KEGG   ENZYME: 1.5.1.52Help
Entry
EC 1.5.1.52                 Enzyme                                 

Name
staphylopine dehydrogenase;
cntM (gene name);
staphylopine synthase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
staphylopine:NADP+ oxidoreductase [(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate]-forming
Reaction(IUBMB)
staphylopine + NADP+ + H2O = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + pyruvate + NADPH + H+ [RN:R12237]
Reaction(KEGG)
Substrate
staphylopine [CPD:C22024];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate [CPD:C22025];
pyruvate [CPD:C00022];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.
History
EC 1.5.1.52 created 2018
Orthology
K23122  staphylopine dehydrogenase
Genes
SDO: SD1155_03775
BHA: BH2073
LSP: Bsph_1831
LFU: HR49_11880
LYB: C3943_14845
SAU: SA2256
SAV: SAV2468
SAW: SAHV_2452
SAH: SaurJH1_2544
SAJ: SaurJH9_2495
SAM: MW2392
SAS: SAS2359
SAR: SAR2555
SAC: SACOL2477
SAE: NWMN_2365
SAD: SAAV_2534
SUZ: MS7_2481
SUG: SAPIG2518
SAUA: SAAG_00294
SAUS: SA40_2216
SAUU: SA957_2300
SAUG: SA268_2373
SAUF: X998_2452
SAB: SAB2351c
SAUB: C248_2518
SAUC: CA347_2547
SAUR: SABB_01209
SAUI: AZ30_12960
SAUD: CH52_06645
SAMS: NI36_12270
SEP: SE0203
SER: SERP2373
SEPP: SEB_00131
SEPS: DP17_1261
SDT: SPSE_2399
SPAS: STP1_1304
SSCH: LH95_11150
SSCZ: RN70_11900
SAGQ: EP23_10520
PMW: B2K_11205
AMI: Amir_3918
 » show all
Taxonomy
Reference
1  [PMID:27230378]
  Authors
Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezee-Durant E, Arnoux P
  Title
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
  Journal
Science 352:1105-9 (2016)
DOI:10.1126/science.aaf1018
  Sequence
[sav:SAV2468]
Reference
2  [PMID:29618515]
  Authors
McFarlane JS, Davis CL, Lamb AL
  Title
Staphylopine, pseudopaline, and yersinopine dehydrogenases: A structural and kinetic analysis of a new functional class of opine dehydrogenase.
  Journal
J Biol Chem 293:8009-8019 (2018)
DOI:10.1074/jbc.RA118.002007
  Sequence
[sav:SAV2468]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.52
IUBMB Enzyme Nomenclature: 1.5.1.52
ExPASy - ENZYME nomenclature database: 1.5.1.52
BRENDA, the Enzyme Database: 1.5.1.52

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