KEGG   ENZYME: 1.5.1.51
Entry
EC 1.5.1.51                 Enzyme                                 

Name
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase;
SbnB
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate:NAD+ dehydrogenase (L-2,3-diaminopropanoate-forming)
Reaction(IUBMB)
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD+ + H2O = 2-oxoglutarate + L-2,3-diaminopropanoate + NADH + H+ [RN:R11655]
Reaction(KEGG)
R11655
Substrate
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate [CPD:C21559];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
2-oxoglutarate [CPD:C00026];
L-2,3-diaminopropanoate [CPD:C03401];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B.
History
EC 1.5.1.51 created 2017
Pathway
ec00997  Biosynthesis of various secondary metabolites - part 3
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21721  N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase
Genes
SPE: Spro_0340
SPLY: Q5A_016925(arcB_2)
SERA: Ser39006_012175
SERQ: CWC46_12170
DDA: Dd703_1673
PVA: Pvag_pPag20158
XBV: XBW1_4005
XOR: XOC_2070
XOZ: BE73_09785
PPG: PputGB1_3516
PPUN: PP4_18810
PSYR: N018_13840
PFS: PFLU_3072
PEN: PSEEN2151
PSES: PSCI_4540
ACC: BDGL_001498(ocd2)
AGU: AS4_16160
SDN: Sden_0589
SPSW: Sps_04806
CEK: D0B88_14055(sbnB)
CEG: D0C16_05385(sbnB)
PSE: NH8B_2510
DEE: HQN60_15875(sbnB)
RSO: RSp0418
RSE: F504_3906
RSY: RSUY_34860(rapL_2)
CNC: CNE_2c14840(ocd)
RME: Rmet_1116(ocd)
BGU: KS03_3536
BGO: BM43_2791
PPNO: DA70_13855
PPNM: LV28_16825
PPUL: RO07_10965
PSPU: NA29_06790
PAPI: SG18_11370
PFIB: PI93_002410(sbnB)
VEI: Veis_1206
JAG: GJA_5088
CPEL: CPEL_0302
CHYO: CHH_1362(arcB)
CPIN: CPIN18020_1620(arcB)
SCL: sce2388(ocd)
CCRO: CMC5_048530(ocd)
OAN: Oant_4593
MNO: Mnod_6949
RCP: RCAP_rcc01475(ocd)
AZL: AZL_a08790(ocd)
TMO: TMO_2352
BTHI: BTK_29569
BJS: MY9_0677
SAU: SA0113(sbnB)
SAV: SAV0117
SAW: SAHV_0116
SAM: MW0090(sbnB)
SAS: SAS0091
SAR: SAR0120
SAC: SACOL0101
SAX: USA300HOU_0128(ocd)
SAE: NWMN_0061(sbnB)
SAD: SAAV_0085
SUU: M013TW_0107(sbnB)
SUE: SAOV_0064
SUC: ECTR2_73
SUZ: MS7_0109
SUX: SAEMRSA15_00830(sbnB)
SUW: SATW20_01290(sbnB)
SUG: SAPIG0128
SUF: SARLGA251_00920(sbnB)
SAUA: SAAG_00601
SAUS: SA40_0084(sbnB)
SAUU: SA957_0099(sbnB)
SAUG: SA268_0096(sbnB)
SAUZ: SAZ172_0128(sbnB)
SAUF: X998_0096
SAB: SAB0056
SUY: SA2981_0118(sbnB)
SAUB: C248_0105
SAUM: BN843_1190
SAUC: CA347_128
SAUR: SABB_01723(sbnB)
SAUI: AZ30_00610
SAUD: CH52_05135
SAMS: NI36_00505
SDT: SPSE_2123(sbnB)
SHU: SHYC_00360(sbnB)
SSCH: LH95_00360
SSCZ: RN70_00580
SAGQ: EP23_09765(sbnB)
SFF: FOB90_07430(sbnB)
SDP: NCTC12225_02340(sbnB)
PRI: PRIO_2664
PSWU: SY83_09665
COHN: KCTCHS21_04460(ocd2)
SACA: FFV09_03655(sbnB)
KPUL: GXN76_14220(sbnB)
CSR: Cspa_c49120(ocd)
AWO: Awo_c27820(ocd)
BPRM: CL3_27510
STED: SPTER_09860(ala)
CGB: cg1784(ocd)
CGU: WA5_1520(Ocd)
CGT: cgR_1630
CGM: cgp_1784(ocd)
CGJ: AR0_08415
CEF: CE1700
CUR: cu1276(ocd)
CUA: CU7111_1259(ocd)
COA: DR71_345
CMQ: B840_08625(ocd1) B840_09950(ocd2)
RHB: NY08_3271
SMA: SAVERM_7163(arcB4)
SGB: WQO_01055
SCT: SCAT_2692(arcB)
SFA: Sfla_0080
SVE: SVEN_6262
SALS: SLNWT_4346
STRP: F750_6946
STRE: GZL_07297
SLD: T261_1316
SPRI: SPRI_5660
SLAU: SLA_7467
SALJ: SMD11_6086
SGE: DWG14_08223(arcB_3)
SRJ: SRO_6288
KSK: KSE_22780(ocd2) KSE_42360(ocd1)
RTE: GSU10_11140(sbnB)
KRS: EQG70_12320(sbnB)
PACC: PAC1_06765
PACD: EGX94_06795(sbnB)
TCU: Tcur_1883
ACTW: F7P10_04560(sbnB)
NML: Namu_3876
GOB: Gobs_3075
SEN: SACE_3017(arcB4) SACE_4281(arcB4)
SACG: FDZ84_26435(sbnB)
AMD: AMED_4040(ocd)
AMN: RAM_20590
AMM: AMES_3992(ocd)
AMZ: B737_3992(ocd)
AOI: AORI_4009(ocd)
PSEA: WY02_05020
PSEE: FRP1_00750
PSEH: XF36_12300
SESP: BN6_32450
KAL: KALB_6148
ACTI: UA75_17680
ACAD: UA74_17140
SAQ: Sare_0367
MTEM: GCE86_08145(sbnB)
ASE: ACPL_1001(ocd) ACPL_4121(ocd)
ACTN: L083_2989(ocd)
PFLA: Pflav_032920(ocd)
PSUU: Psuf_070550(ocd_1) Psuf_092890(ocd_2)
HAU: Haur_1864
RUL: UC8_56800(rapL)
PDI: BDI_1464
FLN: FLA_1938
 » show all
Reference
1  [PMID:21906287]
  Authors
Beasley FC, Cheung J, Heinrichs DE
  Title
Mutation of L-2,3-diaminopropionic acid synthase genes blocks staphyloferrin B synthesis in Staphylococcus aureus.
  Journal
BMC Microbiol 11:199 (2011)
DOI:10.1186/1471-2180-11-199
Reference
2  [PMID:24485762]
  Authors
Kobylarz MJ, Grigg JC, Takayama SJ, Rai DK, Heinrichs DE, Murphy ME
  Title
Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor.
  Journal
Chem Biol 21:379-88 (2014)
DOI:10.1016/j.chembiol.2013.12.011
  Sequence
[sae:NWMN_0061]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.51
IUBMB Enzyme Nomenclature: 1.5.1.51
ExPASy - ENZYME nomenclature database: 1.5.1.51
BRENDA, the Enzyme Database: 1.5.1.51

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