KEGG ENZYME: 1.5.1.30

ENZYME: 1.5.1.30

Entry

EC 1.5.1.30                 Enzyme

Name

flavin reductase (NADPH);
NADPH:flavin oxidoreductase;
riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase;
flavin mononucleotide reductase;
flavine mononucleotide reductase;
FMN reductase (NADPH);
NADPH-dependent FMN reductase;
NADPH-flavin reductase;
NADPH-FMN reductase;
NADPH-specific FMN reductase;
riboflavin mononucleotide reductase;
riboflavine mononucleotide reductase;
NADPH2 dehydrogenase (flavin);
NADPH2:riboflavin oxidoreductase

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

reduced-riboflavin:NADP+ oxidoreductase

Reaction(IUBMB)

reduced riboflavin + NADP+ = riboflavin + NADPH + H+ [RN:R05707]

Reaction(KEGG)

R05707;
(other) R09520

Substrate

reduced riboflavin [CPD:C01007];
NADP+ [CPD:C00006]

Product

riboflavin [CPD:C00255];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme reduces riboflavin, and, less efficiently, FMN and FAD. NADH is oxidized less efficiently than NADPH.

History

EC 1.5.1.30 created 1982 as EC 1.6.8.2, transferred 2002 to EC 1.5.1.30, modified 2011

Pathway

ec00740

Riboflavin metabolism

ec01100

Metabolic pathways

Orthology

K05901

biliverdin reductase / flavin reductase

Genes

HSA:	645(BLVRB)

PTR:	456039(BLVRB)

PPS:	100989093(BLVRB)

GGO:	101142015(BLVRB)

PON:	100446184(BLVRB)

NLE:	100587172(BLVRB)

HMH:	116480674(BLVRB)

MCC:	703020(BLVRB)

MCF:	102142962(BLVRB)

MTHB:

126942092

MNI:	105495336(BLVRB)

CSAB:

103234707(BLVRB)

CATY:

105597983(BLVRB)

PANU:

101021963(BLVRB)

TGE:	112613110(BLVRB)

MLEU:

105542622(BLVRB)

RRO:	104676113(BLVRB)

RBB:	108539085(BLVRB)

TFN:	117091948(BLVRB) 117092438

PTEH:

111553962(BLVRB)

CANG:

105519183(BLVRB)

CJC:	100391206(BLVRB)

SBQ:	101043206(BLVRB)

CIMI:

108285782(BLVRB)

CSYR:

103272286(BLVRB)

MMUR:

105876763(BLVRB)

LCAT:

123624314(BLVRB)

PCOQ:

105820481(BLVRB)

OGA:	100956880(BLVRB)

MMU:	233016(Blvrb)

MCAL:

110297893(Blvrb)

MPAH:

110331802(Blvrb)

RNO:	292737(Blvrb)

MCOC:

116101881(Blvrb)

ANU:	117698969(Blvrb)

MUN:	110556744(Blvrb)

CGE:	100768929(Blvrb)

MAUA:

101844617(Blvrb)

PROB:

127238361(Blvrb)

PLEU:

114681553(Blvrb)

MORG:

121449703(Blvrb) 121453592

MFOT:

126492547

AAMP:

119821315 119821342(Blvrb)

NGI:	103750766(Blvrb)

HGL:	101697384(Blvrb)

CPOC:

100723970(Blvrb)

CCAN:

109688540(Blvrb)

DORD:

105998024(Blvrb)

DSP:	122097439(Blvrb)

NCAR:

124966872

OCU:

100340115

OPI:	101535891(BLVRB)

TUP:	102490802(BLVRB)

GVR:	103598605(BLVRB)

CFA:	476456(BLVRB)

CLUD:

112645456(BLVRB)

VVP:	112928368(BLVRB)

VLG:	121485710(BLVRB)

AML:	100467254(BLVRB)

UMR:	103661047(BLVRB)

UAH:	113243564(BLVRB)

UAR:	123784022(BLVRB)

ELK:

111161593

LLV:	125088933 125098045

MPUF:

