KEGG   ENZYME: 1.5.3.22
Entry
EC 1.5.3.22                 Enzyme                                 
Name
coenzyme F420H2 oxidase;
FprA
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
Sysname
reduced coenzyme F420:oxygen oxidoreductase
Reaction(IUBMB)
2 reduced coenzyme F420 + O2 = 2 oxidized coenzyme F420 + 2 H2O [RN:R10602]
Reaction(KEGG)
R10602
Substrate
reduced coenzyme F420 [CPD:C01080];
O2 [CPD:C00007]
Product
oxidized coenzyme F420 [CPD:C00876];
H2O [CPD:C00001]
Comment
The enzyme contains FMN and a binuclear iron center. The enzyme from the archaeon Methanothermobacter marburgensis is Si-face specific with respect to C-5 of coenzyme F420 [2].
History
EC 1.5.3.22 created 2013
Orthology
K19817  coenzyme F420H2 oxidase
Genes
MJAMJ_0748
MFEMefer_1066
MVUMetvu_0447
MFSMFS40622_1428
MIFMetin_0358
MJHJH146_1173
MESGMLAUSG7_0421(fprA)
MESAMLASG1_1600(fprA)
MIGMetig_0112
MMPMMP1134
MMQMmarC5_0450
MMZMmarC7_0386
MMDGYY_06520 GYY_06525
MMAKMMKA1_13130(fprA) MMKA1_13140(fprA)
MMAOMMOS7_12430(fprA) MMOS7_12440(fprA)
MMADMMJJ_17110(fprA_2)
MAEMaeo_0955
MVNMevan_0456 Mevan_0457
MVOMvol_0029 Mvol_0089
MOKMetok_0623
METFCFE53_02040
MTHMTH_1350
MMGMTBMA_c06690(fprA2) MTBMA_c17400(fprA3)
METCMTCT_0182 MTCT_1224
MWOMWSIV6_0632(fprA) MWSIV6_1734(fpaA)
METEtca_00200(fprA_2) tca_01304(fprA_3)
METZMETMT2_0665
METKFVF72_01205 FVF72_04815
MTHMFZP57_03005 FZP57_08485
METJFZP68_02240 FZP68_08040
METBAW729_03335 AW729_05285
MRUmru_0131(fprA2) mru_1507(fprA1)
MSIMsm_0222 Msm_1349
MEBAbm4_0699(fprA1) Abm4_1680(fprA2)
MMILsm9_1011(fprA1) sm9_2237(fprA2)
MEYETL18_00440 TL18_05365
MOLYLM1_0883 YLM1_1543
MAROMarbSA_12840
MELMetbo_0137 Metbo_0708
MEWMSWAN_1545 MSWAN_2352
METHMBMB1_1267(fprA) MBMB1_1978(fpaA)
MFCBRM9_0483(fprA) BRM9_2322
MFIDSM1535_0464(fprA1) DSM1535_1256(fprA3)
MCUBMCBB_1482(fprA1) MCBB_2279(fprA3)
MSUBBK009_05250 BK009_09185
METNBK008_00795 BK008_04810
METTCIT01_04960 CIT01_09555
METOCIT02_07615 CIT02_11720
MEMEHYG87_05990
MFVMfer_0426
MHUMhun_1554
MRTJKHC33_06000
MEMMemar_0432
MBGBN140_0391
MEMAMMAB1_0501(fprA)
MCHKMchiMG62_05600(fprA)
MPIMpet_0105
MBNMboo_1153
MPLMpal_2265
MEZMtc_2433(fprA-2)
 » show all
Reference
1  [PMID:15340796]
  Authors
Seedorf H, Dreisbach A, Hedderich R, Shima S, Thauer RK
  Title
F420H2 oxidase (FprA) from Methanobrevibacter arboriphilus, a coenzyme F420-dependent enzyme involved in O2 detoxification.
  Journal
Arch Microbiol 182:126-37 (2004)
DOI:10.1007/s00203-004-0675-3
  Sequence
Reference
2  [PMID:16218963]
  Authors
Seedorf H, Kahnt J, Pierik AJ, Thauer RK
  Title
Si-face stereospecificity at C5 of coenzyme F420 for F420H2 oxidase from methanogenic Archaea as determined by mass spectrometry.
  Journal
FEBS J 272:5337-42 (2005)
DOI:10.1111/j.1742-4658.2005.04931.x
Reference
3  [PMID:17480207]
  Authors
Seedorf H, Hagemeier CH, Shima S, Thauer RK, Warkentin E, Ermler U
  Title
Structure of coenzyme F420H2 oxidase (FprA), a di-iron flavoprotein from methanogenic Archaea catalyzing the reduction of O2 to H2O.
  Journal
FEBS J 274:1588-99 (2007)
DOI:10.1111/j.1742-4658.2007.05706.x
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.22
IUBMB Enzyme Nomenclature: 1.5.3.22
ExPASy - ENZYME nomenclature database: 1.5.3.22
BRENDA, the Enzyme Database: 1.5.3.22

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