KEGG   ENZYME: 1.5.1.33
Entry
EC 1.5.1.33                 Enzyme                                 

Name
pteridine reductase;
PTR1;
pteridine reductase 1
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase
Reaction(IUBMB)
5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 NADPH + 2 H+ [RN:R01812]
Reaction(KEGG)
R01812;
(other) R11765 R12644
Substrate
5,6,7,8-tetrahydrobiopterin [CPD:C00272];
NADP+ [CPD:C00006]
Product
biopterin [CPD:C06313];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from Leishmania (both amastigote and promastigote forms) catalyses the reduction by NADPH of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms. It also catalyses the reduction of 7,8-dihydropterins and 7,8-dihydrofolate to their tetrahydro forms. In contrast to EC 1.5.1.3 (dihydrofolate reductase) and EC 1.5.1.34 (6,7-dihydropteridine reductase), pteridine reductase will not catalyse the reduction of the quinonoid form of dihydrobiopterin. The enzyme is specific for NADPH; no activity has been detected with NADH. It also differs from EC 1.5.1.3 (dihydrofolate reductase) in being specific for the Si-face of NADPH.
History
EC 1.5.1.33 created 1999 as EC 1.1.1.253, transferred 2003 to EC 1.5.1.33
Pathway
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K03793  pteridine reductase
Genes
PVM: 113812901 113816341
EPA: 110237103
TBR: Tb927.8.2210
LMA: LMJF_23_0270(PTR1)
LIF: LINJ_23_0310(PTR1)
LDO: LDBPK_230310
LMI: LMXM_23_0270
LBZ: LBRM_23_0300(PTR1)
LPAN: LPMP_230300(PTR1)
PLU: plu2798
XFA: XF_1457
XFT: PD_0677(ptr1)
XCC: XCC3431(ptr1)
XCB: XC_0733
XCA: xcc-b100_0765(fabG1)
XCP: XCR_3772
XCV: XCV0748
XAX: XACM_0692(ptr1)
XAC: XAC0688(ptr1)
XCI: XCAW_03893(fabG)
XOM: XOO3709(XOO3709)
XOO: XOO3932(ptr1)
XOP: PXO_04308
XOR: XOC_0747
XAL: XALC_0833
XPH: XppCFBP6546_08140(XppCFBP6546P_08140)
SML: Smlt4030
SMT: Smal_3430
SMZ: SMD_3621
SINC: DAIF1_35510(ycdF)
PSUW: WQ53_06825
PSD: DSC_00315
LEZ: GLE_3011
LEM: LEN_2023
DKO: I596_2416
RBD: ALSL_2650
PAR: Psyc_1369
PALI: A3K91_1557
PSYA: AOT82_624
MCT: MCR_0453
MCS: DR90_1454
MCAT: MC25239_00469(ycdF)
MCUN: NCTC10297_00961(fabG_2)
SAZ: Sama_1764
SLO: Shew_2034
SPL: Spea_2265
SHL: Shal_2019
SWP: swp_2460
SVO: SVI_2305
SPSW: Sps_01082
SKH: STH12_01447(ycdF)
CPS: CPS_2677
PAT: Patl_2501
MAQ: Maqu_3161
MHC: MARHY3101
MAD: HP15_2995
AMAL: I607_07410
AMAE: I876_07680
AMAO: I634_07800
AMAD: I636_08215
AMAI: I635_08145
AMAG: I533_07675
AMAC: MASE_07300
AAUS: EP12_08200
GPS: C427_2441
SALH: HMF8227_01346(ptr1)
FBL: Fbal_1844
CJA: CJA_0772
SDE: Sde_0726
MICC: AUP74_01286(fabG_2)
MICT: FIU95_01950(fabG1)
ALG: AQULUS_18510(fabG_3)
ASIP: AQUSIP_20820(fabG_3)
LPN: lpg2863
LPH: LPV_3220(phaB)
LPO: LPO_3167(phaB)
LPM: LP6_2892
LPF: lpl2775
LPP: lpp2921
LPC: LPC_3148(phaB)
LPA: lpa_04163
LPE: lp12_2852
LLO: LLO_0172(phaB)
LFA: LFA_3594
LHA: LHA_0209
LOK: Loa_02936
LCD: clem_14155(fabG_5)
LLG: 44548918_00092(fabG_1)
LJR: NCTC11533_00087(phaB)
LCJ: NCTC11976_00798(phaB_2)
LWA: SAMEA4504053_3391(fabG_11)
LSS: NCTC12082_01923(fabG_7)
TMC: LMI_0151
MCA: MCA2986
METL: U737_21865
MMAI: sS8_4691
CYQ: Q91_0095
TIG: THII_0394
TEE: Tel_14965
THIP: N838_01580
TGR: Tgr7_0328
TKM: TK90_0152
TVR: TVD_12885
ABO: ABO_2053
ADI: B5T_00970
APAC: S7S_14975
AXE: P40_04625