101682683(BLVRB)

NVS:	122912043(BLVRB)

ORO:	101371765(BLVRB)

EJU:	114202467(BLVRB)

ZCA:	113936395(BLVRB)

MLX:	118022653(BLVRB)

NSU:	110590243(BLVRB)

LWW:	102749984(BLVRB)

FCA:	101092315(BLVRB)

PYU:	121011436(BLVRB)

PBG:	122494035(BLVRB)

LRUF:

124511113

PTG:	102957700(BLVRB)

PPAD:

109256587(BLVRB)

PUC:

125915658

AJU:	106979604(BLVRB)

HHV:	120240932(BLVRB)

BTA:	281650(BLVRB)

BOM:	102277747(BLVRB)

BIU:	109572681(BLVRB)

BBUB:

102402107(BLVRB)

BBIS:

104995362(BLVRB)

CHX:	102187796(BLVRB)

OAS:	101119750(BLVRB)

ODA:	120872449(BLVRB)

CCAD:

122420884(BLVRB) 122443458

SSC:	100625219(BLVRB)

CFR:	102522968(BLVRB)

CBAI:

105062862(BLVRB)

CDK:	105093394(BLVRB)

VPC:	102543677(BLVRB)

BACU:

103014515(BLVRB)

LVE:	103082225(BLVRB)

OOR:	101269881(BLVRB)

DLE:	111180848(BLVRB)

PCAD:

102992855(BLVRB)

PSIU:

116743687(BLVRB)

ECB:	100068145(BLVRB)

EPZ:	103560493(BLVRB)

EAI:	106843297(BLVRB)

MYB:	102251416(BLVRB)

MYD:	102759928(BLVRB)

MMYO:

118674559(BLVRB)

MLF:	102432652(BLVRB)

MNA:	107534172(BLVRB)

PKL:	118702235(BLVRB)

HAI:	109374869(BLVRB)

DRO:	112320111(BLVRB)

SHON:

118988083(BLVRB)

AJM:	119040590(BLVRB)

PDIC:

114511105(BLVRB)

PHAS:

123823786(BLVRB)

MMF:	118639318(BLVRB)

RFQ:	117035103(BLVRB)

PALE:

102879551(BLVRB)

PGIG:

120595620(BLVRB)

PVP:	105300209(BLVRB)

RAY:	107521823(BLVRB)

MJV:	108404844(BLVRB)

TOD:	119249327(BLVRB)

SARA:

101557111(BLVRB)

LAV:	100665167(BLVRB)

TMU:

101354315

ETF:	101645971(BLVRB)

DNM:	101437673(BLVRB)

MDO:	100017892(BLVRB)

GAS:	123255652(BLVRB)

SHR:	100930351(BLVRB)

AFZ:

127556203

PCW:	110202810(BLVRB)

OAA:	100073853(BLVRB)

MGP:	100303679(BLVRB)

APLA:

113841036(BLVRB)

PHI:	102113532(BLVRB)

CCAE:

111943368(BLVRB)

ACHC:

115337712

HALD:

104321959(BLVRB)

AGEN:

126036625 126037224

SHAB:

115603330(BLVRB)

AAM:	106493723(BLVRB)

AROW:

112960997(BLVRB)

NPD:	112955489(BLVRB)

TGT:	104572768(BLVRB)

DNE:	112996331(BLVRB)

ASN:	102387963(BLVRB)

AMJ:	102574563(BLVRB)

CMY:	114022374(BLVRB)

CPIC:

101948417(BLVRB)

TST:	117888630(BLVRB)

CABI:

116833857(BLVRB)

MRV:	120388171(BLVRB)

ACS:	100564796(blvrb)

PVT:	110075662(BLVRB)

SUND:

121916153(BLVRB)

PBI:	103053858(BLVRB)

PMUR:

107285666(BLVRB)

CTIG:

120316372(BLVRB)

TSR:	106541075(BLVRB)

PGUT:

117677851(BLVRB)

VKO:	123021032(BLVRB)

PMUA:

114603071(BLVRB)

