KEGG   ENZYME: 1.5.1.6
Entry
EC 1.5.1.6                  Enzyme                                 
Name
formyltetrahydrofolate dehydrogenase;
10-formyl tetrahydrofolate:NADP oxidoreductase;
10-formyl-H2PtGlu:NADP oxidoreductase ;
10-formyl-H4folate dehydrogenase;
N10-formyltetrahydrofolate dehydrogenase ;
10-formyltetrahydrofolate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
10-formyltetrahydrofolate:NADP+ oxidoreductase
Reaction(IUBMB)
10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+ [RN:R00941]
Reaction(KEGG)
R00941
Substrate
10-formyltetrahydrofolate [CPD:C00234];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
tetrahydrofolate [CPD:C00101];
CO2 [CPD:C00011];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.5.1.6 created 1972
Pathway
ec00670  One carbon pool by folate
ec01100  Metabolic pathways
Orthology
K00289  formyltetrahydrofolate dehydrogenase
Genes
HSA10840(ALDH1L1) 160428(ALDH1L2)
PTR452195(ALDH1L2) 460655(ALDH1L1)
PPS100978685(ALDH1L2) 100989341(ALDH1L1)
GGO101134299(ALDH1L1) 101139377(ALDH1L2)
PON100172380(ALDH1L1) 100459691(ALDH1L2)
NLE100587670(ALDH1L1) 100604236(ALDH1L2)
MCC701242(ALDH1L2) 716977(ALDH1L1)
MCF102115759(ALDH1L2) 102146254(ALDH1L1)
CSAB103228129(ALDH1L1) 103239007(ALDH1L2)
CATY105573273(ALDH1L2) 105589811(ALDH1L1)
PANU101021537(ALDH1L2) 101025922(ALDH1L1)
TGE112619430(ALDH1L1) 112635275(ALDH1L2)
RRO104657483(ALDH1L2) 104675907(ALDH1L1)
RBB108528191(ALDH1L1) 108544280(ALDH1L2)
TFN117083372(ALDH1L1) 117089496(ALDH1L2)
PTEH111540530(ALDH1L2) 111544651(ALDH1L1)
CJC100391281(ALDH1L1) 100403455(ALDH1L2)
SBQ101028391(ALDH1L2) 101052460(ALDH1L1)
CSYR103273966(ALDH1L2) 103276884(ALDH1L1)
MMUR105862258 105875597(ALDH1L2)
OGA100946787(ALDH1L2) 100948849(ALDH1L1)
MMU107747(Aldh1l1) 216188(Aldh1l2)
MCAL110295709(Aldh1l1) 110303271(Aldh1l2)
MPAH110315010(Aldh1l1) 110326326(Aldh1l2)
RNO299699(Aldh1l2) 64392(Aldh1l1)
MCOC116076480(Aldh1l2) 116099258(Aldh1l1)
MUN110549855(Aldh1l1) 110550767(Aldh1l2)
CGE100762089(Aldh1l1) 100772371(Aldh1l2)
PLEU114681208(Aldh1l1) 114702991(Aldh1l2)
NGI103730367(Aldh1l1) 103742132(Aldh1l2)
HGL101697075(Aldh1l2) 101709289(Aldh1l1)
CPOC100717976(Aldh1l2) 100730205(Aldh1l1)
CCAN109681401(Aldh1l1) 109685514(Aldh1l2)
DORD105981372(Aldh1l1) 105988073(Aldh1l2)
DSP122107953(Aldh1l1) 122119300(Aldh1l2)
NCAR124970944 124983834
OCU100355778(ALDH1L2) 100356705(ALDH1L1)
OPI101523021(ALDH1L1) 101523052(ALDH1L2)
TUP102499911(ALDH1L1) 102502729(ALDH1L2)
CFA474534(ALDH1L2) 476506(ALDH1L1)
VVP112914495(ALDH1L1) 112929137(ALDH1L2)
VLG121492117(ALDH1L2) 121494574(ALDH1L1)
AML100465263(ALDH1L1) 100476798(ALDH1L2)
UMR103669466(ALDH1L1) 103676565(ALDH1L2)
UAH113255960(ALDH1L2) 113257287(ALDH1L1)
UAR123780833(ALDH1L2) 123802050(ALDH1L1)
ELK111142084 111159051
LLV125106619 125107476
MPUF101670776(ALDH1L2) 101683491(ALDH1L1)
ORO101369691(ALDH1L1) 101380649(ALDH1L2)
EJU114207725(ALDH1L1) 114222944(ALDH1L2)
ZCA113917843(ALDH1L1) 113922912(ALDH1L2)
MLX117998787(ALDH1L2) 118005896(ALDH1L1)
FCA101088592(ALDH1L2) 101091432(ALDH1L1)
PYU121022275(ALDH1L1) 121040494(ALDH1L2)
