KEGG   ENZYME: 1.5.3.22Help
Entry
EC 1.5.3.22                 Enzyme                                 

Name
coenzyme F420H2 oxidase;
FprA
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
reduced coenzyme F420:oxygen oxidoreductase
Reaction(IUBMB)
2 reduced coenzyme F420 + O2 = 2 oxidized coenzyme F420 + 2 H2O [RN:R10602]
Reaction(KEGG)
Substrate
reduced coenzyme F420 [CPD:C01080];
O2 [CPD:C00007]
Product
oxidized coenzyme F420 [CPD:C00876];
H2O [CPD:C00001]
Comment
The enzyme contains FMN and a binuclear iron center. The enzyme from the archaeon Methanothermobacter marburgensis is Si-face specific with respect to C-5 of coenzyme F420 [2].
History
EC 1.5.3.22 created 2013
Orthology
K19817  coenzyme F420H2 oxidase
Genes
MJA: MJ_0748
MFE: Mefer_1066
MVU: Metvu_0447
MFS: MFS40622_1428
MIF: Metin_0358
MJH: JH146_1173
MIG: Metig_0112
MAE: Maeo_0955
MVN: Mevan_0457
MVO: Mvol_0029 Mvol_0089
MTH: MTH_1350
MMG: MTBMA_c17400(fprA3)
METC: MTCT_1224
MSI: Msm_1349
MRU: mru_0131(fprA2)
MEB: Abm4_1680(fprA2)
METH: MBMB1_1978(fpaA)
MFC: BRM9_2322
MFI: DSM1535_1256(fprA3)
MFV: Mfer_0426
 » show all
Taxonomy
Reference
1  [PMID:15340796]
  Authors
Seedorf H, Dreisbach A, Hedderich R, Shima S, Thauer RK
  Title
F420H2 oxidase (FprA) from Methanobrevibacter arboriphilus, a coenzyme F420-dependent enzyme involved in O2 detoxification.
  Journal
Arch Microbiol 182:126-37 (2004)
DOI:10.1007/s00203-004-0675-3
  Sequence
Reference
2  [PMID:16218963]
  Authors
Seedorf H, Kahnt J, Pierik AJ, Thauer RK
  Title
Si-face stereospecificity at C5 of coenzyme F420 for F420H2 oxidase from methanogenic Archaea as determined by mass spectrometry.
  Journal
FEBS J 272:5337-42 (2005)
DOI:10.1111/j.1742-4658.2005.04931.x
Reference
3  [PMID:17480207]
  Authors
Seedorf H, Hagemeier CH, Shima S, Thauer RK, Warkentin E, Ermler U
  Title
Structure of coenzyme F420H2 oxidase (FprA), a di-iron flavoprotein from methanogenic Archaea catalyzing the reduction of O2 to H2O.
  Journal
FEBS J 274:1588-99 (2007)
DOI:10.1111/j.1742-4658.2007.05706.x
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.22
IUBMB Enzyme Nomenclature: 1.5.3.22
ExPASy - ENZYME nomenclature database: 1.5.3.22
BRENDA, the Enzyme Database: 1.5.3.22

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