KEGG ENZYME: 1.5.1.30

ENZYME: 1.5.1.30

Entry

EC 1.5.1.30                 Enzyme

Name

flavin reductase (NADPH);
NADPH:flavin oxidoreductase;
riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase;
flavin mononucleotide reductase;
flavine mononucleotide reductase;
FMN reductase (NADPH);
NADPH-dependent FMN reductase;
NADPH-flavin reductase;
NADPH-FMN reductase;
NADPH-specific FMN reductase;
riboflavin mononucleotide reductase;
riboflavine mononucleotide reductase;
NADPH2 dehydrogenase (flavin);
NADPH2:riboflavin oxidoreductase

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

reduced-riboflavin:NADP+ oxidoreductase

Reaction(IUBMB)

reduced riboflavin + NADP+ = riboflavin + NADPH + H+ [RN:R05707]

Reaction(KEGG)

R05707;
(other) R09520

Substrate

reduced riboflavin [CPD:C01007];
NADP+ [CPD:C00006]

Product

riboflavin [CPD:C00255];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme reduces riboflavin, and, less efficiently, FMN and FAD. NADH is oxidized less efficiently than NADPH.

History

EC 1.5.1.30 created 1982 as EC 1.6.8.2, transferred 2002 to EC 1.5.1.30, modified 2011

Pathway

ec00740

Riboflavin metabolism

ec01100

Metabolic pathways

Orthology

K05901

biliverdin reductase / flavin reductase

Genes

HSA:	645(BLVRB)

PTR:	456039(BLVRB)

PPS:	100989093(BLVRB)

GGO:	101142015(BLVRB)

PON:	100446184(BLVRB)

PPYG:

129020793(BLVRB)

NLE:	100587172(BLVRB)

HMH:	116480674(BLVRB)

SSYN:

129467021(BLVRB)

MCC:	703020(BLVRB)

MCF:	102142962(BLVRB)

MTHB:

126942092

MNI:	105495336(BLVRB)

CSAB:

103234707(BLVRB)

CATY:

105597983(BLVRB)

PANU:

101021963(BLVRB)

TGE:	112613110(BLVRB)

MLEU:

105542622(BLVRB)

RRO:	104676113(BLVRB)

RBB:	108539085(BLVRB)

TFN:	117091948(BLVRB) 117092438

PTEH:

111553962(BLVRB)

CANG:

105519183(BLVRB)

CJC:	100391206(BLVRB)

SBQ:	101043206(BLVRB)

CIMI:

108285782(BLVRB)

ANAN:

105723427(BLVRB)

CSYR:

103272286(BLVRB)

MMUR:

105876763(BLVRB)

LCAT:

123624314(BLVRB)

ERUF:

138374453(BLVRB)

PCOQ:

105820481(BLVRB)

OGA:	100956880(BLVRB)

MMU:	233016(Blvrb)

MCAL:

110297893(Blvrb)

MPAH:

110331802(Blvrb)

RNO:	292737(Blvrb)

MCOC:

116101881(Blvrb)

ANU:	117698969(Blvrb)

ASYL:

127672855(Blvrb)

MUN:	110556744(Blvrb)

CGE:	100768929(Blvrb)

MAUA:

101844617(Blvrb)

PROB:

127238361(Blvrb)

PLEU:

114681553(Blvrb)

PMAV:

102919665 143273921(Blvrb)

MORG:

121449703(Blvrb) 121453592

MFOT:

126492547

AAMP:

119821315 119821342(Blvrb)

CNL:	130869781(Blvrb)

NGI:	103750766(Blvrb)

HGL:	101697384(Blvrb)

CPOC:

100723970(Blvrb)

CCAN:

109688540(Blvrb)

DORD:

105998024(Blvrb)

DSP:	122097439(Blvrb)

DMER:

138811214 138813100

PLOP:

125368345(Blvrb)

NCAR:

124966872

MMMA:

107151453(Blvrb)

ITI:	101955814(Blvrb)

OCU:

100340115

OPI:	101535891(BLVRB)

OCZ:	121153639(BLVRB)