PBG122472631(ALDH1L2) 122487613(ALDH1L1)
PTG102969433(ALDH1L2) 102971961(ALDH1L1)
PPAD109261178(ALDH1L1) 109265446(ALDH1L2)
AJU106968242 106971881(ALDH1L2) 106985431(ALDH1L1)
HHV120221253(ALDH1L1) 120245710(ALDH1L2)
BTA505677(ALDH1L1) 516864(ALDH1L2)
BOM102269375(ALDH1L2)
BIU109556620(ALDH1L1) 109559467(ALDH1L2)
BBUB102408419(ALDH1L1) 102416005(ALDH1L2)
CHX102179144(ALDH1L1) 102189931(ALDH1L2)
OAS100913154(ALDH1L1) 101114182(ALDH1L2)
ODA120858635(ALDH1L2) 120868039(ALDH1L1)
CCAD122423681(ALDH1L2) 122424683(ALDH1L1)
SSC100151976(ALDH1L2) 100622210(ALDH1L1)
CFR102512961(ALDH1L1) 102521632(ALDH1L2)
CBAI105071688(ALDH1L1) 105081391(ALDH1L2)
CDK105102962(ALDH1L2) 105104512(ALDH1L1)
VPC102534100(ALDH1L1) 102543803(ALDH1L2)
BACU103005570(ALDH1L2) 103015395(ALDH1L1)
LVE103079904(ALDH1L2) 103083157(ALDH1L1)
OOR101286106(ALDH1L2) 101287203(ALDH1L1)
DLE111168786(ALDH1L1) 111187792(ALDH1L2)
PCAD102974464(ALDH1L1) 102980582(ALDH1L2)
PSIU116761354(ALDH1L2) 116762583(ALDH1L1)
ECB100053705(ALDH1L2) 100061108(ALDH1L1)
EPZ103552696(ALDH1L2) 103567591
EAI106834458(ALDH1L1) 106846797(ALDH1L2)
MYB102246127(ALDH1L1) 102256559(ALDH1L2)
MYD102751421(ALDH1L1) 102763705(ALDH1L2)
MMYO118651256(ALDH1L2) 118663424(ALDH1L1)
MLF102433777(ALDH1L2) 102435890(ALDH1L1)
MNA107525201(ALDH1L1) 107545107(ALDH1L2)
PKL118708220(ALDH1L1) 118730514(ALDH1L2)
HAI109377662(ALDH1L1) 109387752(ALDH1L2)
DRO112321822(ALDH1L2) 112322753(ALDH1L1)
SHON119002192(ALDH1L2)
AJM119060456(ALDH1L2)
PDIC114506345(ALDH1L1) 114514058(ALDH1L2)
PHAS123810697(ALDH1L2) 123825970(ALDH1L1)
MMF118618641(ALDH1L1) 118623650(ALDH1L2)
RFQ117028624(ALDH1L2) 117038749(ALDH1L1)
PALE102886245(ALDH1L2) 102893157(ALDH1L1)
PGIG120586980(ALDH1L1) 120614929(ALDH1L2)
PVP105302834(ALDH1L1) 105310852(ALDH1L2)
RAY107501175(ALDH1L2) 107518670(ALDH1L1)
MJV108384558(ALDH1L1) 108387648(ALDH1L2)
TOD119247349(ALDH1L2) 119256429(ALDH1L1)
SARA101540284(ALDH1L1) 101545100(ALDH1L2)
LAV100667848(ALDH1L2) 100671746(ALDH1L1)
TMU101344531 101350101
DNM101411027(ALDH1L1) 101429958(ALDH1L2)
MDO100022528(ALDH1L2) 100026594(ALDH1L1)
GAS123247283(ALDH1L1) 123250103(ALDH1L2)
SHR100918967(ALDH1L1) 100922488(ALDH1L2)
PCW110204922(ALDH1L1) 110205675(ALDH1L2)
OAA100074128(ALDH1L2) 100078554(ALDH1L1)
GGA418078(ALDH1L2)
PCOC116233259(ALDH1L2)
MGP100545356(ALDH1L2)
CJO107314831(ALDH1L2)
NMEL110393737(ALDH1L2)
APLA101803074(ALDH1L2)
ACYG106035909(ALDH1L2)
AFUL116501972(ALDH1L2)
TGU100230131(ALDH1L2)
LSR110473543(ALDH1L2)
SCAN103813189(ALDH1L2)
PMOA120507634(ALDH1L2)
OTC121347881(ALDH1L2)
PRUF121354226(ALDH1L2)
GFR102034252(ALDH1L2)
FAB101806345(ALDH1L2)
PHI102110155(ALDH1L2)
PMAJ107205083(ALDH1L2)
CCAE111931314(ALDH1L2)
CCW104696244(ALDH1L2)
ETL114060728(ALDH1L2)
ZAB102074981(ALDH1L2)
FPG101912914(ALDH1L2)
FCH102059837(ALDH1L2)
CLV102096623(ALDH1L2)
EGZ104132735(ALDH1L2)
NNI104013369(ALDH1L2)
ACUN113491113(ALDH1L2)
TALA104359730(ALDH1L2)
PADL103924532(ALDH1L2)
ACHC115352613(ALDH1L2)
AAM106488260(ALDH1L2)
AROW112961537(ALDH1L2)
NPD112958409(ALDH1L2)
DNE112993928(ALDH1L2)
ASN102384520(ALDH1L2)
