KEGG   ENZYME: 1.5.98.1
Entry
EC 1.5.98.1                 Enzyme                                 
Name
methylenetetrahydromethanopterin dehydrogenase;
N5,N10-methylenetetrahydromethanopterin dehydrogenase;
5,10-methylenetetrahydromethanopterin dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With other, known, physiological acceptors
Sysname
5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Reaction(IUBMB)
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420 [RN:R04456]
Reaction(KEGG)
R04456
Substrate
5,10-methylenetetrahydromethanopterin [CPD:C04377];
oxidized coenzyme F420 [CPD:C00876]
Product
5,10-methenyltetrahydromethanopterin [CPD:C04330];
reduced coenzyme F420 [CPD:C01080]
Comment
Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin derivative; methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in the methanogen Methanothermobacter thermautotrophicus.
History
EC 1.5.98.1 created 1989 as EC 1.5.99.9, modified 2004, transferred to EC 1.5.98.1 2014
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00319  methylenetetrahydromethanopterin dehydrogenase
Genes
MJAMJ_1035
MFEMefer_1257
MVUMetvu_0302
MFSMFS40622_1652
MIFMetin_0918
MJHJH146_0907
MESGMLAUSG7_1174(mtd)
MESAMLASG1_0617(mtd)
MMPMMP0372(mtd)
MMQMmarC5_1303
MMXMmarC6_0579
MMZMmarC7_1368
MMDGYY_01920
MMAKMMKA1_03910(mtd)
MMAOMMOS7_03850(mtd)
MMADMMJJ_07050
MAEMaeo_1367
MVNMevan_1360
MVOMvol_1675
MOKMetok_0668
METFCFE53_05635
MTHMTH_1464
MMGMTBMA_c00500(mtd)
METCMTCT_1331
MWOMWSIV6_0005(mtd)
METEtca_01413
METZMETMT2_1375
METKFVF72_04285
MTHMFZP57_09025
METJFZP68_01710
MSTMsp_0163(mtd)
METBAW729_06295
MRUmru_2142(mtd)
MSIMsm_1204
MEBAbm4_0039(mtd)
MMILsm9_0086(mtd1) sm9_1352(mtd2)
MEYETL18_10280
MOLYLM1_1676
MAROMarbSA_11530
MELMetbo_0080
MEWMSWAN_0008
METHMBMB1_0003(mtd)
MFCBRM9_0042(mtd)
MFIDSM1535_1363(mtd)
MCUBMCBB_0002(mtd)
MSUBBK009_09725
METNBK008_05395
METTCIT01_05640
METOCIT02_07115
MEMEHYG87_06515
MFVMfer_0811
MKAMK0011(mtd)
AFUAF_0714
AFGAFULGI_00007960
APOArcpr_1586
AVEArcve_1338
ASTAsulf_02280
FPLFerp_1018
GACGACE_0596
GAHGAH_01690
MBAMbar_A1095
MBYMSBRM_3350
MBWMSBRW_3627
MBARMSBR2_3303
MBAKMSBR3_3304
MACMA_4430(mtd)
MMAMM_1108
MMAZMmTuc01_1147
MMJMSMAS_0195
MMACMSMAC_0200
MVCMSVAZ_0176
MEKMSKOL_0171
MLSMSLAZ_2924
METMMSMTP_0225
MEFMSWH1_0494
MEQMSWHS_0504
MSJMSSAC_4111
MSZMSSIH_3647
MSWMSSIT_3702
MTHRMSTHT_1723
MTHEMSTHC_1565
MHORMSHOH_0247
MFZAOB57_007795
MBUMbur_0929(mtd)
MMETMCMEM_1436
MELOJ7W08_05895
MMHMmah_0679
MHAZBHR79_10205
MEVMetev_1727
MZHMzhil_0239
MPYMpsy_1459
MZIHWN40_01520
MHZMetho_0243
MTPMthe_0809
MCJMCON_1052(mtd)
MHIMhar_1470
MHUMhun_2255
MRTJKHC33_15685
MLAMlab_0079
MEMMemar_0562
MBGBN140_1676(mtd)
MEMAMMAB1_2159(mtd)
MCHKMchiMG62_06880
MPIMpet_2185
MBNMboo_0530
MFOMetfor_2657
MPLMpal_0329
MPDMCP_1313(mtd)
MEZMtc_1592(mtd)
RCIRCIX2230(mtd)
MEAMMU439_04045
 » show all
Reference
1  [PMID:4084309]
  Authors
Hartzell PL, Zvilius G, Escalante-Semerena JC, Donnelly MI.
  Title
Coenzyme F420 dependence of the methylenetetrahydromethanopterin dehydrogenase of Methanobacterium thermoautotrophicum.
  Journal
Biochem Biophys Res Commun 133:884-90 (1985)
DOI:10.1016/0006-291X(85)91218-5
Reference
2  [PMID:1911853]
  Authors
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
  Journal
Biochim Biophys Acta 1079:293-302 (1991)
DOI:10.1016/0167-4838(91)90072-8
Other DBs
ExplorEnz - The Enzyme Database: 1.5.98.1
IUBMB Enzyme Nomenclature: 1.5.98.1
ExPASy - ENZYME nomenclature database: 1.5.98.1
BRENDA, the Enzyme Database: 1.5.98.1
CAS: 100357-01-5

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