KEGG   ENZYME: 1.5.1.33
Entry
EC 1.5.1.33                 Enzyme                                 
Name
pteridine reductase;
PTR1;
pteridine reductase 1
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase
Reaction(IUBMB)
5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 NADPH + 2 H+ [RN:R01812]
Reaction(KEGG)
R01812;
(other) R11765 R12644
Substrate
5,6,7,8-tetrahydrobiopterin [CPD:C00272];
NADP+ [CPD:C00006]
Product
biopterin [CPD:C06313];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from Leishmania (both amastigote and promastigote forms) catalyses the reduction by NADPH of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms. It also catalyses the reduction of 7,8-dihydropterins and 7,8-dihydrofolate to their tetrahydro forms. In contrast to EC 1.5.1.3 (dihydrofolate reductase) and EC 1.5.1.34 (6,7-dihydropteridine reductase), pteridine reductase will not catalyse the reduction of the quinonoid form of dihydrobiopterin. The enzyme is specific for NADPH; no activity has been detected with NADH. It also differs from EC 1.5.1.3 (dihydrofolate reductase) in being specific for the Si-face of NADPH.
History
EC 1.5.1.33 created 1999 as EC 1.1.1.253, transferred 2003 to EC 1.5.1.33
Pathway
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K03793  pteridine reductase
Genes
BBEL109484195
PVM113812901 113816341
PJA122255683
HAME121868146
PTRU123498688 123500407
EPA110237103
TBRTb927.8.2210
LMALMJF_23_0270(PTR1)
LIFLINJ_23_0310(PTR1)
LDOLDBPK_230310
LMILMXM_23_0270
LBZLBRM_23_0300(PTR1)
LPANLPMP_230300(PTR1)
PLUplu2798
PLUMA4R40_13950
PAKHB0X70_14265
PLUICE143_14260
XFAXF_1457
XFTPD_0677(ptr1)
XFMXfasm12_0800
XFNXfasM23_0711
XFFXFLM_08970
XFLP303_03310
XFSD934_04920
XFHXFHB_04160
XCCXCC3431(ptr1)
XCBXC_0733
XCAxcc-b100_0765(fabG1)
XCPXCR_3772
XCVXCV0748
XAXXACM_0692(ptr1)
XACXAC0688(ptr1)
XCIXCAW_03893(fabG)
XCTJ151_00808
XCJJ158_00805
XCUJ159_00805
XCNJ169_00804
XCWJ162_00804
XCRJ163_00804
XCMJ164_00804
XCFJ172_00799
XFUXFF4834R_chr06960
XAOXAC29_03495
XOMXOO3709(XOO3709)
XOOXOO3932(ptr1)
XOPPXO_04308
XOYAZ54_04225
XORXOC_0747
XOZBE73_20640
XALXALC_0833
XSASB85_16855
XTNFD63_15800
XFRBER92_02905
XVEBJD12_16285
XPEBJD13_13260
XHRXJ27_19550
XGABI317_20040
XPHXppCFBP6546_08140(XppCFBP6546P_08140)
XVAC7V42_03745
XANAC801_03455
XARXB05_20345
XHYFZ025_12325
XCZEBN15_15960
XTHG4Q83_19325
