KEGG   ENZYME: 1.5.1.8
Entry
EC 1.5.1.8                  Enzyme                                 

Name
saccharopine dehydrogenase (NADP+, L-lysine-forming);
lysine-2-oxoglutarate reductase;
lysine-ketoglutarate reductase;
L-lysine-alpha-ketoglutarate reductase;
lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming);
saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase;
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+ [RN:R00716]
Reaction(KEGG)
R00716
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
L-lysine [CPD:C00047];
2-oxoglutarate [CPD:C00026];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.5.1.8 created 1972
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K14157  alpha-aminoadipic semialdehyde synthase
Genes
HSA: 10157(AASS)
PTR: 472493(AASS)
PPS: 100983928(AASS)
GGO: 101143865(AASS)
PON: 100454072(AASS)
NLE: 100607105(AASS)
MCC: 694594(AASS)
MCF: 102145151(AASS)
CSAB: 103226802(AASS)
RRO: 104657067(AASS)
RBB: 108518504(AASS)
CJC: 100385723(AASS)
SBQ: 101030460(AASS)
MMU: 30956(Aass)
MCAL: 110296036(Aass)
MPAH: 110316418(Aass)
RNO: 296925(Aass)
MUN: 110560725(Aass)
CGE: 100751161(Aass)
NGI: 103730601(Aass)
HGL: 101707268(Aass)
CCAN: 109685533(Aass)
OCU: 100352070(AASS)
TUP: 102489208(AASS)
CFA: 482429(AASS)
VVP: 112910607(AASS)
AML: 100468913(AASS)
UMR: 103676605(AASS)
UAH: 113263479(AASS)
ORO: 101383022(AASS)
ELK: 111152037
FCA: 101091272(AASS)
PTG: 102960744(AASS)
PPAD: 109268907(AASS)
AJU: 106970654(AASS)
BTA: 520865(AASS)
BOM: 102275417(AASS)
BIU: 109557575(AASS)
BBUB: 102394960(AASS)
CHX: 102185894(AASS)
OAS: 101103973
SSC: 100513962(AASS)
CFR: 102520837(AASS)
CDK: 105085335(AASS)
BACU: 103016134(AASS)
LVE: 103085872(AASS)
OOR: 101285244(AASS)
DLE: 111179042(AASS)
PCAD: 102992598(AASS)
ECB: 100056260(AASS)
EPZ: 103547307(AASS)
EAI: 106829857(AASS)
MYB: 102254732(AASS)
MYD: 102770634(AASS)
MNA: 107537367(AASS)
HAI: 109371287(AASS)
DRO: 112299931(AASS)
PALE: 102881018(AASS)
RAY: 107500210(AASS)
MJV: 108404217(AASS)
LAV: 100665204(AASS)
TMU: 101358790
MDO: 100016400(AASS)
SHR: 100923009(AASS)
PCW: 110194178(AASS)
OAA: 100076030(AASS)
GGA: 417757(AASS)
MGP: 100543809(AASS)
CJO: 107308784(AASS)
NMEL: 110392561(AASS)
APLA: 101793380(AASS)
ACYG: 106044525(AASS)
TGU: 100222251(AASS)
LSR: 110483501(AASS)
SCAN: 103813475(AASS)
GFR: 102036981(AASS)
FAB: 101818954(AASS)
PHI: 102112915(AASS)
PMAJ: 107204864(AASS)
CCAE: 111922957(AASS)
CCW: 104686812(AASS)
ETL: 114064186(AASS)
FPG: 101923487(AASS)
FCH: 102047696(AASS)
CLV: 102094241(AASS)
EGZ: 104125682(AASS)
NNI: 104011825(AASS)
ACUN: 113490507(AASS)
PADL: 103923842(AASS)
AAM: 106495938(AASS)
ASN: 102376316(AASS)
AMJ: 102574453(AASS)
PSS: 102454542(AASS)
CMY: 102948389(AASS)
CPIC: 101934272(AASS)
ACS: 100553247(aass)
PVT: 110084070(AASS)
PBI: 103054458(AASS)
PMUR: 107293701(AASS)
TSR: 106555089(AASS)
PMUA: 114605071(AASS)
GJA: 107111118(AASS)
XLA: 444409(aass.L)
XTR: 496923(aass)
NPR: 108788040(AASS)
DRE: 556229(aass)
SGH: 107575779
CCAR: 109050748(aass) 109061151
IPU: 108274751(aass)
PHYP: 113529768(aass)
AMEX: 103040216(aass)
EEE: 113582558(aass)
TRU: 101061348(aass)
LCO: 104927983(aass)
MZE: 101483693(aass)
ONL: 100700037(aass)
OLA: 101155996(aass)
XMA: 102235893(aass)
XCO: 114136268(aass)
PRET: 103465787(aass)
CVG: 107092787(aass)
NFU: 107389491(aass)
KMR: 108247341(aass)
