KEGG   ENZYME: 1.5.1.50Help
Entry
EC 1.5.1.50                 Enzyme                                 

Name
dihydromonapterin reductase;
FolM;
H2-MPt reductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
5,6,7,8-tetrahydromonapterin:NADP+ oxidoreductase
Reaction(IUBMB)
5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+ [RN:R11019]
Reaction(KEGG)
Substrate
5,6,7,8-tetrahydromonapterin [CPD:C21007];
NADP+ [CPD:C00006]
Product
7,8-dihydromonapterin [CPD:C21008];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, found in many Gram negative bacteria, also slowly reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate (cf. EC 1.5.1.3, dihydrofolate reductase). The enzyme has no activity with NADH.
History
EC 1.5.1.50 created 2015
Pathway
ec00790  Folate biosynthesis
Orthology
K13938  dihydromonapterin reductase / dihydrofolate reductase
Genes
ECO: b1606(folM)
ECJ: JW1598(folM)
ECD: ECDH10B_1739(folM)
EBW: BWG_1421(folM)
ECOK: ECMDS42_1276(folM)
ECE: Z2606(ydgB)
ECS: ECs2312
ECF: ECH74115_2317
ETW: ECSP_2170(folM)
ELX: CDCO157_2149
EOJ: ECO26_2334(folM)
EOI: ECO111_2075(folM)
EOH: ECO103_1746(folM)
ECOO: ECRM13514_2098(ydgB)
ECOH: ECRM13516_2000(ydgB)
ECG: E2348C_1691(folM)
EOK: G2583_2000(folM)
ESO: O3O_13430
ESM: O3M_12170
ESL: O3K_12205
ELH: ETEC_1640
ECC: c1998(ydgB)
ECP: ECP_1550
ECI: UTI89_C1794(ydgB)
ECV: APECO1_689(ydgB)
ECY: ECSE_1727
ECR: ECIAI1_1656(folM)
ECQ: ECED1_1805(folM)
ECK: EC55989_1771(folM)
ECT: ECIAI39_1452(folM)
EOC: CE10_1878(folM)
EUM: ECUMN_1894(folM)
ECZ: ECS88_1651(folM)
ESE: ECSF_1467
EBR: ECB_01575(ydgB)
EBD: ECBD_2040
EKF: KO11_14725(folM)
EAB: ECABU_c18020(ydgB)
EDJ: ECDH1ME8569_1549(folM)
ELW: ECW_m1771(folM)
ELL: WFL_08675(folM)
ELC: i14_1818(ydgB)
ELD: i02_1818(ydgB)
ELP: P12B_c1477(ydgB)
EBL: ECD_01575(folM)
EBE: B21_01565(folM)
ELF: LF82_0727(folM)
ECOI: ECOPMV1_01701(folM)
ECOJ: P423_08600
ECOS: EC958_1825(ydgB)
EFE: EFER_1431(folM)
SFL: SF1627(ydgB)
SFX: S1759(ydgB)
SFV: SFV_1621(ydgB)
SFE: SFxv_1823(folM)
SFN: SFy_2328
SFS: SFyv_2381
SFT: NCTC1_01765(folM)
SSN: SSON_1554(ydgB)
SBO: SBO_1530(ydgB)
SDY: SDY_1547(ydgB)
ENC: ECL_02267
ECLX: LI66_09795
ECLY: LI62_10560
ECLZ: LI64_09860
EEC: EcWSU1_01946(folM)
EBG: FAI37_19425(folM)
CSK: ES15_2112(folB2)
CTU: CTU_20270(folM)
KPN: KPN_01523(ydgB)
KPU: KP1_2533(ydgB)
KPP: A79E_2714
KPE: KPK_2936
KPR: KPR_2820(folM)
KPJ: N559_2806
KPX: PMK1_03841(folM)
KPNU: LI86_14000
KPNK: BN49_2585(folM)
KVA: Kvar_2835
KOX: KOX_21840
KOE: A225_3243
EAE: EAE_18090
EAR: CCG30275
KLW: DA718_13195(folM)
CKO: CKO_01615
CRO: ROD_14581
CAMA: F384_06665
EBT: EBL_c22390(ydgB)
RTG: NCTC13098_03368(folM)
CLAP: NCTC11466_02531(folM)
KIE: NCTC12125_01441(folM)
AHN: NCTC12129_02425(folM)
