KEGG   ENZYME: 1.5.99.16
Entry
EC 1.5.99.16                Enzyme                                 
Name
2-(methylaminoethyl)phosphonate dehydrogenase (acceptor);
pbfC (gene name);
N-methyl-2-aminoethylphosphonate dehydrogenase (acceptor)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With unknown physiological acceptors
Sysname
2-(methylaminoethyl)phosphonate:acceptor oxidoreductase (phosphonoacetaldehyde-forming)
Reaction(IUBMB)
2-(methylaminoethyl)phosphonate + acceptor + H2O = phosphonoacetaldehyde + methylamine + reduced acceptor [RN:R13438]
Reaction(KEGG)
R13438
Substrate
2-methylaminoethylphosphonate [CPD:C05679];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product
phosphonoacetaldehyde [CPD:C03167];
methylamine [CPD:C00218];
reduced acceptor [CPD:C00030]
Comment
Contains FAD. The enzyme from the bacterium Azospirillum sp. B510 reacts about tenfold less efficiently with 2-(ethylaminoethyl)phosphonate and about 400-fold less efficiently with (2-aminoethyl)phosphonate. Oxygen is used poorly as an electron acceptor (at least 50-fold less efficiently than the artificial acceptor DCPIP). The physiological electron acceptor is unknown.
History
EC 1.5.99.16 created 2024
Pathway
ec00440  Phosphonate and phosphinate metabolism
Orthology
K28018  2-(methylaminoethyl)phosphonate dehydrogenase (acceptor)
Genes
MHC: MARHY1152
MARJ: MARI_09730(abo)
MRX: MspRI1_29330
MACA: J2887_03925
HCH: HCH_03082
HAHE: ENC22_15820
HAHH: O5O45_11120
TWAN: HUF19_06260
OAI: OLEAN_C33630
MSEC: LN244_10425
BACZ: KFF03_11595
OME: OLMES_3997
RGE: RGE_31450
DDEN: KI615_17820
AHV: AADV58_05040
SHUM: STHU_17800
SVC: STVA_16530
AZL: AZL_a10470
ATI: AL072_19345
AZZ: DEW08_01185
AZP: E6C67_12660
DEX: HWD60_11405
PCOP: I6J50_13810
PCLR: PC1C4_15260
PSTY: BFS30_02915
PCEA: J3359_00695
LUT: Lupro_02580
AALG: AREALGSMS7_02101(abo)
 » show all
Reference
1  [PMID:37876809]
  Authors
Zangelmi E, Ruffolo F, Dinhof T, Gerdol M, Malatesta M, Chin JP, Rivetti C, Secchi A, Pallitsch K, Peracchi A.
  Title
Deciphering the role of recurrent FAD-dependent enzymes in bacterial phosphonate catabolism.
  Journal
iScience 26:108108 (2023)
DOI:10.1016/j.isci.2023.108108
  Sequence
[azl:AZL_a10470]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.99.16
IUBMB Enzyme Nomenclature: 1.5.99.16
ExPASy - ENZYME nomenclature database: 1.5.99.16
BRENDA, the Enzyme Database: 1.5.99.16

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