XEUXSP_000710
XHDLMG31886_08040(ycdF_2)
SMLSmlt4030
SMTSmal_3430
BUJBurJV3_3473
SMZSMD_3621
SACZAOT14_07080
STEKAXG53_06040
SRHBAY15_3183
SLMBIZ42_06735
STENCCR98_17815
STEMCLM74_18040
STESMG068_17765
SINCDAIF1_35510(ycdF)
SPAQSTNY_R36430
PSUPsesu_0202
PSUWWQ53_06825
PSDDSC_00315
PMEXH4W19_14145
PJPLAG73_18925
PDDMNQ95_05360
LABLA76x_2232
LAQGLA29479_1602
LCPLC55x_2229
LGULG3211_3018
LEZGLE_3011
LEMLEN_2023
LMBC9I47_3026
LYTDWG18_12070
LUEDCD74_09240
LYJFKV23_01220
LSOLGOY17_17625
LSXH8B22_06240
LAREHIV01_015290
LHXLYSHEL_14390(ptr1)
LCASLYSCAS_14390(ptr1)
LCICINQ41_11730
LUMCNR27_03570
LUSE5843_01530
LUGFPZ22_06415
THESFHQ07_09720
THEHG7079_02420
XBCELE36_18430
FAUFraau_2722
RHDR2APBS1_0232
RGLCS053_02805
RTHLRK53_01100
DJICH75_17880
DJAHY57_05160
DTXATSB10_25540
DYEEO087_14035
DCSISN74_01380
DTLH8F01_11960
DKOI596_2416
LRZBJI69_09340
LPYFIV34_18865
XBAC7S18_01860
RBDALSL_2650
MAQMaqu_3161
MHCMARHY3101
MADHP15_2995
MSRAU15_11695
MARIACP86_05365
MLQASQ50_07220
MSQBKP64_18765
MARAD0851_08975
PARPsyc_1369
PCRPcryo_0995
PSOPSYCG_05220
PURAOC03_11725
PALIA3K91_1557
PSPGAK823_05590
PSYGAK825_05660
PSYCDABAL43B_1187
PSYAAOT82_624
PSYPE5677_05600
MCTMCR_0453
MCSDR90_1454
MCATMC25239_00469(ycdF)
MOIMOVS_07560
MOSAXE82_02770
MBLAAX09_02355
MBOIDQF64_10765
MCUNNCTC10297_00961(fabG_2)
MNNI6G26_09465
SAZSama_1764
SLOShew_2034
SPLSpea_2265
SHLShal_2019
SWPswp_2460
SVOSVI_2305
SPSWSps_01082
SMAVCFF01_09165
SBKSHEWBE_2628
SKHSTH12_01447(ycdF)
SLITJQC75_08810
SPSHFM037_14980
SEURFM038_011725
SCYPJYB88_08850
SSEMJYB85_09035
CPSCPS_2677
COMCMT41_08790
PATPatl_2501
PTUPTUN_a0497
PSAZPA25_22780(ptr1)
PSYMJ1N51_02125
AMCMADE_1008070
AMHI633_08270
AMAAamad1_08155
AMALI607_07410
AMAEI876_07680
AMAOI634_07800
AMADI636_08215
AMAII635_08145
AMAGI533_07675
AMACMASE_07300
AMBAMBAS45_07820
AMGAMEC673_07350
AMKAMBLS11_07300
ALTambt_10705
AALEP13_08025
AAUSEP12_08200
ASPAOR13_1975
ASQAVL57_08600
AAWAVL56_07495
ALEAV939_07615
ALZAV940_07445
APELCA267_001310
SALMD0Y50_07360
SALKFBQ74_10315
SMAAIT774_10005
GAGGlaag_2553
GPSC427_2441
PMESFX988_00857
LALAT746_09125
CATEC2869_13215
SALHHMF8227_01346(ptr1)
FBLFbal_1844
FESHER31_06365
CJACJA_0772
CEBB0D95_19530
CELLCBR65_18945
CEKD0B88_19070
CEGD0C16_12225
SDESde_0726
TTUTERTU_3155
MARQMARGE09_P1384
ZALAZF00_17215
OSGBST96_09275
MTHDA3224_01990
MICCAUP74_01286(fabG_2)
MAGAMag101_02035
