KEGG   ENZYME: 1.5.1.47Help
Entry
EC 1.5.1.47                 Enzyme                                 

Name
dihydromethanopterin reductase [NAD(P)+];
DmrA;
H2MPT reductase;
5,6,7,8-tetrahydromethanopterin 5,6-oxidoreductase;
dihydromethanopterin reductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
5,6,7,8-tetrahydromethanopterin:NAD(P)+ 5,6-oxidoreductase
Reaction(IUBMB)
5,6,7,8-tetrahydromethanopterin + NAD(P)+ = 7,8-dihydromethanopterin + NAD(P)H + H+ [RN:R03388 R10332]
Reaction(KEGG)
Substrate
5,6,7,8-tetrahydromethanopterin [CPD:C01217];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
7,8-dihydromethanopterin [CPD:C05927];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Methylobacterium extorquens, is involved in biosynthesis of dephospho-tetrahydromethanopterin. The specific activity with NADH is 15% of that with NADPH at the same concentration [1]. It does not reduce 7,8-dihydrofolate (cf. EC 1.5.1.3, dihydrofolate reductase).
History
EC 1.5.1.47 created 2013, modified 2014
Pathway
ec00790  Folate biosynthesis
Orthology
K17364  dihydromethanopterin reductase
Genes
SNO: Snov_3597
MEX: Mext_3930
MEA: Mex_1p4312(dmrA)
MDI: METDI4922(dmrA)
MCH: Mchl_4298
MPO: Mpop_4405
MRD: Mrad2831_3892
MET: M446_2602
MNO: Mnod_4627
MOR: MOC_4443
META: Y590_19545
MAQU: Maq22A_c11465(dmrA)
MSL: Msil_2640
HDN: Hden_1417
HMC: HYPMC_1563(dmrA)
 » show all
Taxonomy
Reference
1  [PMID:15028691]
  Authors
Caccamo MA, Malone CS, Rasche ME
  Title
Biochemical characterization of a dihydromethanopterin reductase involved in tetrahydromethanopterin biosynthesis in Methylobacterium extorquens AM1.
  Journal
J Bacteriol 186:2068-73 (2004)
DOI:10.1128/JB.186.7.2068-2073.2004
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.47
IUBMB Enzyme Nomenclature: 1.5.1.47
ExPASy - ENZYME nomenclature database: 1.5.1.47
BRENDA, the Enzyme Database: 1.5.1.47

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