Entry
Name
flavin reductase (NADH);
NADH-dependent flavin reductase;
flavin:NADH oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
flavin:NAD+ oxidoreductase
Reaction(IUBMB)
reduced flavin + NAD+ = flavin + NADH + H+ [RN:
R09662 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme from Escherichia coli W catalyses the reduction of free flavins by NADH. The enzyme has similar affinity to FAD, FMN and riboflavin. Activity with NADPH is more than 2 orders of magnitude lower than activity with NADH.
History
EC 1.5.1.36 created 2011
Pathway
Orthology
K00484 flavin reductase (NADH)
K21297 flavin reductase (NADH)
K22393 flavin reductase (NADH) subunit 1
K22394 flavin reductase (NADH) subunit 2
K23462 flavin-dependent trigonelline monooxygenase, reductase component
K23470 4-hydroxyphenylacetate 3-hydroxylase, reductase component
Genes
SETC : CFSAN001921_11685(hpaC)
SEEN : SE451236_11340(hpaC)
SENH : CFSAN002069_03530(hpaC)
SEEH : SEEH1578_14715(hpaC)
SENJ : CFSAN001992_06155(hpaC)
SEEC : CFSAN002050_11885(hpaC)
SEEB : SEEB0189_014080(hpaC)
SENC : SEET0819_12150(hpaC)
EAE : EAE_03415 EAE_10310(hpaC)
RTG : NCTC13098_06431(hpaC)
REE : electrica_04381(hpaC)
KIE : NCTC12125_02692(hpaC)
YPG : YpAngola_A1639(hpaC)
YPI : YpsIP31758_2356(hpaC)
SMAR : SM39_1852 SM39_4968(hpaC)
SMW : SMWW4_v1c05910(rutF)
SMAF : D781_0579 D781_1304
SRZ : AXX16_3791 AXX16_4528
SERM : CLM71_02805(hpaC) CLM71_06370
SFJ : SAMEA4384070_0662(hpaC) SAMEA4384070_3301(C1-hpah)
SOF : NCTC11214_00921(hpaC) NCTC11214_04442(C1-hpah)
SRHZ : FO014_03475 FO014_07035(hpaC)
SFO : Z042_02310 Z042_16845(hpaC)
PHEI : NCTC12003_00815(hpaC)
PRJ : NCTC6933_00872(hpaC)
PVC : G3341_03815(hpaC) G3341_16335
PDAG : 4362423_01844(hpaC)
ALIG : NCTC10568_01672(hpaC)
PAEB : NCGM1900_0868(hpaC)
PRE : PCA10_16280 PCA10_27140
PCQ : PcP3B5_30280(hpaC) PcP3B5_43320(C1-hpah)
PMUI : G4G71_15220(hpaC) G4G71_18515
PNT : G5B91_06795 G5B91_16890(hpaC) G5B91_20005
PPRC : PFLCHA0_c33870(hpaC)
PSEC : CCOS191_2760(C1-hpah)
PYM : AK972_2165 AK972_3768
PPHA : BVH74_16325 BVH74_17950
EMO : DM558_00740(hpaC) DM558_04920(hpaC)
ABC : ACICU_01362 ACICU_01968
ABB : ABBFA_01577(hpah_1) ABBFA_02133(hpah_3)
ABZ : ABZJ_01524 ABZJ_02149
ABR : ABTJ_01740 ABTJ_02346
ABD : ABTW07_1531 ABTW07_2180
ABJ : BJAB07104_01525 BJAB07104_01771
ABAJ : BJAB0868_01477 BJAB0868_02107
ABAZ : P795_10580 P795_8070
ABK : LX00_06725 LX00_09695
ABAU : IX87_03655 IX87_20435
ABW : BL01_00760 BL01_01960
ACC : BDGL_000704(ntaB) BDGL_001336
ASOL : BEN76_02090 BEN76_05005
ABER : BSR55_08080 BSR55_16590
ACIU : A3K93_02955 A3K93_14235
MMW : Mmwyl1_2478 Mmwyl1_3189
MRHI : KDW99_07395 KDW99_14405
MGEO : CFI10_04405 CFI10_04670
MSEC : LN244_04785 LN244_11495 LN244_12260
IGN : MMG00_03800 MMG00_11015
NMM : NMBM01240149_0343(hpaC)
NMS : NMBM01240355_1776(hpaC)
NMQ : NMBM04240196_1783(hpaC)
NMZ : NMBNZ0533_0480(hpaC)
NWE : SAMEA3174300_1574(hpaC)
NZO : SAMEA4504057_0425(hpaC)
NCI : NCTC10296_01006(hpaC)
NCZ : NCTC10294_01307(hpaC)
NANI : NCTC12227_02146(hpaC)
BPM : BURPS1710b_2215(ntaB)
BCJ : BCAM0638 BCAM2115(hpaC)
BCEN : DM39_4519(hpaC) DM39_4923
BCEO : I35_4534 I35_5997(hpaC)
BMJ : BMULJ_05410 BMULJ_05415
BMU : Bmul_5076 Bmul_5089 Bmul_6116 Bmul_6121