ALIM: 106530280(aass)
AOCE: 111567529(aass)
CSEM: 103379906(aass)
POV: 109624603(aass)
LCF: 108902912(aass)
SDU: 111235992(aass)
SLAL: 111665076(aass)
HCQ: 109522992(aass)
BPEC: 110166755(aass)
MALB: 109956395(aass)
SASA: 106584550
OTW: 112220815
SALP: 111971984
ELS: 105018620(aass)
SFM: 108931602(aass)
PKI: 111851693(aass)
LCM: 102353181(AASS)
CMK: 103179368(aass)
RTP: 109937592(aass)
CIN: 104265748
SPU: 592682
APLC: 110989169
DME: Dmel_CG7144(LKRSDH)
DER: 6542219
DSE: 6611574
DSI: Dsimw501_GD22468(Dsim_GD22468)
DAN: 6505494
DSR: 110177043
DMN: 108163154
DWI: 6642305
DAZ: 108609826
DNV: 115562596
DHE: 111592904
DVI: 6628879
MDE: 101897193
LCQ: 111679431
AAG: 5565118
AME: 552130
BIM: 100740455
BTER: 100649340
CCAL: 108624730
OBB: 114872249
SOC: 105196134
MPHA: 105839608
AEC: 105151834
ACEP: 105617717
PBAR: 105430393
VEM: 105559362
HST: 105187630
DQU: 106742161
CFO: 105250242
LHU: 105677283
PGC: 109862633
OBO: 105279439
PCF: 106791120
NVI: 100123521
CSOL: 105362224
MDL: 103579460
TCA: 660388
ATD: 109604531
BMOR: 101743783
BMAN: 114246112
PMAC: 106714130
PRAP: 111001125
HAW: 110384393
DNX: 107166523
AGS: 114121214
RMD: 113557325
BTAB: 109042690
CLEC: 106664604
ZNE: 110831369
TUT: 107367889
DPTE: 113793337
CSCU: 111632261
PTEP: 107451145
CEL: CELE_R02D3.1(aass-1)
CBR: CBG13546
PCAN: 112571884
CRG: 105322594
MYI: 110443085
OBI: 106869155
NVE: 5509803
EPA: 110241709
ADF: 107348484
AMIL: 114959146
PDAM: 113684100
SPIS: 111338891
DGT: 114521682
AQU: 100641330
ATH: AT4G33150
THJ: 104804447
CPAP: 110812057
CIT: 102608315
TCC: 18588195
GRA: 105772791
GAB: 108486121
EGR: 104437949
VRA: 106769194
VAR: 108320668
VUN: 114178190
CCAJ: 109807314
CAM: 101500267
LJA: Lj4g3v2215480.1(Lj4g3v2215480.1) Lj4g3v2215480.2(Lj4g3v2215480.2)
ADU: 107495845
AIP: 107638430
LANG: 109356534
FVE: 101310736
RCN: 112185872
PPER: 18769367
PMUM: 103340501
PAVI: 110748930
PXB: 103959117
CSV: 101214976
CMO: 103492407
MCHA: 111016508
RCU: 8259021
JCU: 105638037
MESC: 110603783
PEU: 105111406
JRE: 108993578
QSU: 111987337
VVI: 100268037
SLY: 101261722
SPEN: 107026571
SOT: 102586908
CANN: 107877934
NSY: 104234932
NTO: 104110270
NAU: 109206597
INI: 109190601
SIND: 105173734
OEU: 111403740
HAN: 110928432
LSV: 111910406
DCR: 108192546
SOE: 110799548
OSA: 4330940
OBR: 102714890
BDI: 100824912
ATS: 109771574(LOC109771574)
SBI: 8081954
ZMA: 541648(lkrsdh1)
SITA: 101756273
PDA: 103716942
EGU: 105041974
MUS: 103969029
DCT: 110110517
PEQ: 110033140
AOF: 109844832
ATR: 18423952
PPP: 112278437
CNE: CNA02370
CNB: CNBA2210
TASA: A1Q1_07452
ABP: AGABI1DRAFT77562(AGABI1DRAFT_77562)
ABV: AGABI2DRAFT188762(AGABI2DRAFT_188762)
DDI: DDB_G0284835(aass)
DFA: DFA_03752(aass)
PTI: PHATRDRAFT_54394(LKRSDH)
SPAR: SPRG_16261
 » show all
Reference
1  [PMID:4385118]
  Authors
Hutzler J, Dancis J.
  Title
Conversion of lysine to saccharopine by human tissues.
  Journal
Biochim Biophys Acta 158:62-9 (1968)
DOI:10.1016/0304-4165(68)90072-X
Reference
2  [PMID:6434529]
  Authors
Markovitz PJ, Chuang DT, Cox RP.
  Title
Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
  Journal
J Biol Chem 259:11643-6 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.8
IUBMB Enzyme Nomenclature: 1.5.1.8
ExPASy - ENZYME nomenclature database: 1.5.1.8
BRENDA, the Enzyme Database: 1.5.1.8
CAS: 9031-19-0

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