KEGG ENZYME: 1.5.1.53

ENZYME: 1.5.1.53

Entry

EC 1.5.1.53                 Enzyme

Name

methylenetetrahydrofolate reductase (NADPH);
MTHFR (gene name);
methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase;
5,10-methylenetetrahydrofolate reductase (NADPH);
5,10-methylenetetrahydrofolic acid reductase (ambiguous);
5,10-CH2-H4folate reductase (ambiguous);
methylenetetrahydrofolate reductase (NADPH2);
5,10-methylenetetrahydrofolate reductase (ambiguous);
methylenetetrahydrofolate reductase (ambiguous);
N5,10-methylenetetrahydrofolate reductase (ambiguous);
5,10-methylenetetrahydropteroylglutamate reductase (ambiguous);
N5,N10-methylenetetrahydrofolate reductase (ambiguous);
methylenetetrahydrofolic acid reductase (ambiguous);
5-methyltetrahydrofolate:(acceptor) oxidoreductase (incorrect);
5,10-methylenetetrahydrofolate reductase (FADH2) (ambiguous)

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

5-methyltetrahydrofolate:NADP+ oxidoreductase

Reaction(IUBMB)

5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH + H+ [RN:R01224]

Reaction(KEGG)

R01224

Substrate

5-methyltetrahydrofolate [CPD:C00440];
NADP+ [CPD:C00006]

Product

5,10-methylenetetrahydrofolate [CPD:C00143];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

A flavoprotein (FAD). The enzyme from yeast and mammals catalyses a physiologically irreversible reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using NADPH as the electron donor. It plays an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. The enzyme contains an N-terminal catalytic domain and a C-terminal allosteric regulatory domain that binds S-adenosyl-L-methionine, which acts as an inhibitor. cf. EC 1.5.1.54, methylenetetrahydrofolate reductase (NADH); EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]; and EC 1.5.7.1, methylenetetrahydrofolate reductase (ferredoxin).

History

EC 1.5.1.53 created 2021

Pathway

ec00670

One carbon pool by folate

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K25004

methylenetetrahydrofolate reductase (NADPH)

Genes

HSA:	4524(MTHFR)

PTR:	469800(MTHFR)

PPS:	100975693(MTHFR)

GGO:	101134157(MTHFR)

PON:	100454623(MTHFR)

NLE:	105738058(MTHFR)

MCC:	714840(MTHFR)

MCF:	102117536(MTHFR)

CSAB:

103225598(MTHFR)

CATY:

105580856(MTHFR)

PANU:

101019898(MTHFR)

TGE:	112616737(MTHFR)

RRO:	104657549(MTHFR)

RBB:	108539360(MTHFR)

TFN:	117093311(MTHFR)

PTEH:

111526316(MTHFR)

CJC:	100391000(MTHFR)

SBQ:	101043467(MTHFR)

CSYR:

103266205(MTHFR)

MMUR:

105882714(MTHFR)

OGA:	100960485(MTHFR)

MMU:	17769(Mthfr)

MCAL:

110293543(Mthfr)

MPAH:

110323320(Mthfr)

RNO:	362657(Mthfr)

MCOC:

116097006(Mthfr)

MUN:	110555748(Mthfr)

CGE:	100774930(Mthfr)

PLEU:

114709673(Mthfr)

NGI:	103747470(Mthfr)

HGL:	101719335(Mthfr)

CPOC:

100715703(Mthfr)

CCAN:

109697792(Mthfr)

DORD:

105997431(Mthfr)

DSP:	122121484(Mthfr)

NCAR:

124983882

OCU:	100352874(MTHFR)

OPI:	101527929(MTHFR)

TUP:	102476978(MTHFR)

CFA:	478230(MTHFR)

VVP:	112929750(MTHFR)

VLG:	121496764(MTHFR)

AML:	100469351(MTHFR)

UMR:	103666650(MTHFR)

