KEGG   ENZYME: 1.5.1.7Help
Entry
EC 1.5.1.7                  Enzyme                                 

Name
saccharopine dehydrogenase (NAD+, L-lysine-forming);
lysine-2-oxoglutarate reductase;
dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming);
epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming);
N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming);
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+ [RN:R00715]
Reaction(KEGG)
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
L-lysine [CPD:C00047];
2-oxoglutarate [CPD:C00026];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.5.1.7 created 1972
Pathway
ec00300  Lysine biosynthesis
ec00310  Lysine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K00290  saccharopine dehydrogenase (NAD+, L-lysine forming)
Genes
NVE: NEMVE_v1g165768
EPA: 110253051
ADF: 107350380
SCE: YIR034C(LYS1)
AGO: AGOS_ACR167C
ERC: Ecym_5636
KLA: KLLA0_E07987g
KMX: KLMA_40368(LYS1)
LTH: KLTH0C00594g
VPO: Kpol_1057p13
NCS: NCAS_0A08650(NCAS0A08650)
NDI: NDAI_0G05090(NDAI0G05090)
TPF: TPHA_0N01860(TPHA0N01860)
TBL: TBLA_0C01000(TBLA0C01000)
TDL: TDEL_0B07590(TDEL0B07590)
KAF: KAFR_0A00160(KAFR0A00160)
PIC: PICST_86170(LYS1)
SPAA: SPAPADRAFT_147229(LYS1)
CAL: CAALFM_C405320WA(LYS1)
CAUR: QG37_02101
SLB: AWJ20_1568(LYS1)
NCR: NCU03118
NTE: NEUTE1DRAFT91293(NEUTE1DRAFT_91293)
MGR: MGG_01359
SSCK: SPSK_03427
MAW: MAC_09690
MAJ: MAA_06003
BFU: BCIN_05g04270(Bclys1)
MBE: MBM_03432
ANG: ANI_1_1044024(An02g07500)
ABE: ARB_05726
TVE: TRV_03009
PTE: PTT_12058
SPO: SPAC227.18(lys3)
CNE: CND06290
CNB: CNBD0140
MRR: Moror_145
ABP: AGABI1DRAFT96692(AGABI1DRAFT_96692)
ABV: AGABI2DRAFT133180(AGABI2DRAFT_133180)
MGL: MGL_0554
PPR: PBPRB1102(SAV1788)
SVO: SVI_3927
SPSW: Sps_03208
ILO: IL1999
PAT: Patl_0748
AMAL: I607_14825
AMAE: I876_15125
AMAO: I634_15070
AMAD: I636_14935
AMAI: I635_15510
AMAG: I533_14650
AMAC: MASE_14680
AAUS: EP12_15405
ASP: AOR13_357
GNI: GNIT_2771
GPS: C427_0697
SALH: HMF8227_02643(lys1)
CJA: CJA_1512
SDE: Sde_1597
TTU: TERTU_1609(lys1)
FTN: FTN_0964
MEJ: Q7A_1601
MEC: Q7C_158
GPB: HDN1F_21040(LYS1)
BPL: BURPS1106A_2136(lys1)
BAM: Bamb_1645
BXE: Bxe_A1992
HPY: HP1507
HPJ: jhp_1400
HPL: HPB8_22(lys1)
HPO: HMPREF4655_20104(LYS1)
HPZ: HPKB_1410
HPX: HMPREF0462_1493(LYS1)
HPD: KHP_1359
HEY: MWE_1695
HPYR: K747_03640
HPYI: K750_01025
HPYU: K751_00220
HPYM: K749_06405
HEB: U063_1528
HEZ: U064_1532
HHE: HH_1098
HAC: Hac_0077(lys1)
HMS: HMU04660
HCE: HCW_01395
HCM: HCD_04495
HCP: HCN_0065
WSU: WS0167
SUA: Saut_1041
SULR: B649_05735
CJE: Cj0172c
CJU: C8J_0166
CJI: CJSA_0162
CJM: CJM1_0172(lys1)
CJS: CJS3_0168
CJEJ: N564_00164
CJEU: N565_00160
CJEN: N755_00216
CJEI: N135_00226
CJER: H730_01180
CJQ: UC78_0172
CJR: CJE0165
CFF: CFF8240_0285(lys)
CFZ: CSG_3660
CHA: CHAB381_0061(lys1)
CLA: Cla_0458
CCQ: N149_1538
CCF: YSQ_09040
CCY: YSS_08785
CCOI: YSU_08025
CCOF: VC76_07875
CIS: CINS_0435
CVO: CVOL_0449
CPEL: CPEL_0468
CGRA: CGRAC_1895
CURE: CUREO_1210
CHYO: CHH_0278
CSPF: CSF_1450
CCUN: CCUN_1762
CLX: CLAN_0255
CAVI: CAV_1442
ABU: Abu_1706
ABT: ABED_1560
ARC: ABLL_2163
SDL: Sdel_2142
SMUL: SMUL_2982
SHAL: SHALO_2761
SULJ: SJPD1_2652
NIS: NIS_1295
SUN: SUN_1368
NAM: NAMH_0224(lys)
GSU: GSU2539
GME: Gmet_0902
GUR: Gura_0981
GLO: Glov_1676
GBM: Gbem_2918
GEO: Geob_1676
GEM: GM21_1307
GEB: GM18_2804
PCA: Pcar_2095
PPD: Ppro_2607
DEU: DBW_2867
DVU: DVU0418(lys1)