MIIBTJ40_02250
MICTFIU95_01950(fabG1)
MHYDGTQ55_16140
MCELLPW13_17770
MICZGL2_09440(ptr1)
RVIRVIR1_06010
ALGAQULUS_18510(fabG_3)
ASIPAQUSIP_20820(fabG_3)
LPNlpg2863
LPHLPV_3220(phaB)
LPOLPO_3167(phaB)
LPULPE509_00163
LPMLP6_2892
LPFlpl2775
LPPlpp2921
LPCLPC_3148(phaB)
LPAlpa_04163
LPElp12_2852
LLOLLO_0172(phaB)
LFALFA_3594
LHALHA_0209
LOKLoa_02936
LCDclem_14155(fabG_5)
LSHCAB17_04885
LLG44548918_00092(fabG_1)
LIBE4T55_06260
LGTE4T54_06425
LJRNCTC11533_00087(phaB)
LCJNCTC11976_00798(phaB_2)
LWASAMEA4504053_3391(fabG_11)
LSSNCTC12082_01923(fabG_7)
LANTTUM19329_33860
TMCLMI_0151
MCAMCA2986
METUGNH96_03220
MMTMetme_0749
MDNJT25_012965
MDHAYM39_02775
MKOMKLM6_0597
METLU737_21865
MPADKEF85_14100
MELLIVG45_20220
MAHMEALZ_0083
MBUREQU24_00475
MMAIsS8_4691
MEINmethR_P3361
MOZMoryE10_31930(ptr1)
MESLKKZ03_01850
CYQQ91_0095
CZACYCME_0095
CYYCPC19_01040
TIGTHII_0394
BLEPAL038_17615
THISHZT40_01785
TUNJ9260_14235
TLOJ9253_18905
TSBHMY34_14530
TANIJ8380_02050
TMBThimo_0562
TEETel_14965
RHHE0Z06_08995
THIPN838_01580
EBSECTOBSL9_0362
TGRTgr7_0328
TKMTK90_0152
TNITVNIR_0185
TTITHITH_16555
TVRTVD_12885
WMAWM2015_2591
WOCBA177_14515
HCSFF32_05190
HAKKO116_00346
HHHCLM76_06620
HALKCUU95_06980
HVNEI420_19320
HOLHORIV_68250
HSRHSBAA_62630
HTTHZS52_06165
ABOABO_2053
ADIB5T_00970
APACS7S_14975
ALNAS19_21170
AXEP40_04625
KAKKalk_16825
MGEOCFI10_03065
MSECLN244_13575
BMARHF888_02235
AJPAMJAP_0641
GSNYC6258_02249
OMEOLMES_1627
OCEGU3_10140
OCMCBP12_03290
OPFCBP31_00175
ZDFAN401_09340
SDFACG33_01140
SOKD0B54_22905
SINIGT972_11245
FCEJN531_007270
SLIMSCL_0170
SVASVA_0160
ACIIC4901_15825
ATYA9R16_014265
TBNTBH_C2057
SEDSAAY24_15445
TSNW908_03520
THINCRN91_06750
THOSP60_00555
PSPIPS2015_2738
REVHUE57_00680
RMARmag_0437
REOHUE58_01765
VOKCOSY_0407
EBHBSEPE_0556
BTHGMS2017_0857
ENMEBS_0539
IFOCVFO_0262
APHFCVPH_0407
CVICV_4132
CVCBKX93_16790
CHROCXB49_18600
CHRIDK842_10850
CHRBDK843_16285
CRZD1345_02445
CHRMFYK34_19585
CHAECH06BL_04690(ptr1)
IODEJO50_15370
IFLC1H71_10450
LHKLHK_00282
PSENH8B_0410
JEUBJP62_09065
AQLBXU06_11620
AMAHDLM_4442
AQSDKK66_05325
CFONHZU75_05770
VOGLCH97_14380
BMVBMASAVP1_1195
BMNBMA10247_A0052
BMALDM55_3656
BMAEDM78_4531
BMAQDM76_4352
BMAIDM57_05220
BMAFDM51_3818
BMAZBM44_3615
BMABBM45_4393
BPMBURPS1710b_A1548
BPLBURPS1106A_A0050
BPDBURPS668_A0063
BPSEBDL_5871
BPSMBBQ_3705
BPSUBBN_5895
