KEGG   ENZYME: 1.5.1.25
Entry
EC 1.5.1.25                 Enzyme                                 
Name
thiomorpholine-carboxylate dehydrogenase;
ketimine reductase;
ketimine-reducing enzyme
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase
Reaction(IUBMB)
thiomorpholine 3-carboxylate + NAD(P)+ = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+ [RN:R04339 R04340]
Reaction(KEGG)
R04339 R04340
Substrate
thiomorpholine 3-carboxylate [CPD:C03901];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3,4-dehydro-thiomorpholine-3-carboxylate;
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine. In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, but more slowly.
History
EC 1.5.1.25 created 1990
Orthology
K18258  thiomorpholine-carboxylate dehydrogenase
Genes
HSA1428(CRYM)
PTR742586(CRYM)
PPS100970861(CRYM)
GGO101125433(CRYM)
PON100454622(CRYM)
NLE100594088(CRYM)
HMH116471118(CRYM)
MCC697588(CRYM)
MCF102132895(CRYM)
MTHB126944498
MNI105484997(CRYM)
CSAB103229503(CRYM)
CATY105586398(CRYM)
PANU101025490(CRYM)
TGE112614188(CRYM)
MLEU105536638(CRYM)
RRO104682086(CRYM)
RBB108514145(CRYM)
TFN117087518(CRYM)
PTEH111551182(CRYM)
CANG105504453(CRYM)
CJC100388738(CRYM)
SBQ101054393(CRYM)
CIMI108308498(CRYM)
CSYR103260311(CRYM)
MMUR105885306(CRYM)
LCAT123632462(CRYM)
PCOQ105810952(CRYM)
OGA100949570(CRYM)
MMU12971(Crym)
MCAL110298556(Crym)
MPAH110326647(Crym)
RNO117024(Crym)
MCOC116102880(Crym)
ANU117696895(Crym)
MUN110547855(Crym)
CGE100771156(Crym)
MAUA101834937(Crym)
PROB127228263(Crym)
PLEU114692171(Crym)
MORG121457723(Crym)
MFOT126502337
AAMP119820992(Crym)
NGI103742752(Crym)
HGL101706899(Crym)
CPOC100717691(Crym)
CCAN109681372(Crym)
DORD105981989(Crym)
DSP122116149(Crym) 122124921
PLOP125340370(Crym)
NCAR124970413
MMMA107146854(Crym)
OCU100352494
OPI101525910(CRYM)
TUP102468903(CRYM)
GVR103606558(CRYM)
CFA479818(CRYM)
CLUD112640271(CRYM)
VVP112923396(CRYM)
VLG121488290(CRYM)
NPO129520244(CRYM)
AML100467188(CRYM)
UMR103668887(CRYM)
UAH113267544(CRYM)
UAR123778808(CRYM)
ELK111146000
LLV125091002
MPUF101694506(CRYM)
MNP132027194(CRYM)
MLK131819853(CRYM)
NVS122895724(CRYM)
ORO101380467(CRYM)
EJU114202182(CRYM)
ZCA113932771(CRYM)
MLX117999161(CRYM)
NSU110582261(CRYM)
LWW102745778(CRYM)
FCA101080756(CRYM)
PYU121019413(CRYM)
PCOO112853322(CRYM)
PBG122471581(CRYM)
LRUF124517685
PTG102963483(CRYM)
PPAD109255564(CRYM)
PUC125928465
AJU106970514
HHV120233243(CRYM)
BTA505167(CRYM)
BOM102287512(CRYM)
BIU109578830(CRYM)
BBUB102411143(CRYM)
BBIS104986554(CRYM)
CHX100861024(CRYM)
OAS101102280(CRYM)
BTAX128043517(CRYM)
ODA120875743(CRYM)
CCAD122433350(CRYM)
MBEZ129545107(CRYM)
SSC100525333(CRYM)
CFR102507933(CRYM)
CBAI105073693(CRYM)
