KEGG   ENZYME: 1.5.1.51Help
Entry
EC 1.5.1.51                 Enzyme                                 

Name
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase;
SbnB
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate:NAD+ dehydrogenase (L-2,3-diaminopropanoate-forming)
Reaction(IUBMB)
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD+ + H2O = 2-oxoglutarate + L-2,3-diaminopropanoate + NADH + H+ [RN:R11655]
Reaction(KEGG)
Substrate
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate [CPD:C21559];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
2-oxoglutarate [CPD:C00026];
L-2,3-diaminopropanoate [CPD:C03401];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B.
History
EC 1.5.1.51 created 2017
Pathway
ec00998  Biosynthesis of secondary metabolites - other antibiotics
ec00999  Biosynthesis of secondary metabolites - unclassified
Orthology
K21721  N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase
Genes
KMI: VW41_11565
CNT: JT31_00760
CEM: LH23_16755
CEN: LH86_15735
CLAP: NCTC11466_02209
SPE: Spro_0340
SPLY: Q5A_016925(arcB_2)
SERA: Ser39006_012175
SERQ: CWC46_12170
ROX: BV494_05265
XBV: XBW1_4005
XOR: XOC_2070
ACC: BDGL_001498(ocd2)
SDN: Sden_0589
SPSW: Sps_04806
RSO: RSp0418
RSE: F504_3906
CNC: CNE_2c14840(ocd)
RME: Rmet_1116(ocd)
BGO: BM43_2791
PPNO: DA70_13855
PPNM: LV28_16825
PPUL: RO07_10965
PSPU: NA29_06790
PAPI: SG18_11370
VEI: Veis_1206
JAG: GJA_5088
CCRO: CMC5_048530(ocd)
MNO: Mnod_6949
TMO: TMO_2352
BTHI: BTK_29569
BJS: MY9_0677
SAU: SA0113(sbnB)
SAV: SAV0117
SAW: SAHV_0116
SAM: MW0090(sbnB)
SAS: SAS0091
SAR: SAR0120
SAC: SACOL0101
SAX: USA300HOU_0128(ocd)
SAE: NWMN_0061(sbnB)
SAD: SAAV_0085
SUE: SAOV_0064
SUC: ECTR2_73
SUZ: MS7_0109
SUX: SAEMRSA15_00830(sbnB)
SUW: SATW20_01290(sbnB)
SUG: SAPIG0128
SUF: SARLGA251_00920(sbnB)
SAUA: SAAG_00601
SAUS: SA40_0084(sbnB)
SAUU: SA957_0099(sbnB)
SAUG: SA268_0096(sbnB)
SAUZ: SAZ172_0128(sbnB)
SAUF: X998_0096
SAB: SAB0056
SUY: SA2981_0118(sbnB)
SAUB: C248_0105
SAUM: BN843_1190
SAUC: CA347_128
SAUR: SABB_01723(sbnB)
SAUI: AZ30_00610
SAUD: CH52_05135
SAMS: NI36_00505
SDT: SPSE_2123(sbnB)
SHU: SHYC_00360(sbnB)
SSCH: LH95_00360
SSCZ: RN70_00580
SAGQ: EP23_09765
PRI: PRIO_2664
PSWU: SY83_09665
CAMG: CAMM_04435
RHB: NY08_3271
SGR: SGR_2591
SGB: WQO_01055
SCT: SCAT_2692(arcB)
SVE: SVEN_6262
SALS: SLNWT_4346
STRE: GZL_07297
SLD: T261_1316
SPRI: SPRI_5660
SLAU: SLA_7467
SALJ: SMD11_6086
KSK: KSE_22780(ocd2) KSE_42360(ocd1)
PACC: PAC1_06765
PACD: EGX94_06795(sbnB)
NML: Namu_3876
AMD: AMED_4040(ocd)
AMN: RAM_20590
AMM: AMES_3992(ocd)
AMZ: B737_3992(ocd)
AOI: AORI_4009(ocd)
PSEA: WY02_05020
PSEE: FRP1_00750
PSEH: XF36_12300
SESP: BN6_32450
KAL: KALB_6148
ACTI: UA75_17680
ACAD: UA74_17140
ALO: CRK56752
ASE: ACPL_1001(ocd) ACPL_4121(ocd)
ACTN: L083_2989(ocd)
FLN: FLA_1938
 » show all
Taxonomy
Reference
1  [PMID:21906287]
  Authors
Beasley FC, Cheung J, Heinrichs DE
  Title
Mutation of L-2,3-diaminopropionic acid synthase genes blocks staphyloferrin B synthesis in Staphylococcus aureus.
  Journal
BMC Microbiol 11:199 (2011)
DOI:10.1186/1471-2180-11-199
Reference
2  [PMID:24485762]
  Authors
Kobylarz MJ, Grigg JC, Takayama SJ, Rai DK, Heinrichs DE, Murphy ME
  Title
Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor.
  Journal
Chem Biol 21:379-88 (2014)
DOI:10.1016/j.chembiol.2013.12.011
  Sequence
[sae:NWMN_0061]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.51
IUBMB Enzyme Nomenclature: 1.5.1.51
ExPASy - ENZYME nomenclature database: 1.5.1.51
BRENDA, the Enzyme Database: 1.5.1.51

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