BPSDBBX_5040
BPZBP1026B_II0040
BPQBPC006_II0051
BPKBBK_5178
BPSHDR55_5332
BPSABBU_3593
BPSOX996_5102
BUTX994_4652
BTEBTH_II0042
BTQBTQ_3331
BTJBTJ_4363
BTZBTL_5163
BTDBTI_4713
BTVBTHA_5053
BTHEBTN_4825
BTHMBTRA_5093
BTHADR62_4928
BTHLBG87_5160
BOKDM82_3915
BOCBG90_4113
BUUWS70_17880
BSAVWS86_30710
BVIBcep1808_3747
BVEAK36_4959
BCNBcen_5117
BCHBcen2424_5742
BCMBcenmc03_4481
BCJBCAM0054
BCENDM39_4946
BCEOI35_4054
BAMBamb_5013
BMJBMULJ_03229
BMUBmul_5292
BMKDM80_4504
BMULNP80_3445
BPYRABD05_21135
BCONNL30_25210
BUBBW23_4076
BPSLWS57_12670
BSTLBBJ41_28250
BGLbglu_2g00580
BGUKS03_3580
BULBW21_4242
BGPBGL_2c00750
BPLAbpln_2g00760
BUDAQ610_19700
CARIFNU76_09630
PBHAAW51_1653
JABVN23_19545
NEUNE1165
NETNeut_1504
NITNAL212_0819
NIINit79A3_1051
NCOAAW31_03745
NURATY38_07385
NSTNstercoris_01637
NMUNmul_A0336
NLCEBAPG3_003770
SHDSUTH_00188
METRBSY238_1608
DOEDENOEST_3780
TBDTbd_2701
MFAMfla_0229
MMBMmol_0291
MEHM301_0284
MEIMsip34_0246
MEPMPQ_0259(fabG)
MBACBN1209_0181
MBATBN1208_0162
MEUACJ67_02315
MPAUZMTM_02240(ptr1)
SLTSlit_0168
GCAGalf_0191
FAMOYT1_ch2728
NIMW01_16360(ptr1)
FKUFGKAn22_02000(ptr1)
SEMEMIZ01_0132
SDRSCD_n00413
SULFCAP31_02230
SPLBSFPGR_31800(ptr1)
SNIVSFSGTM_26400
SLACSKTS_02040(ptr1)
URUDSM104443_03566(gdh_2)
UPLDSM104440_03089(gdh_2)
DSUDsui_0694
ARESIWH25_02850
AIQAzoinq_07485
RBUPG1C_14070
OTROTERR_30750
NIVJY500_21070
EBAebA3368
ABREpbN1_15950
APETToN1_22490
ATWC0099_13885
RBHB4966_00170
AZOazo0486
AOAdqs_0497
AZAAZKH_4339
AZIAzCIB_4275
ACOMCEW83_20100
AZDCDA09_20915
AZRCJ010_03300
TMZTmz1t_0696
THUAC731_016565
TCLTchl_1517
THKCCZ27_16930
TAKTharo_2983
AZQG3580_01980
ZPAC3497_14580
FPHOSHINM1_020640(ptr1)
FMYHO273_13075
APPCAP2UW1_0269
DDZDSYM_30160
BEBAEM42_13735
BEBABWI17_09205
ADEAdeh_3477
ACPA2cp1_3629
AFWAnae109_3588
ANKAnaeK_3561
MXAMXAN_6879
MYMA176_007677
MFBMFUL124B02_39665
CCXCOCOR_07451(fabG13)
MFULILAB_12085
MMASMYMAC_006572
SURSTAUR_0985
AGEAA314_05485
AVMJQX13_36950 JQX13_40850
MBDMEBOL_001994
CFUSCYFUS_008750
SCLsce8666
SCUSCE1572_49760
CCROCMC5_021140 CMC5_048810
PAUUE8A73_031060 E8A73_034845
SAMYDB32_003183
LLUAKJ09_09769
MRMA7982_02841 A7982_08527
AMFAMF_041(ptr1)
AMWU370_00225
AMPU128_00205
ECHECH_0195
ECHAECHHL_0881
ECHJECHJAX_0898
ECHLECHLIB_0901
ECHSECHOSC_0896
ECHVECHSTV_0887
ECHWECHWAK_0897
ECHPECHWP_0876
EMREMUR_00635
EHHEHF_0867
MGMMmc1_1660
AFRAFE_0129