UAH:	113270501(MTHFR)

UAR:	123779081(MTHFR)

ELK:

111154700

LLV:

125096774

MPUF:

101694159(MTHFR)

ORO:	101367692(MTHFR)

EJU:	114213206(MTHFR)

ZCA:	113933704(MTHFR)

MLX:	118020001(MTHFR)

FCA:	101100576(MTHFR)

PYU:	121021216(MTHFR)

PBG:	122479932(MTHFR)

PTG:	102969340(MTHFR)

PPAD:

109274118(MTHFR)

AJU:	106971872(MTHFR)

HHV:	120233615(MTHFR)

BTA:	497032(MTHFR)

BOM:	102286710(MTHFR)

BIU:	109570335(MTHFR)

BBUB:

102395627(MTHFR)

CHX:	102182523(MTHFR)

OAS:	101111645(MTHFR)

ODA:	120880227(MTHFR)

CCAD:

122451796(MTHFR)

SSC:	397180(MTHFR)

CFR:	102505417(MTHFR)

CBAI:

105070965(MTHFR)

CDK:	105107034(MTHFR)

VPC:	102532634(MTHFR)

BACU:

102998853(MTHFR)

LVE:	103079236(MTHFR)

OOR:	101287316(MTHFR)

DLE:	111187289(MTHFR)

PCAD:

102986652(MTHFR)

PSIU:

116748237(MTHFR)

ECB:	100050979(MTHFR)

EPZ:	103552183(MTHFR)

EAI:	106836668(MTHFR)

MYB:	102245334(MTHFR)

MYD:	102764267(MTHFR)

MMYO:

118675486(MTHFR)

MLF:	102437960(MTHFR)

MNA:	107531557(MTHFR)

PKL:	118732048(MTHFR)

HAI:	109381260(MTHFR)

DRO:	112299114(MTHFR)

SHON:

118986343(MTHFR)

AJM:	119064129(MTHFR)

PDIC:

114496601(MTHFR)

PHAS:

123831738(MTHFR)

MMF:	118626195(MTHFR)

RFQ:	117027712(MTHFR)

PALE:

102882062(MTHFR)

PGIG:

120585812(MTHFR)

PVP:	105294362(MTHFR)

RAY:	107513124(MTHFR)

MJV:	108385719(MTHFR)

TOD:	119236603(MTHFR)

SARA:

101554814(MTHFR)

LAV:	100661160(MTHFR)

TMU:

101359718

DNM:	101428504(MTHFR)

MDO:	100018128(MTHFR)

GAS:	123240311(MTHFR)

SHR:	100929400(MTHFR)

PCW:	110199057(MTHFR)

OAA:	100086119(MTHFR)

GGA:	419489(MTHFR)

PCOC:

116242702(MTHFR)

MGP:	100543073(MTHFR)

CJO:	107323372(MTHFR)

NMEL:

110408579(MTHFR)

APLA:

101805333(MTHFR)

ACYG:

106040241(MTHFR)

AFUL:

116497721(MTHFR)

TGU:	100220660(MTHFR)

LSR:	110479731(MTHFR)

SCAN:

103820847(MTHFR)

PMOA:

120496725(MTHFR)

OTC:	121343904(MTHFR)

PRUF:

121358379(MTHFR)

GFR:	102033068(MTHFR)

FAB:	101817361(MTHFR)

PHI:	102109675(MTHFR)

PMAJ:

107213633(MTHFR)

CCAE:

111938714(MTHFR)

CCW:	104693242(MTHFR)

ETL:	114056920(MTHFR)

ZAB:	102071430(MTHFR)

FPG:	101920680(MTHFR)

FCH:	102053108(MTHFR)

CLV:	102089900(MTHFR)

EGZ:	104133086(MTHFR)

NNI:	104009002(MTHFR)

ACUN:

113487781(MTHFR)

TALA:

104368439(MTHFR)

