KEGG   ENZYME: 1.5.1.47
Entry
EC 1.5.1.47                 Enzyme                                 
Name
dihydromethanopterin reductase [NAD(P)+];
DmrA;
H2MPT reductase;
5,6,7,8-tetrahydromethanopterin 5,6-oxidoreductase;
dihydromethanopterin reductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
5,6,7,8-tetrahydromethanopterin:NAD(P)+ 5,6-oxidoreductase
Reaction(IUBMB)
5,6,7,8-tetrahydromethanopterin + NAD(P)+ = 7,8-dihydromethanopterin + NAD(P)H + H+ [RN:R03388 R10332]
Reaction(KEGG)
R03388 R10332
Substrate
5,6,7,8-tetrahydromethanopterin [CPD:C01217];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
7,8-dihydromethanopterin [CPD:C05927];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Methylobacterium extorquens, is involved in biosynthesis of dephospho-tetrahydromethanopterin. The specific activity with NADH is 15% of that with NADPH at the same concentration [1]. It does not reduce 7,8-dihydrofolate (cf. EC 1.5.1.3, dihydrofolate reductase).
History
EC 1.5.1.47 created 2013, modified 2014
Pathway
ec00790  Folate biosynthesis
Orthology
K17364  dihydromethanopterin reductase
Genes
MESMEJ066_09050
PHTBLM14_22295
SNOSnov_3597
STARG3545_22355
MEAMex_1p4312(dmrA) Mex_2p0242(dfrB)
MDIMETDI4922(dmrA)
MEXMext_3930
MCHMchl_4298
MPOMpop_4405
MZAB2G69_01545
MRDMrad2831_3892
METM446_2602
MNOMnod_4627
MORMOC_4443
METAY590_19545
MAQUMaq22A_c11465(dmrA)
MPHYMCBMB27_03370
MEEDA075_06570 DA075_29485
METDC0214_21670
METXA3862_11985
METSDK389_16520
METIDK427_07405
MMESMMSR116_10245
MTEADK419_08915
MINDmvi_35670 mvi_63270(folA_2)
MOGMMB17_10405
MTADM6G65_28595
MSLMsil_2640
MTUNMTUNDRAET4_2815(dmrA)
MLGCWB41_14515
HDNHden_1417
HDTHYPDE_31568
HMCHYPMC_1563(dmrA)
HNIW911_16605
FILBN1229_v1_0392
FIYBN1229_v1_0396
MCGGL4_1886
METGHT051_09710
CMETK6K41_11655
PLEOOHA_1_01951(dmrA)
AALAIGS74_19355
AALMLUX29_21715
AUZSa4125_01520
AUBLXB15_17510
GBEGbCGDNIH1_1342
GBHGbCGDNIH2_1342
GBCGbCGDNIH3_1342
GBSGbCGDNIH4_1342
APBSAR116_2444
MSHOMSHO_23040
LPAVPLANPX_4182
 » show all
Reference
1  [PMID:15028691]
  Authors
Caccamo MA, Malone CS, Rasche ME
  Title
Biochemical characterization of a dihydromethanopterin reductase involved in tetrahydromethanopterin biosynthesis in Methylobacterium extorquens AM1.
  Journal
J Bacteriol 186:2068-73 (2004)
DOI:10.1128/JB.186.7.2068-2073.2004
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.47
IUBMB Enzyme Nomenclature: 1.5.1.47
ExPASy - ENZYME nomenclature database: 1.5.1.47
BRENDA, the Enzyme Database: 1.5.1.47

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