KEGG   ENZYME: 1.5.98.3
Entry
EC 1.5.98.3                 Enzyme                                 

Name
coenzyme F420:methanophenazine dehydrogenase;
F420H2 dehydrogenase;
fpoBCDIF (gene names)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With other, known, physiological acceptors
Sysname
reduced coenzyme F420:methanophenazine oxidoreductase
Reaction(IUBMB)
reduced coenzyme F420 + methanophenazine = oxidized coenzyme F420 + dihydromethanophenazine [RN:R11874]
Reaction(KEGG)
R11874
Substrate
reduced coenzyme F420 [CPD:C01080];
methanophenazine [CPD:C11903]
Product
oxidized coenzyme F420 [CPD:C00876];
dihydromethanophenazine [CPD:C11904]
Comment
The enzyme, found in some methanogenic archaea, is responsible for the reoxidation of coenzyme F420, which is reduced during methanogenesis, and for the reduction of methanophenazine to dihydromethanophenazine, which is required by EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase. The enzyme is membrane-bound, and is coupled to proton translocation across the cytoplasmic membrane, generating a proton motive force that is used for ATP generation.
History
EC 1.5.98.3 created 2017
Orthology
K22158  F420H2 dehydrogenase subunit A
K22159  F420H2 dehydrogenase subunit B
K22160  F420H2 dehydrogenase subunit C
K22161  F420H2 dehydrogenase subunit D
K22162  F420H2 dehydrogenase subunit F
K22163  F420H2 dehydrogenase subunit H
K22164  F420H2 dehydrogenase subunit I
K22165  F420H2 dehydrogenase subunit J
K22166  F420H2 dehydrogenase subunit K
K22167  F420H2 dehydrogenase subunit L
K22168  F420H2 dehydrogenase subunit M
K22169  F420H2 dehydrogenase subunit N
K22170  F420H2 dehydrogenase subunit O
Genes
MBA: Mbar_A0255 Mbar_A3400 Mbar_A3401 Mbar_A3402 Mbar_A3403 Mbar_A3404 Mbar_A3405 Mbar_A3406 Mbar_A3407 Mbar_A3408 Mbar_A3409 Mbar_A3410 Mbar_A3411 Mbar_A3412
MBY: MSBRM_1550 MSBRM_1551 MSBRM_1552 MSBRM_1553 MSBRM_1554 MSBRM_1555 MSBRM_1556 MSBRM_1557 MSBRM_1558 MSBRM_1559 MSBRM_1560 MSBRM_1561 MSBRM_1562 MSBRM_2697
MBW: MSBRW_0740 MSBRW_1322 MSBRW_1323 MSBRW_1324 MSBRW_1325 MSBRW_1326 MSBRW_1327 MSBRW_1328 MSBRW_1329 MSBRW_1330 MSBRW_1331 MSBRW_1332 MSBRW_1333 MSBRW_1334
MBAR: MSBR2_0847 MSBR2_0848 MSBR2_0849 MSBR2_0850 MSBR2_0851 MSBR2_0852 MSBR2_0853 MSBR2_0854 MSBR2_0855 MSBR2_0856 MSBR2_0857 MSBR2_0858 MSBR2_0859 MSBR2_2653
MBAK: MSBR3_1273 MSBR3_1275 MSBR3_1276 MSBR3_1277 MSBR3_1278 MSBR3_1279 MSBR3_1280 MSBR3_1281 MSBR3_1282 MSBR3_1283 MSBR3_1284 MSBR3_1285 MSBR3_1286 MSBR3_1287 MSBR3_2772
MAC: MA_1495(fpoA) MA_1496(fpoB) MA_1497(fpoC) MA_1498(fpoD) MA_1499(fpoH) MA_1500(fpoI) MA_1501(fpoJ) MA_1502(fpoJ) MA_1503(fpoK) MA_1504(fpoL) MA_1505(fpoM) MA_1506(fpoN) MA_1507(fpoO) MA_1509(fpoO) MA_3732(fpoF)
MMA: MM_0627 MM_2479(fpoO) MM_2480(fpoN) MM_2481(fpoM) MM_2482(fpoL) MM_2483(fpoK) MM_2484(fpoJ) MM_2485(fpoJ) MM_2486(fpoI) MM_2487(fpoH) MM_2488(fpoD) MM_2489(fpoC) MM_2490(fpoB) MM_2491(fpoA)
MMAZ: MmTuc01_0640 MmTuc01_2530 MmTuc01_2531 MmTuc01_2532 MmTuc01_2533 MmTuc01_2534 MmTuc01_2535 MmTuc01_2536 MmTuc01_2537 MmTuc01_2541
MMJ: MSMAS_0682 MSMAS_2211 MSMAS_2212 MSMAS_2213 MSMAS_2214 MSMAS_2215 MSMAS_2216 MSMAS_2217 MSMAS_2218 MSMAS_2219 MSMAS_2220 MSMAS_2221 MSMAS_2222 MSMAS_2223
MMAC: MSMAC_0683 MSMAC_2231 MSMAC_2232 MSMAC_2233 MSMAC_2234 MSMAC_2235 MSMAC_2236 MSMAC_2237 MSMAC_2238 MSMAC_2239 MSMAC_2240 MSMAC_2241 MSMAC_2242 MSMAC_2243
MCJ: MCON_2389(fpoO) MCON_3060(fpoA) MCON_3061(fpoB) MCON_3062(fpoD) MCON_3063(fpoH) MCON_3064 MCON_3067(fpoK) MCON_3068(fpoL) MCON_3069(fpoM) MCON_3070(fpoN)
 » show all
Reference
1  [PMID:9914308]
  Authors
Brodersen J, Gottschalk G, Deppenmeier U
  Title
Membrane-bound F420H2-dependent heterodisulfide reduction in methanococcus voltae
  Journal
Arch Microbiol 171:115-21 (1999)
DOI:10.1007/s002030050686
Reference
2  [PMID:10751389]
  Authors
Baumer S, Ide T, Jacobi C, Johann A, Gottschalk G, Deppenmeier U
  Title
The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases.
  Journal
J Biol Chem 275:17968-73 (2000)
DOI:10.1074/jbc.M000650200
  Sequence
Reference
3  [PMID:15168610]
  Authors
Deppenmeier U
  Title
The membrane-bound electron transport system of Methanosarcina species.
  Journal
J Bioenerg Biomembr 36:55-64 (2004)
DOI:10.1023/B:JOBB.0000019598.64642.97
Reference
4
  Authors
Abken H. J. and Deppenmeier, U.
  Title
Purification and properties of an F420H2 dehydrogenase from Methanosarcina mazei Go1.
  Journal
FEMS Microbiol Lett 154:231-237 (2006)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.98.3
IUBMB Enzyme Nomenclature: 1.5.98.3
ExPASy - ENZYME nomenclature database: 1.5.98.3
BRENDA, the Enzyme Database: 1.5.98.3

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