KEGG   ENZYME: 1.5.1.52Help
Entry
EC 1.5.1.52                 Enzyme                                 

Name
staphylopine dehydrogenase;
cntM (gene name);
staphylopine synthase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
staphylopine:NADP+ oxidoreductase [(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate]-forming
Reaction(IUBMB)
staphylopine + NADP+ + H2O = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + pyruvate + NADPH + H+ [RN:R12237]
Reaction(KEGG)
Substrate
staphylopine [CPD:C22024];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate [CPD:C22025];
pyruvate [CPD:C00022];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.
History
EC 1.5.1.52 created 2018
Orthology
K23122  staphylopine/pseudopaline/yersinopine synthase
Genes
YPE: YPO1347
YPK: y2835
YPH: YPC_2840
YPA: YPA_0633
YPN: YPN_2637
YPM: YP_1249
YPP: YPDSF_2352
YPG: YpAngola_A1577
YPZ: YPZ3_1229
YPT: A1122_18850
YPD: YPD4_1192
YPX: YPD8_0953
YPW: CH59_495
YPJ: CH55_1201
YPV: BZ15_2207
YPL: CH46_3782
YPS: YPTB1373
YPO: BZ17_1146
YPY: YPK_2716
YPB: YPTS_1472
YPQ: DJ40_855
YPU: BZ21_649
YPR: BZ20_606
YPC: BZ23_983
YPF: BZ19_781
SERF: L085_18090
PAE: PA4835
PAEV: N297_5004
PAEI: N296_5004
PAEP: PA1S_26280
PAEM: U769_26535
PAEL: T223_26730
PAEG: AI22_07720
PAEC: M802_5002
PAEO: M801_4869
BHA: BH2073
LSP: Bsph_1831
SAU: SA2256
SAV: SAV2468
SAW: SAHV_2452
SAM: MW2392
SAS: SAS2359
SAR: SAR2555
SAC: SACOL2477
SAE: NWMN_2365
SAD: SAAV_2534
SUU: M013TW_2428(cntM)
SUZ: MS7_2481
SUG: SAPIG2518
SAUA: SAAG_00294
SAUS: SA40_2216
SAUU: SA957_2300
SAUG: SA268_2373
SAUF: X998_2452
SAB: SAB2351c
SAUB: C248_2518
SAUC: CA347_2547
SAUR: SABB_01209
SAUI: AZ30_12960
SAUD: CH52_06645
SAMS: NI36_12270
SEP: SE0203
SER: SERP2373
SEPP: SEB_00131
SEPS: DP17_1261
SDT: SPSE_2399
SPAS: STP1_1304
SSCH: LH95_11150
SSCZ: RN70_11900
SAGQ: EP23_10520
SCAR: DWB96_00450(cntM)
PMW: B2K_11205
AMI: Amir_3918
 » show all
Taxonomy
Reference
1  [PMID:27230378]
  Authors
Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezee-Durant E, Arnoux P
  Title
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
  Journal
Science 352:1105-9 (2016)
DOI:10.1126/science.aaf1018
  Sequence
[sav:SAV2468]
Reference
2  [PMID:29618515]
  Authors
McFarlane JS, Davis CL, Lamb AL
  Title
Staphylopine, pseudopaline, and yersinopine dehydrogenases: A structural and kinetic analysis of a new functional class of opine dehydrogenase.
  Journal
J Biol Chem 293:8009-8019 (2018)
DOI:10.1074/jbc.RA118.002007
  Sequence
[sav:SAV2468]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.52
IUBMB Enzyme Nomenclature: 1.5.1.52
ExPASy - ENZYME nomenclature database: 1.5.1.52
BRENDA, the Enzyme Database: 1.5.1.52

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