TUP:	102490802(BLVRB)

GVR:	103598605(BLVRB)

CFA:	476456(BLVRB)

CLUD:

112645456(BLVRB)

VVP:	112928368(BLVRB)

VLG:	121485710(BLVRB)

NPO:	129500870(BLVRB)

AML:	100467254(BLVRB)

UMR:	103661047(BLVRB)

UAH:	113243564(BLVRB)

UAR:	123784022(BLVRB)

ELK:

111161593

LLV:	125088933 125098045

MPUF:

101682683(BLVRB)

MNP:	132005993(BLVRB)

MLK:	131818594(BLVRB)

NVS:	122912043(BLVRB)

ORO:	101371765(BLVRB)

EJU:	114202467(BLVRB)

ZCA:	113936395(BLVRB)

MLX:	118022653(BLVRB)

MANO:

123855671(BLVRB)

NSU:	110590243(BLVRB)

LWW:	102749984(BLVRB)

FCA:	101092315(BLVRB)

PYU:	121011436(BLVRB)

PBG:	122494035(BLVRB)

PVIV:

125152916(BLVRB)

LRUF:

124511113

LGF:	123578935(BLVRB)

AJU:

106979604

PTG:	102957700(BLVRB)

PPAD:

109256587(BLVRB)

PUC:

125915658

PLEZ:

122208317(BLVRB)

HHV:	120240932(BLVRB)

CCRU:

144239548(BLVRB)

BTA:	281650(BLVRB)

BOM:	102277747(BLVRB)

BIU:	109572681(BLVRB)

BJV:	133230611(BLVRB)

BBUB:

102402107(BLVRB)

BKE:	129631832(BLVRB)

BBIS:

104995362(BLVRB)

CHX:	102187796(BLVRB)

OAS:	101119750(BLVRB)

OCAN:

138418865(BLVRB)

BTAX:

128063605(BLVRB)

CSUM:

138096686(BLVRB)

ODA:	120872449(BLVRB)

CCAD:

122420884(BLVRB) 122443458

MREE:

136158780(BLVRB)

OVR:	110122434(BLVRB)

MBEZ:

129546807(BLVRB)

SSC:	100625219(BLVRB)

CFR:	102522968(BLVRB)

CBAI:

105062862(BLVRB)

CDK:	105093394(BLVRB)

VPC:	102543677(BLVRB)

BACU:

103014515(BLVRB)

BMUS:

118885044(BLVRB)

LVE:	103082225(BLVRB)

OOR:	101269881(BLVRB)

LALB:

132510176(BLVRB)

DDP:	132415876(BLVRB)

DLE:	111180848(BLVRB)

PCAD:

102992855(BLVRB)

PSIU:

116743687(BLVRB)

PPHC:

136141127(BLVRB)

NASI:

112415632(BLVRB)

ECB:	100068145(BLVRB)

EPZ:	103560493(BLVRB)

EAI:	106843297(BLVRB)

MYB:	102251416(BLVRB)

MYD:	102759928(BLVRB)

MMYO:

118674559(BLVRB)

MLF:	102432652(BLVRB)

MDT:	132216881(BLVRB)

MYUM:

138997034(BLVRB)

PKL:	118702235(BLVRB)

EFUS:

103284696(BLVRB) 103290292

MNA:	107534172(BLVRB)

DRO:	112320111(BLVRB)

SHON:

118988083(BLVRB)

AJM:	119040590(BLVRB)

PDIC:

114511105(BLVRB)

PHAS:

123823786(BLVRB)

MMF:	118639318(BLVRB)

PPAM:

129076686(BLVRB)

HAI:	109374869(BLVRB)

RFQ:	117035103(BLVRB)

PALE:

102879551(BLVRB)

PGIG:

120595620(BLVRB)

PVP:	105300209(BLVRB)

RAY:	107521823(BLVRB)

MJV:	108404844(BLVRB)

TOD:	119249327(BLVRB)

SARA:

101557111(BLVRB)

SFUM:

130044131(BLVRB)

SETR:

126028163(BLVRB)

LAV:	100665167(BLVRB)

TMU:

101354315

ETF:	101645971(BLVRB)

DNM:	101437673(BLVRB)

MDO:	100017892(BLVRB)

GAS:	123255652(BLVRB)

SHR:	100930351(BLVRB)

AFZ:

127556203

PCW:	110202810(BLVRB)

TVP:	118836107 118840391(BLVRB)

PBRV:

138154389(BLVRB)

MLAO:

141509487(BLVRB)

OAA:	100073853(BLVRB)

TACU:

119946004(BLVRB)

MGP:	100303679(BLVRB)

APLA:

113841036(BLVRB)

AACU:

137849132(BLVRB)

ACYG:

136787513(BLVRB)

CATA:

118261579(BLVRB)

ATRC:

139586799(BLVRB)

PHI:	102113532(BLVRB)

CCAE:

111943368(BLVRB)

ZLE:	135441467(BLVRB)

SHAB:

115603330(BLVRB)

ACHC:

115337712

HALD:

104321959(BLVRB)

AGEN:

126036625 126037224

HHAR:

128138135(BLVRB)

BBUT:

142027052(BLVRB)

CBOR:

142074021(BLVRB)

CBOY:

140645463(BLVRB)

CNIC:

136001143(BLVRB)

BREG:

104641217(BLVRB)

RTD:	128903851(BLVRB)

CRID:

134507696(BLVRB)

LMIC:

141737088(BLVRB)

AAM:	106493723(BLVRB)

AROW:

112960997(BLVRB)

NPD:	112955489(BLVRB)

TGT:	104572768(BLVRB)

DNE:	112996331(BLVRB)

ASN:	102387963(BLVRB)

AMJ:	102574563(BLVRB)

CIZ:	142024394(BLVRB)

CMY:	114022374(BLVRB)

CCAY:

125628119(BLVRB)

LKP:	140902137(BLVRB)

NDS:	141976236(BLVRB)

DCC:	119847368(BLVRB)

CPIC:

101948417(BLVRB)

TST:	117888630(BLVRB)

CABI:

116833857(BLVRB)

MRV:	120388171(BLVRB)

ACS:	100564796(blvrb)

ASAO:

132780135(BLVRB)

PVT:	110075662(BLVRB)

SUND:

121916153(BLVRB)

PBI:	103053858(BLVRB)

PMUR:

107285666(BLVRB)

CTIG:

120316372(BLVRB)

TSR:	106541075(BLVRB)

PGUT:

117677851(BLVRB)

PCAE:

139321072(BLVRB)

APRI:

131204274(BLVRB)

PTEX:

113450296(BLVRB)

NSS:	113425551(BLVRB)

VKO:	123021032(BLVRB)

PMUA:

114603071(BLVRB)

PRAF:

128418178(BLVRB)

ZVI:	118078075 118086651(BLVRB)

HCG:	128332650(BLVRB)

GJA:	107107369(BLVRB)

STOW:

125430722(BLVRB)

EMC:	129343090(BLVRB)

XLA:	443881(blvrb.L)

XTR:	100124834(blvrb) 116406791

NPR:	108791950(BLVRB)

RTEM:

120913299(BLVRB)

ACAT:

141107643(BLVRB)

PADS:

140344122(BLVRB)

BBUF:

120977966(BLVRB)

BGAR:

122923946(BLVRB)

DTC:	141052078(BLVRB)

PCOB:

134949224

PWL:	138259461(BLVRB)

MUO:	115480591(BLVRB)

GSH:	117364657(BLVRB)

DRE:	436959(blvrb)

SRX:	107717620(blvrb)

SANH:

107670601 107692505

SGH:	107602119(blvrb)

CCAR:

109109302 109109306(blvrb)

CAUA:

113061728 113082608 113118645

CGIB:

127934336 127977858

PTET:

122323140(blvrb)

LROH:

127180549(blvrb)

GRF:	141345883 141345918

OMC:	131523974(blvrb)

PPRM:

120460021 120460038

RKG:	130069968(blvrb)

MAMB:

125254500(blvrb)

CIDE:

127499299

CERY:

137022554(blvrb)

MASI:

127455779

TROS:

130562861(blvrb)

TDW:	130435551(blvrb)

MANU:

129419592(blvrb)

PDAB:

135773344(blvrb)

IPU:

124626957

IFU:	128606874(blvrb)

PHYP:

113526426(blvrb)

SMEO:

124396010(blvrb)

TFD:	113638812(blvrb)

TVC:	132851041(blvrb)

CGAR:

128528350(blvrb)

NGRA:

132887848(blvrb)

TRN:	134322999(blvrb)

AMEX:

103040962(blvrb)

CMAO:

118818247(blvrb)

EEE:	113580124(blvrb)

CHAR:

105909718(blvrb)

SPIL:

134099319(blvrb)

ASAD:

121683994(blvrb)

TRU:	101061122(blvrb)

TFS:	130534656(blvrb)

TNG:	GSTEN00035152G001

LCO:	104927805(blvrb)

NCC:	104965039(blvrb)

TBEN:

117471124(blvrb)

CGOB:

115018241(blvrb)

PGEO:

117457425(blvrb)

GACU:

117555581(blvrb)

EMAC:

134880858(blvrb)

ELY:	117259444(blvrb)

EFO:	125888677(blvrb)

PLEP:

121943190(blvrb)

SLUC:

116053283(blvrb)

SVIT:

144515837(blvrb)

ECRA:

117942519(blvrb)

ESP:	116687001(blvrb)

PFLV:

114552606(blvrb)

PFLT:

120553226(blvrb)

GAT:	120829425(blvrb)

PPUG:

119222042(blvrb)

AFB:	129090654(blvrb)

CLUM:

117741131(blvrb)

PSWI:

130210565(blvrb)

CANA:

137790521(blvrb) 137799596

CVE:	137882065(blvrb)

AMIR:

142971495(blvrb)

MSAM:

119882831(blvrb)

SCHU:

122879513(blvrb)

EARM:

139285187(blvrb)

CUD:	121526977(blvrb)

SPUL:

138597214(blvrb)

LMIX:

132980822(blvrb)

HTC:	141798099(blvrb)

ALAT:

119033096(blvrb)

ASTR:

137596573(blvrb)

PKLU:

139200448(blvrb)

MZE:	101484658(blvrb)

ONL:	100702669(blvrb)

OAU:	116320348(blvrb)

OLA:	101163919(blvrb)

OML:	112149783(blvrb)

CSAI:

133442247(blvrb)

XMA:	102228591(blvrb)

XCO:	114133538(blvrb)

XHE:	116707592 116707593

PRET:

103475161(blvrb)

PFOR:

103138303(blvrb)

PLAI:

106947919(blvrb)

PMEI:

106921476(blvrb)

GAF:	122832913(blvrb)

PPRL:

129358719(blvrb)

CVG:	107094869(blvrb)

CTUL:

119796633(blvrb)

GMU:	124883659(blvrb)

NFU:	107379787(blvrb)

KMR:	108247879(blvrb)

ALIM:

106522783(blvrb)

NWH:	119411413(blvrb)

AOCE:

111586211(blvrb)

EJA:	138205433(blvrb)

BFRE:

138632581(blvrb)

MCEP:

125012958(blvrb)

CSEM:

103377891(blvrb)

POV:	109630121(blvrb)

SSEN:

122773296(blvrb)

SSOE:

131462914(blvrb)

HHIP:

117773323(blvrb)

HSP:	118105862(blvrb)

PPLT:

128439617(blvrb)

SMAU:

118294571(blvrb)

LCF:

108876241

SDU:	111216890(blvrb)

SLAL:

111662215(blvrb)

XGL:	120792571(blvrb)

HCQ:	109529422(blvrb)

SSCV:

125972512(blvrb)

SBIA:

133504585(blvrb)

PEE:	133405512(blvrb)

PTAO:

133482614(blvrb)

BPEC:

110172712(blvrb)

ENY:	140373236(blvrb)

MALB:

109963258(blvrb)

BSPL:

114867627(blvrb)

SJO:	128360742(blvrb)

SSCO:

133980389(blvrb)

