| Entry |
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| Name |
dihydrofolate reductase;
tetrahydrofolate dehydrogenase;
DHFR;
pteridine reductase:dihydrofolate reductase;
dihydrofolate reductase:thymidylate synthase;
thymidylate synthetase-dihydrofolate reductase;
folic acid reductase;
folic reductase;
dihydrofolic acid reductase;
dihydrofolic reductase;
7,8-dihydrofolate reductase;
NADPH-dihydrofolate reductase
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| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
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| Reaction(IUBMB) |
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ [RN: R00939]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate.
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| History |
EC 1.5.1.3 created 1961, modified 1976 (EC 1.5.1.4 created 1961, incorporated 1976)
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| Pathway |
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| Orthology |
| K00287 | dihydrofolate reductase |
| K13938 | dihydromonapterin reductase / dihydrofolate reductase |
| K13998 | dihydrofolate reductase / thymidylate synthase |
| K18589 | dihydrofolate reductase (trimethoprim resistance protein) |
| K18590 | dihydrofolate reductase (trimethoprim resistance protein) |
| K18591 | dihydrofolate reductase (trimethoprim resistance protein) |
| K19643 | dihydrofolate reductase (trimethoprim resistance protein) |
| K19644 | dihydrofolate reductase (trimethoprim resistance protein) |
| K19645 | dihydrofolate reductase (trimethoprim resistance protein) |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Blakley, R.L. and MacDougall, B.M. |
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| Title |
Dihydrofolic reductase from Streptococcus faecalis R. |
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| Journal |
J Biol Chem 236:1163 (1961) |
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| Reference |
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| Authors |
Bolin JT, Filman DJ, Matthews DA, Hamlin RC, Kraut J. |
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| Title |
Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate. |
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| Journal |
J Biol Chem 257:13650-62 (1982) |
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| Reference |
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| Authors |
Kaufman BT, Gardiner RC. |
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| Title |
Studies on dihydrofolic reductase. I. Purification and properties of dihydrofolic reductase from chicken liver. |
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| Journal |
J Biol Chem 241:1319-28 (1966) |
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| Reference |
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| Authors |
Young IG, Gibson F. |
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| Title |
Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.5.1.3 |
| ExPASy - ENZYME nomenclature database: | 1.5.1.3 |
| BRENDA, the Enzyme Database: | 1.5.1.3 |
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