KEGG   ENZYME: 1.5.3.21Help
Entry
EC 1.5.3.21                 Enzyme                                 

Name
4-methylaminobutanoate oxidase (methylamine-forming);
mao (gene name, ambiguous)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
4-methylaminobutanoate methylamidohydrolase
Reaction(IUBMB)
4-methylaminobutanoate + O2 + H2O = succinate semialdehyde + methylamine + H2O2 [RN:R10101]
Reaction(KEGG)
Substrate
4-methylaminobutanoate;
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
succinate semialdehyde [CPD:C00232];
methylamine [CPD:C00218];
H2O2 [CPD:C00027]
Comment
The enzyme participates in the nicotine degradation pathway of the soil bacterium Arthrobacter nicotinovorans. Has a very weak monoamine oxidase (EC 1.4.3.4) activity with 4-aminobutanoate [1].
History
EC 1.5.3.21 created 2012
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K20155  4-methylaminobutanoate oxidase (methylamine-forming)
Genes
NCA: Noca_0585
Taxonomy
Reference
1  [PMID:15606755]
  Authors
Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R
  Title
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism  of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
  Journal
Eur J Biochem 271:4677-84 (2004)
DOI:10.1111/j.1432-1033.2004.04432.x
  Sequence
Reference
2  [PMID:16689938]
  Authors
Chiribau CB, Mihasan M, Ganas P, Igloi GL, Artenie V, Brandsch R
  Title
Final steps in the catabolism of nicotine.
  Journal
FEBS J 273:1528-36 (2006)
DOI:10.1111/j.1742-4658.2006.05173.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.21
IUBMB Enzyme Nomenclature: 1.5.3.21
ExPASy - ENZYME nomenclature database: 1.5.3.21
UM-BBD (Biocatalysis/Biodegradation Database): 1.5.3.21
BRENDA, the Enzyme Database: 1.5.3.21

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