KEGG   ENZYME: 1.5.98.2Help
Entry
EC 1.5.98.2                 Enzyme                                 

Name
5,10-methylenetetrahydromethanopterin reductase;
5,10-methylenetetrahydromethanopterin cyclohydrolase;
N5,N10-methylenetetrahydromethanopterin reductase;
methylene-H4MPT reductase;
coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase;
N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase
Reaction(IUBMB)
5-methyltetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420 [RN:R04464]
Reaction(KEGG)
Substrate
5-methyltetrahydromethanopterin [CPD:C04488];
oxidized coenzyme F420 [CPD:C00876]
Product
5,10-methylenetetrahydromethanopterin [CPD:C04377];
reduced coenzyme F420 [CPD:C01080]
Comment
Catalyses an intermediate step in methanogenesis from CO2 and H2 in methanogenic archaea.
History
EC 1.5.98.2 created 2000 as EC 1.5.99.11, modified 2004, transferred to EC 1.5.98.2 2014
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00320  5,10-methylenetetrahydromethanopterin reductase
Genes
PSPW: BJG93_33595
BIC: LMTR13_24555 LMTR13_24680
RPB: RPB_4431
SWI: Swit_0724
SPHD: HY78_23075
MCHI: AN480_20895
MSA: Mycsm_06803
MDX: BTO20_23080
MSM: MSMEG_2103 MSMEG_2456 MSMEG_3445
MSG: MSMEI_2056 MSMEI_2395 MSMEI_3365
MVQ: MYVA_2357
SPRI: SPRI_6783
SLE: sle_06190(sle_06190)
NCA: Noca_1630
PSIM: KR76_07600
MMAR: MODMU_5441
SESP: BN6_46520
MIL: ML5_2085
MJA: MJ_1534
MMP: MMP0058(mer)
MMD: GYY_00295
MAE: Maeo_0749
MVO: Mvol_1374
MTH: MTH_1752
MMG: MTBMA_c03270(mer)
METC: MTCT_1602
MWO: MWSIV6_0292(mer)
METE: tca_01698
MST: Msp_1128(mer)
MSI: Msm_0542
MRU: mru_0569(mer)
MEB: Abm4_1417(mer)
MMIL: sm9_0419(mer)
MEYE: TL18_02180
MOL: YLM1_0233
METH: MBMB1_1520(mer)
MFC: BRM9_0745(mer)
MFI: DSM1535_0704(mer)
MCUB: MCBB_1769(mer)
METT: CIT01_07510(mer)
METO: CIT02_10410(mer)
MFV: Mfer_0274
MKA: MK0524(mer)
AFU: AF_1066
FPL: Ferp_0743
GAC: GACE_0389
GAH: GAH_01105
MAC: MA_3733(mer)
MBAR: MSBR2_2654
MMA: MM_0628
MMAC: MSMAC_0682
METM: MSMTP_0746
MTHE: MSTHC_0892
MTHR: MSTHT_2388
MHOR: MSHOH_0799
MFZ: AOB57_003480(mer)
MBU: Mbur_2372(mer)
MMET: MCMEM_0517
MMH: Mmah_1513
MPY: Mpsy_2035
MTP: Mthe_0205
MCJ: MCON_2394(mer)
MHI: Mhar_0856
MHU: Mhun_2257
MLA: Mlab_0076
MBG: BN140_1674(mer)
MEMA: MMAB1_2155(mer)
MPI: Mpet_2180
MBN: Mboo_0528
MPL: Mpal_0327
MPD: MCP_2681(mer)
MEZ: Mtc_0135(mer)
RCI: RCIX564(mer)
HHB: Hhub_1106(mer)
HSU: HLASF_0416(mer)
HSF: HLASA_0415(mer)
HMA: rrnAC2437(mer1)
HHI: HAH_2870(mer3)
NPH: NP_1056A(mer)
NMO: Nmlp_1133(mer)
HUT: Huta_1395
HTI: HTIA_1288
HMU: Hmuk_0341
HWA: HQ_3154A(mer)
HWC: Hqrw_3697(mer)
HVO: HVO_1937(mer)
HME: HFX_2030(mer)
HLA: Hlac_1680
HTU: Htur_3573
NMG: Nmag_1582(mer)
NAT: NJ7G_2905
SALI: L593_00135
BARC: AOA65_0782(mer_2)
 » show all
Taxonomy
Reference
1  [PMID:2379499]
  Authors
Ma K, Thauer RK.
  Title
Purification and properties of N5, N10-methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 191:187-93 (1990)
DOI:10.1111/j.1432-1033.1990.tb19109.x
  Sequence
Reference
2  [PMID:1911853]
  Authors
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD.
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
  Journal
Biochim Biophys Acta 1079:293-302 (1991)
DOI:10.1016/0167-4838(91)90072-8
Reference
3  [PMID:1696553]
  Authors
Ma K, Thauer RK.
  Title
Single step purification of methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum by specific binding to blue sepharose CL-6B.
  Journal
FEBS Lett 268:59-62 (1990)
DOI:10.1016/0014-5793(90)80972-L
Reference
4  [PMID:2298726]
  Authors
te Brommelstroet BW, Hensgens CM, Keltjens JT, van der Drift C, Vogels GD.
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin reductase, a coenzyme F420-dependent enzyme, from Methanobacterium thermoautotrophicum strain delta H.
  Journal
J Biol Chem 265:1852-7 (1990)
  Sequence
[mth:MTH_1752]
Reference
5  [PMID:2298699]
  Authors
te Brommelstroet BW, Hensgens CM, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD.
  Title
Purification and properties of 5,10-methenyltetrahydromethanopterin cyclohydrolase from Methanosarcina barkeri.
  Journal
J Bacteriol 172:564-71 (1990)
DOI:10.1128/JB.172.2.564-571.1990
Other DBs
ExplorEnz - The Enzyme Database: 1.5.98.2
IUBMB Enzyme Nomenclature: 1.5.98.2
ExPASy - ENZYME nomenclature database: 1.5.98.2
BRENDA, the Enzyme Database: 1.5.98.2

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