KEGG ENZYME: 1.5.1.45

ENZYME: 1.5.1.45

Entry

EC 1.5.1.45                 Enzyme

Name

FAD reductase [NAD(P)H];
GTNG_3158 (gene name)

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

FADH2:NAD(P)+ oxidoreductase

Reaction(IUBMB)

FADH2 + NAD(P)+ = FAD + NAD(P)H + H+ [RN:R09520 R09748]

Reaction(KEGG)

R09520 R09748

Substrate

FADH2 [CPD:C01352];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

FAD [CPD:C00016];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and EC 1.14.14.8, anthranilate 3-monooxygenase (FAD). It can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. The enzyme has a slight preference for NADPH as acceptor. cf. EC 1.5.1.37, FAD reductase (NADH).

History

EC 1.5.1.45 created 2012

Pathway

ec00740

Riboflavin metabolism

ec01100

Metabolic pathways

Orthology

K16902

FAD reductase [NAD(P)H]

Genes

BMET:

BMMGA3_15280

GST:	HW35_13015

BACO:

OXB_0115

BDA:	FSZ17_13420

BMQ:

BMQ_3594

BMD:

BMD_3579

BMEG:

BG04_468

BKO:	CKF48_21905

GTN:

GTNG_3158

GMC:	GY4MC1_3653

PTL:	AOT13_04015

ASED:

IRT44_17660

APAK:

AP3564_00250

BMUR:

ABE28_004135

PASA:

BAOM_0491

PFRI:

L8956_02840

BVJ:	I5776_05115

BOU:	I5818_06410

PBJ:	VN24_18680 VN24_25630

PNP:	IJ22_33750

EFF:	skT53_06260

SSIL:

SOLI23_13720

SPOO:

J3U78_18220

HSAI:

HPS36_14230

» show all

Reference

1 [PMID:19942660]

Authors

Liu X, Dong Y, Li X, Ren Y, Li Y, Wang W, Wang L, Feng L

Title

Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2.

Journal

Microbiology 156:589-95 (2010)
DOI:10.1099/mic.0.031880-0

Sequence

[gtn:GTNG_3158]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.45

IUBMB Enzyme Nomenclature:

1.5.1.45

ExPASy - ENZYME nomenclature database:

1.5.1.45

BRENDA, the Enzyme Database:

1.5.1.45

DBGET integrated database retrieval system