BMK : DM80_4251 DM80_4266(hpaC) DM80_6570 DM80_6575
BMUL : NP80_3634(hpaC) NP80_3647 NP80_5323 NP80_5328
BCON : NL30_22660 NL30_35585
BTEI : WS51_01665 WS51_01730
BPSL : WS57_00575 WS57_00600 WS57_10735 WS57_12535
BGL : bglu_2g00870 bglu_2g17480
BGU : KS03_3551(hpaC) KS03_4181
BUG : BC1001_4399 BC1001_5788
BGD : bgla_1g15200 bgla_2g20760 bgla_2g22850
BYI : BYI23_A013770 BYI23_B005870
BUE : BRPE67_ACDS14190 BRPE67_BCDS08150
BURK : DM992_17900 DM992_17925 DM992_28725(hpaC)
BPX : BUPH_00976 BUPH_06008
BPY : Bphyt_2167 Bphyt_6112
BCAI : K788_0003934 K788_0005053 K788_0007443
PSPW : BJG93_31305 BJG93_31365
PHS : C2L64_07300(hpaC) C2L64_36225(hpaC) C2L64_38005
PTER : C2L65_07035(hpaC) C2L65_31435(hpaC) C2L65_33980
PCAF : DSC91_003402 DSC91_007526
PTRO : G5S35_25775 G5S35_25835
PACP : FAZ97_25760 FAZ97_25790
PACS : FAZ98_23330 FAZ98_23390 FAZ98_33425(hpaC)
PDIO : PDMSB3_0783.1(hpaC) PDMSB3_2781.1
PSPU : NA29_09695 NA29_23280
PCOM : NTU39_13760 NTU39_19945
PLG : NCTC10937_03008(hpaC)
LMIR : NCTC12852_00710(C1-hpah)
CABA : SBC2_49970 SBC2_51660(hpaC_3) SBC2_65470(tgnA) SBC2_82000(hpaC_4)
HSE : Hsero_1338 Hsero_1480
HSZ : ACP92_06700 ACP92_07435
HHF : E2K99_06565(hpaC) E2K99_07490
HFR : G5S34_06915(hpaC) G5S34_08220
MCI : Mesci_6249 Mesci_6274
MAMO : A6B35_23750 A6B35_30565
SFD : USDA257_c12480(ntaB)
SIX : BSY16_4968 BSY16_5837
SAME : SAMCFNEI73_pC1124(ntaB)
ATU : Atu4239 Atu5229(ntaB)
AVV : RvVAT039_42650 RvVAT039_pl07090
RET : RHE_PC00024 RHE_PF00197
RLT : Rleg2_5504 Rleg2_5585
RLU : RLEG12_04940 RLEG12_08650
RPHA : AMC79_PA00027 AMC79_PD00424
BVV : BHK69_08815 BHK69_09810
RUT : FIU92_06550(C1-hpah)
MALG : MALG_01994 MALG_04998
RID : RIdsm_01101(hsaB_1) RIdsm_01320(ntaB_2)
GFU : KM031_06910 KM031_18020
SEDI : EBB79_11390 EBB79_22505
PAED : G5B38_01250 G5B38_09825
LJF : FI9785_1676 FI9785_1677
LJN : T285_08435 T285_08440
LDE : LDBND_1905 LDBND_1906
LHL : LBHH_1806 LBHH_1807 LBHH_1850 LBHH_1851
LHR : R0052_10675 R0052_10680
LCR : LCRIS_01858 LCRIS_01859
LAI : LAC30SC_09985 LAC30SC_09990
LAY : LAB52_09035 LAB52_09040
LAW : LACWKB8_0276 LACWKB8_0277
LGL : AO203_03910 AO203_03915
LJE : BUE77_07795 BUE77_07800
LAMY : B1745_06615 B1745_06620
LPW : LpgJCM5343_16810 LpgJCM5343_16820
LKL : DKL58_01185 DKL58_01190
LAPI : DKL56_00880 DKL56_00885
LHS : DLD54_01380 DLD54_01385
LTA : H1A07_08500 H1A07_08505
LUU : H4B44_09975 H4B44_09980
LPAI : GYM71_01380 GYM71_01385
LID : GYK47_05010 GYK47_05015
LIQ : KBW87_07415 KBW87_07420
NFR : ERS450000_01248(hpaC)
RKO : JWS14_14995 JWS14_38875
SRC : M271_01535 M271_04295 M271_09870
STRE : GZL_02226 GZL_02917
SRW : TUE45_00621(rbmH_1) TUE45_06418(rbmH_2)
SNR : SNOUR_09915 SNOUR_12600
SSUB : CP968_16675 CP968_32175
SPLA : CP981_13855 CP981_21750
SAOV : G3H79_23740 G3H79_33555
STRH : GXP74_20075 GXP74_21290
AOI : AORI_4210(hpaC) AORI_5335
SESP : BN6_32530 BN6_35870
KAL : KALB_2183 KALB_5899 KALB_6285
VER : HUT12_05560 HUT12_06275
DVC : Dvina_05880 Dvina_38690
DMAT : Dmats_05360 Dmats_33650
» show all
Taxonomy
Reference
Authors
Galan B, Diaz E, Prieto MA, Garcia JL
Title
Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new Flavin:NAD(P)H reductase subfamily.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.36
ExPASy - ENZYME nomenclature database: 1.5.1.36