| Entry |
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| Name |
pyrimidodiazepine synthase;
PDA synthase;
pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening, cyclizing);
pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
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| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With a disulfide as acceptor
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| Sysname |
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
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| Reaction(IUBMB) |
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyltetrahydropterin + 2 glutathione [RN: R03984]
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| Reaction(KEGG) |
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| Substrate |
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one [CPD: C02587];
glutathione disulfide [CPD: C00127];
H2O [CPD: C00001]
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| Product |
6-pyruvoyltetrahydropterin [CPD: C03684];
glutathione [CPD: C00051]
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| Comment |
In the reverse direction, the reduction of 6-pyruvoyl-tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring. The pyrimidodiazepine formed is an acetyldihydro derivative. Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster.
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| History |
EC 1.5.4.1 created 1990, modified 2014
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| Pathway |
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| Orthology |
| K00310 | pyrimidodiazepine synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Wiederrecht GJ, Brown GM. |
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| Title |
Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins. |
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| Journal |
J Biol Chem 259:14121-7 (1984) |
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| Reference |
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| Authors |
Kim J, Suh H, Kim S, Kim K, Ahn C, Yim J |
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| Title |
Identification and characteristics of the structural gene for the Drosophila eye colour mutant sepia, encoding PDA synthase, a member of the omega class glutathione S-transferases. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.5.4.1 |
| ExPASy - ENZYME nomenclature database: | 1.5.4.1 |
| BRENDA, the Enzyme Database: | 1.5.4.1 |
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