KEGG   ENZYME: 1.5.4.1
Entry
EC 1.5.4.1                  Enzyme                                 
Name
pyrimidodiazepine synthase;
PDA synthase;
pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening, cyclizing);
pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a disulfide as acceptor
Sysname
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
Reaction(IUBMB)
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyltetrahydropterin + 2 glutathione [RN:R03984]
Reaction(KEGG)
R03984
Substrate
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one [CPD:C02587];
glutathione disulfide [CPD:C00127];
H2O [CPD:C00001]
Product
6-pyruvoyltetrahydropterin [CPD:C03684];
glutathione [CPD:C00051]
Comment
In the reverse direction, the reduction of 6-pyruvoyl-tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring. The pyrimidodiazepine formed is an acetyldihydro derivative. Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster.
History
EC 1.5.4.1 created 1990, modified 2014
Pathway
ec00480  Glutathione metabolism
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K00310  pyrimidodiazepine synthase
Genes
BFO: 118417884 118418016 118418017
SCLV: 120347446
APLC: 110980055 110980113
SKO: 102801608 102805287 102805394
DME: Dmel_CG6673(GstO2) Dmel_CG6776(GstO3) Dmel_CG6781(se)
DER: 6545776 6545777 6545778
DSE: 6604889 6604890
DSI: Dsimw501_GD12980(Dsim_GD12980) Dsimw501_GD14099(Dsim_GD14099) Dsimw501_GD14100(Dsim_GD14100)
DYA: Dyak_GE20748 Dyak_GE20749 Dyak_GE21298
DAN: 6506964
DSR: 110189883 110189884 110190145
DPO: 4813077 6900705 6900706
DPE: 6601434 6601435 6601436
DMN: 108151105 108151107 108151108
DWI: 6645944 6645945 6645946
DGR: 6558456 6558466 6558470
DMO: Dmoj_GI11973 Dmoj_GI11974 Dmoj_GI13342
DAZ: 108613357 108613358 108613359
DNV: 108650771 108650772 108650773
DHE: 111601723 111601724 111601725
DVI: 6622272 6624546
MDE: 101891696
HIS: 119648365
AGA: AgaP_AGAP005749(GSTO1)
ACOZ: 120953261
AARA: 120908851
AMER: 121591998
ASTE: 118513164
AFUN: 125770357
AALI: 118467705
AAG: 23687505
AALB: 109410292 109426263
CQU: CpipJ_CPIJ000031
CPII: 120421894
CNS: 116336677 116336678 116344085 116345203
AME: 552118
ACER: 108001760
ALAB: 122716860
ADR: 102678785
AFLR: 100872096
BIM: 100745560
BBIF: 117211745
BVK: 117236127
BVAN: 117153685
BTER: 100646742
BAFF: 126913925 126915750
BPYO: 122569507
CCAL: 108628071
OBB: 114882731
MGEN: 117221474 117221703
NMEA: 116424254
CGIG: 122395362
SOC: 105200535
AEC: 105147922
ACEP: 105622284
PBAR: 105424214
VEM: 105563796
HST: 105185767
DQU: 106745381
CFO: 105256274
FEX: 115237135
LHU: 105676415
PGC: 109858549
OBO: 105280891
PCF: 106789144
PFUC: 122518209
VPS: 122627925 122637254
NVI: 100116224(GstO1)
CSOL: 105363631
TPRE: 106652488
LBD: 127282006
MDL: 103577336
CGLO: 123266973 123266974
FAS: 105273999
DAM: 107048478
CCIN: 107263414
TCA: 655757 659748
DPA: 109534346 109542472
SOY: 115877807 115880910
AGRG: 126737031
ATD: 109594047 109594062 109600220
AGB: 108909339 108909342 108915256
LDC: 111501821 111503060 111507790
NVL: 108564623
APLN: 108743348
PPYR: 116174034 116179350 116180517 116181187
OTU: 111417405 111421098