CDK105091116(CRYM)
VPC102538439(CRYM)
BACU102999498(CRYM)
LVE103071882(CRYM)
OOR101269297(CRYM)
DLE111182269(CRYM)
PCAD102996229(CRYM)
PSIU116740923(CRYM)
NASI112399470(CRYM)
ECB100057895(CRYM)
EPZ103558982(CRYM)
EAI106841751(CRYM)
MYB102263573(CRYM)
MYD102759132(CRYM)
MMYO118656627(CRYM)
MLF102420283(CRYM)
MNA107544808(CRYM)
PKL118731574(CRYM)
EFUS103302874(CRYM)
HAI109386574(CRYM)
DRO112304882(CRYM)
SHON118984191(CRYM)
AJM119054881(CRYM)
PDIC114500168(CRYM)
PHAS123825690(CRYM)
MMF118642202(CRYM)
RFQ117019773(CRYM)
PPAM129076754(CRYM)
PALE102893293(CRYM)
PGIG120611501(CRYM)
PVP105309569(CRYM)
RAY107520608(CRYM)
MJV108383276(CRYM)
TOD119241849(CRYM)
SARA101545298(CRYM)
LAV100668667(CRYM)
TMU101350705
ETF101660687(CRYM)
DNM101427269(CRYM)
MDO100019705(CRYM)
GAS123231200(CRYM)
SHR100931649(CRYM)
AFZ127564609
PCW110193546(CRYM)
OAA100087208(CRYM)
GGA427008(CRYM)
PCOC116230352(CRYM)
MGP100541881 104913518(CRYM)
CJO107306902 107321007(CRYM)
TPAI128079005(CRYM)
LMUT125701006(CRYM)
NMEL110405949(CRYM)
APLA101796429(CRYM)
ACYG106033492(CRYM)
CATA118249054(CRYM)
AFUL116495092(CRYM)
TGU100229846(CRYM)
LSR110475473(CRYM)
SCAN103817679 115484293
PMOA120513093(CRYM)
OTC121334419(CRYM)
PRUF121350715(CRYM)
GFR102036801(CRYM)
FAB101819247(CRYM)
OMA130259309(CRYM)
PHI102108632(CRYM)
PMAJ107211222(CRYM)
CCAE111936010(CRYM)
CCW104684868(CRYM)
CBRC103615620(CRYM)
ETL114065935(CRYM)
ZAB102072353(CRYM)
ACHL103808719(CRYM)
SVG106848945(CRYM)
MMEA130582231(CRYM)
HRT120759844(CRYM)
FPG101911191(CRYM)
FCH102048264(CRYM)
CLV102090474(CRYM)
EGZ104135830(CRYM)
NNI104015050(CRYM)
PCRI104024069(CRYM)
PLET104622654(CRYM)
EHS104509278(CRYM)
PCAO104048508(CRYM)
ACUN113485869(CRYM)
TALA104364134(CRYM)
PADL103915043(CRYM)
AFOR103900836(CRYM)
ACHC115335644(CRYM)
HALD104310809(CRYM)
HLE104833499(CRYM)
AGEN126034108
GCL127022644
CCRI104154715(CRYM)
CSTI104549756
CMAC104485908(CRYM)
MUI104536020(CRYM)
BREG104629276(CRYM)
FGA104081985(CRYM)
GSTE104257486(CRYM)
LDI104342775(CRYM)
MNB103768711(CRYM)
OHA104329067(CRYM)
NNT104407079(CRYM)
SHAB115606176(CRYM)
DPUB104299141(CRYM)
PGUU104457800(CRYM)
ACAR104517759(CRYM)
CPEA104393727(CRYM)
AVIT104272921(CRYM)
CVF104287816(CRYM)
RTD128913858(CRYM)
CUCA104063772(CRYM)
TEO104378537(CRYM)
BRHI104489743(CRYM)
AAM106491377(CRYM)
AROW112974409(CRYM)
NPD112959850(CRYM)
TGT104572885(CRYM)
DNE112992878(CRYM)
SCAM104149662(CRYM)
ASN102368044(CRYM)
AMJ102562821(CRYM)
CPOO109314865(CRYM)
GGN109290885(CRYM)
PSS102459235(CRYM)
CMY102942903(CRYM)
CCAY125643382(CRYM)
DCC119862418(CRYM)
CPIC101934927(CRYM)
TST117884358(CRYM)
CABI116837591(CRYM)
MRV120373273(CRYM)
ACS100561928(crym)
ASAO132782003(CRYM)
PVT110082175(CRYM)
SUND121914852(CRYM)