PADL:

103918045(MTHFR)

ACHC:

115343387(MTHFR)

AAM:	106482439(MTHFR)

AROW:

112970030(MTHFR)

NPD:	112959653(MTHFR)

DNE:	112980540(MTHFR)

ASN:	102373612(MTHFR)

AMJ:	102573230(MTHFR)

CPOO:

109314267(MTHFR)

GGN:	109293666(MTHFR)

PSS:	102448267(MTHFR)

CMY:	102945698(MTHFR)

CPIC:

101950023(MTHFR)

TST:	117867765(MTHFR)

CABI:

116821910(MTHFR)

MRV:	120387999(MTHFR)

ACS:	100554267(mthfr)

PVT:	110073216(MTHFR)

SUND:

121936126(MTHFR)

PBI:	103051539(MTHFR)

PMUR:

107294169(MTHFR)

TSR:

106553080

PGUT:

117659694(MTHFR)

VKO:	123031059(MTHFR)

PMUA:

114602804 114602982

ZVI:	118087419(MTHFR)

GJA:	107117727(MTHFR)

STOW:

125445948(MTHFR)

XLA:	108697556(mthfr.S) 379784(mthfr.L)

XTR:	100125082(mthfr)

NPR:	108799423(MTHFR)

RTEM:

120915514(MTHFR)

BBUF:

120999546(MTHFR)

BGAR:

122928824(MTHFR)

DRE:	567547(mthfr)

SRX:	107710792(mthfr) 107748978

SANH:

107687111 107691055

SGH:	107595790 107602465

CCAR:

109092734

CAUA:

113097248 113107832

PPRM:

120490013(mthfr)

MAMB:

125280298(mthfr)

IPU:	108265037(mthfr)

PHYP:

113533585(mthfr)

SMEO:

124399833(mthfr)

TFD:	113656298(mthfr)

AMEX:

103033176(mthfr)

EEE:	113578182(mthfr)

TRU:	101078210(mthfr)

TNG:	GSTEN00004910G001

LCO:	104936586(mthfr)

NCC:

104955699

ELY:	117258736(mthfr)

PLEP:

121947149(mthfr)

SLUC:

116058866(mthfr)

ECRA:

117948295

PFLV:

114558693(mthfr)

GAT:	120829205(mthfr)

PPUG:

119223711(mthfr)

MSAM:

119904965(mthfr)

CUD:	121518041(mthfr)

MZE:	101481615(mthfr)

ONL:	100706052(mthfr)

OAU:	116326127(mthfr)

OLA:	101173920(mthfr)

OML:	112140866(mthfr)

XMA:	102216417(mthfr)

XCO:	114141964(mthfr)

XHE:	116724335(mthfr)

PRET:

103466998(mthfr)

PFOR:

103154252(mthfr)

PLAI:

106947843(mthfr)

PMEI:

106926580(mthfr)

GAF:	122832650 122833189

CVG:	107102655(mthfr)

CTUL:

119786289(mthfr)

GMU:	124872528(mthfr)

NFU:	107391521(mthfr)

KMR:	108249409(mthfr)

ALIM:

106529348(mthfr)

NWH:	119429280 119429296

AOCE:

111566112(mthfr)

CSEM:

103384826(mthfr)

POV:

109630958

SSEN:

122777158(mthfr)

HHIP:

117765126(mthfr)

LCF:	108900502(mthfr)

SDU:	111233770(mthfr)

SLAL:

111658836(mthfr)

XGL:	120803549(mthfr)

HCQ:	109528734(mthfr)

BPEC:

110165619(mthfr)

MALB:

109951049(mthfr)

SASA:

106572128(mthfr)

OTW:	112215984 112221595

OMY:	110491842 110532243

OGO:	124031907 124046174

ONE:	115102605 115132121

SALP:

111976745 112068446

SNH:	120059363 120060956

ELS:	105013771(mthfr)