TTY:	137186461(blvrb)

GMH:	115560834(blvrb)

SASA:

106580739(blvrb) 106612705(BLVRB)

STRU:

115163034(blvrb) 115205994

OTW:	112265119 112266772

OMY:	110503591 110507468

OGO:	123993025 124005618

ONE:	115137042 115141548

OKI:	109905459 109908908

OKE:	118385438 118397176

OMM:	135546137 135552619

OCLA:

139382399 139385633

SALP:

111982788 111982809

SNH:	120018812 120028367

SFON:

129821921 129832364

CCLU:

121562566 121568255

ELS:	105023068(blvrb)

OEP:	134028704(blvrb)

SFM:	108928749(blvrb)

PKI:	111844029(blvrb)

AANG:

118209415(blvrb)

AROT:

135236095(blvrb)

CCOG:

133108634(blvrb)

LOC:	102698532(blvrb)

PSPA:

121303818 121304996(blvrb)

ARUT:

117397815 117415212

PSEX:

120538736(blvrb)

LCM:	102358034(BLVRB)

CMK:	103173572(blvrb)

RTP:	109926910(blvrb)

CPLA:

122542852(blvrb)

CPUN:

140454502(blvrb)

HOC:	132836604(blvrb)

SCAU:

119957985(blvrb)

LERI:

129714249(blvrb)

PMRN:

116953899(BLVRB)

LRJ:

133356338

CIN:

100185152

SCLV:

120347803 120347819 120347831 120347846 120347854 120347866

DME:	Dmel_CG9471(CG9471)

DER:

6552273

DSE:

6607040

DSI:	Dsimw501_GD20759(Dsim_GD20759)

DYA:	Dyak_GE24730

DAN:

6505836

DSR:

110188190

DPO:

4801507

DPE:

6588134

DMN:

108156553

DWI:

6647397

DMO:	Dmoj_GI24882

DAZ:

108618551

DNV:

108659243

DHE:

111602756

DVI:

6630042

CCAT:

101455152

BOD:

106623986

BDR:

105231095

RZE:

108368232

AOQ:

129235377

ALUD:

128854877

TDA:

119683508

MDE:

101892800

SCAC:

106088079

LCQ:

111676095

LSQ:

119604323

CVJ:

135964047

GFS:

119634816

ECOE:

129938982

CLON:

129611628

HIS:

119652638

AGA:

1281857

ACOZ:

120949584

AMER:

121588441

ASTE:

118507626

AMAP:

126559099

AFUN:

125760443

AMOU:

128297711

AMRS:

128707374

AALI:

118461718

ADAR:

125949560

ACOS:

131260598

AAG:

5565330

AALB:

109405306 109406365 115258289

ASUA:

134205303

CQU:	CpipJ_CPIJ011826

CPII:

120431012

CBRI:

134828183

CNS:

116352016

BCOO:

119067850

LLL:

129787276

PPAP:

129799734 129809276

AME:

412445

ACER:

107994237

ALAB:

122714807

ADR:

102680187

AFLR:

105736343

BIM:

100749252

BBIF:

117205099

BVK:

117231092

BVAN:

117157637

BHUN:

126871633

BTER:

100646178

BAFF:

126921994

BPYO:

122567783

BPAS:

132912730

FVI:

122538628

CCAL:

108630984

OBB:

114877540

OLG:

117603050

MGEN:

117219339

NMEA:

116423944

CGIG:

122399091

SOC:	105203443 105203453 105204185

MPHA:

105830426 118647767

AEC:

105144797

ACEP:

105624072

ACOC:

108686543

MZT:

108720535

CCOA:

108773653

TCZ:

108757714

TSEP:

108749056

PBAR:

105426660

VEM:

105557622

COBS:

139105001

TLN:

139821568

TAME:

143904425

HST:

105187135

DQU:

106744067

CFO:

105252649

FEX:

115234327

PMEC:

138941039

LHU:

105674651

PGC:

109861802

OBO:

105281931

PCF:

106793889

PFUC:

122526549

VPS:

122634421

VVE:

124947535

NVI:

100113525

CSOL:

105360908

TPRE:

106653900

LHT:

122498967

LBD:

127280477

MDL:	103574018 103575546

CGLO:

123265630 123268538

CTYP:

141530452

FAS:

105271813

DAM:

107036908

AGIF:

122854794

CINS:

118064459

VCAN:

122408838 122408839

CCIN:

107270862

DSM:

124411805

NPT:

124220145

NFB:

124183337

NLO:

107221269

NVG:

124305854

AROA:

105686570

TCA:

664311

TMOL:

138123682

DPA:

109534878

ESIM:

136416975

EFOR:

136342253

SOY:

115876520

RFG:

143195188

AGRG:

126736645

ATD:

109595167

CSET:

123308381

HAXR:

123670834

AGB:

108917320

LDC:

111511470

DVV:

114325400

NVL:

108556546

DCOR:

135798964

APLN:

108739508

PPYR:

116167174

OTU:

111422790

BMOR:

101736226

BMAN:

114248437

MSEX:

115449431

DPL:	KGM_212873

BANY:

112054677

MJU:

123874749

NIQ:

126775902

VCD:

124538436

MCIX:

123662021

PMAC:

106708927

PPOT:

106101151

PXU:

106120319

BPHI:

137919782

PRAP:

111001233

PBX:

123718550

PNAP:

125054450

ZCE:

119828598

CCRC:

123699980

LSIN:

126964809

AAGE:

121726639

HAW:

110382146

HZE:

124640134

TNL:

113504959

SLIU:

111350206

OFU:

114353154

ONU:

135080487

ATRA:

106137869

GMW:

113512708

ECLR:

140742621

PXY:

105393340

PGW:

126375316

LGLY:

125232571

CSTB:

134748197

CFUM:

141432464

CFEL:

113387723

CCRN:

123292441

API:	100168586(Blvrb) 100574136

DNX:

107162985

AGS:

114130365

RMD:

113557849

ACOO:

126833512

DVT:

126906640

BTAB:

109043576

NLU:

111052374

LDA:

142324936

HVI:	124353097 124353098 124353110 124373554

MQU:

129006004

PHU:	Phum_PHUM514080

FOC:

113215946

TPAL:

117644131

ZNE:

110828593

CSEC:

111868350

PAME:

138704742 138704751

SGRE:

126359882

BROR:

134535992

IEL:

124168153

HAMR:

139698719

DPX:	DAPPUDRAFT_230602

DMK:

116929398

DPZ:

124311410

PMOO:

119585705

MNZ:

135210720

HAZT:

108664641

OOT:

143020936

ISC:

8030073

DSV:

119458384

DALB:

135917222

RSAN:

119373566

RMP:

119167602

TUT:	107359695 107367634

CSCU:

111640897

CVS:

136978293

PTEP:

107444427

ABRU:

129957424

UDV:

129229318

SDM:

118193070

LPOL:

106471531

LJP:

135466868

» show all

Reference

1 [PMID:3453680]

Authors

Yubisui T, Tamura M, Takeshita M.

Title

Characterization of a second form of NADPH-flavin reductase purified from human erythrocytes.

Journal

Biochem Int 15:1-8 (1987)

Reference

2 [PMID:10620517]

Authors

Cunningham O, Gore MG, Mantle TJ

Title

Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B).

Journal

Biochem J 345 Pt 2:393-9 (2000)
DOI:10.1042/bj3450393

Sequence

[hsa:645]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.30

IUBMB Enzyme Nomenclature:

1.5.1.30

ExPASy - ENZYME nomenclature database:

1.5.1.30

BRENDA, the Enzyme Database:

1.5.1.30

CAS:	56626-29-0

All links

Gene (207)   
   MGENES (48)   
   RefGene (159)   
Protein sequence (345)   
   UniProt (328)   
   SWISS-PROT (5)   
   RefSeq(pep) (6)   
   PDBSTR (6)   
DNA sequence (486)   
   RefSeq(nuc) (6)   
   GenBank (245)   
   EMBL (235)   
3D Structure (6)   
   PDB (6)   
All databases (1044)   

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