PBI103066829(CRYM)
PMUR107292093(CRYM) 107300571
CTIG120315853(CRYM)
TSR106552860(CRYM)
PGUT117678100(CRYM)
APRI131185273(CRYM)
PTEX113452661 113452668
NSS113424086(CRYM)
VKO123025253(CRYM)
PMUA114584538(CRYM)
PRAF128401654(CRYM)
ZVI118092914(CRYM)
HCG128336542(CRYM)
GJA107123046(CRYM)
STOW125432023(CRYM)
EMC129338634(CRYM)
XLA100101313(crym.L) 447114(crym.S)
XTR100125176(crym)
NPR108794751(CRYM)
RTEM120943502(CRYM)
BBUF121007527(CRYM)
BGAR122944854(CRYM)
MUO115476375(CRYM)
GSH117369086(CRYM)
DRE791205(crym)
SRX107745653 107753321
SANH107684776
SGH107569187
CCAR109054010(crym)
CAUA113111916(crym)
CGIB127969249
PTET122355778(crym)
LROH127174082(crym)
OMC131551014(crym)
PPRM120463964(crym)
RKG130080492(crym)
MAMB125254944(crym)
CIDE127524273
MASI127426845
TROS130569041(crym)
TDW130438844(crym)
MANU129420876(crym)
IPU100528988(crym)
IFU128617003(crym)
PHYP113527451(crym)
SMEO124389189(crym)
TFD113662644(crym)
TVC132840364(crym)
AMEX103034376(crym)
CMAO118809208(crym)
EEE113584624(crym)
CHAR122130088(crym)
TRU101080177(crym)
TFS130529235(crym)
TNGGSTEN00024152G001
LCO104918063(crym)
NCC104961642(crym)
TBEN117473332(crym)
CGOB115024722(crym)
PGEO117464309(crym)
GACU117544902(crym)
ELY117246835(crym)
EFO125881053(crym)
PLEP121959238(crym)
SLUC116044234(crym)
ECRA117937040(crym)
ESP116670941(crym)
PFLV114547619(crym)
GAT120818917(crym)
PPUG119213323(crym)
AFB129091557(crym)
CLUM117748868(crym)
MSAM119915420(crym)
SCHU122867757(crym)
CUD121527894(crym)
ALAT119009702(crym)
MZE101484163(crym)
ONL100709479(crym)
OAU116320171(crym)
OLA101169817(crym)
OML112154656(crym)
XMA102219012(crym)
XCO114151418(crym)
XHE116727625(crym)
PRET103481974(crym)
PFOR103143043(crym)
PLAI106961744(crym)
PMEI106925833(crym)
GAF122823715(crym)
CVG107099874(crym)
CTUL119793271(crym)
GMU124874727(crym)
NFU107388174(crym)
KMR108237170(crym)
ALIM106531824(crym)
NWH119423387(crym)
AOCE111575380(crym)
MCEP125023005(cryM)
CSEM103382357(crym)
POV109626934(crym)
SSEN122759194(crym)
HHIP117752831(crym)
HSP118100453(crym)
LCF108880772
SDU111220228(crym)
SLAL111672004(crym)
XGL120794828(crym)
HCQ109516409(crym)
SSCV125991570
SBIA133495757(crym)
PEE133417647(crym)
BPEC110159667(crym)
MALB109969179(crym)
BSPL114845921(crym)
SJO128381251(crym)
SASA100286546(crym)
STRU115201412(crym)
OTW112224477(crym)
OMY110499216(crym)
OGO124040198 124040199
ONE115144252(crym)
OKI109869906(crym)
OKE118402917(crym)
SALP111967956(crym)
SNH120030094(crym)
CCLU121547546(crym)
ELS105031485(crym)
SFM108939939(crym)
PKI111853874(crym)
AANG118220735(crym)
LOC102688874(crym)
PSPA121308026(crym)
ARUT117431340(crym)
PSEX120542789(crym)
LCM102367345(CRYM)
CMK103178740(crym)
RTP109937894(crym)
