KEGG   ENZYME: 1.5.1.49Help
Entry
EC 1.5.1.49                 Enzyme                                 

Name
1-pyrroline-2-carboxylate reductase [NAD(P)H]
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-proline:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ [RN:R01246 R01249]
Reaction(KEGG)
Substrate
L-proline [CPD:C00148];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
1-pyrroline-2-carboxylate [CPD:C03564];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from the bacterium Colwellia psychrerythraea is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with 1-piperideine-2-carboxylate and 1-pyrroline-2-carboxylate, this enzyme is specific for the latter. While the enzyme is active with both NADH and NADPH, activity is higher with NADPH.
History
EC 1.5.1.49 created 2015
Pathway
ec00330  Arginine and proline metabolism
Orthology
K19742  1-pyrroline-2-carboxylate reductase [NAD(P)H]
Genes
VPA: VP1333
VPB: VPBB_1257
VPK: M636_15145
VPF: M634_08575
VPH: VPUCM_1890
VAG: N646_0368
VEX: VEA_003670
VDB: AL552_14870
VHR: AL538_01790
VOW: A9237_01110
SAZ: Sama_2610
SLO: Shew_2955
SSE: Ssed_3503
SPL: Spea_3170
SHL: Shal_3252
SWD: Swoo_3726
SWP: swp_3859
SVO: SVI_3429
SPSW: Sps_04403
CPS: CPS_1455
PSEO: OM33_02120
PTN: PTRA_b0312(ocd)
PSPO: PSPO_a3016(ocd)
PTU: PTUN_a0321(ocd)
PIN: Ping_2540
SAGA: M5M_03795
 » show all
Taxonomy
Reference
1  [PMID:24649405]
  Authors
Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y
  Title
Identification and characterization of trans-3-hydroxy-l-proline dehydratase and  Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline  metabolism of bacteria.
  Journal
FEBS Open Bio 4:240-50 (2014)
DOI:10.1016/j.fob.2014.02.010
  Sequence
[cps:CPS_1455]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.49
IUBMB Enzyme Nomenclature: 1.5.1.49
ExPASy - ENZYME nomenclature database: 1.5.1.49
BRENDA, the Enzyme Database: 1.5.1.49

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