KEGG   ENZYME: 1.5.4.1Help
Entry
EC 1.5.4.1                  Enzyme                                 

Name
pyrimidodiazepine synthase;
PDA synthase;
pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening, cyclizing);
pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
Reaction(IUBMB)
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyltetrahydropterin + 2 glutathione [RN:R03984]
Reaction(KEGG)
Substrate
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one [CPD:C02587];
glutathione disulfide [CPD:C00127];
H2O [CPD:C00001]
Product
6-pyruvoyltetrahydropterin [CPD:C03684];
glutathione [CPD:C00051]
Comment
In the reverse direction, the reduction of 6-pyruvoyl-tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring. The pyrimidodiazepine formed is an acetyldihydro derivative. Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster.
History
EC 1.5.4.1 created 1990, modified 2014
Pathway
ec00480  Glutathione metabolism
ec00790  Folate biosynthesis
Orthology
K00310  pyrimidodiazepine synthase
Genes
BFO: BRAFLDRAFT_100191 BRAFLDRAFT_217390
APLC: 110980055 110980113 110980118
SKO: 102801608 102805287 102805394
DME: Dmel_CG6673(GstO2) Dmel_CG6776(GstO3) Dmel_CG6781(se)
DPO: Dpse_GA19859
DAN: Dana_GF10161 Dana_GF24330 Dana_GF24331
DER: 6545776 6545777 6545778
DPE: 6601434 6601435 6601436
DSE: Dsec_GM24931 Dsec_GM24932 Dsec_GM25061 Dsec_GM25062
DSI: Dsimw501_GD12980(Dsim_GD12980) Dsimw501_GD14099(Dsim_GD14099) Dsimw501_GD14100(Dsim_GD14100)
MDE: 101891696
AGA: AgaP_AGAP005749(GSTO1)
AAG: 23687505
AME: 552118
BIM: 100745560
BTER: 100646742
SOC: 105200535
AEC: 105147922
ACEP: 105622284
PBAR: 105424214
HST: 105185767
DQU: 106745381
CFO: 105256274
LHU: 105676415
PGC: 109858549
PCF: 106789144
NVI: 100116224(GstO1)
MDL: 103577336
NVL: 108564623
BMOR: 100141441(GSTo4) 692819(GSTo1) 692941(GSTo2) 732973(GSTo3)
DNX: 107163884
CLEC: 106668275
LAK: 106162221
 » show all
Taxonomy
Reference
1  [PMID:6438092]
  Authors
Wiederrecht GJ, Brown GM.
  Title
Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins.
  Journal
J Biol Chem 259:14121-7 (1984)
Reference
2  [PMID:16712527]
  Authors
Kim J, Suh H, Kim S, Kim K, Ahn C, Yim J
  Title
Identification and characteristics of the structural gene for the Drosophila eye  colour mutant sepia, encoding PDA synthase, a member of the omega class glutathione S-transferases.
  Journal
Biochem J 398:451-60 (2006)
DOI:10.1042/BJ20060424
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.4.1
IUBMB Enzyme Nomenclature: 1.5.4.1
ExPASy - ENZYME nomenclature database: 1.5.4.1
BRENDA, the Enzyme Database: 1.5.4.1
CAS: 93586-06-2

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