KEGG   ENZYME: 1.5.1.30Help
Entry
EC 1.5.1.30                 Enzyme                                 

Name
flavin reductase (NADPH);
NADPH:flavin oxidoreductase;
riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase;
flavin mononucleotide reductase;
flavine mononucleotide reductase;
FMN reductase (NADPH);
NADPH-dependent FMN reductase;
NADPH-flavin reductase;
NADPH-FMN reductase;
NADPH-specific FMN reductase;
riboflavin mononucleotide reductase;
riboflavine mononucleotide reductase;
NADPH2 dehydrogenase (flavin);
NADPH2:riboflavin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
reduced-riboflavin:NADP+ oxidoreductase
Reaction(IUBMB)
reduced riboflavin + NADP+ = riboflavin + NADPH + H+ [RN:R05707]
Reaction(KEGG)
R05707;
(other) R09520
Show
Substrate
reduced riboflavin [CPD:C01007];
NADP+ [CPD:C00006]
Product
riboflavin [CPD:C00255];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme reduces riboflavin, and, less efficiently, FMN and FAD. NADH is oxidized less efficiently than NADPH.
History
EC 1.5.1.30 created 1982 as EC 1.6.8.2, transferred 2002 to EC 1.5.1.30, modified 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K05901  biliverdin reductase / flavin reductase
Genes
HSA: 645(BLVRB)
PTR: 456039(BLVRB)
PPS: 100989093(BLVRB)
GGO: 101142015(BLVRB)
PON: 100446184(BLVRB)
NLE: 100587172(BLVRB)
MCC: 703020(BLVRB)
MCF: 102142962(BLVRB)
CSAB: 103234707(BLVRB)
RRO: 104676113(BLVRB)
RBB: 108539085(BLVRB)
CJC: 100391206(BLVRB)
SBQ: 101043206(BLVRB)
MMU: 233016(Blvrb)
RNO: 292737(Blvrb)
CGE: 100768929(Blvrb)
NGI: 103750766(Blvrb)
HGL: 101697384(Blvrb)
CCAN: 109688540(Blvrb)
OCU: 100340115(BLVRB)
TUP: 102490802(BLVRB)
CFA: 476456(BLVRB)
AML: 100467254(BLVRB)
UMR: 103661047(BLVRB)
ORO: 101371765(BLVRB)
FCA: 101092315(BLVRB)
PTG: 102957700(BLVRB)
AJU: 106979604(BLVRB)
BTA: 281650(BLVRB)
BOM: 102277747(BLVRB)
BIU: 109572681(BLVRB)
CHX: 102187796(BLVRB)
OAS: 101119750(BLVRB)
SSC: 100625219(BLVRB)
CFR: 102522968(BLVRB)
CDK: 105093394(BLVRB)
BACU: 103014515(BLVRB)
LVE: 103082225(BLVRB)
OOR: 101269881(BLVRB)
ECB: 100068145(BLVRB)
EPZ: 103560493(BLVRB)
EAI: 106843297(BLVRB)
MYB: 102251416(BLVRB)
MYD: 102759928(BLVRB)
HAI: 109374869(BLVRB)
RSS: 109458110(BLVRB)
PALE: 102879551(BLVRB)
LAV: 100665167(BLVRB)
TMU: 101354315
MDO: 100017892(BLVRB)
SHR: 100930351(BLVRB)
OAA: 100073853(BLVRB)
MGP: 100303679(BLVRB)
PHI: 102113532(BLVRB)
CCAE: 111943368(BLVRB)
CLV: 110356600(BLVRB)
AAM: 106493723(BLVRB)
ASN: 102387963(BLVRB)
AMJ: 102574563(BLVRB)
CPIC: 101948417(BLVRB)
ACS: 100564796(blvrb)
PVT: 110075662(BLVRB)
PBI: 103053858(BLVRB)
GJA: 107107369(BLVRB)
XLA: 443881(blvrb.L)
XTR: 100124834(blvrb)
NPR: 108791950(BLVRB)
DRE: 436959(blvrb)
SRX: 107717620(blvrb)
SGH: 107602119(blvrb)
IPU: 108264654(blvrb)
AMEX: 103040962(blvrb)
TRU: 101061122(blvrb)
LCO: 104927805(blvrb) 109140017
NCC: 104965039(blvrb)
MZE: 101484658(blvrb)
OLA: 101163919(blvrb)
XMA: 102228591(blvrb)
PRET: 103475161(blvrb)
NFU: 107379787(blvrb)
KMR: 108247879(blvrb)
CSEM: 103377891(blvrb)
LCF: 108876241(blvrb)
SDU: 111216890(blvrb)
HCQ: 109529422(blvrb)
BPEC: 110172712(blvrb)
MALB: 109963258(blvrb)
SASA: 106580739(blvrb) 106612705(BLVRB)
ELS: 105023068(blvrb)
SFM: 108928749(blvrb)
LCM: 102358034(BLVRB)
CMK: 103173572(blvrb)
CIN: 100185152
DER: 6552273
DPE: 6588134
DSI: Dsimw501_GD20759(Dsim_GD20759)
DWI: 6647397
MDE: 101892800
AAG: 5565330
BIM: 100749252
BTER: 100646178
AEC: 105144797
ACEP: 105624072
PBAR: 105426660
HST: 105187135
DQU: 106744067
CFO: 105252649
LHU: 105674651
PGC: 109861802
PCF: 106793889
NVI: 100113525
TCA: 664311
DPA: 109534878
NVL: 108556546
BMOR: 101736226
PMAC: 106708927
PRAP: 111001233
HAW: 110382146
PXY: 105393340
API: 100168586(Blvrb) 100574136
DNX: 107162985
ZNE: 110828593
 » show all
Taxonomy
Reference
1  [PMID:3453680]
  Authors
Yubisui T, Tamura M, Takeshita M.
  Title
Characterization of a second form of NADPH-flavin reductase purified from human erythrocytes.
  Journal
Biochem Int 15:1-8 (1987)
Reference
2  [PMID:10620517]
  Authors
Cunningham O, Gore MG, Mantle TJ
  Title
Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B).
  Journal
Biochem J 345 Pt 2:393-9 (2000)
  Sequence
[hsa:645]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.30
IUBMB Enzyme Nomenclature: 1.5.1.30
ExPASy - ENZYME nomenclature database: 1.5.1.30
BRENDA, the Enzyme Database: 1.5.1.30
CAS: 56626-29-0

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