KEGG ENZYME: 1.5.99.6

ENZYME: 1.5.99.6

Entry

EC 1.5.99.6                 Enzyme

Name

spermidine dehydrogenase;
spermidine:(acceptor) oxidoreductase

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With unknown physiological acceptors

Sysname

spermidine:acceptor oxidoreductase

Reaction(IUBMB)

spermidine + acceptor + H2O = propane-1,3-diamine + 4-aminobutanal + reduced acceptor [RN:R01915]

Reaction(KEGG)

R01915 > R01914

Substrate

spermidine [CPD:C00315];
acceptor [CPD:C00028];
H2O [CPD:C00001]

Product

propane-1,3-diamine [CPD:C00986];
4-aminobutanal [CPD:C00555];
reduced acceptor [CPD:C00030]

Comment

A flavohemoprotein (FAD). Ferricyanide, 2,6-dichloroindophenol and cytochrome c can act as acceptor. 4-Aminobutanal condenses non-enzymically to 1-pyrroline.

History

EC 1.5.99.6 created 1976

Pathway

ec00330

Arginine and proline metabolism

ec00410

beta-Alanine metabolism

ec01100

Metabolic pathways

Orthology

K00316

spermidine dehydrogenase

Genes

ESA:

ESA_01921

CSK:

ES15_2077

CSZ:	CSSP291_09175

CSJ:	CSK29544_03197

CCON:

AFK62_09295

CDM:	AFK67_09545

CSI:	P262_03032

CMJ:	AFK66_010080

CUI:	AFK65_09710

CMW:	AFK63_09185

CTU:

CTU_20670

KMI:	VW41_06525

CFD:	CFNIH1_17015

CBRA:

A6J81_03215

CWE:	CO701_11225

CYO:	CD187_13100

CPOT:

FOB25_00845

CFQ:	C2U38_13050

CIF:	AL515_11225

CIE:	AN232_18840

CPAR:

CUC49_06850

CITZ:

E4Z61_04215

CARS:

E1B03_12350

CIX:	M4I31_12815

CIB:	HF677_012770

CITR:

GUC46_12825

CNT:	JT31_18855

CEM:	LH23_22070

CEN:	LH86_20635

CLAP:

NCTC11466_01225

BUF:	D8682_04225

BAGE:

BADSM9389_18700

BFT:	MNO13_11265

BSEL:

RHD99_10420

ASUB:

NLZ15_10725

YRE:	HEC60_20590

EBB:

F652_44

YRU:

BD65_631

YRB:	UGYR_03390

SMAR:

SM39_3239

SMAC:

SMDB11_3029

SMW:	SMWW4_v1c37420

SPE:

Spro_3641

SRL:	SOD_c35700

SRY:	M621_19320

SPLY:

Q5A_019235

SLQ:	M495_18730

SERF:

L085_09905

SERS:

SERRSCBI_18220

SFW:	WN53_00860

SQU:	E4343_22530

SFJ:	SAMEA4384070_3751

SSUR:

ATE40_015340

SURI:

J0X03_05190

SENP:

KHA73_18255

SNEM:

NLX84_18775

SNEV:

OI978_13460

SGRI:

SGBXF1_03706

SSAR:

SSARUM_003624

SERB:

QEP77_03700

SFO:	Z042_05125

ROX:	BV494_20915

RBON:

QNM34_04035

RIU:	I2123_06005

GQU:	AWC35_17565

EAME:

GXP68_03285

EBI:

EbC_23290

EPE:	CI789_01390

EGE:	EM595_p0027

PGZ:	C2E15_08835

MINT:

C7M51_01023

MTHI:

C7M52_01792

TATU:

EFZ10_07355

HAV:	AT03_05255

HPAR:

AL518_00355

OPO:	DSM2777_21160

PFQ:	QQ39_09650

POJ:	PtoMrB4_28930(spdH)

PAE:	PA3713(spdH)

PAEV:

N297_3837

PAEI:

N296_3837

PAU:	PA14_16360

PAG:	PLES_12691(spdH)

PAF:	PAM18_1233(spdH)

PNC:	NCGM2_4844

PAEB:

NCGM1900_2563

PDK:	PADK2_05775

PSG:	G655_06230

PRP:	M062_19630

PAEP:

PA1S_06530

PAER:

PA1R_gp1570

PAEM:

U769_06320

PAEL:

T223_06255

PAES:

SCV20265_1296

PAEU:

BN889_04106(spdH)

PAEG:

AI22_27060

PAEC:

M802_3834

PAEO:

M801_3702

SECH:

B18_01550

PMUI:

G4G71_25135

PNT:	G5B91_08860

PAP:	PSPA7_1422

PPAA:

B7D75_06585

PPG:	PputGB1_3728

PFS:

PFLU_1208

PTV:	AA957_08055

PAZO:

AYR47_13255

PRX:	HRH33_06865

PMAB:

U0037_06055

PFW:	PF1751_v1c11590

PFF:	PFLUOLIPICF702315

PFX:	A7318_05275

PPUU:

PputUW4_01030(spdH)

PALK:

PSAKL28_41610

PYM:	AK972_4779

PDW:

BV82_0475

PVW:	HU752_006640

PTRT:

HU722_0007120

PAZE:

KSS91_06010

PTK:	EXN22_07135

PTW:	TUM18999_47690(spdH)

PPEG:

KUA23_06130

PSOA:

PSm6_08250(spdH)

PKJ:	Q1W70_05075

PTRL:

OU419_21735

PSNC:

C0058_05905

PQE:	OSC50_18350

PDEN:

F1C79_00870

MBOI:

DQF64_00025

TPSY:

RGQ13_00230 RGQ13_17990 RGQ13_18075 RGQ13_19005

SAGA:

M5M_17030

OSG:	BST96_02515 BST96_02685 BST96_02705 BST96_02735

HJA:	BST95_16350

KIM:	G3T16_03345 G3T16_16705

PAQM:

E0F26_01080 E0F26_01100 E0F26_07190

WOC:	BA177_01660 BA177_01665 BA177_13505

HPIS:

P1P91_03360

APAC:

S7S_17560

AHA:

AHA_2947

AHY:	AHML_15920

AHD:	AI20_04690

AHR:	V428_16455

AHP:	V429_16490

AHJ:	V469_06805

AHH:	RY45_15220

AHI:	VU14_06940

AAJ:	BOQ57_15110

ASA:

ASA_2962

AEO:	O23A_p2232

AVR:

B565_1361

AVO:	AMS64_12895

ASR:	WL1483_2823

ADH:	CK627_11060

AEM:	CK911_03865

AALL:

I6G90_08425

AJD:	I6H43_18500

AEJ:	E5E97_20305

ABES:

IU367_06780

WCN:	PE074_02525

GPB:	HDN1F_23230

NWE:	SAMEA3174300_1695

NEK:	CGZ77_00665

NZL:	D0T92_08035

NZO:	SAMEA4504057_0868

NCI:	NCTC10296_00057

NANI:

NCTC12227_00500

NWD:	H3L96_00440

NMUS:

H7A79_0450

NDN:	H3L92_04715

NDU:	LVJ88_03355

KKI:	KKKWG1_1549

KOA:	H3L93_02660

ACRS:

LVJ80_14620

CSTE:

H3L98_04890

CKH:	LVJ77_10400

WBO:	MIS45_06955

CVI:

CV_3055

CVC:	BKX93_05980

CHRO:

CXB49_06230

CHRI:

DK842_22320

CHRB:

DK843_05095

AQS:	DKK66_16065

IFL:	C1H71_04215

RPJ:	N234_07935

REH:	H16_A1592(h16_A1592)

CNC:	CNE_1c16180

CUH:	BJN34_08095

REU:	Reut_A1454

RME:

Rmet_1600

CTI:	RALTA_A1519

CBW:	RR42_m2171

CCUP:

BKK81_10840

CUP:	BKK80_11095

CUU:	BKK79_01740

CPAU:

EHF44_13455

COX:	E0W60_17705

CCAM:

M5D45_08285

CUK:	KB879_08175

CNAN:

A2G96_11040

BOZ:	DBV39_16695

RGE:

RGE_05530

PAIS:

PFX98_11860

IDC:	LRM40_16440

AAK:	AA2016_0050

AMIS:

Amn_06780

MEDK:

QEV83_14935

BBAI:

CU048_14495

RHZ:	RHPLAN_14480

MTW:	CQW49_15740

MECQ:

MSC49_13890(spdH)

PSIN:

CAK95_13105

NOH:	G5V57_28460

CAUF:

CSW63_17680

CAUL:

KCG34_02825 KCG34_02865

NOR:	FA702_19490

NDR:	HT578_14655 HT578_14665

NCP:	U0041_18060

SWI:	Swit_1075 Swit_4617

SPHD:

HY78_02055

SABI:

PBT88_12950

SSY:

SLG_33610

SPCA:

GL174_14770

SMIC:

SmB9_04860(spdH)

ALB:	AEB_P3128 AEB_P3133

GXL:	H845_1155 H845_1156

KNA:	B0W47_06455

KEU:	S101446_00290(spdH) S101446_00291

ASZ:	ASN_2151(spdH)

ATO:	CIW82_01925

ECOG:

FIV45_11480

PAQI:

KW060_01025 KW060_09880 KW060_10635 KW060_12085

GSO:	PH603_07080

HAD:	CDV25_08495

HET:	BBW65_05035

CJI:

CJSA_1098

CJEJ:

N564_01122

CJEU:

N565_01166

CJEN:

N755_01160

CJEI:

N135_01194

CJY:	QZ67_01235

CJW:	PJ18_05730

CLA:

CLA_1077

CLR:	UPTC16701_1047

CLM:	UPTC16712_1077

CLQ:	UPTC4110_1056

CLN:	UPTC3659_1290

CLL:	CONCH_1031

CIS:

CINS_1041

CVO:

CVOL_1051

CPEL:

CPEL_1181

CAMR:

CAQ16704_1066

CSM:	CSUB8521_1242

CSF:	CSUB8523_1348

COJ:

CORN_1144

CARM:

CARM_1095

CNV:	CNZW441b_1018

ALAN:

ALANTH_2065

SBF:	JCM31447_18670

PIJ:	QEJ31_01180 QEJ31_05860

SAQI:

AXG55_09350 AXG55_13155

BPIT:

BPIT_32260

ABA:	Acid345_0574 Acid345_1633

ABAS:

ACPOL_3784 ACPOL_4884

GBA:	J421_5243 J421_5945

NJA:

NSJP_0330

NGV:	CDO52_10945

SPIQ:

OHA34_33390

SRO:

Sros_0365

NOA:	BKM31_44155

NCX:	Nocox_01175

NGN:	LCN96_01240

NFS:	OIE67_48930

MCRA:

ID554_28120

VER:	HUT12_18865

MSV:	Mesil_3083

» show all

Reference

1 [PMID:4918845]

Authors

Tabor CW, Kellogg PD.

Title

Identification of flavin adenine dinucleotide and heme in a homogeneous spermidine dehydrogenase from Serratia marcescens.

Journal

J Biol Chem 245:5424-33 (1970)

Reference

Authors

Tabor H, Tabor CW.

Title

Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. IIE2a Speridine dehydrogenase.

Journal

Adv Enzymol Relat Areas Mol Biol 36:225-226 (1972)

Other DBs

ExplorEnz - The Enzyme Database:

1.5.99.6

IUBMB Enzyme Nomenclature:

1.5.99.6

ExPASy - ENZYME nomenclature database:

1.5.99.6

BRENDA, the Enzyme Database:

1.5.99.6

CAS:

9076-64-6

DBGET integrated database retrieval system