DVL: Dvul_2516
DVM: DvMF_1535
DDE: Dde_0572
DDS: Ddes_0125
DTR: RSDT_0639
DAS: Daes_0893
DPI: BN4_10684
DBA: Dbac_2320
DSF: UWK_00577
DAL: Dalk_4658
DAT: HRM2_01410(lysA1)
DTO: TOL2_C01090(lys1)
HOH: Hoch_6504
SFU: Sfum_1922
RLE: RL0376
BBK: BARBAKC583_0028(lys1)
HDN: Hden_1144
CAK: Caul_4440
SIL: SPO0601 SPO3307(lkr)
RSP: RSP_1086(sdh)
JAN: Jann_4015
RDE: RD1_0698
PDE: Pden_2709
PSF: PSE_3136
PGD: Gal_03330
OTM: OSB_29950(ald_3)
MALG: MALG_00109
RMM: ROSMUCSMR3_00818(ald)
HNE: HNE_0588(lys1)
HBA: Hbal_0824
NAR: Saro_1790
SAL: Sala_1201
SPHP: LH20_11605
SMAZ: LH19_07835
SGI: SGRAN_1982(lys1.2)
SPHU: SPPYR_1863
SSY: SLG_24390
SPMI: K663_07865
SPHB: EP837_00148(lys1)
SPHR: BSY17_225
SINB: SIDU_05720
SPHT: K426_13345
BLAS: BSY18_983
ELI: ELI_04720
AAY: WYH_00754
ALB: AEB_P1964
MGM: Mmc1_1081
BHA: BH3957
BAG: Bcoa_1339
BCOA: BF29_2204
BACO: OXB_3524
LSP: Bsph_3480
PPY: PPE_01639
PPM: PPSC2_08685(lyS2)
PPO: PPM_1652(lyS2)
PPOL: X809_08940
PPOY: RE92_03620
PSAB: PSAB_09355
PRI: PRIO_2443
SIV: SSIL_1363
SPN: SP_0919
SPD: SPD_0812(lys1)
SPR: spr0820
SPW: SPCG_0896
SJJ: SPJ_0860(lys)
SPX: SPG_0845
SNT: SPT_1280(lys)
SND: MYY_1280
SPNN: T308_05995
SPV: SPH_1028(lys)
SNC: HMPREF0837_11566(LYS1)
SNM: SP70585_0958(lys)
SPP: SPP_0927(lys)
SNB: SP670_1400(lys)
SNP: SPAP_0951
SSUT: TL13_1239
SUB: SUB1319
SOR: SOR_1016
STRN: SNAG_1016
CBK: CLL_A1014
CBT: CLH_0948
CBE: Cbei_4409
CBZ: Cbs_4409
CBEI: LF65_04944
CLO: HMPREF0868_0009(LYS1)
CCE: Ccel_1128
CSD: Clst_1728
CCEL: CCDG5_1249
RCH: RUM_16860
RUM: CK1_02290
FPR: FP2_18080
FPA: FPR_20600
BPB: bpr_I1198
BFI: CIY_29960
BHU: bhn_I1115
RIX: RO1_05620
RIM: ROI_13440
CCT: CC1_03140
ROB: CK5_14020
RTO: RTO_08360
CPY: Cphy_3052
CSO: CLS_12090
HSD: SD1D_1343
CPRO: CPRO_20210
ERT: EUR_04860
ERA: ERE_14650
DSY: DSY3821
DHD: Dhaf_1555
SGY: Sgly_3179
AWO: Awo_c05360(sdh)
OVA: OBV_12680
BPRM: CL3_09040
BPRS: CK3_17620
MHG: MHY_16130
MAV: MAV_1723
SHY: SHJG_7558
SERJ: SGUI_2172
SEN: SACE_1566(lys1)
AMI: Amir_3541
SAQ: Sare_1048
SYN: slr0049
SYY: SYNGTS_2301(slr0049)
SYT: SYNGTI_2300(slr0049)
SYS: SYNPCCN_2299(slr0049)
SYQ: SYNPCCP_2299(slr0049)
DRA: DR_1252
DGE: Dgeo_0999
DFC: DFI_04480
CAA: Caka_0667
AMU: Amuc_0148
AGL: PYTT_2014
LBA: Lebu_0786
FSC: FSU_0920
BTH: BT_4612
BFR: BF1215
BVU: BVU_2379
BXY: BXY_37200
PGI: PG_0677(LYS1)
PGN: PGN_0713
PGT: PGTDC60_1802(lys1)
PDI: BDI_1450
TFO: BFO_2571
PSAC: PSM36_2037
APS: CFPG_304
PRU: PRU_0067(lys1)
PMZ: HMPREF0659_A5557(LYS1)
PDN: HMPREF9137_1758(LYS1)
AFD: Alfi_3014
ASH: AL1_04530
DORI: FH5T_01740
SRU: SRU_1725(lys1)
CHU: CHU_2707(lys)
DFE: Dfer_2888
SLI: Slin_3519
LBY: Lbys_1539
FAE: FAES_2748
PSEZ: HME7025_01355(lys1)
MPI: Mpet_0844
VMO: VMUT_1174
 » show all
Taxonomy
Reference
1  [PMID:4339117]
  Authors
Fujioka M, Nakatani Y.
  Title
Saccharopine dehydrogenase. Interaction with substrate analogues.
  Journal
Eur J Biochem 25:301-7 (1972)
DOI:10.1111/j.1432-1033.1972.tb01697.x
Reference
2  [PMID:4287986]
  Authors
Saunders PP, Broquist HP.
  Title
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. IV. Saccharopine dehydrogenase.
  Journal
J Biol Chem 241:3435-40 (1966)
  Sequence
[sce:YIR034C]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.7
IUBMB Enzyme Nomenclature: 1.5.1.7
ExPASy - ENZYME nomenclature database: 1.5.1.7
BRENDA, the Enzyme Database: 1.5.1.7
CAS: 9073-96-5

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