AFELferr_0300
ACUAtc_2772
ACZAcaty_c2618
AFIAcife_0030
ATXGCD22_03579
AFPK1Y48_04655
SYPSYNPCC7002_A0308
LEPLepto7376_1117
RRSRoseRS_0542
RCARcas_3869
HAUHaur_2919
ABAOBEQ56_10065
CAPCLDAP_39610
THUGKNN16_02245
PUVPUV_20540
RBARB10272
PSLPsta_1052
PIRVN12_23180(fabG_8)
RULUC8_18150(ycdF_2)
RMLFF011L_52380(ycdF_3)
AHELQ31a_22170(fabG_3)
LCREPla8534_24810(fabG_2)
AAGGETAA8_15230(ydaD_2)
BVOPan97_34650(ycdF_2)
RLCK227x_54200(gdhB_1)
TTFTHTE_1784
PLMPlim_1577
PEHSpb1_23850(novJ)
PBSPlabr_1428
PLHVT85_14980(fabG_2)
SDYNMal52_42330(fabG_9)
GESVT84_02760(lvr_1) VT84_23615(ycdF_2)
GOGC1280_02740
GMSSOIL9_48040 SOIL9_83010
TIMGMBLW1_13940
LRSPX52LOC_07301
FTJFTUN_5714
ULIETAA1_44840(fabG_7)
TSPHKIH39_22205
IPAIsop_0230
SACISinac_5624
PBORBSF38_03993(fabG_6)
PBUL21SP3_02191(fabG_2)
PBPSTSP1_00957(fabG_2)
HBSIPV69_00735
SBUSpiBuddy_0801
SGPSpiGrapes_1207
ACAACP_0727
ACMAciX9_1328
TSAAciPR4_2192
TRSTerro_2660
TALBFTW19_18030
ABASACPOL_1055
EDAGWR55_05495
PFERIRI77_32730
GAUGAU_1989
GPHGEMMAAP_10335
GGRHKW67_04375
GBAJ421_3591
DORIFH5T_08695
DRCG0Q07_00700
MCOSGM418_07900
ASXCDL62_00795
MBASALGA_3591
CJGNCTC13459_01261(folM)
CCASEIB73_06225
CANTNCTC13489_01277(folM)
CLZBIU88_02135
CCHCag_0259
CPBCphamn1_0460
CLIClim_0368
PVICvib_1495
PAAPaes_0424
PROCPtc2401_00442(fabG_2)
PRSB9H02_02015
CTSCtha_1818
TALThal_0290
TRDTHERU_07630
PMXPERMA_0966
CABYCabys_722
NLIG3M70_08565
MOXDAMO_0882
CMACmaq_0518
 » show all
Reference
1  [PMID:9153248]
  Authors
Nare B, Hardy LW, Beverley SM
  Title
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major.
  Journal
J Biol Chem 272:13883-91 (1997)
DOI:10.1074/jbc.272.21.13883
  Sequence
Reference
2  [PMID:11373620]
  Authors
Gourley DG, Schuttelkopf AW, Leonard GA, Luba J, Hardy LW, Beverley SM, Hunter WN.
  Title
Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites.
  Journal
Nat Struct Biol 8:521-5 (2001)
DOI:10.1038/88584
  Sequence
Reference
3  [PMID:10800597]
  Authors
Fitzpatrick PF.
  Title
The aromatic amino acid hydroxylases.
  Journal
Adv Enzymol Relat Areas Mol Biol 74:235-94 (2000)
DOI:10.1002/9780470123201.ch6
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.33
IUBMB Enzyme Nomenclature: 1.5.1.33
ExPASy - ENZYME nomenclature database: 1.5.1.33
BRENDA, the Enzyme Database: 1.5.1.33
CAS: 131384-61-7

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