BMOR: 100141441(GSTo4) 692819(GSTo1) 692941(GSTo2) 732973(GSTo3)
BMAN: 114246189 114251041 114251046 114251054
MSEX: 115440015 115440017 115440018 115450765
DPL: KGM_213590 KGM_213591 KGM_215101
BANY: 112045709 112052091 112052101 112052216
MJU: 123868217 123868218 123868219 123878841
NIQ: 126774242 126779641
VCD: 124536245 124536413 124541532
MCIX: 123659506 123659928 123666863
PMAC: 106708065
PPOT: 106107676
PXU: 106115870 106121024 106121486
PRAP: 110991775 110991776 110993706
PBX: 123718010
PNAP: 125058658
ZCE: 119828334 119839062 119840698 119840898 119840913
CCRC: 123702386
LSIN: 126972490 126978185
HAW: 110380331 110380334 110382088
HZE: 124635065 124644130
TNL: 113501099 113505714
SLIU: 111351376 111358895 111359043
OFU: 114358125 114363188
PXY: 105385065 105385083 105391501 105393538 105393990 105393991 105393992 105398022
PGW: 126372314 126372316 126378972
API: 100167548 103310566
DNX: 107163884
AGS: 114121972
RMD: 113551979
BTAB: 109042194
DCI: 103512934 103519641
CLEC: 106668275
HHAL: 106679272 106679413
NLU: 111048776
HVI: 124370452 124371540
PHU: Phum_PHUM530530
FOC: 113209890
ZNE: 110829188 110841526 110841528
CSEC: 111861574 111861586 111868728
SGRE: 126269683 126305734
IEL: 124159002
FCD: 110846827 110848295 110848529 110860205
DPX: DAPPUDRAFT_318250
PVM: 113808340 113818669
PJA: 122256350
PCHN: 125037357 125037499
HAME: 121872925 121878606
PCLA: 123768218
ESN: 127009500 127009511
ISC: IscW_ISCW003939 IscW_ISCW006477
RSAN: 119396330
RMP: 119174552
VDE: 111247779
VJA: 111261323
TUT: 107364114
CSCU: 111617892 111617895 111634163
LPOL: 106464115
PMEO: 129585152 129585304 129586526 129586557 129601368 129601635
HRO: HELRODRAFT_180211
MMER: 123548299
LAK: 106159330 106162221
SMM: Smp_152710.1
OVI: T265_01660
TAD: TRIADDRAFT_16556 TRIADDRAFT_21044 TRIADDRAFT_33986 TRIADDRAFT_34018 TRIADDRAFT_62355 TRIADDRAFT_62357
RSX: RhiXN_01595
MORE: E1B28_005236
 » show all
Reference
1  [PMID:6438092]
  Authors
Wiederrecht GJ, Brown GM.
  Title
Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins.
  Journal
J Biol Chem 259:14121-7 (1984)
Reference
2  [PMID:16712527]
  Authors
Kim J, Suh H, Kim S, Kim K, Ahn C, Yim J
  Title
Identification and characteristics of the structural gene for the Drosophila eye colour mutant sepia, encoding PDA synthase, a member of the omega class glutathione S-transferases.
  Journal
Biochem J 398:451-60 (2006)
DOI:10.1042/BJ20060424
  Sequence
[dme:Dmel_CG6781]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.4.1
IUBMB Enzyme Nomenclature: 1.5.4.1
ExPASy - ENZYME nomenclature database: 1.5.4.1
BRENDA, the Enzyme Database: 1.5.4.1
CAS: 93586-06-2

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Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (464)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (286)   
   RefGene (177)   
Protein sequence (3)   
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   RefSeq(pep) (1)   
DNA sequence (4)   
   RefSeq(nuc) (2)   
   GenBank (1)   
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Protein domain (6)   
   InterPro (6)   
All databases (491)   

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