Entry Name FMN reductase (NADH);
Class Oxidoreductases;BRITE hierarchy
Sysname FMNH2:NAD+ oxidoreductase
Reaction(IUBMB) FMNH2 + NAD+ = FMN + NADH + H+ [RN:
R05705 ]
Reaction(KEGG) Substrate Product Comment The enzyme often forms a two-component system with monooxygenases. Unlike EC
1.5.1.38 , FMN reductase (NADPH), and EC
1.5.1.39 , FMN reductase [NAD(P)H], this enzyme has a strong preference for NADH over NADPH, although some activity with the latter is observed [1,2].
While FMN is the preferred substrate, FAD can also be used with much lower activity [1,3].
History EC 1.5.1.42 created 2011
Pathway Orthology K20146 nitrilotriacetate monooxygenase reductase component
Genes AAK : AA2016_6033 AA2016_6429
Taxonomy Reference Authors Duane W, Hastings JW.
Title Flavin mononucleotide reductase of luminous bacteria.
Journal Reference Authors Gerlo E, Charlier J
Title Identification of NADH-specific and NADPH-specific FMN reductases in Beneckea harveyi.
Journal Reference Authors Uetz T, Schneider R, Snozzi M, Egli T
Title Purification and characterization of a two-component monooxygenase that hydroxylates nitrilotriacetate from "Chelatobacter" strain ATCC 29600.
Journal Sequence Reference Authors Izumoto Y, Mori T, Yamamoto K
Title Cloning and nucleotide sequence of the gene for NADH:FMN oxidoreductase from Vibrio harveyi.
Journal Other DBs ExplorEnz - The Enzyme Database: 1.5.1.42
ExPASy - ENZYME nomenclature database: 1.5.1.42