AMJ102558655(ALDH1L2)
CPOO109315935(ALDH1L2)
PSS102444892(ALDH1L2)
CMY102943513(ALDH1L2)
CPIC101938032(ALDH1L2)
TST117881299(ALDH1L2)
CABI116814636(ALDH1L2)
MRV120370291(ALDH1L2)
ACS100552265(aldh1l2)
PVT110084777(ALDH1L2)
SUND121930417(ALDH1L2)
PBI103068063(ALDH1L2)
PMUR107286673(ALDH1L2)
TSR106537922
PGUT117655651(ALDH1L2)
VKO123028917(ALDH1L2)
PMUA114605405(ALDH1L2)
ZVI118091289(ALDH1L2)
GJA107124197(ALDH1L2)
STOW125434442(ALDH1L2)
XLA108711033(aldh1l2.L) 108713198(aldh1l2.S) 444321(aldh1l1.L)
XTR100127737(aldh1l2) 496436(aldh1l1)
NPR108784934(ALDH1L2) 108795920
RTEM120932117(ALDH1L2) 120945119
BBUF120978592(ALDH1L1) 120979352(ALDH1L2)
BGAR122923157 122928092(ALDH1L2) 122943341(ALDH1L1)
DRE100333269(aldh1l2) 100526683(aldh1l1)
SRX107710173 107726046(aldh1l2) 107743541 107755669
SANH107656123 107656317 107658818 107691487
SGH107580561 107586352 107592231
CCAR109106415
CAUA113048288 113050708 113059007
PPRM120466934(aldh1l1) 120476576(aldh1l2)
MAMB125245544(aldh1l2) 125278104(aldh1l1)
IPU108272091(aldh1l1) 108280121(aldh1l2)
PHYP113530536 113532247(aldh1l2)
SMEO124390046(aldh1l1) 124401507(aldh1l2)
TFD113642874(aldh1l1) 113645752(aldh1l2)
AMEX103022276 103024881(aldh1l2)
EEE113581548 113584409(aldh1l2)
TRU101063025 101078185(aldh1l2)
TNGGSTEN00003776G001 GSTEN00032475G001
LCO104923764(aldh1l2) 104936356
NCC104948869
CGOB115008648 115028413
ELY117249218(aldh1l2) 117257498(aldh1l1)
PLEP121951872(aldh1l1) 121961501(aldh1l2)
SLUC116042053(aldh1l2) 116050232
ECRA117939092(aldh1l2) 117943786(aldh1l1)
PFLV114549841 114553837
GAT120818154(aldh1l2) 120835586(aldh1l1)
PPUG119211597(aldh1l2) 119229951(aldh1l1)
MSAM119885546 119918162(aldh1l2)
CUD121505314(aldh1l2) 121506812(aldh1l1)
MZE101480024 101485420 112433931
ONL100704523 100710779(aldh1l2)
OAU116313687(aldh1l1) 116316283(aldh1l2)
OLA101167504(aldh1l2) 101174660
OML112145476(aldh1l1) 112157195(aldh1l2)
XMA102232560(aldh1l2) 102235454 102237507 111605848
XCO114135580 114160830(aldh1l2)
XHE116709908 116736641(aldh1l2)
PRET103459710 103465496
PFOR103151786(aldh1l2) 103152725
PLAI106959693 106960202(aldh1l2)
PMEI106926622(aldh1l2) 106929322
GAF122826500(aldh1l2) 122833744(aldh1l1)
CVG107100664 107103970
CTUL119772607 119775063(aldh1l2)
GMU124857202(aldh1l1) 124883334(aldh1l2)
NFU107385971 107395064
KMR108228235 108228428(aldh1l2)
ALIM106526877 106530822(aldh1l2)
NWH119412177(aldh1l1)
AOCE111580328 111589053(aldh1l2)
CSEM103382426(aldh1l2) 103386628
POV109629008 109637471(aldh1l2)
SSEN122760542 122766131(aldh1l2)
HHIP117757373(aldh1l2) 117760918(aldh1l1)
LCF108877470 108897497(aldh1l2)
SDU111221548 111224720(aldh1l2)
SLAL111664233(aldh1l2) 111668621
XGL120800781(aldh1l2) 120807326(aldh1l1)
HCQ109514831 109520145
BPEC110167873 110170281
MALB109960958(aldh1l2) 109970592
SASA106576152 106583638 106609325
OTW112214304 112246202 112256543(aldh1l2)
OMY110490304(aldh1l2) 110500181 110528507
OGO123994601 124014283 124026926
ONE115106988 115133131 115143729
SALP111970466 112072655
SNH120032248 120050022 120065415
ELS105024789 105030469(aldh1l2)
SFM108918573 108921000(aldh1l2)