ZVI:	118078075 118086651(BLVRB)

GJA:	107107369(BLVRB)

STOW:

125430722(BLVRB)

XLA:	443881(blvrb.L)

XTR:	100124834(blvrb) 116406791

NPR:	108791950(BLVRB)

RTEM:

120913299(BLVRB)

BBUF:

120977966(BLVRB)

BGAR:

122923946(BLVRB)

DRE:	436959(blvrb)

SRX:	107717620(blvrb)

SANH:

107670601 107692505

SGH:	107602119(blvrb)

CCAR:

109109302 109109306

CAUA:

113061728 113082608 113118645

CGIB:

127934336 127977858

PPRM:

120460021 120460038

MAMB:

125254500(blvrb)

CIDE:

127499299

MASI:

127455779

IPU:	108264654 124626957

PHYP:

113526426(blvrb)

SMEO:

124396010(blvrb)

TFD:	113638812(blvrb)

AMEX:

103040962(blvrb)

EEE:	113580124(blvrb)

TRU:	101061122(blvrb)

TNG:	GSTEN00035152G001

LCO:	104927805(blvrb)

NCC:	104965039(blvrb)

CGOB:

115018241(blvrb)

ELY:	117259444(blvrb)

EFO:	125888677(blvrb)

PLEP:

121943190(blvrb)

SLUC:

116053283(blvrb)

ECRA:

117942519(blvrb)

ESP:	116687001(blvrb)

PFLV:

114552606(blvrb)

GAT:	120829425(blvrb)

PPUG:

119222042(blvrb)

MSAM:

119882831(blvrb)

CUD:	121526977(blvrb)

ALAT:

119033096(blvrb)

MZE:	101484658(blvrb)

ONL:	100702669(blvrb)

OAU:	116320348(blvrb)

OLA:	101163919(blvrb)

OML:	112149783(blvrb)

XMA:	102228591(blvrb)

XCO:	114133538(blvrb)

XHE:	116707592 116707593

PRET:

103475161(blvrb)

PFOR:

103138303(blvrb)

PLAI:

106947919(blvrb)

PMEI:

106921476(blvrb)

GAF:	122832913(blvrb)

CVG:	107094869(blvrb)

CTUL:

119796633(blvrb)

GMU:	124883659(blvrb)

NFU:	107379787(blvrb)

KMR:	108247879(blvrb)

ALIM:

106522783(blvrb)

NWH:	119411413(blvrb)

AOCE:

111586211(blvrb)

MCEP:

125012958(blvrb)

CSEM:

103377891(blvrb)

POV:	109630121(blvrb)

SSEN:

122773296(blvrb)

HHIP:

117773323(blvrb)

HSP:	118105862(blvrb)

LCF:

108876241

SDU:	111216890(blvrb)

SLAL:

111662215(blvrb)

XGL:	120792571(blvrb)

HCQ:	109529422(blvrb)

SSCV:

125972512

BPEC:

110172712(blvrb)

MALB:

109963258(blvrb)

BSPL:

114867627(blvrb)

SASA:

106580739(blvrb) 106612705(BLVRB)

STRU:

115163034(blvrb) 115205994

OTW:	112265119 112266772

OMY:	110503591 110507468

OGO:	123993025 124005618

ONE:	115137042 115141548

SALP:

111982788 111982809

SNH:	120018812 120028367

CCLU:

121562566 121568255

ELS:	105023068(blvrb)

SFM:	108928749(blvrb)

PKI:	111844029(blvrb)

AANG:

118209415(blvrb)

LOC:	102698532(blvrb)

PSPA:

121303818 121304996(blvrb)

ARUT:

117397815 117415212

PSEX:

120538736(blvrb)

LCM:	102358034(BLVRB)

CMK:	103173572(blvrb)

RTP:	109926910(blvrb)

BFO:	118410084 118414353 118424422

CIN:

100185152

SCLV:

120347803 120347819 120347831 120347846 120347854 120347866

SPU:	100889296 576533 578603

APLC:

110978883 110978939

SKO:

