KEGG   ENZYME: 1.5.1.37
Entry
EC 1.5.1.37                 Enzyme                                 
Name
FAD reductase (NADH);
NADH-FAD reductase;
NADH-dependent FAD reductase;
NADH:FAD oxidoreductase;
NADH:flavin adenine dinucleotide oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
FADH2:NAD+ oxidoreductase
Reaction(IUBMB)
FADH2 + NAD+ = FAD + NADH + H+ [RN:R09748]
Reaction(KEGG)
R09748
Substrate
FADH2 [CPD:C01352];
NAD+ [CPD:C00003]
Product
FAD [CPD:C00016];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from Burkholderia phenoliruptrix can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. Unlike EC 1.5.1.36, flavin reductase (NADH), the enzyme can not reduce riboflavin. The enzyme does not use NADPH as acceptor.
History
EC 1.5.1.37 created 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K15245  flavin reductase
Genes
RPJN234_22410
CNCCNE_BB1p03430(rutF)
REUReut_A1584
COXE0W60_29400
CNANA2G96_12455
PHSC2L64_40515
PTERC2L65_19200
Reference
1  [PMID:12700257]
  Authors
Gisi MR, Xun L
  Title
Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:flavin adenine dinucleotide oxidoreductase (TftC) of Burkholderia cepacia AC1100.
  Journal
J Bacteriol 185:2786-92 (2003)
DOI:10.1128/JB.185.9.2786-2792.2003
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.37
IUBMB Enzyme Nomenclature: 1.5.1.37
ExPASy - ENZYME nomenclature database: 1.5.1.37
BRENDA, the Enzyme Database: 1.5.1.37

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