PKI111844275(aldh1l2) 111851698
AANG118210495(aldh1l1) 118218844(aldh1l2)
LOC102683454(aldh1l2) 102687756
PSPA121298085 121318469 121319628
ARUT117411986 117413641 117415484 117419439
LCM102358231(ALDH1L1) 102358739(ALDH1L2)
CMK103176681(aldh1l1) 103189341(aldh1l2)
RTP109921813 109925323
BFO118416886
BBEL109477301
CIN100184767
SCLV120339567
SPU579576
APLC110988231
SKO100377034
DMEDmel_CG8665(CG8665)
DER6549051
DSE6618276
DSIDsimw501_GD24321(Dsim_GD24321)
DYADyak_GE12917
DAN6497158
DSR110185619
DPODpse_GA21245
DPE6596524
DMN108163121
DWI6646785
DGR6566387
DMODmoj_GI12253
DAZ108611319
DNV108649362
DHE111600430
DVI6634053
CCAT101452556
BOD106617684
MDE101890653
SCAC106084409
LCQ111679234
AGAAgaP_AGAP009591
ACOZ120956759
AARA120902656
AAG110673980
AALB109409300 109419523 115258594
CQUCpipJ_CPIJ011996
CPII120427986
CNS116339492
AME551401
ACER107992622
ALAB122717318
BIM100746301
BBIF117214367
BVK117242354
BVAN117161122
BTER100649608
BPYO122576299
CCAL108626937
OBB114872183
MGEN117226795
NMEA116426038
CGIG122404444
SOC105206141
MPHA105840458
AEC105153649
ACEP105622759
PBAR105424800
VEM105562673
HST105187366
DQU106749188
CFO105248128
FEX115245043
LHU105679818
PGC109861483
OBO105275280
PCF106785278
PFUC122526356
VPS122627706
NVI100119020
CSOL105365306
TPRE106652434
MDL103568156
CGLO123260877
FAS105268688
DAM107045710
AGIF122848362
CCIN107270074
TCA658435
DPA109543725
SOY115890824
ATD109602753
CSET123320407
AGB108911977
LDC111504132
NVL108569633
APLN108735799
PPYR116161356
OTU111418399
BMOR101747054
MSEX115452884
DPLKGM_206880
BANY112056728
PMAC106709931
PPOT106109249
PXU106117866
PRAP111001935
ZCE119836154
HAW110370815
TNL113502774
SLIU111360026
OFU114361881
PXY105393550 105394963
API100164524
DNX107173475
AGS114127948 114127976
RMD113551508
BTAB109038673
DCI103523378
NLU111054495
FOC113209527
ZNE110839967
CSEC111869339
FCD110852894
DPXDAPPUDRAFT_326816
DMK116930373
PVM113817880
PJA122254241
PCHN125045866
HAME121868414
PCLA123764363
PTRU123499957
HAZT108681516
EAF111710248
LSM121115688
DSV119431415
RSAN119406860
RMP119163364
TUT107359586
DPTE113789477
DFR124500458
CSCU111623722
PTEP107446985
SDM118182453
CELCELE_F36H1.6(alh-3)
CBRCBG_05984(Cbr-alh-3)
NAINECAME_13084
HROHELRODRAFT_108094
LGILOTGIDRAFT_237306
PCAN112572536
BGT106070094
GAE121367582
HRF124134281
HRJ124258635
CRG105347685
MYI110441897
PMAX117330840
OBI106875996
OSN115216749
LAK106163076
NVE5518304
EPA110242486
ATEN116305890
ADF107340102
AMIL114962228
PDAM113677236
SPIS111330761
DGT114530510
XEN124434062
TADTRIADDRAFT_37496
AQU100636359
 » show all
Reference
1  [PMID:4384443]
  Authors
Kutzbach C, Stokstad EL.
  Title
Partial purification of a 10-formyl-tetrahydrofolate: NADP oxidoreductase from mammalian liver.
  Journal
Biochem Biophys Res Commun 30:111-7 (1968)
DOI:10.1016/0006-291X(68)90456-7
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.6
IUBMB Enzyme Nomenclature: 1.5.1.6
ExPASy - ENZYME nomenclature database: 1.5.1.6
BRENDA, the Enzyme Database: 1.5.1.6
CAS: 37256-25-0

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