100374763

DER:

6552273

DSI:	Dsimw501_GD20759(Dsim_GD20759)

DYA:	Dyak_GE24730

DSR:

110188190

DPO:

4801507

DPE:

6588134

DMN:

108156553

DWI:

6647397

DMO:	Dmoj_GI24882

DAZ:

108618551

DNV:

108659243

DHE:

111602756

DVI:

6630042

MDE:

101892800

LCQ:

111676095

AGA:	AgaP_AGAP001321

ACOZ:

120949584

AAG:

5565330

AALB:

109405306 109406365 115258289

CQU:	CpipJ_CPIJ011826

CPII:

120431012

AME:

412445

ACER:

107994237

ALAB:

122714807

BIM:

100749252

BBIF:

117205099

BVK:

117231092

BVAN:

117157637

BTER:

100646178

BPYO:

122567783

CCAL:

108630984

OBB:

114877540

MGEN:

117219339

NMEA:

116423944

SOC:	105203387 105203429 105203443 105203453 105204185 113003480

MPHA:

105830426

AEC:

105144797

ACEP:

105624072

PBAR:

105426660

VEM:

105557622

HST:

105187135

DQU:

106744067

CFO:

105252649

FEX:

115234327

LHU:

105674651

PGC:

109861802

OBO:

105281931

PCF:

106793889

PFUC:

122526549

VPS:

122634421

NVI:

100113525

CSOL:

105360908

MDL:	103574018 103575546

TCA:

664311

DPA:

109534878

ATD:

109595167

NVL:

108556546

BMOR:

101736226

BMAN:

114248437

DPL:	KGM_212873

BANY:

112054677

NIQ:

126775902

PMAC:

106708927

PPOT:

106101151

PXU:

106120319

PRAP:

111001233

PBX:

123718550

PNAP:

125054450

ZCE:

119828598

CCRC:

123699980

HAW:

110382146

HZE:

124640134

TNL:

113504959

SLIU:

111350206

OFU:

114353154

PXY:

105393340

API:	100168586(Blvrb) 100574136

DNX:

107162985

AGS:

114130365

RMD:

113557849

BTAB:

109043576

NLU:

111052374

PHU:	Phum_PHUM514080

ZNE:

110828593

CSEC:

111868350

DPX:	DAPPUDRAFT_230602

DMK:

116929398

DPZ:

124311410

PVM:

113830326

PMOO:

119585705

HAZT:

108664641

ISC:	IscW_ISCW003581

DSV:

119458384

RSAN:

119373566

RMP:

119167602

TUT:	107359695 107367634

CSCU:

111640897

PTEP:

107444427

SDM:

118193070

LGI:	LOTGIDRAFT_113739 LOTGIDRAFT_145414

PCAN:

112555334 112555727

HRJ:

124291888

MYI:	110441547 110448057 110462494

LAK:	106151286 106161246 106163455 106163456 106163458

NVE:

5503663

EPA:	110232712 110232713

ADF:

107351009

AMIL:

114961956

PDAM:

113669019 113669042 113678890 113678891

SPIS:

111322492 111322494 111325275 111325299

GTT:	GUITHDRAFT_77488

NGR:	NAEGRDRAFT_69441 NAEGRDRAFT_71868(FM182)

» show all

Reference

1 [PMID:3453680]

Authors

Yubisui T, Tamura M, Takeshita M.

Title

Characterization of a second form of NADPH-flavin reductase purified from human erythrocytes.

Journal

Biochem Int 15:1-8 (1987)

Reference

2 [PMID:10620517]

Authors

Cunningham O, Gore MG, Mantle TJ

Title

Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B).

Journal

Biochem J 345 Pt 2:393-9 (2000)
DOI:10.1042/bj3450393

Sequence

[hsa:645]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.30

IUBMB Enzyme Nomenclature:

1.5.1.30

ExPASy - ENZYME nomenclature database:

1.5.1.30

BRENDA, the Enzyme Database:

1.5.1.30

CAS:	56626-29-0

DBGET integrated database retrieval system