OCE: GU3_10140
SLIM: SCL_0170
SVA: SVA_0160
TBN: TBH_C2057
RMA: Rmag_0437
VOK: COSY_0407
ENM: EBS_0539
CVI: CV_4132
CHAE: CH06BL_04690(ptr1)
LHK: LHK_00282
PSE: NH8B_0410
AMAH: DLM_4442
BMAL: DM55_3656
BMAE: DM78_4531
BMAQ: DM76_4352
BMAI: DM57_05220
BMAF: DM51_3818
BMAZ: BM44_3615
BMAB: BM45_4393
BPSE: BDL_5871
BPSM: BBQ_3705
BPSU: BBN_5895
BPSD: BBX_5040
BPK: BBK_5178
BPSH: DR55_5332
BPSA: BBU_3593
BPSO: X996_5102
BUT: X994_4652
BTQ: BTQ_3331
BTJ: BTJ_4363
BTZ: BTL_5163
BTD: BTI_4713
BTV: BTHA_5053
BTHE: BTN_4825
BTHM: BTRA_5093
BTHA: DR62_4928
BTHL: BG87_5160
BOK: DM82_3915
BOC: BG90_4113
BVE: AK36_4959
BCN: Bcen_5117
BCJ: BCAM0054
BCEN: DM39_4946
BCEO: I35_4054
BAM: Bamb_5013
BMU: Bmul_5292
BMK: DM80_4504
BMUL: NP80_3445
BCON: NL30_25210
BUB: BW23_4076
BPSL: WS57_12670
BGU: KS03_3580
BUL: BW21_4242
NEU: NE1165
NET: Neut_1504
TBD: Tbd_2701
MFA: Mfla_0229
MMB: Mmol_0291
MEH: M301_0284
MEP: MPQ_0259(fabG)
SLT: Slit_0168
GCA: Galf_0191
NIM: W01_16360(ptr1)
FKU: FGKAn22_02000(ptr1)
SPLB: SFPGR_31800(ptr1)
SLAC: SKTS_02040(ptr1)
URU: DSM104443_03566(gdh_2)
UPL: DSM104440_03089(gdh_2)
EBA: ebA3368
ABRE: pbN1_15950
APET: ToN1_22490
DSU: Dsui_0694
AZO: azo0486
AOA: dqs_0497
AZA: AZKH_4339
TCL: Tchl_1517
FPHO: SHINM1_020640(ptr1)
ADE: Adeh_3477
MXA: MXAN_6879
CCX: COCOR_07451(fabG13)
SCL: sce8666
AMF: AMF_041(ptr1)
ECH: ECH_0195
ECHA: ECHHL_0881
ECHP: ECHWP_0876
EHH: EHF_0867
SFLA: SPHFLASMR4Y_03055(fabG)
BLAS: BSY18_534
MGM: Mmc1_1660
AFR: AFE_0129
ACU: Atc_2772
RCA: Rcas_3869
HAU: Haur_2919
PUV: PUV_20540
RBA: RB10272
PSL: Psta_1052
PIR: VN12_23180(fabG_8)
RUL: UC8_18150(ycdF_2)
AHEL: Q31a_22170(fabG_3)
LCRE: Pla8534_24810(fabG_2)
AAGG: ETAA8_15230(ydaD_2)
BVO: Pan97_34650(ycdF_2)
TTF: THTE_1784
PLM: Plim_1577
PEH: Spb1_23850(novJ)
PLH: VT85_14980(fabG_2)
SDYN: Mal52_42330(fabG_9)
GES: VT84_02760(lvr_1) VT84_23615(ycdF_2)
FTJ: FTUN_5714
ULI: ETAA1_44840(fabG_7)
IPA: Isop_0230
SACI: Sinac_5624
PBOR: BSF38_03993(fabG_6)
PBU: L21SP3_02191(fabG_2)
PBP: STSP1_00957(fabG_2)
ACA: ACP_0727
ABAS: ACPOL_1055
GAU: GAU_1989
GBA: J421_3591
DORI: FH5T_08695
MBAS: ALGA_3591
CJG: NCTC13459_01261(folM)
CANT: NCTC13489_01277(folM)
CCH: Cag_0259
CLI: Clim_0368
PVI: Cvib_1495
PAA: Paes_0424
PROC: Ptc2401_00442(fabG_2)
CTS: Ctha_1818
TAL: Thal_0290
CABY: Cabys_722
MOX: DAMO_0882
CMA: Cmaq_0518
 » show all
Reference
1  [PMID:9153248]
  Authors
Nare B, Hardy LW, Beverley SM
  Title
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major.
  Journal
J Biol Chem 272:13883-91 (1997)
DOI:10.1074/jbc.272.21.13883
  Sequence
Reference
2  [PMID:11373620]
  Authors
Gourley DG, Schuttelkopf AW, Leonard GA, Luba J, Hardy LW, Beverley SM, Hunter WN.
  Title
Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites.
  Journal
Nat Struct Biol 8:521-5 (2001)
DOI:10.1038/88584
  Sequence
Reference
3  [PMID:10800597]
  Authors
Fitzpatrick PF.
  Title
The aromatic amino acid hydroxylases.
  Journal
Adv Enzymol Relat Areas Mol Biol 74:235-94 (2000)
DOI:10.1002/9780470123201.ch6
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.33
IUBMB Enzyme Nomenclature: 1.5.1.33
ExPASy - ENZYME nomenclature database: 1.5.1.33
BRENDA, the Enzyme Database: 1.5.1.33
CAS: 131384-61-7

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