_08140

APG:	APA12_08140

APQ:	APA22_08140

APX:	APA26_08140

APZ:	APA32_08140

APK:	APA386B_2319

ASZ:	ASN_1466(ocd)

ASV:	WG31_04555

APOM:

CPF11_03415

ATO:	CIW82_00155 CIW82_04965

AASC:

A4S02_02110

ACET:

DS739_04260

AOY:	EOV40_003815

NCH:	A0U93_11420

KHA:	IFJ82_02935

NGU:	QN315_15595

AZL:	AZL_d02350(ocd)

ALI:	AZOLI_p40331

ATI:	AL072_25090

AZM:	DM194_22605

AOZ:	HUE56_04635

AZS:	E6C72_20585

DFL:

DFE_1833

DMA:	DMR_28030(ocd)

DCB:	C3Y92_12855

DGG:

DGI_1547

DAF:	Desaf_2510

DSX:	GD604_10005

DSD:	GD606_02995

RXY:

Rxyl_2927

RUB:	GBA63_16515

RMAR:

GBA65_08750

DDR:	Deide_3p02181

DMB:	E5F05_17570

TRA:

Trad_0061

TANT:

KNN15_12430

MRB:

Mrub_0429

MRE:	K649_01770

MTAI:

Mtai_v1c03530

MSV:	Mesil_1519

OPR:	Ocepr_1284

MHD:	Marky_1461

» show all

Reference

1 [PMID:13502341]

Authors

MEISTER A, RADHAKRISHNAN AN, BUCKLEY SD.

Title

Enzymatic synthesis of L-pipecolic acid and L-proline.

Journal

J Biol Chem 229:789-800 (1957)

Reference

2 [PMID:24649405]

Authors

Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y

Title

Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria.

Journal

FEBS Open Bio 4:240-50 (2014)
DOI:10.1016/j.fob.2014.02.010

Sequence

[bur:Bcep18194_B1663]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.1

IUBMB Enzyme Nomenclature:

1.5.1.1

ExPASy - ENZYME nomenclature database:

1.5.1.1

BRENDA, the Enzyme Database:

1.5.1.1

CAS:

9029-16-7

DBGET integrated database retrieval system