KEGG   ENZYME: 1.5.98.3
Entry
EC 1.5.98.3                 Enzyme                                 

Name
coenzyme F420:methanophenazine dehydrogenase;
F420H2 dehydrogenase;
fpoBCDIF (gene names)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With other, known, physiological acceptors
Sysname
reduced coenzyme F420:methanophenazine oxidoreductase
Reaction(IUBMB)
reduced coenzyme F420 + methanophenazine = oxidized coenzyme F420 + dihydromethanophenazine [RN:R11874]
Reaction(KEGG)
R11874
Substrate
reduced coenzyme F420 [CPD:C01080];
methanophenazine [CPD:C11903]
Product
oxidized coenzyme F420 [CPD:C00876];
dihydromethanophenazine [CPD:C11904]
Comment
The enzyme, found in some methanogenic archaea, is responsible for the reoxidation of coenzyme F420, which is reduced during methanogenesis, and for the reduction of methanophenazine to dihydromethanophenazine, which is required by EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase. The enzyme is membrane-bound, and is coupled to proton translocation across the cytoplasmic membrane, generating a proton motive force that is used for ATP generation.
History
EC 1.5.98.3 created 2017
Orthology
K22158  F420H2 dehydrogenase subunit A
K22159  F420H2 dehydrogenase subunit B
K22160  F420H2 dehydrogenase subunit C
K22161  F420H2 dehydrogenase subunit D
K22162  F420H2 dehydrogenase subunit F
K22163  F420H2 dehydrogenase subunit H
K22164  F420H2 dehydrogenase subunit I
K22165  F420H2 dehydrogenase subunit J
K22166  F420H2 dehydrogenase subunit K
K22167  F420H2 dehydrogenase subunit L
K22168  F420H2 dehydrogenase subunit M
K22169  F420H2 dehydrogenase subunit N
K22170  F420H2 dehydrogenase subunit O
Genes
NAM: NAMH_1414 NAMH_1422
NAP: C3L23_07410 C3L23_07450
CMED: FE773_02885 FE773_02925
CPAF: C6V80_07790
DDN: DND132_0834
DFL: DFE_0149(nuoN)
DAF: Desaf_1615
DPI: BN4_10802(nuoN)
DEJ: AWY79_10085
PPRF: DPRO_0779(nuoN)
FPA: FPR_19390
ATM: ANT_22070
MFV: Mfer_0629
MEAR: Mpt1_c12550(fpoN) Mpt1_c12560(fpoM3) Mpt1_c12570(fpoL) Mpt1_c12580(fpoK) Mpt1_c12600(fpoJ)
MAC: MA_1495(fpoA) MA_1496(fpoB) MA_1497(fpoC) MA_1498(fpoD) MA_1499(fpoH) MA_1500(fpoI) MA_1501(fpoJ) MA_1502(fpoJ) MA_1503(fpoK) MA_1504(fpoL) MA_1505(fpoM) MA_1506(fpoN) MA_1507(fpoO) MA_1509(fpoO) MA_3732(fpoF)
MMA: MM_0627 MM_2479(fpoO) MM_2480(fpoN) MM_2481(fpoM) MM_2482(fpoL) MM_2483(fpoK) MM_2484(fpoJ) MM_2485(fpoJ) MM_2486(fpoI) MM_2487(fpoH) MM_2488(fpoD) MM_2489(fpoC) MM_2490(fpoB) MM_2491(fpoA)
MCJ: MCON_2389(fpoO) MCON_3060(fpoA) MCON_3061(fpoB) MCON_3062(fpoD) MCON_3063(fpoH) MCON_3064 MCON_3067(fpoK) MCON_3068(fpoL) MCON_3069(fpoM) MCON_3070(fpoN)
MLA: Mlab_0961
HSL: OE_1967F(nuoN)
HALH: HTSR_1171
HHSR: HSR6_1206(nuoN)
HUT: Huta_2223
HTI: HTIA_2023
HME: HFX_0986(nuoN)
DKA: DKAM_0953
TAG: Tagg_1028
NMR: Nmar_0286
NCT: NMSP_1424(fpoN)
NGA: Ngar_c11610(nuoN)
NVN: NVIE_011580(nuoN)
NEV: NTE_02549
TAA: NMY3_02152(nuoN)
NFN: NFRAN_2937(nuoN)
NCV: NCAV_0276(nuoN)
NBV: T478_1161
NDV: NDEV_1820(nuoN)
KCR: Kcr_0146
 » show all
Reference
1  [PMID:9914308]
  Authors
Brodersen J, Gottschalk G, Deppenmeier U
  Title
Membrane-bound F420H2-dependent heterodisulfide reduction in methanococcus voltae
  Journal
Arch Microbiol 171:115-21 (1999)
DOI:10.1007/s002030050686
Reference
2  [PMID:10751389]
  Authors
Baumer S, Ide T, Jacobi C, Johann A, Gottschalk G, Deppenmeier U
  Title
The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump  closely related to NADH dehydrogenases.
  Journal
J Biol Chem 275:17968-73 (2000)
DOI:10.1074/jbc.M000650200
  Sequence
Reference
3  [PMID:15168610]
  Authors
Deppenmeier U
  Title
The membrane-bound electron transport system of Methanosarcina species.
  Journal
J Bioenerg Biomembr 36:55-64 (2004)
DOI:10.1023/B:JOBB.0000019598.64642.97
Reference
4
  Authors
Abken H. J. and Deppenmeier, U.
  Title
Purification and properties of an F420H2 dehydrogenase from Methanosarcina mazei Go1.
  Journal
FEMS Microbiol Lett 154:231-237 (2006)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.98.3
IUBMB Enzyme Nomenclature: 1.5.98.3
ExPASy - ENZYME nomenclature database: 1.5.98.3
BRENDA, the Enzyme Database: 1.5.98.3

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