KEGG   ENZYME: 1.5.98.3Help
Entry
EC 1.5.98.3                 Enzyme                                 

Name
coenzyme F420:methanophenazine dehydrogenase;
F420H2 dehydrogenase;
fpoBCDIF (gene names)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
reduced coenzyme F420:methanophenazine oxidoreductase
Reaction(IUBMB)
reduced coenzyme F420 + methanophenazine = oxidized coenzyme F420 + dihydromethanophenazine [RN:R11874]
Reaction(KEGG)
Substrate
reduced coenzyme F420 [CPD:C01080];
methanophenazine [CPD:C11903]
Product
oxidized coenzyme F420 [CPD:C00876];
dihydromethanophenazine [CPD:C11904]
Comment
The enzyme, found in some methanogenic archaea, is responsible for the reoxidation of coenzyme F420, which is reduced during methanogenesis, and for the reduction of methanophenazine to dihydromethanophenazine, which is required by EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase. The enzyme is membrane-bound, and is coupled to proton translocation across the cytoplasmic membrane, generating a proton motive force that is used for ATP generation.
History
EC 1.5.98.3 created 2017
Orthology
K22158  F420H2 dehydrogenase subunit A
K22159  F420H2 dehydrogenase subunit B
K22160  F420H2 dehydrogenase subunit C
K22161  F420H2 dehydrogenase subunit D
K22162  F420H2 dehydrogenase subunit F
K22163  F420H2 dehydrogenase subunit H
K22164  F420H2 dehydrogenase subunit I
K22165  F420H2 dehydrogenase subunit J
K22166  F420H2 dehydrogenase subunit K
K22167  F420H2 dehydrogenase subunit L
K22168  F420H2 dehydrogenase subunit M
K22169  F420H2 dehydrogenase subunit N
K22170  F420H2 dehydrogenase subunit O
Genes
MIG: Metig_0286
AST: Asulf_01806 Asulf_01811
FAC: FACI_IFERC01G1647 FACI_IFERC01G1648 FACI_IFERC01G1649
FAI: FAD_0626 FAD_0627 FAD_0628
CDIV: CPM_1697 CPM_1698 CPM_1699 CPM_1700
TAR: TALC_00210 TALC_00217 TALC_00218 TALC_00219 TALC_00220
MAX: MMALV_02050 MMALV_02060
MER: MMINT_02050
MEAR: Mpt1_c12550(fpoN) Mpt1_c12560(fpoM3) Mpt1_c12570(fpoL) Mpt1_c12580(fpoK)
MARC: AR505_1622 AR505_1623 AR505_1624 AR505_1625 AR505_1633
MAC: MA_1495(fpoA) MA_1496(fpoB) MA_1497(fpoC) MA_1498(fpoD) MA_1499(fpoH) MA_1500(fpoI) MA_1501(fpoJ) MA_1502(fpoJ) MA_1503(fpoK) MA_1504(fpoL) MA_1505(fpoM) MA_1506(fpoN) MA_1507(fpoO) MA_3732(fpoF)
MMA: MM_0627 MM_2479(fpoO) MM_2480(fpoN) MM_2481(fpoM) MM_2482(fpoL) MM_2483(fpoK) MM_2484(fpoJ) MM_2485(fpoJ) MM_2486(fpoI) MM_2487(fpoH) MM_2488(fpoD) MM_2489(fpoC) MM_2490(fpoB) MM_2491(fpoA)
MCJ: MCON_2389(fpoO) MCON_3060(fpoA) MCON_3061(fpoB) MCON_3062(fpoD) MCON_3063(fpoH) MCON_3064 MCON_3067(fpoK) MCON_3068(fpoL) MCON_3069(fpoM) MCON_3070(fpoN)
NMR: Nmar_0286
NCT: NMSP_1424(fpoN)
NGA: Ngar_c11610(nuoN)
NVN: NVIE_011580(nuoN)
NEV: NTE_02549
TAA: NMY3_02152(nuoN)
NFN: NFRAN_2937(nuoN)
NCV: NCAV_0276(nuoN)
NBV: T478_1161
NDV: NDEV_1820(nuoN)
 » show all
Taxonomy
Reference
1  [PMID:9914308]
  Authors
Brodersen J, Gottschalk G, Deppenmeier U
  Title
Membrane-bound F420H2-dependent heterodisulfide reduction in methanococcus voltae
  Journal
Arch Microbiol 171:115-21 (1999)
Reference
2  [PMID:10751389]
  Authors
Baumer S, Ide T, Jacobi C, Johann A, Gottschalk G, Deppenmeier U
  Title
The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump  closely related to NADH dehydrogenases.
  Journal
J Biol Chem 275:17968-73 (2000)
DOI:10.1074/jbc.M000650200
  Sequence
Reference
3  [PMID:15168610]
  Authors
Deppenmeier U
  Title
The membrane-bound electron transport system of Methanosarcina species.
  Journal
J Bioenerg Biomembr 36:55-64 (2004)
DOI:10.1023/B:JOBB.0000019598.64642.97
Reference
4
  Authors
Abken H. J. and Deppenmeier, U.
  Title
Purification and properties of an F420H2 dehydrogenase from Methanosarcina mazei Go1.
  Journal
FEMS Microbiol Lett 154:231-237 (2006)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.98.3
IUBMB Enzyme Nomenclature: 1.5.98.3
ExPASy - ENZYME nomenclature database: 1.5.98.3
BRENDA, the Enzyme Database: 1.5.98.3

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