CPLA122560436(crym)
HOC132825396(crym)
PMRN116949696(CRYM)
LRJ133345496(CRYM)
BFO118416787
BBEL109486476
CIN100181943 100186711
SCLV120342475 120348143 120348144
SPU100890368 115926012 579068 593410
LPIC129274865 129274935
APLC110986982 110988835
AJC117110799 117115460
SKO100376681 100377686 100378729
DMEDmel_CG4872(CG4872)
DER6550041
DSE6618005
DSIDsimw501_GD17316(Dsim_GD17316)
DYADyak_GE17631
DSR110179090
DPO4814197
DPE6602695
DMN108151684
DGR6565957
DMODmoj_GI14778
DAZ108618961
DNV108657178
DHE111603352
CCAT101453488
BOD106625075
BDR105223808 125775323
TDA119667178 119672084
MDE101899954 131805978
SCAC106085711 106085713
LCQ111688476
LSQ119604121
GFS119637367
ECOE129945485
HIS119657156
AGA1270790
ACOZ120956393
AARA120903023
AMER121599047
ASTE118505858
AFUN125768511
AMOU128297881
AALI118466603
AAG5579138
AALB109406880
CQUCpipJ_CPIJ008207
CPII120424114
CNS116343291 116348995
BCOO119073013 119079613 119079830 119084539
NPT124218968
NFB124182507
NLO107226258
NVG124306437
TCA662385
DPA109545379
SOY115888864
AGRG126737506
AGB108918009
LDC111511439
NVL108566671
APLN108737829
PPYR116179010 116179070 116179241 116179244 116179251 116179252
OTU111413575
CCRN123294538
BTAB109039789
DCI103509244
CLEC106665164
HHAL106685913
NLU111047339
HVI124353598 124353696 124373265
PHUPhum_PHUM216920
CSEC111867600
DPXDAPPUDRAFT_16502 DAPPUDRAFT_187780
DMK116928593
DPZ124352628
PVM113812170
PJA122256025 122256026
PCHN125025609
PMOO119577248
HAME121875754
PCLA123765097
CQD128703309
ESN126998803
PPOI119103991
DSV119448136 119449445
RSAN119382639
RMP119160087
PTEP107454830
UDV129230081
LPOL106462012
HROHELRODRAFT_93760
LGILOTGIDRAFT_235748
PVUL126812394
PCAN112558408
BGT106057249
GAE121378575
HRF124110838 124129349
HRJ124291700 124291755
CRG105347352
CVN111121979
CANU128164517
OED125670791
MYI110455669
PMAX117331855
MCAF127707490
RPHI132719796
DPOL127851041
OBI106870447
OSN115213112
LAK106150712 106158002
NVE5501799
EPA110246543 110249574
ATEN116291186
ADF107347081
AMIL114964721
PDAM113678588
SPIS111340308
DGT114519413 114519436
XEN124440578
HMG101237510
HSY130656597
TADTRIADDRAFT_22495
AQU100640786
MBRMONBRDRAFT_29093
STHRBXT84_09070
 » show all
Reference
1  [PMID:3371353]
  Authors
Nardini M, Ricci G, Caccuri AM, Solinas SP, Vesci L, Cavallini D.
  Title
Purification and characterization of a ketimine-reducing enzyme.
  Journal
Eur J Biochem 173:689-94 (1988)
DOI:10.1111/j.1432-1033.1988.tb14053.x
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.25
IUBMB Enzyme Nomenclature: 1.5.1.25
ExPASy - ENZYME nomenclature database: 1.5.1.25
BRENDA, the Enzyme Database: 1.5.1.25
CAS: 115232-54-7

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