IZH: FEM41_16675(folM)
EBF: D782_2069
SPE: Spro_2589
SRL: SOD_c24430(folM)
SPLY: Q5A_013555(folM)
SMAF: D781_2166
SMW: SMWW4_v1c25720(folM)
SMAR: SM39_2018
SERF: L085_15825
SQU: E4343_03275(folM)
ECA: ECA2018
PATR: EV46_09715
PATO: GZ59_25800
PCT: PC1_2270
PEC: W5S_2552
ETR: ETAE_1753
ETD: ETAF_1585(folM)
ETE: ETEE_3801(folM)
PSHI: SAMEA2665130_1500(folM)
VSP: VS_1751
SALY: E8E00_16725(folM)
SKS: FCN78_15650(folM)
PAE: PA3437(folM)
PAEV: N297_3559
PAEI: N296_3559
PAU: PA14_19640(ydgB)
PNC: NCGM2_4574(ydgB)
PAEB: NCGM1900_2834(ydgB)
PAEP: PA1S_08135
PAEM: U769_07610
PAEL: T223_08120
PAEG: AI22_25760
PAEC: M802_3558
PAEO: M801_3424
PMY: Pmen_3288
PMK: MDS_3590
PRE: PCA10_47610(folM)
PPSE: BN5_1172
PCQ: PcP3B5_51120(folM)
PPU: PP_4632(folM)
PPF: Pput_4493
PPT: PPS_4459
PPI: YSA_03200
PPX: T1E_1546(ydgB)
PPUH: B479_22425
PPUT: L483_27615
PPUN: PP4_07280(folM)
PPUD: DW66_4850
PMON: X969_21965
PMOT: X970_21600
PSB: Psyr_1021
PSYR: N018_20580
PFL: PFL_0950
PPRC: PFLCHA0_c09650(folM)
PPRO: PPC_0984
PFS: PFLU_5157
PFE: PSF113_4877(folM)
PFB: VO64_1997
PMAN: OU5_2508
PEN: PSEEN4623
PSA: PST_1136
PSTT: CH92_05020
PKC: PKB_4622
PSES: PSCI_0766
PSEM: TO66_04865
PSEC: CCOS191_4520(folM)
PSOS: POS17_0955
PANR: A7J50_4901
PSET: THL1_4764
PSIL: PMA3_24870
SON: SO_0772(folM)
SDN: Sden_0827
SFR: Sfri_3161
SBL: Sbal_0611
SLO: Shew_0048
SSE: Ssed_4223
SWD: Swoo_0378
SWP: swp_0144
ILO: IL1531
THT: E2K93_04300(folM)
PHA: PSHAa0074(folM)
PSM: PSM_A0075(folM)
PSEO: OM33_02965
PPHE: PP2015_40
PTN: PTRA_a0087(folM)
PEA: PESP_a0088(folM)
PSPO: PSPO_a3221(folM)
PART: PARC_a3860(folM)
PTU: PTUN_a3957(folM)
PNG: PNIG_a0087(folM)
PTD: PTET_a0080(folM)
PSEN: PNC201_00315(folM)
AMAL: I607_17605
AMAE: I876_17975
AMAO: I634_17740
AMAD: I636_17835
AMAI: I635_18645
AMAG: I533_17535
AMAC: MASE_17655
GNI: GNIT_3073(folM)
SALH: HMF8227_00510(folM)
FBL: Fbal_1510
TCX: Tcr_1865
MEJ: Q7A_335
MEC: Q7C_2015
THIG: FE785_09610(folM)
RHH: E0Z06_06410(folM)
HCH: HCH_00526
CSA: Csal_0587
HEL: HELO_3782
HCO: LOKO_02959(folM)
HBE: BEI_3194(folM)
TOL: TOL_1022
AHA: AHA_4063
ASA: ASA_0252
AVR: B565_3760
AMED: B224_5041
ACAV: VI35_01150
SALN: SALB1_0544
PLG: NCTC10937_04339(folM)
ABS: AZOBR_10100(folM)
 » show all
Taxonomy
Reference
1  [PMID:19897652]
  Authors
Pribat A, Blaby IK, Lara-Nunez A, Gregory JF 3rd, de Crecy-Lagard V, Hanson AD
  Title
FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa.
  Journal
J Bacteriol 192:475-82 (2010)
DOI:10.1128/JB.01198-09
  Sequence
[eco:b1606]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.50
IUBMB Enzyme Nomenclature: 1.5.1.50
ExPASy - ENZYME nomenclature database: 1.5.1.50
BRENDA, the Enzyme Database: 1.5.1.50

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