KEGG   ENZYME: 1.5.3.22
Entry
EC 1.5.3.22                 Enzyme                                 
Name
coenzyme F420H2 oxidase;
FprA
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
Sysname
reduced coenzyme F420:oxygen oxidoreductase
Reaction(IUBMB)
2 reduced coenzyme F420 + O2 = 2 oxidized coenzyme F420 + 2 H2O [RN:R10602]
Reaction(KEGG)
R10602
Substrate
reduced coenzyme F420 [CPD:C01080];
O2 [CPD:C00007]
Product
oxidized coenzyme F420 [CPD:C00876];
H2O [CPD:C00001]
Comment
The enzyme contains FMN and a binuclear iron center. The enzyme from the archaeon Methanothermobacter marburgensis is Si-face specific with respect to C-5 of coenzyme F420 [2].
History
EC 1.5.3.22 created 2013
Orthology
K19817  coenzyme F420H2 oxidase
Genes
MJA: MJ_0748
MFE: Mefer_1066
MVU: Metvu_0447
MFS: MFS40622_1428
MIF: Metin_0358
MJH: JH146_1173
MESG: MLAUSG7_0421(fprA)
MESA: MLASG1_1600(fprA)
MIG: Metig_0112
MMP: MMP1134 MMP1135
MMQ: MmarC5_0450
MMZ: MmarC7_0386
MMD: GYY_06520 GYY_06525
MMAK: MMKA1_13130(fprA) MMKA1_13140(fprA)
MMAO: MMOS7_12430(fprA) MMOS7_12440(fprA)
MMAD: MMJJ_17110(fprA_2)
MAE: Maeo_0955
MVN: Mevan_0456 Mevan_0457
MVO: Mvol_0029 Mvol_0089
MOK: Metok_0623
METF: CFE53_02040
MTH: MTH_1350 MTH_220
MMG: MTBMA_c06690(fprA2) MTBMA_c17400(fprA3)
MWO: MWSIV6_0632(fprA) MWSIV6_1734(fpaA)
MTEE: MTTB_08620(fprA_2)
METC: MTCT_0182 MTCT_1224
METE: tca_00200(fprA_2) tca_01304(fprA_3)
METZ: METMT2_0665
METK: FVF72_01205 FVF72_04815
MTHM: FZP57_03005 FZP57_08485
METJ: FZP68_02240 FZP68_08040
MST: Msp_0787(fprA)
METB: AW729_03335 AW729_05285
MEIS: PXD04_09260
MRU: mru_0131(fprA2) mru_1507(fprA1)
MSI: Msm_0222 Msm_1349
MEB: Abm4_0699(fprA1) Abm4_1680(fprA2)
MMIL: sm9_1011(fprA1) sm9_2237(fprA2)
MEYE: TL18_00440 TL18_05365
MOL: YLM1_0883 YLM1_1543
MARO: MarbSA_12840
METV: K4897_01570 K4897_04585
MEL: Metbo_0137 Metbo_0708
MEW: MSWAN_1545 MSWAN_2352
METH: MBMB1_1267(fprA) MBMB1_1978(fpaA)
MFC: BRM9_0483(fprA) BRM9_2322
MFI: DSM1535_0464(fprA1) DSM1535_1256(fprA3)
MCUB: MCBB_1482(fprA1) MCBB_2279(fprA3)
MSUB: BK009_05250 BK009_09185
METN: BK008_00795 BK008_04810
METT: CIT01_04960 CIT01_09555
METO: CIT02_07615 CIT02_11720
MEME: HYG87_05990 HYG87_09945
MFEG: GCM10025860_06480 GCM10025860_26120
MEER: NKF70_03130 NKF70_06350
MFV: Mfer_0426
MHU: Mhun_1554
MRTJ: KHC33_06000
MEM: Memar_0432
MBG: BN140_0391
MEMA: MMAB1_0501(fprA)
MCHK: MchiMG62_05600(fprA)
MSUM: OH143_08860
MRC: R6Y96_09625
MPI: Mpet_0105
MOU: OU421_04815
MBN: Mboo_1153
MPL: Mpal_2265
MEZ: Mtc_2433(fprA-2)
RCI: RRC428(fprA-3)
 » show all
Reference
1  [PMID:15340796]
  Authors
Seedorf H, Dreisbach A, Hedderich R, Shima S, Thauer RK
  Title
F420H2 oxidase (FprA) from Methanobrevibacter arboriphilus, a coenzyme F420-dependent enzyme involved in O2 detoxification.
  Journal
Arch Microbiol 182:126-37 (2004)
DOI:10.1007/s00203-004-0675-3
  Sequence
[ag:ACA13278]
Reference
2  [PMID:16218963]
  Authors
Seedorf H, Kahnt J, Pierik AJ, Thauer RK
  Title
Si-face stereospecificity at C5 of coenzyme F420 for F420H2 oxidase from methanogenic Archaea as determined by mass spectrometry.
  Journal
FEBS J 272:5337-42 (2005)
DOI:10.1111/j.1742-4658.2005.04931.x
Reference
3  [PMID:17480207]
  Authors
Seedorf H, Hagemeier CH, Shima S, Thauer RK, Warkentin E, Ermler U
  Title
Structure of coenzyme F420H2 oxidase (FprA), a di-iron flavoprotein from methanogenic Archaea catalyzing the reduction of O2 to H2O.
  Journal
FEBS J 274:1588-99 (2007)
DOI:10.1111/j.1742-4658.2007.05706.x
  Sequence
[mmg:MTBMA_c17400]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.22
IUBMB Enzyme Nomenclature: 1.5.3.22
ExPASy - ENZYME nomenclature database: 1.5.3.22
BRENDA, the Enzyme Database: 1.5.3.22

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (137)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (106)   
   KEGG MGENES (28)   
   RefGene (2)   
Protein sequence (9)   
   UniProt (5)   
   SWISS-PROT (4)   
Protein domain (8)   
   InterPro (8)   
All databases (160)   

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