Entry |
|
Name |
FMN reductase (NADH);
NADH-FMN reductase;
NADH-dependent FMN reductase;
NADH:FMN oxidoreductase;
NADH:flavin oxidoreductase
|
Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
FMNH2:NAD+ oxidoreductase
|
Reaction(IUBMB) |
FMNH2 + NAD+ = FMN + NADH + H+ [RN: R05705]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
|
Comment |
The enzyme often forms a two-component system with monooxygenases. Unlike EC 1.5.1.38, FMN reductase (NADPH), and EC 1.5.1.39, FMN reductase [NAD(P)H], this enzyme has a strong preference for NADH over NADPH, although some activity with the latter is observed [1,2].
While FMN is the preferred substrate, FAD can also be used with much lower activity [1,3].
|
History |
EC 1.5.1.42 created 2011
|
Pathway |
|
Orthology |
K20146 | nitrilotriacetate monooxygenase reductase component |
|
Genes |
|
Reference |
|
Authors |
Duane W, Hastings JW. |
Title |
Flavin mononucleotide reductase of luminous bacteria. |
Journal |
|
Reference |
|
Authors |
Gerlo E, Charlier J |
Title |
Identification of NADH-specific and NADPH-specific FMN reductases in Beneckea harveyi. |
Journal |
|
Reference |
|
Authors |
Uetz T, Schneider R, Snozzi M, Egli T |
Title |
Purification and characterization of a two-component monooxygenase that hydroxylates nitrilotriacetate from "Chelatobacter" strain ATCC 29600. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Izumoto Y, Mori T, Yamamoto K |
Title |
Cloning and nucleotide sequence of the gene for NADH:FMN oxidoreductase from Vibrio harveyi. |
Journal |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 1.5.1.42 |
ExPASy - ENZYME nomenclature database: | 1.5.1.42 |
|