KEGG   ENZYME: 1.5.8.1
Entry
EC 1.5.8.1                  Enzyme                                 
Name
dimethylamine dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a flavin or flavoprotein as acceptor
Sysname
dimethylamine:electron-transfer flavoprotein oxidoreductase
Reaction(IUBMB)
dimethylamine + H2O + electron-transfer flavoprotein = methylamine + formaldehyde + reduced electron-transfer flavoprotein [RN:R01588]
Reaction(KEGG)
R01588
Substrate
dimethylamine [CPD:C00543];
H2O [CPD:C00001];
electron-transfer flavoprotein [CPD:C04253]
Product
methylamine [CPD:C00218];
formaldehyde [CPD:C00067];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains FAD and a [4Fe-4S] cluster.
History
EC 1.5.8.1 created 1999 as EC 1.5.99.10, transferred 2002 to EC 1.5.8.1
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00317  dimethylamine/trimethylamine dehydrogenase
Genes
PMEXH4W19_11290
RHDR2APBS1_0788
RTHLRK53_05475
DJICH75_07125
DTXATSB10_15590
XBAC7S18_14515
PREPCA10_47330
PFCPflA506_4693(tmd)
POIBOP93_22725
PSHHHU773_024440
TSNW908_00015
THINCRN91_01375
RSORSp0682
RSLRPSI07_mp0583
RSNRSPO_m01017(stcD)
RSMCMR15_mp10652
RSEF504_4539
RSYRSUY_38890(tmd)
RPUCDC45_21030
RSGJK151_04710
COXE0W60_31885
BPHBphy_5960
BCAIK788_0001542
PHSC2L64_21885
PTERC2L65_26085
PSPUNA29_08505
CDNBN940_13011
CFUCFU_2684
CPRACPter91_1920(tmd)
IDCLRM40_18490
MEHM301_1400
MEIMsip34_2459
MEPMPQ_2403
AZAAZKH_p0217
AZIAzCIB_2375
MCIMesci_2636
MOPMesop_5984
MAMMesau_02601
MESWA9K65_014455
MESPC1M53_02585
MERDEB233_12920 EB233_26910
MESRFGU64_14490
AAKAA2016_5993
PHTBLM14_27655
KMNHW532_16390
SMESMa0257
SMKSinme_5357
SMXSM11_pC1602
SMIBN406_04939(tmd)
SMEGC770_GR4pC1294
SMELSM2011_a0257
SMERDU99_24725
SMDSmed_1285
SIXBSY16_2386(hdh) BSY16_277
ATAAWN88_01220
RHIDFFM81_027465
SHZshn_10745 shn_30205
SZOK8M09_09840 K8M09_20940
OINIAR37_22770
OANOant_3262
OAHDR92_3227(hdh)
OPSA8A54_15775
OCHCES85_4558(tmd)
OCRHGK82_18870
OCLGTN27_18995
XAUXaut_0917
STARG3545_26390
LNEFZC33_09600 FZC33_21465
HDNHden_0194 Hden_0535
HDTHYPDE_25228 HYPDE_25748 HYPDE_34963
HMCHYPMC_3962 HYPMC_3963
MCGGL4_2663
BLAGBLTE_16710
PLEOOHA_1_00468(tmd_1) OHA_1_00478(tmd_2)
NOHG5V57_02665 G5V57_05590 G5V57_06430 G5V57_31675
CAULKCG34_05695 KCG34_22905
RUAD1823_18085
RDERD1_4141(tmd)
RLIRLO149_c003340(tmd)
RPONG3256_12605 G3256_12610 G3256_12615
OATOAN307_c42970(tmd)
OAROA238_c47830(tmd1) OA238_c47840(tmd2) OA238_c47850(tmd3)
OTMOSB_15670(tmd)
LMDMETH_21805
LEJETW24_01555 ETW24_05525
YANAYJ57_15570
SUAMBOO69_07220
SULIC1J05_06740 C1J05_19580
SINLDSM14862_03441(tmd_1) DSM14862_03666(tmd_2)
RMMROSMUCSMR3_03636(tmd)
ROKRAK1035_2462
RIDRIdsm_00662(tmd_1) RIdsm_04243(tmd_2) RIdsm_04244(tmd_3)
ROMEI983_01485 EI983_01490 EI983_01495 EI983_09835 EI983_12585
ROHFIU89_18495(tmd)
AHTANTHELSMS3_00564
THAACFI11_03135
MALUKU6B_04850
RHPLPB142_07370
RBLB6K69_00080
PAMNpAMV3p0110(dmd) pAMV3p0194(tmd)
DONBSK21_05955
GEHHYN69_03530 HYN69_12980
GFUKM031_01850 KM031_19465
TAWEI545_11145 EI545_19315
SEDIEBB79_22970 EBB79_23890
HMLHmaOT1_18870
PPRUFDP22_03105
PAEDG5B38_12110 G5B38_17400 G5B38_20470
RBZB9057_07560
SNJA7E77_04570
SMYBJP26_14925
SCHSphch_1857
SMICSmB9_20160
HTQFRZ44_06770 FRZ44_10820 FRZ44_23470 FRZ44_47380
HADHFRZ61_06860 FRZ61_11050 FRZ61_23740
MGOAFA91_30545
MDXBTO20_01230
MDFK0O62_08600
MVQMYVA_5919
MMATMMAGJ_23260
MSEIMSEDJ_15750
NYALTV02_09175
RHARHA1_ro01789
ROPROP_14630 ROP_27330
ROAPd630_LPD05948 Pd630_LPD07456
RKOJWS14_09075
GOILK459_16700
TPRTpau_0381
SPHVF9278_41870
SANUK7396_16130
LDNH9L06_06465
NCANoca_0579 Noca_0618
NAROCFH99_14995
PSIMKR76_16005
AGRAAGRA3207_001949
PHHAFB00_19150
PLKCIK06_05545
RRSRoseRS_2964
RCARcas_1934
NAYHYG81_24785
 » show all
Reference
1  [PMID:7556160]
  Authors
Yang CC, Packman LC, Scrutton NS
  Title
The primary structure of Hyphomicrobium X dimethylamine dehydrogenase. Relationship to trimethylamine dehydrogenase and implications for substrate recognition.
  Journal
Eur J Biochem 232:264-71 (1995)
DOI:10.1111/j.1432-1033.1995.tb20808.x
  Sequence
[hdn:Hden_0194]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.8.1
IUBMB Enzyme Nomenclature: 1.5.8.1
ExPASy - ENZYME nomenclature database: 1.5.8.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.5.8.1
BRENDA, the Enzyme Database: 1.5.8.1
CAS: 68247-64-3

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