SFM:	108924892(mthfr)

PKI:	111859074(mthfr)

AANG:

118207739(mthfr)

LOC:	102688415(mthfr)

PSPA:

121329149 121329216

ARUT:

117425554 117426084

LCM:	102358326(MTHFR)

CMK:	103181396(mthfr)

RTP:	109914604(mthfr)

BFO:

118430292

BBEL:

109472626

CIN:

100180174

SCLV:

120326455

SPU:	115924565 589576

APLC:

110979147

SKO:	100368141(MTHFR)

DME:	Dmel_CG7560(CG7560)

DER:

6544580

DSE:

6605265

DSI:	Dsimw501_GD14304(Dsim_GD14304)

DYA:	Dyak_GE21809

DAN:

6507885

DSR:

110181246

DPO:	Dpse_GA20440

DPE:

6598998

DMN:

108152200

DWI:

6638944

DGR:

6558496

DMO:	Dmoj_GI11604

DAZ:

108614675

DNV:

108652425

DHE:	111593115 111601129 115483195

DVI:

6623335

CCAT:

101460408

BOD:

106627885

MDE:

101899703

SCAC:

106085892

LCQ:

111684318

AGA:	AgaP_AGAP007479

ACOZ:

120953025

AARA:

120896047

AAG:

5569213

AALB:

109397828 109418971

CQU:	CpipJ_CPIJ000297

CPII:

120426570

AME:

100578936

ACER:

107992402 107998358

ALAB:

122721074

BIM:

100748829

BBIF:

117210096

BVK:

117241833

BVAN:

117156993

BTER:

100645686

BPYO:

122573640

CCAL:

108622149

OBB:

114872033

MGEN:

117219788

NMEA:

116424754

CGIG:

122401806

SOC:

105204539

MPHA:

105829361

AEC:

105154491

ACEP:

105621269

PBAR:

105430772

VEM:

105563068

HST:

105185895

DQU:

106745791

CFO:

105256449

LHU:

105668934

PGC:

109861296

OBO:

105277295

PCF:

106789672

PFUC:

122518885

NVI:

100117482

CSOL:

105360655

MDL:

103571235

FAS:

105270971

CCIN:

107270032

DPA:

109534565

LDC:

111506350

OTU:

111417540

BMOR:

101735471

BMAN:

114249102

DPL:	KGM_206647

PMAC:

106711396

ZCE:

119833059

HAW:

110376495

TNL:

113495626

PXY:

105388246

BTAB:

109032747

NLU:

111045770

FOC:

113212146

ZNE:

110838326

CSEC:

111867742

FCD:

110842614

DPX:	DAPPUDRAFT_301720

DMK:

116931209

PVM:

113812240

PJA:

122261979

PCHN:

125024515

HAME:

121871205

PCLA:

123760246

PTRU:

123503654

HAZT:

108681433

EAF:

111701357

TUT:

107360415

DPTE:

113790060 113794623

DFR:	124489958 124493973

CSCU:

111641837

CEL:	CELE_C06A8.1(mthf-1)

CBR:

CBG_12960

BMY:	BM_BM1999(Bma-mthf-1)

LOA:	LOAG_08597

NAI:	NECAME_11843

TSP:

Tsp_08753

HRO:	HELRODRAFT_111699

LGI:	LOTGIDRAFT_214878

PCAN:

112556142 112556236

BGT:

106068520

GAE:

121390023

HRF:

124132255

HRJ:

124273373

CRG:

105340188

MYI:

110460561

PMAX:

117344501

MMER:

123527799

OBI:

106882151

OSN:

115209099

LAK:	106154846 106174355

NVE:	5512577 5513626

EPA:	110252119 110252167

ATEN:

116304937 116305961

ADF:

107327049

AMIL:

114962073 114969824

PDAM:

113668139 113679154

SPIS:

111327128 111332195

DGT:	114528959 114537439

XEN:

124457394

HMG:

100207609

TAD:	TRIADDRAFT_26971

AQU:

100636961

QSU:	111983405 111983801 112009590 112012001

SCE:	YGL125W(MET13) YPL023C(MET12)

SEUB:

DI49_1849 DI49_5433

SPAO:

SPAR_G01230 SPAR_P02400

AGO:	AGOS_AAR170W AGOS_AFR457W

ERC:	Ecym_1400 Ecym_3063

KLA:	KLLA0_D12188g KLLA0_F09647g

KMX:	KLMA_20276(MET13) KLMA_60378(MET12)

LTH:	KLTH0E11022g KLTH0H06446g

VPO:	Kpol_1007p12 Kpol_223p6

ZRO:	ZYRO0A02838g ZYRO0E01870g

CGR:	CAGL0F07029g CAGL0J09504g

NCS:	NCAS_0C02530(NCAS0C02530) NCAS_0D03140(NCAS0D03140)

NDI:	NDAI_0E03230(NDAI0E03230) NDAI_0I01770(NDAI0I01770)

TPF:	TPHA_0C01840(TPHA0C01840) TPHA_0J01830(TPHA0J01830)

TBL:	TBLA_0D02780(TBLA0D02780) TBLA_0F02520(TBLA0F02520)

TDL:	TDEL_0B01620(TDEL0B01620) TDEL_0G03480(TDEL0G03480)

TGB:	HG536_0H01660 HG536_0H03600

KAF:	KAFR_0A04630(KAFR0A04630) KAFR_0H01590(KAFR0H01590)

KNG:	KNAG_0A02370(KNAG0A02370) KNAG_0F02500(KNAG0F02500)

ZMK:	HG535_0B03260 HG535_0C01620

PPA:	PAS_chr2-2_0145 PAS_chr2-2_0182

DHA:	DEHA2F08976g DEHA2G01254g

PIC:	PICST_71674 PICST_83803

PGU:	PGUG_01501 PGUG_04648

SPAA:

SPAPADRAFT_137530 SPAPADRAFT_51518

LEL:	LELG_02112 LELG_02622

CAL:	CAALFM_C210460CA(CaO19.5321) CAALFM_C302950CA(MET13)

CTP:	CTRG_02026 CTRG_02573

COT:	CORT_0B03880 CORT_0C03560

CDU:	CD36_24470 CD36_82930

CTEN:

CANTEDRAFT_118482 CANTEDRAFT_131676

YLI:	YALI0B00572g YALI0B14465g

CLU:	CLUG_02387 CLUG_05125

CLUS:

A9F13_03g01133 A9F13_24g00066

CAUR:

CJI97_000409 CJI97_003816

SLB:	AWJ20_3315(MET13) AWJ20_715(MET12)

PKZ:	C5L36_0B07640 C5L36_0D03770

BNN:	FOA43_000536 FOA43_004528

BBRX:

BRETT_001890 BRETT_003148

OPA:	HPODL_00022 HPODL_02993

NCR:	NCU07690 NCU09545

NTE:	NEUTE1DRAFT128536(NEUTE1DRAFT_128536) NEUTE1DRAFT57029(NEUTE1DRAFT_57029)

SMP:	SMAC_00862 SMAC_06582

PAN:	PODANSg7263 PODANSg8765

TTT:	THITE_2107143 THITE_2115191

MTM:	MYCTH_2300974 MYCTH_2314160

CTHR:

CTHT_0033700 CTHT_0065570

MGR:	MGG_01728 MGG_08171

PPEI:

PpBr36_01245 PpBr36_01602

TMN:	UCRPA7_3085 UCRPA7_6818

SSCK:

SPSK_03199 SPSK_05053

FGR:	FGSG_07127 FGSG_09572

FPU:	FPSE_04091 FPSE_05848

FVR:	FVEG_04126 FVEG_08038

FOX:	FOXG_01673 FOXG_06273

NHE:	NECHADRAFT_32750 NECHADRAFT_71723

TRE:	TRIREDRAFT_55055 TRIREDRAFT_81824

TRR:	M419DRAFT_104048 M419DRAFT_135784

MAW:	MAC_00485 MAC_07771

MAJ:	MAA_01221 MAA_07320

CMT:	CCM_04157 CCM_05621

PLJ:	VFPFJ_00742 VFPFJ_07817

VAL:	VDBG_00123 VDBG_00853

VDA:	VDAG_00463 VDAG_08410

CFJ:	CFIO01_02428 CFIO01_07029

CHIG:

CH63R_04201 CH63R_07780

SAPO:

SAPIO_CDS7226

ELA:	UCREL1_6847 UCREL1_9493

PFY:	PFICI_05432 PFICI_08066

SSL:	SS1G_02009 SS1G_09764

BFU:	BCIN_07g02820 BCIN_07g06360

MBE:	MBM_01665 MBM_08501

PSCO:

LY89DRAFT_718062 LY89DRAFT_769751

GLZ:	GLAREA_11463 GLAREA_12614

ANI:	AN5883.2 AN8215.2

AFM:	AFUA_2G11300 AFUA_5G03480

ACT:	ACLA_001700 ACLA_070260

NFI:	NFIA_038640 NFIA_086570

AOR:	AO090026000520 AO090102000557

ANG:	ANI_1_1512084(An09g05860) ANI_1_2398024(An02g03270)

AFV:	AFLA_005756 AFLA_011983

ALUC:

AKAW2_21343A AKAW2_40591A

ACHE:

ACHE_40648S ACHE_50694S

APUU:

APUU_10896A APUU_60645S

PCS:	Pc15g00480 Pc21g15910

PDP:	PDIP_10790 PDIP_48850

TMF:	PMAA_048540 PMAA_082190

TRG:	TRUGW13939_07742 TRUGW13939_08425

CIM:	CIMG_06560 CIMG_08202

CPW:	CPC735_022180 CPC735_030300

URE:	UREG_02453 UREG_03880

PBL:	PAAG_03665 PAAG_04294

PBN:	PADG_03172 PADG_07528

ABE:	ARB_01328 ARB_06846

TVE:	TRV_05244 TRV_07376

AJE:	HCAG_00541 HCAG_07107

BGH:	BDBG_00602 BDBG_01364

PNO:	SNOG_10985(SNOG_10984) SNOG_12690

PTE:	PTT_09481 PTT_18113

BZE:	COCCADRAFT_87884 COCCADRAFT_96319

BSC:	COCSADRAFT_136346 COCSADRAFT_140784

BOR:	COCMIDRAFT_28378 COCMIDRAFT_4719

AALT:

CC77DRAFT_1092254 CC77DRAFT_958941

ZTR:	MYCGRDRAFT_109648 MYCGRDRAFT_75203

PFJ:	MYCFIDRAFT_49642 MYCFIDRAFT_81197

FFU:	CLAFUR5_07224 CLAFUR5_07965

BCOM:

BAUCODRAFT_210105 BAUCODRAFT_237275

NPA:	UCRNP2_6300 UCRNP2_9800

TML:	GSTUM_00003351001 GSTUM_00010817001

SPO:	SPAC343.10(met11) SPAC56F8.10(met9)

CNE:	CNA07390 CNL04820

CNB:	CNBA7210 CNBI2020

CNG:	CNAG_00760 CNAG_05140

CGI:	CGB_A8490W CGB_D2260W

TMS:	TREMEDRAFT_38541 TREMEDRAFT_43239

TASA:

A1Q1_00789 A1Q1_04951

TVS:	TRAVEDRAFT_164884 TRAVEDRAFT_28907

DSQ:	DICSQDRAFT_134054 DICSQDRAFT_177540

PCO:	PHACADRAFT_208793 PHACADRAFT_264540

SHS:	STEHIDRAFT_157081 STEHIDRAFT_75044

HIR:	HETIRDRAFT_445887 HETIRDRAFT_471420

PSQ:	PUNSTDRAFT_113018 PUNSTDRAFT_53586

ADL:	AURDEDRAFT_106360 AURDEDRAFT_142206

FME:	FOMMEDRAFT_100481 FOMMEDRAFT_88181

GTR:	GLOTRDRAFT_105411 GLOTRDRAFT_71781

LBC:	LACBIDRAFT_182479 LACBIDRAFT_244474

MRR:	Moror_1385 Moror_17235

E1B28_007686 E1B28_009106

CCI:	CC1G_00920 CC1G_01198

SCM:	SCHCODRAFT_65419 SCHCODRAFT_67475

ABP:	AGABI1DRAFT111963(AGABI1DRAFT_111963) AGABI1DRAFT68194(AGABI1DRAFT_68194)

ABV:	AGABI2DRAFT193205(AGABI2DRAFT_193205) AGABI2DRAFT216007(AGABI2DRAFT_216007)

CPUT:

CONPUDRAFT_117110 CONPUDRAFT_59824

SLA:	SERLADRAFT_363249

WSE:	WALSEDRAFT_37442 WALSEDRAFT_66783

WIC:	J056_001516 J056_004424

UMA:	UMAG_04612 UMAG_06065

PFP:	PFL1_01460 PFL1_02036

MGL:	MGL_3526 MGL_3786

MRT:	MRET_0589 MRET_0910

MSYM:

MSY001_1846 MSY001_2971

PGR:	PGTG_02893 PGTG_15769

MLR:	MELLADRAFT_42930 MELLADRAFT_45803

» show all

Reference

1 [PMID:13817476]

Authors

DONALDSON KO, KERESZTESY JC.

Title

Naturally occurring forms of folic acid. I. "Prefolic A": preparation of concentrate and enzymatic conversion to citrovorum factor.

Journal

J Biol Chem 234:3235-40 (1959)

Reference

2 [PMID:4399897]

Authors

Kutzbach C, Stokstad EL.

Title

Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine.

Journal

Biochim Biophys Acta 250:459-77 (1971)
DOI:10.1016/0005-2744(71)90247-6

Reference

3 [PMID:6975779]

Authors

Daubner SC, Matthews RG.

Title

Purification and properties of methylenetetrahydrofolate reductase from pig liver.

Journal

J Biol Chem 257:140-5 (1982)

Reference

4 [PMID:2383427]

Authors

Zhou J, Kang SS, Wong PW, Fournier B, Rozen R.

Title

Purification and characterization of methylenetetrahydrofolate reductase from human cadaver liver.

Journal

Biochem Med Metab Biol 43:234-42 (1990)
DOI:10.1016/0885-4505(90)90029-z

Reference

5 [PMID:11729203]

Authors

Roje S, Chan SY, Kaplan F, Raymond RK, Horne DW, Appling DR, Hanson AD.

Title

Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo.

Journal

J Biol Chem 277:4056-61 (2002)
DOI:10.1074/jbc.M110651200

Reference

6 [PMID:29891918]

Authors

Froese DS, Kopec J, Rembeza E, Bezerra GA, Oberholzer AE, Suormala T, Lutz S, Chalk R, Borkowska O, Baumgartner MR, Yue WW.

Title

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.

Journal

Nat Commun 9:2261 (2018)
DOI:10.1038/s41467-018-04735-2

Sequence

[hsa:4524] [sce:YPL023C]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.53

IUBMB Enzyme Nomenclature:

1.5.1.53

ExPASy - ENZYME nomenclature database:

1.5.1.53

BRENDA, the Enzyme Database:

1.5.1.53

CAS:	71822-25-8

All links

Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (701)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (700)   
All databases (714)   

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