| Entry |
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| Name |
FMN reductase (NADH);
NADH-FMN reductase;
NADH-dependent FMN reductase;
NADH:FMN oxidoreductase;
NADH:flavin oxidoreductase
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| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
FMNH2:NAD+ oxidoreductase
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| Reaction(IUBMB) |
FMNH2 + NAD+ = FMN + NADH + H+ [RN: R05705]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme often forms a two-component system with monooxygenases. Unlike EC 1.5.1.38, FMN reductase (NADPH), and EC 1.5.1.39, FMN reductase [NAD(P)H], this enzyme has a strong preference for NADH over NADPH, although some activity with the latter is observed [1,2].
While FMN is the preferred substrate, FAD can also be used with much lower activity [1,3].
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| History |
EC 1.5.1.42 created 2011
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| Pathway |
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| Orthology |
| K20146 | nitrilotriacetate monooxygenase reductase component |
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| Genes |
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| Reference |
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| Authors |
Duane W, Hastings JW. |
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| Title |
Flavin mononucleotide reductase of luminous bacteria. |
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| Journal |
Mol Cell Biochem 6:53-64 (1975) |
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| Reference |
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| Authors |
Gerlo E, Charlier J |
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| Title |
Identification of NADH-specific and NADPH-specific FMN reductases in Beneckea harveyi. |
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| Journal |
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| Reference |
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| Authors |
Uetz T, Schneider R, Snozzi M, Egli T |
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| Title |
Purification and characterization of a two-component monooxygenase that hydroxylates nitrilotriacetate from "Chelatobacter" strain ATCC 29600. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Izumoto Y, Mori T, Yamamoto K |
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| Title |
Cloning and nucleotide sequence of the gene for NADH:FMN oxidoreductase from Vibrio harveyi. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.5.1.42 |
| ExPASy - ENZYME nomenclature database: | 1.5.1.42 |
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